Molecular epidemiology and resistome analysis of multidrug-resistant ST11 Klebsiella pneumoniae strain containing multiple copies of extended-spectrum β-lactamase genes using whole-genome sequencing

New Microbiologica

Volumn 40, Issue 1, 2017, Pages 38-44

  Souza, Roshan D ^a   Pinto, Naina Adren ^a,b   Hwang, Insik ^b   Younjee, Hwang ^a,b   Cho, Young Lag ^c   Kim, Hyunsoo ^a   Yong, Dongeun ^a   Choi, Jongrak ^a   Lee, Kyungwon ^a   Chong, Yunsop ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c LegoChem Biosciences Inc   (South Korea)

Author keywords

Extended spectrum lactamase; Multiple parallel sequencing; ST11

Indexed keywords

ANTIINFECTIVE AGENT; BETA LACTAMASE;

BACTERIAL GENOME; DRUG EFFECTS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN; KLEBSIELLA PNEUMONIAE; MOLECULAR EPIDEMIOLOGY; MULTIDRUG RESISTANCE; PHYLOGENY; PROCEDURES;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENOME, BACTERIAL; GENOME-WIDE ASSOCIATION STUDY; HUMANS; KLEBSIELLA PNEUMONIAE; MOLECULAR EPIDEMIOLOGY; PHYLOGENY;

EID: 85018784995     PISSN: 11217138     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies: Workshop Summary. Institute of medicine (US) forum on Microbial Threats. Washington (DC) 2010.
2. Capobianchi M.R., Giombini E., Rozera G. (2013). Next-generation sequencing technology in clinical virology. Clin. Microbiol. Infect. 19, 1469-0691.
3. Damjanova I., Tóth A., Pászti J., Halbel V.G., Jakab M., Berta J., et al. (2008). Expansion and countrywide dissemination of ST11, ST15, and ST147 ciprofloxacin-resistant CTX-M-15-type â-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005 -The new 'MRSAs'?. J. Antimicrob. Chemother. 62, 978-985.
4. Didelot X., Bowden R., Wilson D.J., Peto T.E., Crook D.W. (2012). Transforming clinical microbiology with bacterial genome sequencing. Nat. Rev. Genet. 13, 601-612.
5. Drögemüller C., Tetens J., Sigurdsson S., Arcangelo G., Stefania T., Kerstin L.T., Tosso L. (2010). Identification of the Bovine Arachnomelia Mutation by Massively Parallel Sequencing Implicates Sulfite Oxidase (SUOX) in Bone Development. PLoS. Genet. 6, e1001079.
6. Fu Y., Zhou J., Zhou H., Yang Q., Wei Z., Yu Y., Li L. (2010). Wide dissemination of OXA-23-producing carbapenem-resistant Acinetobacter baumannii clonal complex 22 in multiple cities of China. J. Antimicrob. Chemother. 65, 644-650.
7. Hudson C.M., Bent Z.W., Meagher R.J., Williams K.P. (2014). Resistance Determinants and Mobile Genetic Elements of an NDM-1-Encoding Klebsiella pneumoniae Strain. PLoS One. 9, e99209.
8. Jennifer A.B., Ellen S.M., Kenneth S.T. (2005). AmpC Disk Test for Detection of Plasmid-Mediated AmpC â-Lactamases in Enterobacteriaceae Lacking Chromosomal AmpC â-Lactamases. J. Clin. Microbiol. 43, 3110-3113.
9. Kim J.M., Lim Y.M., Rheem I., Lee Y., Lee J.C., Seol S.Y., et al. (2005). CTX-M and SHV-12 â-lactamases are the most common extended-spectrum enzymes in clinical isolates of Escherichia coli and Klebsiella pneumoniae collected from 3 university hospitals within Korea. FEMS Microbiology letters. 245, 93-98.
10. Ko K.S., Lee J.Y., Baek J.Y., Suh J.Y., Lee M.Y., Choi J.Y., et al. (2010) Predominance of an ST11 extended-spectrum â-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea. J. med. Microbiol. 59, 822-828.
11. Laxminarayan R, Bhutta Z, Duse A., Jenkins P., O'Brien T., Okeke N.I. et al. (2006). Drug resistance. In: Jamison D.T., Breman J.G., Measham A.R., et al. ed. Disease Control Priorities in Developing Countries. 2nd edition. Washington(DC): World Bank.
12. Li J.J., Sheng Z.K., Deng M., Bi S., Hu F.S., Miao H.F. et al. (2012). Epidemic of Klebsiella pneumoniae ST11 clone coproducing KPC-2 and 16S rRNA methylase RmtB in a chinese university hospital. BMC. Infect. Dis. 12, 373.
13. Liu P., Li P., Jiang X., Bi D., Xie Y., Tai C., et al. (2012). Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae HS11286, a multidrug-resistant strain isolated from human sputum. J. Bacteriol. 194, 1841-1842.
14. Mohanty S., Gaind R., Ranjan R., Deb M. (2009). Use of the cefepime-clavulanate ESBL Etest for detection of extended-spectrum beta-lactamases in AmpC co-producing bacteria. J Infect. Dev. Ctries. 4, 24-29.
15. Shahid M., Malik A., Agarwal M., Singhal S. (2004). Phenotypic detection of extended-spectrum and AmpC â-lactamases by a new spot-inoculation method and modified three-dimensional extract test: Comparison with the conventional three-dimensional extract test. J. Antimicrob. Chemother. 54, 684-687.
16. Tóth A., Damjanova I., Puskás E., Jánvári L., Farkas M., Dobák A., et al. (2010) Emergence of a colistin-resistant KPC-2-producing Klebsiella pneumoniae ST258 clone in Hungary. Eur. J. Clin. Microbiol. Infect. Dis. 29, 765-769.
17. Willems R.J., Top J., van S.M., Robinson D.A., Coque T.M., Baquero F., et al. (2005). Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex. Emerg. Infect. Dis. 11, 821-828.
18. Woloj M., Tolmasky M.E., Roberts M.C., Crosa J.H. (1986). Plasmid-encoded amikacin resistance in multiresistant strains of Klebsiella pneumoniae isolated from neonates with meningitis. Antimicrob. Agents. Chemother. 29, 315-313.
19. Zhu J., Jiang R., Wu J. (2013). Comparative genomics analysis of aminoglycoside resistance in multi-drug resistant Klebsiella pneumoniae JM45 isolate. Chinese Journal of Infec. Dis. 6, 327-333.