Theory and Fact: Revisiting Association and Causation

JACC: Heart Failure

Volumn 5, Issue 5, 2017, Pages 327-328

  Gottlieb, Stephen S ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

biomarkers; endothelin; endothelin antagonists; prognosis

Indexed keywords

BIOLOGICAL MARKER; BOSENTAN; ENDOTHELIN 1; PLACEBO; ANTIHYPERTENSIVE AGENT; ENDOTHELIN RECEPTOR ANTAGONIST;

ADRENERGIC SYSTEM; BLOOD PRESSURE; CARDIAC MUSCLE CELL; CARDIOVASCULAR MORTALITY; CORONARY ARTERY BLOOD FLOW; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DRUG EFFICACY; DRUG TOLERABILITY; EDITORIAL; EXPERIMENTAL AUTOIMMUNE MYOCARDITIS; FLUID RETENTION; HEART FAILURE; HEART HEMODYNAMICS; HIGH RISK PATIENT; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; HYPOTENSION; KIDNEY CORTEX; KIDNEY PROXIMAL TUBULE; NONHUMAN; OBESITY; OUTCOME ASSESSMENT; PREDICTION; PROGNOSIS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANTIHYPERTENSIVE AGENTS; ENDOTHELIN RECEPTOR ANTAGONISTS; HEART FAILURE; HUMANS;

EID: 85018678907     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2017.03.005     Document Type: Editorial

References (6)

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3. 3 Van Beneden, R., Gurné, O., Selvais, P.L., et al. Superiority of big endothelin-1 and endothelin-1 over natriuretic peptides in predicting survival in severe congestive heart failure: a 7-year follow-up study. J Card Fail 10 (2004), 490–495.
4. 4 Masson, S., Latini, R., Anand, I.S., et al. The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in Valsartan Heart Failure Trial (Val-HeFT). J Card Fail 12 (2006), 375–380.
5. 5 Gottlieb, S.S., Harris, K., Todd, J., et al. Prognostic significance of active and modified forms of endothelin 1 in patients with heart failure with reduced ejection fraction. Clin Biochem 48 (2014), 292–296.
6. 6 Packer, M., McMurray, J.J.V., Krum, H., et al. Long-term effect of endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with severe chronic heart failure: primary results of the ENABLE trials. J Am Coll Cardiol HF 5 (2017), 317–326.