메뉴 건너뛰기




Volumn 49, Issue 7, 2017, Pages 731-741

Treatment of Hepatitis C virus infection in Italy: A consensus report from an expert panel

(34)  Viganò, Mauro a   Perno, Carlo Federico d   Craxì, Antonio i   Aghemo, Alessio a   Alberti, Alfredo b   Andreone, Pietro c   Andreoni, Massimo d   Bonora, Stefano e   Brunetto, Maurizia Rossana f   Bruno, Raffaele g   Bruno, Savino h   Calvaruso, Vincenza i   Caporaso, Nicola j   Ceccherini Silberstein, Francesca d   Cento, Valeria d   Ciancio, Alessia e   Colombatto, Piero f   Degasperi, Elisabetta a   Di Marco, Vito i   Di Perri, Giovanni e   more..


Author keywords

Antiviral treatment; Cirrhosis; Direct acting antiviral agents; Hepatitis C; RAV; Treatment failure

Indexed keywords

NONSTRUCTURAL PROTEIN 5A INHIBITOR; PEGINTERFERON; ANTIVIRUS AGENT;

EID: 85018677664     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2017.03.027     Document Type: Article
Times cited : (16)

References (62)
  • 2
    • 84920703518 scopus 로고    scopus 로고
    • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
    • GBD 2013 Mortality and Causes of Death Collaborators, Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet 385 (2015), 117–171.
    • (2015) The Lancet , vol.385 , pp. 117-171
    • GBD 2013 Mortality and Causes of Death Collaborators1
  • 3
    • 34250679750 scopus 로고    scopus 로고
    • Epidemiology of hepatitis C virus infection
    • Alter, M.J., Epidemiology of hepatitis C virus infection. World Journal of Gastroenterology 13 (2007), 2436–2441.
    • (2007) World Journal of Gastroenterology , vol.13 , pp. 2436-2441
    • Alter, M.J.1
  • 4
    • 84921060015 scopus 로고    scopus 로고
    • Global distribution and prevalence of hepatitis C virus genotypes
    • Messina, J.P., Humphreys, I., Flaxman, A., et al. Global distribution and prevalence of hepatitis C virus genotypes. Hepatology 61 (2015), 77–87.
    • (2015) Hepatology , vol.61 , pp. 77-87
    • Messina, J.P.1    Humphreys, I.2    Flaxman, A.3
  • 5
    • 84871487025 scopus 로고    scopus 로고
    • Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis
    • van der Meer, A.J., Veldt, B.J., Feld, J.J., et al. Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis. JAMA 308 (2012), 2584–2593.
    • (2012) JAMA , vol.308 , pp. 2584-2593
    • van der Meer, A.J.1    Veldt, B.J.2    Feld, J.J.3
  • 6
    • 84940793733 scopus 로고    scopus 로고
    • Improvement of liver function parameters in advanced HCV associated liver cirrhosis by IFN-free antiviral therapies
    • Deterding, K., Hoener zu Siederdissen, C., Port, K., et al. Improvement of liver function parameters in advanced HCV associated liver cirrhosis by IFN-free antiviral therapies. Alimentary Pharmacology Therapeutics 42 (2015), 889–901.
    • (2015) Alimentary Pharmacology Therapeutics , vol.42 , pp. 889-901
    • Deterding, K.1    Hoener zu Siederdissen, C.2    Port, K.3
  • 7
    • 85071055984 scopus 로고    scopus 로고
    • A randomized phase 3 trial of Sofosbuvir/Velpatasvir/Voxilaprevir for 8 weeks compared to Sofosbuvir/Velpatasvir for 12 weeks in DAA-naïve genotype 1–6 HCV infected patients: the POLARIS-2 study
    • [Abstract LB12]
    • Jacobson, I.M., Asselah, T., Nahass, R., et al. A randomized phase 3 trial of Sofosbuvir/Velpatasvir/Voxilaprevir for 8 weeks compared to Sofosbuvir/Velpatasvir for 12 weeks in DAA-naïve genotype 1–6 HCV infected patients: the POLARIS-2 study. Hepatology, 64(Suppl. S1), 2016 [Abstract LB12].
    • (2016) Hepatology , vol.64
    • Jacobson, I.M.1    Asselah, T.2    Nahass, R.3
  • 8
    • 85014530126 scopus 로고    scopus 로고
    • A randomized, controlled, phase 3 trial of Sofosbuvir/Velpatasvir/Voxilaprevir or Sofosbuvir/Velpatasvir for 12 weeks in direct-acting antiviral-experienced patients with genotype 1–6 HCV infection: the POLARIS-4 study
    • [Abstract 109]
    • Zeuzem, S., Flamm, S.L., Tong, M., et al. A randomized, controlled, phase 3 trial of Sofosbuvir/Velpatasvir/Voxilaprevir or Sofosbuvir/Velpatasvir for 12 weeks in direct-acting antiviral-experienced patients with genotype 1–6 HCV infection: the POLARIS-4 study. Hepatology, 64(Suppl. S1), 2016 [Abstract 109].
    • (2016) Hepatology , vol.64
    • Zeuzem, S.1    Flamm, S.L.2    Tong, M.3
  • 9
    • 85026401303 scopus 로고    scopus 로고
    • ENDURANCE-1: a phase 3 evaluation of the efficacy and safety of 8- versus 12-week treatment with Glecaprevir/Pibrentasvir (formerly ABT-493/ABT-530) in HCV genotype 1 infected patients with or without HIV-1 co-infection and without cirrhosis
    • [Abstract 253]
    • Zeuzem, S., Feld, J., Wang, S., et al. ENDURANCE-1: a phase 3 evaluation of the efficacy and safety of 8- versus 12-week treatment with Glecaprevir/Pibrentasvir (formerly ABT-493/ABT-530) in HCV genotype 1 infected patients with or without HIV-1 co-infection and without cirrhosis. Hepatology, 64(Suppl. S1), 2016 [Abstract 253].
    • (2016) Hepatology , vol.64
    • Zeuzem, S.1    Feld, J.2    Wang, S.3
  • 10
    • 85029747848 scopus 로고    scopus 로고
    • ENDURANCE-4: efficacy and safety of Glecaprevir/Pibrentasvir (Formerly ABT-493/ABT-530) treatment in patients with chronic HCV genotype 4, 5, or 6 infection
    • [Abstract 114]
    • Asselah, T., Hezode, Zadeikis, N., et al. ENDURANCE-4: efficacy and safety of Glecaprevir/Pibrentasvir (Formerly ABT-493/ABT-530) treatment in patients with chronic HCV genotype 4, 5, or 6 infection. Hepatology, 64(Suppl. S1), 2016 [Abstract 114].
    • (2016) Hepatology , vol.64
    • Asselah, T.1    Hezode2    Zadeikis, N.3
  • 11
    • 85041416047 scopus 로고    scopus 로고
    • ENDURANCE-2: safety and efficacy of Glecaprevir/Pibrentasvir in hepatitis C virus genotype 2-infected patients without cirrhosis: a randomized, double-blind, placebo-controlled study
    • [Abstract 73]
    • Kowdley, K.V., Colombo, M., Zadeikis, N., et al. ENDURANCE-2: safety and efficacy of Glecaprevir/Pibrentasvir in hepatitis C virus genotype 2-infected patients without cirrhosis: a randomized, double-blind, placebo-controlled study. Hepatology(Suppl. S1), 2016, 64 [Abstract 73].
    • (2016) Hepatology , pp. 64
    • Kowdley, K.V.1    Colombo, M.2    Zadeikis, N.3
  • 12
    • 85026357463 scopus 로고    scopus 로고
    • SURVEYOR-II, part 3: efficacy and safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in patients with hepatitis C virus genotype 3 infection with prior treatment experience and/or cirrhosis
    • [Abstract 113]
    • Wyles, D., Poordad, F., Wang, S., et al. SURVEYOR-II, part 3: efficacy and safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in patients with hepatitis C virus genotype 3 infection with prior treatment experience and/or cirrhosis. Hepatology, 64(Suppl. S1), 2016 [Abstract 113].
    • (2016) Hepatology , vol.64
    • Wyles, D.1    Poordad, F.2    Wang, S.3
  • 13
    • 85012252771 scopus 로고    scopus 로고
    • EXPEDITION-4: efficacy and safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in patients with renal impairment and chronic hepatitis C virus genotype 1–6 infection
    • [Abstract LB11]
    • Gane, E., Lawitz, E., Pugatch, D., et al. EXPEDITION-4: efficacy and safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in patients with renal impairment and chronic hepatitis C virus genotype 1–6 infection. Hepatology, 64(Suppl. S1), 2016 [Abstract LB11].
    • (2016) Hepatology , vol.64
    • Gane, E.1    Lawitz, E.2    Pugatch, D.3
  • 14
    • 85017498388 scopus 로고    scopus 로고
    • Safety and efficacy of the fixed-dose combination regimen of MK-3682/Grazoprevir/MK-8408 (Ruzasvir) with or without ribavirin in non-cirrhotic or cirrhotic patients with chronic HCV GT1, 2 or 3 infection (Part B of C-CREST-1 & -2)
    • [Abstract 110]
    • Lawitz, E., Yoshida, E.M., Buti, M., et al. Safety and efficacy of the fixed-dose combination regimen of MK-3682/Grazoprevir/MK-8408 (Ruzasvir) with or without ribavirin in non-cirrhotic or cirrhotic patients with chronic HCV GT1, 2 or 3 infection (Part B of C-CREST-1 & -2). Hepatology, 64(Suppl. S1), 2016 [Abstract 110].
    • (2016) Hepatology , vol.64
    • Lawitz, E.1    Yoshida, E.M.2    Buti, M.3
  • 15
    • 85032049682 scopus 로고    scopus 로고
    • Safety and efficacy of the fixed-dose combination regimen of MK-3682/Grazoprevir/MK-8408 (Ruzasvir) in cirrhotic or non-cirrhotic patients with chronic HCV GT1 infection who previously failed a direct-acting antiviral regimen (C-SURGE)
    • [Abstract 193]
    • Wyles, D., Wedemeyer, H., Reddy, K.R., et al. Safety and efficacy of the fixed-dose combination regimen of MK-3682/Grazoprevir/MK-8408 (Ruzasvir) in cirrhotic or non-cirrhotic patients with chronic HCV GT1 infection who previously failed a direct-acting antiviral regimen (C-SURGE). Hepatology, 64(Suppl. S1), 2016 [Abstract 193].
    • (2016) Hepatology , vol.64
    • Wyles, D.1    Wedemeyer, H.2    Reddy, K.R.3
  • 16
    • 84997285873 scopus 로고    scopus 로고
    • Recommendations on treatment of hepatitis C
    • EASL, Recommendations on treatment of hepatitis C. Journal of Hepatology 66 (2017), 153–194.
    • (2017) Journal of Hepatology , vol.66 , pp. 153-194
    • EASL1
  • 17
    • 84892619580 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection
    • Sulkowski, M.S., Gardiner, D.F., Rodriguez-Torres, M., et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. New England Journal of Medicine 370 (2014), 211–221.
    • (2014) New England Journal of Medicine , vol.370 , pp. 211-221
    • Sulkowski, M.S.1    Gardiner, D.F.2    Rodriguez-Torres, M.3
  • 18
    • 84960145908 scopus 로고    scopus 로고
    • Daclatasvir with sofosbuvir and ribavirin for hepatitis C virus infection with advanced cirrhosis or post-liver transplantation recurrence
    • Poordad, F., Schiff, E.R., Vierling, J.M., et al. Daclatasvir with sofosbuvir and ribavirin for hepatitis C virus infection with advanced cirrhosis or post-liver transplantation recurrence. Hepatology 63 (2016), 1493–1505.
    • (2016) Hepatology , vol.63 , pp. 1493-1505
    • Poordad, F.1    Schiff, E.R.2    Vierling, J.M.3
  • 19
    • 85012086800 scopus 로고    scopus 로고
    • Characterization of NS5A polymorphisms and their impact on response rates in patients with HCV genotype 2 treated with daclatasvir-based regimens
    • Zhou, N., Han, Z., Hartman-Neumann, S., et al. Characterization of NS5A polymorphisms and their impact on response rates in patients with HCV genotype 2 treated with daclatasvir-based regimens. Journal of Antimicrobial Chemotherapy 71 (2016), 3495–3505.
    • (2016) Journal of Antimicrobial Chemotherapy , vol.71 , pp. 3495-3505
    • Zhou, N.1    Han, Z.2    Hartman-Neumann, S.3
  • 20
    • 84979556503 scopus 로고    scopus 로고
    • The combination of daclatasvir and sofosbuvir for curing genotype 2 patients who cannot tolerate ribavirin
    • Mangia, A., Arleo, A., Copetti, M., et al. The combination of daclatasvir and sofosbuvir for curing genotype 2 patients who cannot tolerate ribavirin. Liver International 36 (2016), 971–976.
    • (2016) Liver International , vol.36 , pp. 971-976
    • Mangia, A.1    Arleo, A.2    Copetti, M.3
  • 21
    • 85020895855 scopus 로고    scopus 로고
    • Efficacy of oral direct acting antivirals for treatment of advanced chronic hepatitis or compensated cirrhosis due to hepatitis C virus infection: the real-life experience of the Sicily registry
    • [OC-11]
    • Cacciola, I., Petta, S., Distefano, M., et al. Efficacy of oral direct acting antivirals for treatment of advanced chronic hepatitis or compensated cirrhosis due to hepatitis C virus infection: the real-life experience of the Sicily registry. Digestive and Liver Disease, 49S, 2017, e6 [OC-11].
    • (2017) Digestive and Liver Disease , vol.49S , pp. e6
    • Cacciola, I.1    Petta, S.2    Distefano, M.3
  • 22
    • 84952883325 scopus 로고    scopus 로고
    • Sofosbuvir and Velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection
    • Feld, J.J., Jacobson, I.M., Hézode, C., et al. Sofosbuvir and Velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection. New England Journal of Medicine 373 (2015), 2599–2607.
    • (2015) New England Journal of Medicine , vol.373 , pp. 2599-2607
    • Feld, J.J.1    Jacobson, I.M.2    Hézode, C.3
  • 23
    • 84952909361 scopus 로고    scopus 로고
    • Sofosbuvir and Velpatasvir for HCV genotype 2 and 3 infection
    • Foster, G.R., Afdhal, N., Roberts, S.K., et al. Sofosbuvir and Velpatasvir for HCV genotype 2 and 3 infection. New England Journal of Medicine 373 (2015), 2608–2617.
    • (2015) New England Journal of Medicine , vol.373 , pp. 2608-2617
    • Foster, G.R.1    Afdhal, N.2    Roberts, S.K.3
  • 24
    • 84994340595 scopus 로고    scopus 로고
    • Treatment of HCV genotype 2 with sofosbuvir and ribavirin results in lower sustained virological response rates in real life than expected from clinical trials
    • Tacke, F., Günther, R., Buggisch, P., et al. Treatment of HCV genotype 2 with sofosbuvir and ribavirin results in lower sustained virological response rates in real life than expected from clinical trials. Liver International 37 (2017), 205–211.
    • (2017) Liver International , vol.37 , pp. 205-211
    • Tacke, F.1    Günther, R.2    Buggisch, P.3
  • 25
    • 85029319303 scopus 로고    scopus 로고
    • Effectiveness and safety of sofosbuvir plus ribavirin for the treatment of HCV genotype 2 infection: results of the real-world, clinical practice HCV-TARGET study
    • [Epub ahead of print]
    • Welzel, T.M., Nelson, D.R., Morelli, G., et al. Effectiveness and safety of sofosbuvir plus ribavirin for the treatment of HCV genotype 2 infection: results of the real-world, clinical practice HCV-TARGET study. Gut, 2016 [Epub ahead of print].
    • (2016) Gut
    • Welzel, T.M.1    Nelson, D.R.2    Morelli, G.3
  • 26
    • 84952931354 scopus 로고    scopus 로고
    • Sofosbuvir and Velpatasvir for HCV in patients with decompensated cirrhosis
    • Curry, M.P., O'Leary, J.G., Bzowej, N., et al. Sofosbuvir and Velpatasvir for HCV in patients with decompensated cirrhosis. New England Journal of Medicine 373 (2015), 2618–2628.
    • (2015) New England Journal of Medicine , vol.373 , pp. 2618-2628
    • Curry, M.P.1    O'Leary, J.G.2    Bzowej, N.3
  • 27
    • 84983381410 scopus 로고    scopus 로고
    • Prevalence and clinical importance of hepatitis C virus genotype 2 K/1 B chimeras
    • Susser, S., Dietz, J., Barak, M., et al. Prevalence and clinical importance of hepatitis C virus genotype 2 K/1 B chimeras. Journal of Hepatology, 64, 2016, S136.
    • (2016) Journal of Hepatology , vol.64 , pp. S136
    • Susser, S.1    Dietz, J.2    Barak, M.3
  • 28
    • 85011407344 scopus 로고    scopus 로고
    • European Ravs database: frequency and characteristics of Ravs in treatment-naïve and DAA-experienced patients
    • Susser, S., Dietz, J., Vermehren, J., et al. European Ravs database: frequency and characteristics of Ravs in treatment-naïve and DAA-experienced patients. Journal of Hepatology, 64, 2016, S139.
    • (2016) Journal of Hepatology , vol.64 , pp. S139
    • Susser, S.1    Dietz, J.2    Vermehren, J.3
  • 29
    • 85020895827 scopus 로고    scopus 로고
    • Hepatitis C Guidance: AASLD-IDSA recommendations for testing, managing, and treating Hepatitis C [].
    • AASLD/IDSA HCV Guidance Panel. Hepatitis C Guidance: AASLD-IDSA recommendations for testing, managing, and treating Hepatitis C [ http://www.hcvguidelines.org].
  • 30
    • 84925364974 scopus 로고    scopus 로고
    • All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III study
    • Nelson, D.R., Cooper, J.N., Lalezari, J.P., et al. All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III study. Hepatology 61 (2015), 1127–1135.
    • (2015) Hepatology , vol.61 , pp. 1127-1135
    • Nelson, D.R.1    Cooper, J.N.2    Lalezari, J.P.3
  • 31
    • 84985860840 scopus 로고    scopus 로고
    • Next-generation sequencing analysis of NS5A and NS5 B minor resistance-associated variants in patients with HCV genotype 3 infection who failed treatment with Daclatasvir plus Sofosbuvir
    • McPhee, F., Hernandez, D., Zhou, N., et al. Next-generation sequencing analysis of NS5A and NS5 B minor resistance-associated variants in patients with HCV genotype 3 infection who failed treatment with Daclatasvir plus Sofosbuvir. Journal of Hepatology 64 (2016), S614–S615.
    • (2016) Journal of Hepatology , vol.64 , pp. S614-S615
    • McPhee, F.1    Hernandez, D.2    Zhou, N.3
  • 32
    • 84959559169 scopus 로고    scopus 로고
    • Daclatasvir, sofosbuvir, and ribavirin for hepatitis C virus genotype 3 and advanced liver disease: a randomized phase III study (ALLY-3+)
    • Leroy, V., Angus, P., Bronowicki, J.P., et al. Daclatasvir, sofosbuvir, and ribavirin for hepatitis C virus genotype 3 and advanced liver disease: a randomized phase III study (ALLY-3+). Hepatology 63 (2016), 1430–1441.
    • (2016) Hepatology , vol.63 , pp. 1430-1441
    • Leroy, V.1    Angus, P.2    Bronowicki, J.P.3
  • 33
    • 85020861290 scopus 로고    scopus 로고
    • Genotype 3 infection in DAA era: reports of a real life Northern Italy Network for viral hepatitis after 2 years by the start
    • [F-47]
    • Pasulo, L., Aghemo, A., Quirino, T., et al. Genotype 3 infection in DAA era: reports of a real life Northern Italy Network for viral hepatitis after 2 years by the start. Digestive and Liver Disease, 49S, 2017, e68 [F-47].
    • (2017) Digestive and Liver Disease , vol.49S , pp. e68
    • Pasulo, L.1    Aghemo, A.2    Quirino, T.3
  • 34
    • 85020861303 scopus 로고    scopus 로고
    • Daclatasvir/sofosbuvir and ribavirin 800 mg flat dose is highly efficacy and safe in genotype 3 compensated and decompensated cirrhotic patients: the CLEO experience
    • [F-39]
    • Pellicelli, A., Messina, V., Tarquini, P., et al. Daclatasvir/sofosbuvir and ribavirin 800 mg flat dose is highly efficacy and safe in genotype 3 compensated and decompensated cirrhotic patients: the CLEO experience. Digestive and Liver Disease, 49S, 2017, e64 [F-39].
    • (2017) Digestive and Liver Disease , vol.49S , pp. e64
    • Pellicelli, A.1    Messina, V.2    Tarquini, P.3
  • 35
    • 85014667661 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir, with or without ribavirin, for hepatitis C virus genotype 3 in a French Early Access Programme
    • [Epub ahead of print]
    • Hézode, C., Lebray, P., De Ledinghen, V., et al. Daclatasvir plus sofosbuvir, with or without ribavirin, for hepatitis C virus genotype 3 in a French Early Access Programme. Liver International, 2017 [Epub ahead of print].
    • (2017) Liver International
    • Hézode, C.1    Lebray, P.2    De Ledinghen, V.3
  • 36
    • 85019948713 scopus 로고    scopus 로고
    • A randomized phase 3 trial of Sofosbuvir/Velpatasvir/Voxilaprevir for 8 weeks and Sofosbuvir/Velpatasvir for 12 weeks for patients with genotype 3 HCV infection and cirrhosis: the POLARIS-3 study
    • [Abstract 258]
    • Foster, G.R., Thompson, A.J., Ruane, P.J., et al. A randomized phase 3 trial of Sofosbuvir/Velpatasvir/Voxilaprevir for 8 weeks and Sofosbuvir/Velpatasvir for 12 weeks for patients with genotype 3 HCV infection and cirrhosis: the POLARIS-3 study. Hepatology, 64(Suppl. S1), 2016 [Abstract 258].
    • (2016) Hepatology , vol.64
    • Foster, G.R.1    Thompson, A.J.2    Ruane, P.J.3
  • 37
    • 84986564648 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort
    • Welzel, T.M., Petersen, J., Herzer, K., et al. Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort. Gut 65 (2016), 1861–1870.
    • (2016) Gut , vol.65 , pp. 1861-1870
    • Welzel, T.M.1    Petersen, J.2    Herzer, K.3
  • 38
    • 84989905147 scopus 로고    scopus 로고
    • High Svr rates with ABT-493 + ABT-530 co-administered for 8 weeks in non-cirrhotic patients with HCV genotype 3 infection
    • Muir, A.J., Strasser, S., Wang, S., et al. High Svr rates with ABT-493 + ABT-530 co-administered for 8 weeks in non-cirrhotic patients with HCV genotype 3 infection. Journal of Hepatology, 64, 2016, S186.
    • (2016) Journal of Hepatology , vol.64 , pp. S186
    • Muir, A.J.1    Strasser, S.2    Wang, S.3
  • 39
    • 85073882204 scopus 로고    scopus 로고
    • Endurance-3: a phase 3, randomized, open-label, active-controlled study to compare efficacy and safety of ABT-493/ABT-530 to Sofosbuvir co-administered with Daclatasvir in adults with HCV genotype 3 infection
    • Foster, G.R., Gane, E., Asatryan, A., et al. Endurance-3: a phase 3, randomized, open-label, active-controlled study to compare efficacy and safety of ABT-493/ABT-530 to Sofosbuvir co-administered with Daclatasvir in adults with HCV genotype 3 infection. Journal of Hepatology, 64, 2016, S292.
    • (2016) Journal of Hepatology , vol.64 , pp. S292
    • Foster, G.R.1    Gane, E.2    Asatryan, A.3
  • 40
    • 85020863680 scopus 로고    scopus 로고
    • Sofosbuvir/Velpatasvir/Voxilaprevir for 12 weeks as a salvage regimen in NA inhibitor-experienced patients with genotype 1–6 infection: the phase 3 POLARIS-1 study
    • [Abstract 194]
    • Bourlière, M., Gordon, S.C., Ramji, A., et al. Sofosbuvir/Velpatasvir/Voxilaprevir for 12 weeks as a salvage regimen in NA inhibitor-experienced patients with genotype 1–6 infection: the phase 3 POLARIS-1 study. Hepatology, 64(Suppl. S1), 2016 [Abstract 194].
    • (2016) Hepatology , vol.64
    • Bourlière, M.1    Gordon, S.C.2    Ramji, A.3
  • 41
    • 85073881602 scopus 로고    scopus 로고
    • In the era of new direct acting antiviral agents HCV sequencing allows the most accurate subtype and genotype assignment
    • Aragri, M., Di Maio, V.C., Di Paolo, D., et al. In the era of new direct acting antiviral agents HCV sequencing allows the most accurate subtype and genotype assignment. Journal of Hepatology 64 (2016), S419–S420.
    • (2016) Journal of Hepatology , vol.64 , pp. S419-S420
    • Aragri, M.1    Di Maio, V.C.2    Di Paolo, D.3
  • 42
    • 85073883768 scopus 로고    scopus 로고
    • Multiclass HCV resistance to interferon-free direct acting antivirals regimens in real life failures advocates for tailored second-line therapies
    • [F-14]
    • Di Maio, V.C., Cento, V., Lenci, I., et al. Multiclass HCV resistance to interferon-free direct acting antivirals regimens in real life failures advocates for tailored second-line therapies. Digestive and Liver Disease 49S (2017), e49–e50 [F-14].
    • (2017) Digestive and Liver Disease , vol.49S , pp. e49-e50
    • Di Maio, V.C.1    Cento, V.2    Lenci, I.3
  • 43
    • 84929600780 scopus 로고    scopus 로고
    • Ledipasvir-sofosbuvir plus ribavirin for patients with genotype 1 hepatitis C virus previously treated in clinical trials of sofosbuvir regimens
    • Wyles, D., Pockros, P., Morelli, G., et al. Ledipasvir-sofosbuvir plus ribavirin for patients with genotype 1 hepatitis C virus previously treated in clinical trials of sofosbuvir regimens. Hepatology 61 (2015), 1793–1797.
    • (2015) Hepatology , vol.61 , pp. 1793-1797
    • Wyles, D.1    Pockros, P.2    Morelli, G.3
  • 44
    • 84879683134 scopus 로고    scopus 로고
    • Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials
    • Sullivan, J.C., De Meyer, S., Bartels, D.J., et al. Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials. Clinical Infectious Diseases 57 (2013), 221–229.
    • (2013) Clinical Infectious Diseases , vol.57 , pp. 221-229
    • Sullivan, J.C.1    De Meyer, S.2    Bartels, D.J.3
  • 45
    • 84898669547 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
    • Afdhal, N., Reddy, K.R., Nelson, D.R., et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. New England Journal of Medicine 370 (2014), 1483–1493.
    • (2014) New England Journal of Medicine , vol.370 , pp. 1483-1493
    • Afdhal, N.1    Reddy, K.R.2    Nelson, D.R.3
  • 46
    • 84964762607 scopus 로고    scopus 로고
    • Long-term persistence of HCV NS5A variants after treatment with NS5A inhibitor ledipasvir
    • Dvory-Sobol, H., Wyles, D., Ouyang, W., et al. Long-term persistence of HCV NS5A variants after treatment with NS5A inhibitor ledipasvir. Journal of Hepatology, 62, 2015, S221.
    • (2015) Journal of Hepatology , vol.62 , pp. S221
    • Dvory-Sobol, H.1    Wyles, D.2    Ouyang, W.3
  • 47
    • 85020895965 scopus 로고    scopus 로고
    • Interim analysis of a 3-year follow-up study of NA and NS3 resistance-associated variants (RAVs) after treatment with Grazoprevir-containing regimens in patients with chronic hepatitis C virus (HCV) infection
    • [Abstract 61]
    • Lahser, F., Galloway, A., Hwang, P., et al. Interim analysis of a 3-year follow-up study of NA and NS3 resistance-associated variants (RAVs) after treatment with Grazoprevir-containing regimens in patients with chronic hepatitis C virus (HCV) infection. Hepatology, 64(Suppl. S1), 2016 [Abstract 61].
    • (2016) Hepatology , vol.64
    • Lahser, F.1    Galloway, A.2    Hwang, P.3
  • 48
    • 85020922859 scopus 로고    scopus 로고
    • Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir
    • [Epub ahead of print]
    • Wyles, D., Dvory-Sobol, H., Svarovskaia, E.S., et al. Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir. Journal of Hepatology, 2016, 30699–30707 [Epub ahead of print].
    • (2016) Journal of Hepatology , pp. 30699-30707
    • Wyles, D.1    Dvory-Sobol, H.2    Svarovskaia, E.S.3
  • 49
    • 84989872658 scopus 로고    scopus 로고
    • High efficacy of ABT-493 and ABT-530 in HCV genotype 1-infected patients who have failed direct-acting antiviral-containing regimens: the MAGELLAN-1 study
    • Poordad, F., Gordon, S.C., Asatryan, A., et al. High efficacy of ABT-493 and ABT-530 in HCV genotype 1-infected patients who have failed direct-acting antiviral-containing regimens: the MAGELLAN-1 study. Journal of Hepatology 64 (2016), S160–S161.
    • (2016) Journal of Hepatology , vol.64 , pp. S160-S161
    • Poordad, F.1    Gordon, S.C.2    Asatryan, A.3
  • 50
    • 84936817310 scopus 로고    scopus 로고
    • Hepatitis C virus gene sequencing as a tool for precise genotyping in the era of new direct antiviral agents
    • Ceccherini Silberstein, F., Di Maio, V.C., Aragri, M., et al. Hepatitis C virus gene sequencing as a tool for precise genotyping in the era of new direct antiviral agents. Hepatology 63 (2016), 1058–1059.
    • (2016) Hepatology , vol.63 , pp. 1058-1059
    • Ceccherini Silberstein, F.1    Di Maio, V.C.2    Aragri, M.3
  • 51
    • 84900326091 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis
    • Kowdley, K.V., Gordon, S.C., Reddy, K.R., et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. New England Journal of Medicine 370 (2014), 1879–1888.
    • (2014) New England Journal of Medicine , vol.370 , pp. 1879-1888
    • Kowdley, K.V.1    Gordon, S.C.2    Reddy, K.R.3
  • 52
    • 84937064772 scopus 로고    scopus 로고
    • Grazoprevir-Elbasvir combination therapy for treatment-naive cirrhotic and non cirrhotic patients with chronic hepatitis C virus genotype 1, 4, or 6 infection: a randomized trial
    • Zeuzem, S., Ghalib, R., Reddy, K.R., et al. Grazoprevir-Elbasvir combination therapy for treatment-naive cirrhotic and non cirrhotic patients with chronic hepatitis C virus genotype 1, 4, or 6 infection: a randomized trial. Annals of Internal Medicine 163 (2015), 1–13.
    • (2015) Annals of Internal Medicine , vol.163 , pp. 1-13
    • Zeuzem, S.1    Ghalib, R.2    Reddy, K.R.3
  • 53
    • 84934272467 scopus 로고    scopus 로고
    • Efficacy and safety of grazoprevir/elbasvir plus or minus RBV for 12 weeks in patients with HCV G1 or G4 infection who previously failed peginterferon/RBV: C-EDGE Treatment-Experienced trial
    • Kwo, P., Gane, E., Peng, C.Y., et al. Efficacy and safety of grazoprevir/elbasvir plus or minus RBV for 12 weeks in patients with HCV G1 or G4 infection who previously failed peginterferon/RBV: C-EDGE Treatment-Experienced trial. Journal of Hepatology 62 (2015), S674–S675.
    • (2015) Journal of Hepatology , vol.62 , pp. S674-S675
    • Kwo, P.1    Gane, E.2    Peng, C.Y.3
  • 54
    • 85014057062 scopus 로고    scopus 로고
    • NS5A resistance-associated substitutions in patients with genotype 1 hepatitis C virus: prevalence and effect on treatment outcome
    • [Epub ahead of print]
    • Zeuzem, S., Mizokami, M., Planko, S., et al. NS5A resistance-associated substitutions in patients with genotype 1 hepatitis C virus: prevalence and effect on treatment outcome. Journal of Hepatology, 2017 [Epub ahead of print].
    • (2017) Journal of Hepatology
    • Zeuzem, S.1    Mizokami, M.2    Planko, S.3
  • 55
    • 84995470009 scopus 로고    scopus 로고
    • Prevalence of resistance-associated substitutions in HCV NS5A, NS5B, or NS3 and outcomes of treatment with Ledipasvir and Sofosbuvir
    • Sarrazin, C., Dvory-Sobol, H., Svarovskaia, E.S., et al. Prevalence of resistance-associated substitutions in HCV NS5A, NS5B, or NS3 and outcomes of treatment with Ledipasvir and Sofosbuvir. Gastroenterology 151 (2016), 501–512.
    • (2016) Gastroenterology , vol.151 , pp. 501-512
    • Sarrazin, C.1    Dvory-Sobol, H.2    Svarovskaia, E.S.3
  • 56
    • 84964584562 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and efficacy of a full dose sofosbuvir-based regimen given daily in hemodialysis patients with chronic hepatitis C
    • Desnoyer, A., Pospai, D., Lê, M.P., et al. Pharmacokinetics, safety and efficacy of a full dose sofosbuvir-based regimen given daily in hemodialysis patients with chronic hepatitis C. Journal of Hepatology 65 (2016), 40–47.
    • (2016) Journal of Hepatology , vol.65 , pp. 40-47
    • Desnoyer, A.1    Pospai, D.2    Lê, M.P.3
  • 57
    • 84966783713 scopus 로고    scopus 로고
    • The quest for safe and effective treatments of chronic hepatitis C in patients with kidney impairment
    • De Nicola, S., Aghemo, A., The quest for safe and effective treatments of chronic hepatitis C in patients with kidney impairment. Liver International 36 (2016), 791–793.
    • (2016) Liver International , vol.36 , pp. 791-793
    • De Nicola, S.1    Aghemo, A.2
  • 58
    • 84961843130 scopus 로고    scopus 로고
    • Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function
    • Saxena, V., Koraishy, F.M., Sise, M.E., et al. Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function. Liver International 36 (2016), 807–816.
    • (2016) Liver International , vol.36 , pp. 807-816
    • Saxena, V.1    Koraishy, F.M.2    Sise, M.E.3
  • 59
    • 84966733521 scopus 로고    scopus 로고
    • Efficacy of direct-acting antiviral combination for patients with hepatitis C virus genotype 1 infection and severe renal impairment or end-stage renal disease
    • Pockros, P.J., Reddy, K.R., Mantry, P.S., et al. Efficacy of direct-acting antiviral combination for patients with hepatitis C virus genotype 1 infection and severe renal impairment or end-stage renal disease. Gastroenterology 150 (2016), 1590–1598.
    • (2016) Gastroenterology , vol.150 , pp. 1590-1598
    • Pockros, P.J.1    Reddy, K.R.2    Mantry, P.S.3
  • 60
    • 85019727974 scopus 로고    scopus 로고
    • RUBY-II: efficacy and safety of a ribavirin-free Ombitasvir/Paritaprevir/Ritonavir ± Dasabuvir regimen in patients with severe renal impairment or end-stage renal disease and HCV genotypes 1a or 4 infection
    • [Abstract 935]
    • Gane, E.J., Solà, R., Cohen, E., et al. RUBY-II: efficacy and safety of a ribavirin-free Ombitasvir/Paritaprevir/Ritonavir ± Dasabuvir regimen in patients with severe renal impairment or end-stage renal disease and HCV genotypes 1a or 4 infection. Hepatology, 64(Suppl. S1), 2016 [Abstract 935].
    • (2016) Hepatology , vol.64
    • Gane, E.J.1    Solà, R.2    Cohen, E.3
  • 61
    • 84947338288 scopus 로고    scopus 로고
    • Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study
    • Roth, D., Nelson, D.R., Bruchfeld, A., et al. Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. The Lancet 386 (2015), 1537–1545.
    • (2015) The Lancet , vol.386 , pp. 1537-1545
    • Roth, D.1    Nelson, D.R.2    Bruchfeld, A.3
  • 62
    • 84986601943 scopus 로고    scopus 로고
    • From current status to optimization of HCV treatment: recommendations from an expert panel
    • Craxi, A., Perno, C.F., Viganò, M., et al. From current status to optimization of HCV treatment: recommendations from an expert panel. Digestive and Liver Disease 48 (2016), 995–1005.
    • (2016) Digestive and Liver Disease , vol.48 , pp. 995-1005
    • Craxi, A.1    Perno, C.F.2    Viganò, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.