Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: A case report

BMC Neurology

Volumn 17, Issue 1, 2017, Pages

  Nakamura, Yoshitsugu ^a   Nakajima, Hideto ^a   Tani, Hiroki ^a   Hosokawa, Takafumi ^a   Ishida, Shimon ^a   Kimura, Fumiharu ^a   Kaneko, Kimihiko ^b   Takahashi, Toshiyuki ^c   Nakashima, Ichiro ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Yonezawa National Hospital   (Japan)

Author keywords

Acute disseminate encephalomyelitis; Antecedent infection; Case report; Epstein Barr virus; Myelin oligodendrocyte glycoprotein; Transverse myelitis

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINUCLEAR ANTIBODY; ASPARTATE AMINOTRANSFERASE; BETAMETHASONE; GADOLINIUM; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; METHYLPREDNISOLONE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN ANTIBODY; PROTEIN; PROTEIN ANTIBODY; RO ANTIBODY; UNCLASSIFIED DRUG; AQUAPORIN 4; AUTOANTIBODY; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ACUTE DISSEMINATED ENCEPHALOMYELITIS; ADULT; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID EXAMINATION; CERVICAL LYMPHADENOPATHY; CLINICAL FEATURE; DISEASE EXACERBATION; DYSURIA; EPSTEIN BARR VIRUS INFECTION; FEVER; GAIT DISORDER; HUMAN; HYPERREFLEXIA; IMMUNOASSAY; IMMUNOSUPPRESSIVE TREATMENT; LABORATORY TEST; MALE; MONONUCLEOSIS; NERVE CONDUCTION; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PARESTHESIA; POLYMERASE CHAIN REACTION; SENSORY DYSFUNCTION; SEROLOGY; URETHRAL CATHETERIZATION; URINE RETENTION; CAPSULA INTERNA; CEREBROSPINAL FLUID; CERVICAL SPINAL CORD; COMPLICATION; IMMUNOLOGY; LEUKOCYTOSIS; PATHOLOGY; SPINAL CORD;

ADULT; AQUAPORIN 4; AUTOANTIBODIES; CERVICAL CORD; ENCEPHALOMYELITIS, ACUTE DISSEMINATED; EPSTEIN-BARR VIRUS INFECTIONS; HUMANS; INFECTIOUS MONONUCLEOSIS; INTERNAL CAPSULE; LEUKOCYTOSIS; MAGNETIC RESONANCE IMAGING; MALE; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; SPINAL CORD;

EID: 85018510355     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/s12883-017-0858-6     Document Type: Article

References (17)

1. Reindl M, Di Pauli F, Rostásy K, Berger T. The spectrum of MOG autoantibody-associated demyelinating diseases. Nat Rev Neurol. 2013;9:455-61.
2. Sato DK, Callegaro D, Lana-Peixoto MA, Waters PJ, de Haidar Jorge FM, Takahashi T, et al. Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. Neurology. 2014;82:474-81.
3. Schwarz S, Mohr A, Knauth M, Wildemann B, Storch-Hagenlocher B. Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients. Neurology. 2001;56:1313-8.
4. Amano H, Miyamoto N, Shimura H, Sato DK, Fujihara K, Ueno S, et al. Influenza-associated MOG antibody-positive longitudinally extensive transverse myelitis: a case report. BMC Neurol. 2014;14:224.
5. Tenembaum S, Chitnis T, Ness J, Hahn JS, International Pediatric MS Study Group. Acute disseminated encephalomyelitis. Neurology. 2007;68(16 Suppl 2):S23-36.
6. Baumann M, Sahin K, Lechner C, Hennes EM, Schanda K, Mader S, et al. Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein. J Neurol Neurosurg Psychiatry. 2015;86:265-72.
7. Baumann M, Hennes EM, Schanda K, Karenfort M, Kornek B, Seidl R, et al. Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): extending the spectrum of MOG antibody positive diseases. Mult Scler. 2016;22:1821-9.
8. Silverstein A, Steinberg G, Nathanson M. Nervous system involvement in infectious mononucleosis. The heralding and-or major manifestation. Arch Neurol. 1972;26:353-8.
9. Fujimoto H, Asaoka K, Imaizumi T, Ayabe M, Shoji H, Kaji M. Epstein-Barr virus infections of the central nervous system. Intern Med. 2003;42:33-40.
10. Tselis AC. Epstein-Barr virus infections of the nervous system. Handb Clin Neurol. 2014;123:285-305.
11. Mohsen H, Abu Zeinah GF, Elsotouhy AH, Mohamed K. Acute disseminated encephalomyelitis following infectious mononucleosis in a toddler. BMJ Case Rep 2013; doi: 10.1136/bcr-2013-010048.
12. Caldas C, Bernicker E, Nogare AD, Luby JP. Case report: transverse myelitis associated with Epstein-Barr virus infection. Am J Med Sci. 1994;307:45-8.
13. Junker AK, Roland EH, Hahn G. Transverse myelitis and Epstein-Barr virus infection with delayed antibody responses. Neurology. 1991;41:1523-4.
14. Bahadori HR, Williams VC, Turner RP, Rumboldt Z, Reigart JR, Fowler SL, et al. Acute disseminated encephalomyelitis following infectious mononucleosis. J Child Neurol. 2007;22:324-8.
15. Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, et al. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol. 2002;3:940-3.
16. Wang H, Munger KL, Reindl M, O'Reilly EJ, Levin LI, Berger T, et al. Myelin oligodendrocyte glycoprotein antibodies and multiple sclerosis in healthy young adults. Neurology. 2008;71:1142-6.
17. Kakalacheva K, Regenass S, Wiesmayr S, Azzi T, Berger C, Dale RC, et al. Infectious mononucleosis triggers generation of IgG auto-antibodies against native myelin oligodendrocyte glycoprotein. Viruses. 2016;8:51.