White blood cell count correlates with mood symptom severity and specific mood symptoms in bipolar disorder

Australian and New Zealand Journal of Psychiatry

Volumn 51, Issue 4, 2017, Pages 355-365

  Köhler, Ole ^a   Sylvia, Louisa G ^b,c   Bowden, Charles L ^d   Calabrese, Joseph R ^e   Thase, Michael ^f   Shelton, Richard C ^g   McInnis, Melvin ^h   Tohen, Mauricio ⁱ   Kocsis, James H ^j   Ketter, Terence A ^k   Friedman, Edward S ^l   Deckersbach, Thilo ^b,c   Ostacher, Michael J ^k,m   Iosifescu, Dan V ⁿ   McElroy, Susan ^o,p   Nierenberg, Andrew A ^b,c  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Mays Cancer Center at UT Health San Antonio   (United States)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^h UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

ⁱ UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^j WEILL CORNELL MEDICAL COLLEGE   (United States)

^k STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^m VA PALO ALTO HEALTH CARE SYSTEM   (United States)

ⁿ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^o UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^p LINDNER CENTER OF HOPE   (United States)

more..

Author keywords

Bipolar disorder; gender differences; immune system; symptom severity; white blood cells

Indexed keywords

LITHIUM; QUETIAPINE;

ADULT; AGE; BIPOLAR DISORDER; BIPOLAR INVENTORY OF SYMPTOMS SCALE; BODY MASS; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; HYPERTENSION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONTGOMERY ASBERG DEPRESSION RATING SCALE; MOOD DISORDER; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SCORING SYSTEM; SEX DIFFERENCE; SMOKING; SYMPTOM; ADOLESCENT; AFFECT; CLINICAL TRIAL; IMMUNE SYSTEM; IMMUNOLOGY; MIDDLE AGED; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; SEVERITY OF ILLNESS INDEX; SEXUAL DEVELOPMENT; STATISTICAL MODEL; UNITED STATES; YOUNG ADULT;

ADOLESCENT; ADULT; AFFECT; BIPOLAR DISORDER; FEMALE; HUMANS; IMMUNE SYSTEM; LEUKOCYTE COUNT; LINEAR MODELS; LITHIUM; LOGISTIC MODELS; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX; SEX CHARACTERISTICS; UNITED STATES; YOUNG ADULT;

EID: 85018353100     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1177/0004867416644508     Document Type: Review

References (41)

1. Akaho R, Sasaki T, Mori S, et al. (2003) Psychological factors and survival after bone marrow transplantation in patients with leukemia. Psychiatry and Clinical Neurosciences 57: 91-96.
2. Amitai M, Zivony A, Kronenberg S, et al. (2014) Short-term effects of lithium on white blood cell counts and on levels of serum thyroid-stimulating hormone and creatinine in adolescent inpatients: A retrospective naturalistic study. Journal of Child and Adolescent Psychopharmacology 24: 494-500.
3. Angele MK, Pratschke S, Hubbard WJ, et al. (2014) Gender differences in sepsis: Cardiovascular and immunological aspects. Virulence 5: 12-19.
4. Arabzadeh S, Ameli N, Zeinoddini A, et al. (2015) Celecoxib adjunctive therapy for acute bipolar mania: A randomized, double-blind, placebo-controlled trial. Bipolar Disorders 17: 606-614.
5. Ayorech Z, Tracy DK, Baumeister D, et al. (2015) Taking the fuel out of the fire: Evidence for the use of anti-inflammatory agents in the treatment of bipolar disorders. Journal of Affective Disorders 174: 467-478.
6. Bai YM, Su TP, Tsai SJ, et al. (2014) Comparison of inflammatory cytokine levels among type I/type II and manic/hypomanic/euthymic/depressive states of bipolar disorder. Journal of Affective Disorders 166: 187-192.
7. Bowden CL, Singh V, Thompson P, et al. (2007) Development of the bipolar inventory of symptoms scale. Acta Psychiatrica Scandinavica 116: 189-194.
8. Bowden CL, Vieta E, Ice KS, et al. (2010) Ziprasidone plus a mood stabilizer in subjects with bipolar I disorder: A 6-month, randomized, placebo-controlled, double-blind trial. The Journal of Clinical Psychiatry 71: 130-137.
9. Brod S, Rattazzi L, Piras G, et al. (2014) 'As above, so below' examining the interplay between emotion and the immune system. Immunology 143: 311-318.
10. Dargel AA, Godin O, Kapczinski F, et al. (2015) C-reactive protein alterations in bipolar disorder: A meta-analysis. The Journal of Clinical Psychiatry 76: 142-150.
11. Drexhage RC, Knijff EM, Padmos RC, et al. (2010) The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder. Expert Review of Neurotherapeutics 10: 59-76.
12. Goldstein BI, Young LT, (2013) Toward clinically applicable biomarkers in bipolar disorder: Focus on BDNF, inflammatory markers, and endothelial function. Current Psychiatry Reports 15: 425.
13. Gonzalez JM, Bowden CL, Katz MM, et al. (2008) Development of the Bipolar Inventory of Symptoms Scale: Concurrent validity, discriminant validity and retest reliability. International Journal of Methods in Psychiatric Research 17: 198-209.
14. Hope S, Dieset I, Agartz I, et al. (2011) Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. Journal of Psychiatric Research 45: 1608-1616.
15. Hope S, Hoseth E, Dieset I, et al. (2015) Inflammatory markers are associated with general cognitive abilities in schizophrenia and bipolar disorder patients and healthy controls. Schizophrenia Research 165: 188-194.
16. Hope S, Ueland T, Steen NE, et al. (2013) Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. Schizophrenia Research 145: 36-42.
17. Horne BD, Anderson JL, John JM, et al. (2005) Which white blood cell subtypes predict increased cardiovascular risk? Journal of the American College of Cardiology 45: 1638-1643.
18. Kannel WB, Anderson K, Wilson PW, (1992) White blood cell count and cardiovascular disease. Insights from the Framingham Study. Journal of the American Medical Association 267: 1253-1256.
19. Köhler O, Benros ME, Nordentoft M, et al. (2014) Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: A systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry 71: 1381-1391.
20. Krogh J, Benros ME, Jorgensen MB, et al. (2014) The association between depressive symptoms, cognitive function, and inflammation in major depression. Brain, Behavior, and Immunity 35: 70-76.
21. Lally J, MacCabe JH, (2015) Antipsychotic medication in schizophrenia: A review. British Medical Bulletin 114: 169-179.
22. Laske C, Schmohl M, Leyhe T, et al. (2013) Immune profiling in blood identifies sTNF-R1 performing comparably well as biomarker panels for classification of Alzheimer's disease patients. Journal of Alzheimer's Disease 34: 367-375.
23. Li H, Hong W, Zhang C, et al. (2015) IL-23 and TGF-beta1 levels as potential predictive biomarkers in treatment of bipolar I disorder with acute manic episode. Journal of Affective Disorders 174: 361-366.
24. Liu B, Taioli E, (2015) Seasonal variations of complete blood count and inflammatory biomarkers in the US population-Analysis of NHANES data. PLoS ONE 10: e0142382.
25. Lotrich FE, Butters MA, Aizenstein H, et al. (2014) The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder. International Journal of Geriatric Psychiatry 29: 635-644.
26. Montgomery SA, Asberg M, (1979) A new depression scale designed to be sensitive to change. The British Journal of Psychiatry 134: 382-389.
27. Nierenberg AA, Sylvia LG, Leon AC, et al. (2009) Lithium treatment-Moderate dose use study (LiTMUS) for bipolar disorder: Rationale and design. Clinical Trials 6: 637-648.
28. Nierenberg AA, Sylvia LG, Leon AC, et al. (2014) Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE): A pragmatic trial of complex treatment for a complex disorder. Clinical Trials 11: 114-127.
29. Rabkin JG, Wagner G, Rabkin R, (1994) Effects of sertraline on mood and immune status in patients with major depression and HIV illness: An open trial. The Journal of Clinical Psychiatry 55: 433-439.
30. Raison CL, Rutherford RE, Woolwine BJ, et al. (2013) A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: The role of baseline inflammatory biomarkers. JAMA Psychiatry 70: 31-41.
31. Rocha NP, Teixeira AL, Scalzo PL, et al. (2014) Plasma levels of soluble tumor necrosis factor receptors are associated with cognitive performance in Parkinson's disease. Movement Disorders: Official Journal of the Movement Disorder Society 29: 527-531.
32. Schwartz M, Kipnis J, Rivest S, et al. (2013) How do immune cells support and shape the brain in health, disease, and aging? The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 33: 17587-17596.
33. Sheehan DV, Lecrubier Y, Sheehan KH, et al. (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry 59 (Suppl. 20): 22-33; quiz 34-57.
34. Soreca I, Fagiolini A, Frank E, et al. (2008) Relationship of general medical burden, duration of illness and age in patients with bipolar I disorder. Journal of Psychiatric Research 42: 956-961.
35. Spearing MK, Post RM, Leverich GS, et al. (1997) Modification of the Clinical Global Impressions (CGI) Scale for use in bipolar illness (BP): The CGI-BP. Psychiatry Research 73: 159-171.
36. Thompson PM, Gonzalez JM, Singh V, et al. (2010) Principal domains of behavioral psychopathology identified by the Bipolar Inventory of Signs and Symptoms Scale (BISS). Psychiatry Research 175: 221-226.
37. Vieta E, T'Joen C, McQjade RD, et al. (2008) Efficacy of adjunctive aripiprazole to either valproate or lithium in bipolar mania patients partially nonresponsive to valproate/lithium monotherapy: A placebo-controlled study. The American Journal of Psychiatry 165 (10): 1316-1325.
38. Walker AJ, Kim Y, Price JB, et al. (2014) Stress, inflammation, and cellular vulnerability during early stages of affective disorders: Biomarker strategies and opportunities for prevention and intervention. Frontiers in Psychiatry 5: 34.
39. Walsh JT, Watson N, Kipnis J, (2014) T cells in the central nervous system: Messengers of destruction or purveyors of protection? Immunology 141: 340-344.
40. Young RC, Biggs JT, Ziegler VE, et al. (1978) A rating scale for mania: Reliability, validity and sensitivity. The British Journal of Psychiatry 133: 429-435.
41. Zorrilla EP, Luborsky L, Mckay JR, et al. (2001) The relationship of depression and stressors to immunological assays: A meta-analytic review. Brain, Behavior, and Immunity 15: 199-226.