Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions

British Journal of Haematology

Volumn 181, Issue 3, 2018, Pages 410-413

  Al Battat, Sami ^a,b   Rand, Margaret L ^a,b,c   Bouskill, Vanessa ^a   Lau, Wendy ^a   Blanchette, Victor S ^a,b   Kahr, Walter H A ^a,b,c,d   Rivard, Georges Etienne ^e   Carcao, Manuel D ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Glanzmann thrombasthenia; paediatric haemostasis; platelet function; Platelet Function Analyser; platelet transfusions

Indexed keywords

FIBRINOGEN RECEPTOR; HEMOGLOBIN; HLA ANTIGEN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBOCYTE ANTIBODY; TRANEXAMIC ACID;

ADOLESCENT; ANTIBODY DETECTION; BLEEDING; BLEEDING TIME; CHILD; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPISTAXIS; FEMALE; FLOW CYTOMETRY; GENERAL CONDITION IMPROVEMENT; GLANZMANN DISEASE; HEMOGLOBIN BLOOD LEVEL; HEMOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LETTER; MALE; NASAL PACKING; PRESCHOOL CHILD; PRIORITY JOURNAL; REFRACTORY THROMBOCYTOPENIA; RISK REDUCTION; SCHOOL CHILD; THIRD MOLAR; THROMBOCYTE AGGREGATION; THROMBOCYTE TRANSFUSION; TOOTH EXTRACTION; BLOOD; BLOOD CLOTTING PARAMETERS; GENETICS; METABOLISM; PATHOLOGY; THROMBOCYTE;

ADOLESCENT; BLOOD PLATELETS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; MALE; PLATELET FUNCTION TESTS; PLATELET TRANSFUSION; THROMBASTHENIA;

EID: 85018292020     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.14623     Document Type: Letter

References (10)

1. ® ): a novel in-vitro system for evaluation of primary haemostasis in children. British Journal of Haematology, 101, 70–73.
2. Cesar, J.M. & Vecino, A.M. (2009) Survival and function of transfused platelets. Studies in two patients with congenital deficiencies of platelet membrane glycoproteins. Platelets, 20, 158–162.
3. Favaloro, E.J. (2008) Clinical utility of the PFA-100. Seminars in Thrombosis and Hemostasis, 34, 709–733.
4. George, J., Caen, J. & Nurden, A. (1990) Glanzmann's thrombasthenia: the spectrum of clinical disease. Blood, 75, 1383–1395.
5. Jennings, L., Wang, W., Jackson, C., Fox, C. & Bell, A. (1991) Hemostasis in Glanzmann's thrombasthenia (GT): GT platelets interfere with the aggregation of normal platelets. The American Journal of Pediatric Hematology/Oncology, 13, 84–90.
6. Male, C., Koren, D., Eichelberger, B., Kaufmann, K. & Panzer, S. (2006) Monitoring survival and function of transfused platelets in Glanzmann thrombasthenia by flow cytometry and thrombelastography. Vox Sanguinis, 91, 174–177.
7. Nurden, A.T. & Nurden, P. (2014) Congenital platelet disorders and understanding of platelet function. British Journal of Haematology, 165, 165–178.
8. Nurden, A., Combrie, R. & Nurden, P. (2002) Detection of transfused platelets in a patient with Glanzmann thrombasthenia. Thrombosis and Haemostasis, 87, 543–544.
9. Nurden, A., Pillois, X., Fiore, M., Alessi, M., Bonduel, M., Dreyfus, M., Goudemand, J., Gruel, Y., Benabdallah-Guerida, S., Latger-Cannard, V., Negrier, C., Nugent, D., Orion, R., Rand, M., Sie, P., Trossaert, M., Alberio, L., Martins, N., Sirvain-Trukniewicz, P., Couloux, A., Canault, M., Fronthroth, J., Fretigny, M., Nurden, P., Heilig, R. & Vinciguerra, C. (2015) Expanding the mutation spectrum affecting alphaIIbbeta3 integrin in Glanzmann thrombasthenia: screening of the ITGA2B and ITGB3 genes in a large international cohort. Human Mutation, 36, 548–561.
10. Poon, M.C., D'Oiron, R., Von Depka, M., Khair, K., Négrier, C., Karafoulidou, A., Huth-Kuehne, A. & Morfini, M.; for the International Data Collection on recombinant Factor VIIa and Congenital Platelet Disorders study group. (2004) Prophylactic and therapeutic recombinant factor VIIa administration to patients with Glanzmann's thrombasthenia: results of an international survey. Journal of Thrombosis and Haemostasis: JTH, 2, 1096–1103.