Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

PloS one

Volumn 10, Issue 7, 2015, Pages e0131861-

  Rais, Rana ^a   Wozniak, Krystyna ^a   Wu, Ying ^a   Niwa, Minae ^a   Stathis, Marigo ^a   Alt, Jesse ^a   Giroux, Marc ^a   Sawa, Akira ^a   Rojas, Camilo ^a   Slusher, Barbara S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2-(3-MERCAPTOPROPYL)PENTANEDIOIC ACID; 2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID; GLUTAMATE CARBOXYPEPTIDASE II; GLUTARIC ACID DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; THIOL DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; AREA UNDER THE CURVE; CENTRAL NERVOUS SYSTEM; CEREBELLUM CORTEX; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRANASAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MACACA FASCICULARIS; MALE; METABOLISM; OLFACTORY BULB; RAT; RECEIVER OPERATING CHARACTERISTIC; TANDEM MASS SPECTROMETRY; WISTAR RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; AREA UNDER CURVE; CENTRAL NERVOUS SYSTEM; CEREBELLAR CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUTAMATE CARBOXYPEPTIDASE II; GLUTARATES; HALF-LIFE; INJECTIONS, INTRAPERITONEAL; MACACA FASCICULARIS; MALE; OLFACTORY BULB; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, WISTAR; ROC CURVE; SULFHYDRYL COMPOUNDS; TANDEM MASS SPECTROMETRY;

EID: 85018235686     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0131861     Document Type: Article

References (0)