Predominance of international clone 2 OXA-23-producing-Acinetobacter baumannii clinical isolates in Greece, 2015: results of a nationwide study

International Journal of Antimicrobial Agents

Volumn 49, Issue 6, 2017, Pages 749-753

  Pournaras, Spyros ^k   Dafopoulou, Konstantina ^h,k   Del Franco, Mariateresa ^l   Zarkotou, Olympia ^b   Dimitroulia, Evangelia ^k   Protonotariou, Efi ^a   Poulou, Aggeliki ^m   Zarrilli, Raffaele ^l   Tsakris, Athanasios ^k   Skoura, L ^a   Themeli Digalaki, K ^b   Perivolioti, E ^c   Tsiplakou, S ^d   Karavassilis, V ^e   Panopoulou, M ^f   Orfanidou, M ^g   Hadjichristodoulou, C ^h   Levidiotou, S ⁱ   Gikas, A ^j  

^a AHEPA UNIVERSITY HOSPITAL   (Greece)

^b TZANEIO GENERAL HOSPITAL OF PIRAEUS   (Greece)

^c EVANGELISMOS HOSPITAL   (Greece)

^d KAT HOSPITAL   (Greece)

^e IASO   (Greece)

^f DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^g G GENNIMATAS GENERAL HOSPITAL   (Greece)

^h UNIVERSITY OF THESSALY   (Greece)

ⁱ UNIVERSITY OF IOANNINA   (Greece)

^j UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^k UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^l UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^m Serres Hospital   (Greece)

more..

Author keywords

Clonal complex; Molecular epidemiology; Multilocus sequence typing; Oxacillinase; Single locus blaOXA 51 like sequence based typing

Indexed keywords

AMIKACIN; CARBAPENEMASE; CEFEPIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; MINOCYCLINE; SULTAMICILLIN; TETRACYCLINE; TIGECYCLINE; TOBRAMYCIN; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA-LACTAMASE OXA-23;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLAOXA 23 LIKE GENE; BLAOXA 40 LIKE GENE; BLAOXA 58 LIKE GENE; DILUTION; FEMALE; GENE IDENTIFICATION; GREECE; HUMAN; MALE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; TERTIARY CARE CENTER; ACINETOBACTER INFECTION; CLASSIFICATION; ENZYMOLOGY; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; POLYMERASE CHAIN REACTION; SECRETION (PROCESS);

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; ELECTROPHORESIS, GEL, PULSED-FIELD; FEMALE; GENOTYPE; GREECE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; POLYMERASE CHAIN REACTION; TERTIARY CARE CENTERS;

EID: 85018172654     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2017.01.028     Document Type: Article

References (26)

1. Visca, P., Seifert, H., Towner, K.J., Acinetobacter infection—an emerging threat to human health. IUBMB Life 63 (2011), 1048–1054.
2. European Centre for Disease Prevention and Control, Antimicrobial resistance surveillance in Europe. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2014. Stockholm, Sweden: ECDC; Available from: http://ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-europe-2014.pdf, 2015 [Accessed 12 April 2017].
3. Flamm, R.K., Castanheira, M., Streit, J.M., Jones, R.N., Minocycline activity tested against Acinetobacter baumannii complex, Stenotrophomonas maltophilia, and Burkholderia cepacia species complex isolates from a global surveillance program (2013). Diagn Microbiol Infect Dis 85 (2016), 352–355.
4. Fishbain, J., Peleg, A.Y., Treatment of Acinetobacter infections. Clin Infect Dis 51 (2010), 79–84.
5. Zarrilli, R., Pournaras, S., Giannouli, M., Tsakris, A., Global evolution of multidrug-resistant Acinetobacter baumannii clonal lineages. Int J Antimicrob Agents 41 (2013), 11–19.
6. Gogou, V., Pournaras, S., Giannouli, M., Voulgari, E., Piperaki, E.T., Zarrilli, R., et al. Evolution of multidrug-resistant Acinetobacter baumannii clonal lineages: a 10 year study in Greece (2000–09). J Antimicrob Chemother 66 (2011), 2767–2772.
7. D'Arezzo, S., Principe, L., Capone, A., Petrosillo, N., Petrucca, A., Visca, P., Changing carbapenemase gene pattern in an epidemic multidrug-resistant Acinetobacter baumannii lineage causing multiple outbreaks in central Italy. J Antimicrob Chemother 66 (2011), 54–61.
8. Djahmi, N., Dunyach-Remy, C., Pantel, A., Dekhil, M., Sotto, A., Lavigne, J.P., Epidemiology of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries. Biomed Res Int, 2014, 2014, 305784.
9. Liakopoulos, A., Miriagou, V., Katsifas, E.A., Karagouni, A.D., Daikos, G.L., Tzouvelekis, L.S., et al. Identification of OXA-23-producing Acinetobacter baumannii in Greece, 2010 to 2011. Euro Surveill, 17, 2012 pii: 20117.
10. OXA-51-like carbapenemase gene intrinsic to this species. J Clin Microbiol 44 (2006), 2974–2976.
11. Clinical and Laboratory Standards Institute, Performance standards for antimicrobial susceptibility testing; twenty-fifth informational supplement. Document M100-S25. Wayne, PA: CLSI, 2015.
12. Magiorakos, A.P., Srinivasan, A., Carey, R.B., Carmeli, Y., Falagas, M.E., Giske, C.G., et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18 (2012), 268–281.
13. Woodford, N., Ellington, M.J., Coelho, J.M., Turton, J.F., Ward, M.E., Brown, S., et al. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents 27 (2006), 351–353.
14. Higgins, P.G., Lehmann, M., Seifert, H., Inclusion of OXA-143 primers in a multiplex polymerase chain reaction (PCR) for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents, 35, 2010, 305.
15. Poirel, L., Walsh, T.R., Cuvillier, V., Nordmann, P., Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 70 (2011), 119–123.
16. Turton, J.F., Ward, M.E., Woodford, N., Kaufmann, M.E., Pike, R., Livermore, D.M., et al. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol Lett 258 (2006), 72–77.
17. Turton, J.F., Gabriel, S.N., Valderrey, C., Kaufmann, M.E., Pitt, T.L., Use of sequence-based typing and multiplex PCR to identify clonal lineages of outbreak strains of Acinetobacter baumannii. Clin Microbiol Infect 13 (2007), 807–815.
18. Giannouli, M., Cuccurullo, S., Crivaro, V., Di Popolo, A., Bernardo, M., Tomasone, F., et al. Molecular epidemiology of multidrug-resistant Acinetobacter baumannii in a tertiary care hospital in Naples, Italy, shows the emergence of a novel epidemic clone. J Clin Microbiol 48 (2010), 1223–1230.
19. OXA-51-like genes for rapid assignment of Acinetobacter baumannii clinical isolates to international clonal lineages. J Clin Microbiol 52 (2014), 1653–1657.
20. Sahl, J.W., Del Franco, M., Pournaras, S., Colman, R.E., Karah, N., Dijkshoorn, L., et al. Phylogenetic and genomic diversity in isolates from the globally distributed Acinetobacter baumannii ST25 lineage. Sci Rep, 5, 2015, 15188.
21. Tenover, F.C., Arbeit, R.D., Goering, R.V., Mickelsen, P.A., Murray, B.E., Persing, D.H., et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 33 (1995), 2233–2239.
22. Lob, S.H., Hoban, D.J., Sahm, D.F., Badal, R.E., Regional differences and trends in antimicrobial susceptibility of Acinetobacter baumannii. Int J Antimicrob Agents 47 (2016), 317–323.
23. OXA-23 carbapenemase gene of Acinetobacter baumannii. Emerg Infect Dis 16 (2010), 35–40.
24. Schleicher, X., Higgins, P.G., Wisplinghoff, H., Körber-Irrgang, B., Kresken, M., Seifert, H., Molecular epidemiology of Acinetobacter baumannii and Acinetobacter nosocomialis in Germany over a 5-year period (2005–2009). Clin Microbiol Infect 19 (2013), 737–742.
25. Karah, N., Sundsfjord, A., Towner, K., Samuelsen, Ø., Insights into the global molecular epidemiology of carbapenem non-susceptible clones of Acinetobacter baumannii. Drug Resist Updat 15 (2012), 237–247.
26. Viehman, J.A., Nguyen, M.H., Doi, Y., Treatment options for carbapenem-resistant and extensively drug-resistant Acinetobacter baumannii infections. Drugs 74 (2014), 1315–1333.