Alzheimer's disease and glaucoma: can glymphatic system dysfunction underlie their comorbidity?

Acta Ophthalmologica

Volumn 95, Issue 3, 2017, Pages e244-e245

  Wostyn, Peter ^a   De Groot, Veva ^b   Van Dam, Debby ^c   Audenaert, Kurt ^d   Killer, Hanspeter Esriel ^e   De Deyn, Peter Paul ^c,f,g  

^a PC Sint Amandus ^*  (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

^e CANTONAL HOSPITAL AARAU   (Switzerland)

^f MIDDELHEIM HOSPITAL   (Belgium)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; COMORBIDITY; GLAUCOMA; HUMAN; INTERSTITIAL FLUID; INTRAOCULAR PRESSURE; LETTER; NUCLEAR MAGNETIC RESONANCE IMAGING; BRAIN; DIAGNOSTIC IMAGING; EXTRACELLULAR FLUID; METABOLISM;

ALZHEIMER DISEASE; BRAIN; CEREBROSPINAL FLUID; COMORBIDITY; EXTRACELLULAR FLUID; GLAUCOMA; HUMANS; MAGNETIC RESONANCE IMAGING;

EID: 85017436400     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/aos.13068     Document Type: Letter

References (5)

1. Iliff JJ, Wang M, Liao Y, et al. (2012): A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 4: 147ra111.
2. Prins D, Hanekamp S & Cornelissen FW (2016): Structural brain MRI studies in eye diseases: are they clinically relevant? A review of current findings. Acta Ophthalmol 94: 113–121.
3. Wostyn P, De Groot V, Van Dam D, Audenaert K, Killer HE & De Deyn PP (2014): Glaucoma considered as an imbalance between production and clearance of neurotoxins. Invest Ophthalmol Vis Sci 55: 5351–5352.
4. Wostyn P, Van Dam D, Audenaert K, Killer HE, De Deyn PP & De Groot V (2015): A new glaucoma hypothesis: a role of glymphatic system dysfunction. Fluids Barriers CNS 12: 16.
5. Yang L, Kress BT, Weber HJ, et al. (2013): Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J Transl Med 11: 107.