The ketogenic diet metabolite beta-hydroxybutyrate (β-HB) reduces incidence of seizure-like activity (SLA) in a K atp- and GABA b-dependent manner in a whole-animal Drosophila melanogaster model

Epilepsy Research

Volumn 133, Issue , 2017, Pages 6-9

  Li, Jinglu ^a   O'Leary, Emma I ^a,c   Tanner, Geoffrey R ^a,b  

^a MOUNT HOLYOKE COLLEGE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Bang sensitive; GABA b receptor; K atp channel; Ketogenic diet; Ketone bodies; Seizure model

Indexed keywords

3 HYDROXYBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; POTASSIUM CHANNEL; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANTICONVULSIVE AGENT; ANTIDIABETIC AGENT; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; DROSOPHILA PROTEIN; PHOSPHINIC ACID DERIVATIVE; PROPANOLAMINE DERIVATIVE; TOLBUTAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FIRING RATE; INTRACELLULAR SIGNALING; KETOGENIC DIET; MECHANICAL STIMULATION; NONHUMAN; OUTCOME ASSESSMENT; SEIZURE; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; NONPARAMETRIC TEST; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

3-HYDROXYBUTYRIC ACID; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GABA ANTAGONISTS; HYPOGLYCEMIC AGENTS; KATP CHANNELS; PHOSPHINIC ACIDS; PROPANOLAMINES; RECEPTORS, GABA-B; SEIZURES; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TOLBUTAMIDE;

EID: 85017155945     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2017.04.003     Document Type: Article

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