Risk factors for mortality in children with pneumonia admitted to the pediatric intensive care unit

Pediatric Pulmonology

Volumn 52, Issue 8, 2017, Pages 1076-1084

  Koh, Jia Wen Janine Cynthia ^a   Wong, Judith Ju Ming ^b,c   Sultana, Rehena ^c   Wong, Petrina Poh Chen ^b   Mok, Yee Hui ^b   Lee, Jan Hau ^b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

community acquired pneumonia; critically ill children; hospital acquired pneumonia; severe pneumonia

Indexed keywords

AMPICILLIN; CARBAPENEM; CLOXACILLIN; COTRIMOXAZOLE; MACROLIDE; VANCOMYCIN;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; ARTIFICIAL VENTILATION; BACTEREMIA; BACTERIAL PNEUMONIA; BACTERIUM IDENTIFICATION; CHILD; COMMUNITY ACQUIRED PNEUMONIA; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HOSPITAL ACQUIRED PNEUMONIA; HUMAN; KLEBSIELLA PNEUMONIAE; LENGTH OF STAY; LUNG ABSCESS; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOPLASMA PNEUMONIAE; NECROTIZING PNEUMONIA; PEDIATRIC INTENSIVE CARE UNIT; PNEUMONIA; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; STREPTOCOCCUS PNEUMONIAE; TIDAL VOLUME; VIRUS PNEUMONIA; ADOLESCENT; HOSPITALIZATION; INFANT; PRESCHOOL CHILD; PROGNOSIS; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HOSPITALIZATION; HUMANS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; LOGISTIC MODELS; MALE; PNEUMONIA, BACTERIAL; PNEUMONIA, VIRAL; PROGNOSIS; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 85017142008     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.23702     Document Type: Article

References (43)

1. Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008; 86:408–416.
2. Walker CLF, Rudan I, Liu L, et al. Global burden of childhood pneumonia and diarrhoea. Lancet. 381:1405–1416.
3. Global Burden of Disease Pediatrics C. Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013: findings from the global burden of disease 2013 study. JAMA Pediatr. 2016; 170:267–287.
4. Revised WHO Classification and Treatment of Pneumonia in Children at Health Facilities: Evidence Summaries. Geneva: World Health Organization; 2014. 2014.
5. Reed C, Madhi SA, Klugman KP, et al. Development of the Respiratory Index of Severity in Children (RISC) score among young children with respiratory infections in South Africa. PLoS ONE. 2012; 7:e27793.
6. Araya S, Lovera D, Zarate C, et al. Application of a prognostic scale to estimate the mortality of children hospitalized with community-acquired pneumonia. Pediatr Infect Dis J. 2016; 35:369–373.
7. Harris M, Clark J, Coote N, et al. British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011. Thorax. 2011; 66:ii1–ii23.
8. Puumalainen T, Quiambao B, Abucejo-Ladesma E, et al. Clinical case review: a method to improve identification of true clinical and radiographic pneumonia in children meeting the World Health Organization definition for pneumonia. BMC Infect Dis. 2008.
9. Tiewsoh K, Lodha R, Pandey RM, Broor S, Kalaivani M, Kabra SK. Factors determining the outcome of children hospitalized with severe pneumonia. BMC Pediatr. 2009; 9:15.
10. Berger JT, Carcillo JA, Shanley TP, et al. Critical pertussis illness in children: a multicenter prospective cohort study. Pediatr Crit Care Med. 2013; 14:356–365.
11. Delport SD, Brisley T. Aetiology and outcome of severe community-acquired pneumonia in children admitted to a paediatric intensive care unit. S Afr Med J. 2002; 92:907–911.
12. Straliotto SM, Siqueira MM, Machado V, Maia TM. Respiratory viruses in the pediatric intensive care unit: prevalence and clinical aspects. Memorias do Instituto Oswaldo Cruz. 2004; 99:883–887.
13. Kuczmarski RJ, Ogden CL, Guo SS, et al. CDC growth charts for the United States: methods and development. Vital and health statistics Series 11, Data from the national health survey 2000;1–190.
14. Slater A, Shann F, Pearson G. PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med. 2003; 29:278–285.
15. Cherian T, Mulholland EK, Carlin JB, et al. Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies. Bull World Health Organ. 2005; 83:353–359.
16. Group WHOPVTI, Biologicals WHODoVa. Standardization of interpretation of chest radiographs for the diagnosis of pneumonia in children/World Health Organization Pneumonia Vaccine Trial Investigators' Group. 2001. Geneva: World Health Organization.
17. Bradley JS. Considerations unique to pediatrics for clinical trial design in hospital-Acquired pneumonia and ventilator-Associated pneumonia. Clin Infect Dis. 2010; 51:S136–SS43.
18. Berdajs D. Bicaval dual-lumen cannula for venovenous extracorporeal membrane oxygenation: avalon(c) cannula in childhood disease. Perfusion. 2015; 30:182–186.
19. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005; 6:2–8.
20. Revised WHO Classification and Treatment of Pneumonia in Children at Health Facilities: Evidence Summaries. Geneva: World Health Organization; 2014. 2014.
21. Randolph AG, Meert KL, O'Neil ME, et al. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med. 2003; 167:1334–1340.
22. Abebe T, Girmay M, G/Michael G, Tesfaye M. The epidemiological profile of pediatric patients admitted to the general intensive care unit in an Ethiopian university hospital. Int J Gen Med. 2015; 8:63–67.
23. Lanetzki CS, de Oliveira CA, Bass LM, Abramovici S, Troster EJ. The epidemiological profile of Pediatric Intensive Care Center at Hospital Israelita Albert Einstein. Einstein (Sao Paulo, Brazil). 2012; 10:16–21.
24. Ramachandran P, Nedunchelian K, Vengatesan A, Suresh S. Risk factors for mortality in community acquired pneumonia among children aged 1-59 months admitted in a referral hospital. Indian Pediatr. 2012; 49:889–895.
25. Demers AM, Morency P, Mberyo-Yaah F, et al. Risk factors for mortality among children hospitalized because of acute respiratory infections in Bangui, Central African Republic. Pediatr Infect Dis J. 2000; 19: 424–432.
26. Wang LJ, Mu SC, Lin CH, Lin MI, Sung TC. Fatal community-acquired pneumonia: 18 years in a medical center. Pediatr Neonatol. 2013; 54:22–27.
27. Chisti MJ, Tebruegge M, La Vincente S, Graham SM, Duke T. Pneumonia in severely malnourished children in developing countries—mortality risk, aetiology and validity of WHO clinical signs: a systematic review. Trop Med Int Health. 2009; 14:1173–1189.
28. Johnson AW, Osinusi K, Aderele WI, Gbadero DA, Olaleye OD, Adeyemi-Doro FA. Etiologic agents and outcome determinants of community-acquired pneumonia in urban children: a hospital-based study. J Natl Med Assoc. 2008; 100:370–385.
29. Djelantik IG, Gessner BD, Sutanto A, et al. Case fatality proportions and predictive factors for mortality among children hospitalized with severe pneumonia in a rural developing country setting. J Trop Pediatr. 2003; 49:327–332.
30. Jroundi I, Mahraoui C, Benmessaoud R, et al. Risk factors for a poor outcome among children admitted with clinically severe pneumonia to a university hospital in Rabat, Morocco. Int J Infect Dis. 2014; 28:164–170.
31. Luyt CE, Combes A, Trouillet JL, Nieszkowska A, Chastre J. Virus-induced acute respiratory distress syndrome: epidemiology, management and outcome. Presse medicale (Paris, France: 1983). 2011; 40:e561–e568.
32. Bauer TT, Ewig S, Rodloff AC, Müller EE. Acute respiratory distress syndrome and pneumonia: a comprehensive review of clinical data. Clin Infect Dis. 2006; 43:748–756.
33. Rehder KJ, Wilson EA, Zimmerman KO, Cunningham CK, Turner DA. Detection of multiple respiratory viruses associated with mortality and severity of illness in children. Pediatr Crit Care Med. 2015; 16: e201–e206.
34. Liapikou A, Ferrer M, Polverino E, et al. Severe community-Acquired pneumonia: validation of the infectious diseases society of America/American thoracic society guidelines to predict an intensive care unit admission. Clin Infect Dis. 2009; 48:377–385.
35. Weiss AK, Hall M, Lee GE, Kronman MP, Sheffler-Collins S, Shah SS. Adjunct corticosteroids in children hospitalized with community-Acquired pneumonia. Pediatrics. 2011; 127:e255–ee63.
36. Ambroggio L, Test M, Metlay JP, et al. Adjunct systemic corticosteroid therapy in children with community-Acquired pneumonia in the outpatient setting. J Pediatric Infect Dis Soc. 2015; 4:21–27.
37. Nagy B, Gaspar I, Papp A, et al. Efficacy of methylprednisolone in children with severe community acquired pneumonia. Pediatr Pulmonol. 2013; 48:168–175.
38. Marrie TJ. Pneumococcal pneumonia: epidemiology and clinical features. Semin Respir Infect. 1999; 14:227–236.
39. Suwanjutha S, Ruangkanchanasetr S, Chantarojanasiri T, Hotrakitya S. Risk factors associated with morbidity and mortality of pneumonia in Thai children under 5 years. Southeast Asian J Trop Med Public Health. 1994; 25:60–66.
40. Gandhi J, Sangareddi S, Varadarajan P, Suresh S. Pediatric index of mortality 2 score as an outcome predictor in pediatric Intensive Care Unit in India. Indian J Crit Care Med. 2013; 17:288–291.
41. Masterton RG, Galloway A, French G, et al. Guidelines for the management of hospital-acquired pneumonia in the UK: report of the Working Party on Hospital-Acquired Pneumonia of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother. 2008; 62:5–34.
42. Azab SF, Sherief LM, Saleh SH, Elsaeed WF, Elshafie MA, Abdelsalam SM. Impact of the socioeconomic status on the severity and outcome of community-acquired pneumonia among Egyptian children: a cohort study. Infect Dis Poverty. 2014; 3:14.
43. Raghavendran K, Nemzek J, Napolitano LM, Knight PR. Aspiration-Induced lung injury. Crit Care Med. 2011; 39:818–826.