Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells

Cell Death and Disease

Volumn 7, Issue 9, 2016, Pages

  Gao, Qi ^a   Chen, Kexin ^a   Gao, Lu ^a   Zheng, Yang ^a   Yang, Yong Guang ^a,b  

^a JILIN UNIVERSITY   (China)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD47 ANTIGEN; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; KI 67 ANTIGEN; PROTEIN P21; THROMBOSPONDIN 1; CD47 PROTEIN, MOUSE; COLLAGEN; DRUG COMBINATION; LAMININ; MATRIGEL; PROTEOGLYCAN; THROMBOSPONDIN-1, MOUSE;

AGING; ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; IN VITRO STUDY; MOUSE; MRNA EXPRESSION LEVEL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOASSAY; BRAIN; C57BL MOUSE; CELL CYCLE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG COMBINATION; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PRIMARY CELL CULTURE; VASCULARIZATION;

ANIMALS; ANTIGENS, CD47; BIOLOGICAL ASSAY; BRAIN; CELL AGING; CELL CYCLE; CELL PROLIFERATION; COLLAGEN; DRUG COMBINATIONS; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; LAMININ; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; PRIMARY CELL CULTURE; PROTEOGLYCANS; SIGNAL TRANSDUCTION; THROMBOSPONDIN 1;

EID: 85016933490     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2016.155     Document Type: Article

References (30)

1. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part i: aging arteries: a 'set up' for vascular disease. Circulation 2003; 107: 139–146.
2. Rivard A, Fabre J-E, Silver M, Chen D, Murohara T, Kearney M et al. Age-dependent impairment of angiogenesis. Circulation 1999; 99: 111–120.
3. North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res 2012; 110: 1097–1108.
4. Laurent S. Defining vascular aging and cardiovascular risk. J Hypertens 2012; 30 (Suppl):S3–S8.
5. Erusalimsky JD, Kurz DJ. Cellular senescence in vivo: its relevance in ageing and cardiovascular disease. Exp Gerontol 2005; 40: 634–642.
6. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 2002; 105: 1541–1544.
7. Chen J. Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circ Res 2002; 90: 1290–1298.
8. Imanishi T, Hano T, Sawamura T, Nishio I. Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol 2004; 31: 407–413.
9. Rogers SC, Zhang X, Azhar G, Luo S, Wei JY. Exposure to high or low glucose levels accelerates the appearance of markers of endothelial cell senescence and induces dysregulation of nitric oxide synthase. J Gerontol Ser A 2013; 68: 1469–1481.
10. Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J et al. Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. Arterioscler Thromb Vasc Biol 2012; 32: 712–720.
11. Nazari-Shafti TZ, Cooke JP. Telomerase therapy to reverse cardiovascular senescence. Methodist DeBakey Cardiovasc J 2015; 11: 172–175.
12. Zaslavsky A, Baek K, Lynch R, Short S, Grillo J, Italiano J et al. Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis. Blood 2010; 115: 4605–4613.
13. Jimenez B, Volpert O, Reiher F, Chang L, Munoz A, Karin M et al. c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1. Oncogene 2001; 20: 3443–3448.
14. Isenberg JS, Jia Y, Fukuyama J, Switzer CH, Wink DA, Roberts DD. Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J Biol Chem 2007; 282: 15404–15415.
15. Kanda S, Shono T, Tomasinijohansson B, Klint P, Saito Y. Role of thrombospondin-1-derived peptide, 4N1K, in FGF-2-induced angiogenesis. Exp Cell Res 1999; 252: 262–272.
16. Isenberg JS, Ridnour LA, Dimitry J, Frazier WA, Wink DA, Roberts DD. CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1. J Biol Chem 2006; 281: 26069–26080.
17. Sick E, Jeanne A, Schneider C, Dedieu S, Takeda K, Martiny L. CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest. Br J Pharmacol 2012; 167: 1415–1430.
18. Kaur S, Soto-Pantoja DR, Stein EV, Liu C, Elkahloun AG, Pendrak ML et al. Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors. Scientific Rep 2013; 3: 1673.
19. Kuilman T, Michaloglou C, Mooi WJ, Peeper DS. The essence of senescence. Genes Dev 2010; 24: 2463–2479.
20. Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell 2007; 130: 223–233.
21. Leong WF, Chau JF, Li B. p53 Deficiency leads to compensatory up-regulation of p16INK4a. Mol Cancer Res 2009; 7: 354–360.
22. Giacinti C, Giordano A. RB and cell cycle progression. Oncogene 2006; 25: 5220–5227.
23. Connell-Crowley L, Harper JW, Goodrich DW. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell 1997; 8: 287–301.
24. Sherr C, Mccormick F. The RB and p53 pathways in cancer. Cancer Cell 2002; 2: 103–112.
25. Nevins JR. The Rb/E2F pathway and cancer. Hum Mol Genet 2001; 10: 699–703.
26. Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 2009; 106: 326–332.
27. Zieman S, Melenovsky V, Kass D. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005; 25: 932–943.
28. Koshimizu H, Araki T, Takai S, Yokomaku D, Ishikawa Y, Kubota M et al. Expression of CD47/ integrin-associated protein induces death of cultured cerebral cortical neurons. J Neurochem 2002; 82: 249–257.
29. Olson B, Day J, Laping N. Age-related expression of renal thrombospondin 1 mRNA in F344 rats: resemblance to diabetes-induced expression in obese zucker rats. Pharmacology 1999; 58: 200–208.
30. Burek M, Salvador E, Forster CY. Generation of an immortalized murine brain microvascular endothelial cell line as an in vitro blood brain barrier model. J Vis Exp 2012; 29: e4022.