The safety and efficacy of Diphoterine for ocular and cutaneous burns in humans

Cutaneous and Ocular Toxicology

Volumn 36, Issue 2, 2017, Pages 185-192

  Lynn, Darren D ^a   Zukin, Leonid M ^a   Dellavalle, Robert ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

acid burn; alkaloid burn; amphoteric; chemical burn; Prevor

Indexed keywords

CHELATING AGENT; DIPHOTERINE; HYPERTONIC SOLUTION; UNCLASSIFIED DRUG; DERMATOLOGICAL AGENT; EYE DROPS; ORGANIC COMPOUND;

ABSENTEEISM; CHEMICAL BURN; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; EYE BURN; HUMAN; LD50; OUTCOME ASSESSMENT; REVIEW; SYSTEMATIC REVIEW; ANALGESIA; BURNS, CHEMICAL; CHEMICALLY INDUCED; DRUG EFFECTS; ECONOMICS; EYE BURNS; OCCUPATIONAL INJURIES; PROCEDURES; TREATMENT OUTCOME; WOUND HEALING;

BURNS, CHEMICAL; DERMATOLOGIC AGENTS; EYE BURNS; HUMANS; OCCUPATIONAL INJURIES; OPHTHALMIC SOLUTIONS; ORGANIC CHEMICALS; PAIN MANAGEMENT; TREATMENT OUTCOME; WOUND HEALING;

EID: 85016564307     PISSN: 15569527     EISSN: 15569535     Source Type: Journal    
DOI: 10.1080/15569527.2016.1217423     Document Type: Review

References (17)

1. Hardwicke J, Hunter T, Staruch R, Moiemen N. Chemical burns–an historical comparison and review of the literature. Burns 2012;38:383–387.
2. Nehles J, Hall AH, Blomet J, Mathieu L., Diphoterine for emergent decontamination of skin/eye chemical splashes:24 cases. Cutan Ocul Toxicol 2006;25:249–258.
3. Hall AH, Blomet J, Mathieu L., Diphoterine for emergent eye/skin chemical splash decontamination:a review. Vet Hum Toxicol 2002;44:228–231.
4. Hall AH, Maibach HI., Water decontamination of chemical skin/eye splashes:a critical review. Cutan Ocul Toxicol 2006;25:67–83.
5. Rihawi S, Frentz M, Schrage NF., Emergency treatment of eye burns:which rinsing solution should we choose? Graefes Arch Clin Exp Ophthalmol 2006;244:845–854.
6. Donoghue AM, Diphoterine R., Diphoterine® for alkali splashes to the skin. Clin Toxicol (Phila) 2014;52:148
7. Zack-Williams SD, Ahmad Z, Moiemen NS., The clinical efficacy of Diphoterine® in the management of cutaneous chemical burns:a 2-year evaluation study. Ann Burns Fire Disasters 2015;28:9–12.
8. Mathieu L, Burgher F, Hall AH., Diphoterine chemical splash decontamination solution:skin sensitization study in the guinea pig. Cutan Ocul Toxicol 2007;26:181–17.
9. Hall AH, Cavallini M, Mathieu L, Maibach HI., Safety of dermal diphoterine application:an active decontamination solution for chemical splash injuries. Cutan Ocul Toxicol 2009;28:149–156.
10. Scientific publications, studies and articles on DIPHOTERINE® solution:Prevor.com; 2016. Available from:http://www.prevor.com/en/scientific-publications-studies-and-articles-on-diphoterine-solution [last accessed 2 Apr 2016].
11. Donoghue AM., Diphoterine for alkali chemical splashes to the skin at alumina refineries. Int J Dermatol 2010;49:894–900.
12. Dua H, King A, Joseph A., A new classification of ocular surface burns. Br J Ophthalmol 2001;85:1379–1383.
13. Merle H, Donnio A, Ayeboua L, et al. Alkali ocular burns in Martinique (French West Indies) evaluation of the use of an amphoteric solution as the rinsing product. Burns 2005;31:205–211.
14. Viala B, Blomet J, Mathieu L, Hall AH., Prevention of CS “tear gas” eye and skin effects and active decontamination with Diphoterine:preliminary studies in 5 French Gendarmes. J Emerg Med 2005;29:5–8.
15. Ivens U, Serup J, O'Goshi K., Allergy patch test reading from photographic images:disagreement on ICDRG grading but agreement on simplified tripartite reading. Skin Res Technol 2007;13:110–113.
16. Kompa S, Schareck B, Tympner J, et al. Comparison of emergency eye-wash products in burned porcine eyes. Graefes Arch Clin Exp Ophthalmol 2002;240:308–313.
17. Langefeld S, Press UP, Frentz M, et al. Use of lavage fluid containing diphoterine for irrigation of eyes in first aid emergency treatment. Ophthalmologe 2003;100:727–731.