Efficacy of Varenicline for Cigarette Reduction Before Quitting in Japanese Smokers: A Subpopulation Analysis of the Reduce to Quit Trial

Clinical Therapeutics

Volumn 39, Issue 4, 2017, Pages 863-872

  Nakamura, Masakazu ^a   Abe, Masaaki ^b   Ohkura, Masayuki ^b   Treadow, Joan ^b   Yu, Ching Ray ^b   Park, Peter W ^b  

^a Japan Association for Development of Community Medicine   (Japan)

^b PFIZER INC   (United States)

Author keywords

quit approaches; reduce to quit; smoking cessation; varenicline

Indexed keywords

CARBON MONOXIDE; PLACEBO; VARENICLINE; NICOTINIC AGENT;

ABNORMAL DREAMING; ACNE; ADULT; ALLERGIC RHINITIS; ALLERGY; ARTICLE; ASTHMA; BACKACHE; BRONCHITIS; CONSTIPATION; CONTROLLED STUDY; CONTUSION; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG TOLERABILITY; ECZEMA; FALLING; FEMALE; FOLLOW UP; GASTRITIS; GASTROENTERITIS; GASTROESOPHAGEAL REFLUX; HEART PALPITATION; HUMAN; HYPERTENSION; INCREASED APPETITE; INFLUENZA; INSOMNIA; INTESTINE POLYP; IRRITABILITY; JAPANESE (PEOPLE); LIGAMENT INJURY; MAJOR CLINICAL STUDY; MALE; NAUSEA; NIGHTMARE; OROPHARYNX PAIN; PATIENT DROPOUT; PHARYNGITIS; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SMOKING; SMOKING CESSATION; SOMNOLENCE; STOMACH DISEASE; STRESS; TRIACYLGLYCEROL BLOOD LEVEL; UPPER ABDOMINAL PAIN; VOMITING; WEIGHT GAIN; YOUNG ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CLINICAL TRIAL; MIDDLE AGED; MULTICENTER STUDY; ODDS RATIO; TOBACCO USE DISORDER; TREATMENT OUTCOME;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NICOTINIC AGONISTS; ODDS RATIO; SMOKING CESSATION; TOBACCO USE DISORDER; TREATMENT OUTCOME; VARENICLINE;

EID: 85016481147     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2017.03.007     Document Type: Article

References (22)

1. 1 World Health Organization. WHO Report on the Global Tobacco Epidemic. 2015 Accessed May 6, 2016, http://www.who.int/tobacco/surveillance/policy/country_profile/jpn.pdf.
2. 2 Alberg, A.J., Shopland, D.R., Cummings, K.M., The 2014 Surgeon General׳s report: commemorating the 50th anniversary of the 1964 Report of the Advisory Committee to the US Surgeon General and updating the evidence on the health consequences of cigarette smoking. Am J Epidemiol 179 (2014), 403–412.
3. 3 Eriksen, M., Mackay, J., Schluger, N., et al. The Tobacco Atlas, 5th ed, 2015, American Cancer Society, Atlanta, Georgia.
4. 4 Ministry of Health Labour and Welfare. National Health and Nutrition Examination Survey [in Japanese], 2014 Accessed May 6, 2016, http://www.mhlw.go.jp/stf/houdou/0000106405.html.
5. 5 Lader D. (2009). Smoking-related behaviour and attitudes, 2008/2009. Accessed May 6, 2016, http://webarchive.nationalarchives.gov.uk/20160105160709/http://www.ons.gov.uk/ons/rel/lifestyles/smoking-related-behaviour-and-attitudes/2008-09/smoking-related-behaviour-and-attitudes-2008-09.pdf.
6. 6 Hagimoto, A., Nakamura, M., Morita, T., et al. Smoking cessation patterns and predictors of quitting smoking among the Japanese general population: a 1-year follow-up study. Addiction 105 (2010), 164–173.
7. 7 West, R., Brown, J., Smoking and smoking cessation in England 2011: findings from the Smoking Toolkit Study, 2012 Accessed May 6, 2016, http://www.smokinginengland.info/reports/.
8. 8 Nakamura, M., Oshima, A., Fujimoto, Y., et al. Efficacy and tolerability of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, in a 12-week, randomized, placebo-controlled, dose-response study with 40-week follow-up for smoking cessation in Japanese smokers. Clin Ther 29 (2007), 1040–1056.
9. 9 JCS Joint Working Group. Guidelines for Smoking Cessation (JCS 2010) – digest version. Circ J 76 (2012), 1024–1043.
10. 10 Lindson-Hawley, N., Aveyard, P., Hughes, J.R., Reduction versus abrupt cessation in smokers who want to quit. Cochrane Database Syst Rev, 11, 2012, CD008033.
11. 11 Moore, D., Aveyard, P., Connock, M., et al. Effectiveness and safety of nicotine replacement therapy assisted reduction to stop smoking: systematic review and meta-analysis. BMJ, 338, 2009, b1024.
12. 12 Wang, D., Connock, M., Barton, P., et al. ׳Cut down to quit׳ with nicotine replacement therapies in smoking cessation: a systematic review of effectiveness and economic analysis. Health Technol Assess, 12, 2008 iii–iv, ix–xi, 1–135.
13. 13 Gonzales, D., Rennard, S.I., Nides, M., et al. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA 296 (2006), 47–55.
14. 14 Jorenby, D.E., Hays, J.T., Rigotti, N.A., et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA 296 (2006), 56–63.
15. 15 Hughes, J.R., Rennard, S.I., Fingar, J.R., et al. Efficacy of varenicline to prompt quit attempts in smokers not currently trying to quit: a randomized placebo-controlled trial. Nicotine Tob Res 13 (2011), 955–964.
16. 16 Ebbert, J.O., Hughes, J.R., West, R.J., et al. Effect of varenicline on smoking cessation through smoking reduction: a randomized clinical trial. JAMA 313 (2015), 687–694.
17. 17 Ministry of Health Labour and Welfare. Basic principles on global clinical trials, 2007 Accessed May 6, 2016, http://www.pmda.go.jp/files/000153265.pdf.
18. 18 ClinicalTrials.gov. A Study to Evaluate the Efficacy and Safety of Varenicline Compared to Placebo for Smoking Cessation Through Reduction. NCT01370356. Accessed November 24, 2016, https://clinicaltrials.gov/ct2/show/results/NCT01370356?term=NCT01370356&rank=1.
19. 19 Fagerstrom, K., Nakamura, M., Cho, H.J., et al. Varenicline treatment for smoking cessation in Asian populations: a pooled analysis of placebo-controlled trials conducted in six Asian countries. Curr Med Res Opin 26 (2010), 2165–2173.
20. 20 Nakamura, M., Current conditions and future issues of smoking cessation policy in Japan (in Japanese). J Japanese Med Associate 141 (2012), 1917–1922.
21. 21 Eriksen, M., Mackay, J., Ross, H., The Tobacco Atlas, 4th ed, 2012, American Cancer Society, Altanta, Georgia.
22. 22 FCTC. Article 14 tobacco dependence and cessation: evidence from the ITC Project (2010), 2010 Accessed May 6, 2016, http://www.itcproject.org/files/Article/itccessationreport.pdf.