Distinct subclonal tumour responses to therapy revealed by circulating cell-free DNA

Annals of Oncology

Volumn 27, Issue 10, 2016, Pages 1959-1965

  Gremel, G ^a   Lee, R J ^a   Girotti, M R ^a   Mandal, A K ^a   Valpione, S ^b   Garner, G ^a   Ayub, M ^a   Wood, S ^a   Rothwell, D G ^a   Fusi, A ^b   Wallace, A ^c   Brady, G ^a   Dive, C ^a   Dhomen, N ^a   Lorigan, P ^b   Marais, Richard ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Circulating cell free DNA; Clonal response to therapy; Next generation sequencing; Vaginal mucosal melanoma

Indexed keywords

CARBOPLATIN; CELL FREE NUCLEIC ACID; CIRCULATING CELL FREE DNA; DACARBAZINE; DNA; IMATINIB; IPILIMUMAB; LACTATE DEHYDROGENASE; PACLITAXEL; PEMBROLIZUMAB; PROTEIN KIT; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; PHARMACOLOGICAL BIOMARKER; STEM CELL FACTOR RECEPTOR;

ABDOMINAL HYSTERECTOMY; ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER THERAPY; CASE REPORT; CLINICAL ARTICLE; DNA SEQUENCE; DROPLET DIGITAL POLYMERASE CHAIN REACTION; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; GENE AMPLIFICATION; GENE DOSAGE; GENE MUTATION; GYNECOLOGIC SURGERY; HUMAN; HUMAN TISSUE; KIT GENE; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER METASTASIS; LONGITUDINAL STUDY; METASTATIC MELANOMA; METASTATIC VAGINAL MUCOSA MELANOMA; MOLECULAR EVOLUTION; MULTIPLE CYCLE TREATMENT; NEXT GENERATION SEQUENCING; PERSONALIZED MEDICINE; PRIORITY JOURNAL; RECTUM ABDOMINOPERINEAL RESECTION; SALPINGOOOPHORECTOMY; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; VAGINA CANCER; VAGINOVULVECTOMY; WHOLE EXOME SEQUENCING; WILD TYPE; AGED; DRUG EFFECTS; GENETICS; HIGH THROUGHPUT SEQUENCING; MELANOMA; MIDDLE AGED; MUTATION; PATHOLOGY; VAGINA TUMOR;

ADULT; AGED; BIOMARKERS, PHARMACOLOGICAL; CARBOPLATIN; CELL-FREE NUCLEIC ACIDS; DNA, NEOPLASM; FEMALE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMATINIB MESYLATE; MELANOMA; MIDDLE AGED; MUTATION; PACLITAXEL; PRECISION MEDICINE; PROTO-ONCOGENE PROTEINS C-KIT; VAGINAL NEOPLASMS; WHOLE EXOME SEQUENCING;

EID: 85016264335     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdw278     Document Type: Article

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