MicroRNA-181a is upregulated in human atherosclerosis plaques and involves in the oxidative stress-induced endothelial cell dysfunction through direct targeting Bcl-2

European Review for Medical and Pharmacological Sciences

Volumn 20, Issue 14, 2016, Pages 3092-3100

  Liu, G ^a   Li, Y ^a   Gao, X G ^a  

^a TIANJIN HUANHU HOSPITAL   (China)

Author keywords

Bcl 2; Human atherosclerosis plaques; MicorRNA 181a; Oxidative stress.

Indexed keywords

HYDROGEN PEROXIDE; LIPOFECTAMINE; MESSENGER RNA; MICRORNA; MICRORNA 181A; PROTEIN BCL 2; UNCLASSIFIED DRUG; MIRN181 MICRORNA, HUMAN;

APOPTOSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIMIT OF QUANTITATION; MTT ASSAY; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN RNA BINDING; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING; ATHEROSCLEROSIS; GENETICS; METABOLISM; PROTO ONCOGENE;

ATHEROSCLEROSIS; ENDOTHELIAL CELLS; GENES, BCL-2; HUMANS; HYDROGEN PEROXIDE; MICRORNAS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 85016250945     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. AMERES SL, ZAMORE PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol 2013; 14: 475-488.
2. CROCE CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009; 10: 704-714.
3. ZHENG T, WANG J, CHEN X, LIU L. Role of microRNA in anticancer drug resistance. Int J Cancer 2010; 126: 2-10.
4. MA J, DONG C, JI C. MicroRNA and drug resistance. Cancer Gene Ther 2010; 17: 523-531.
5. WENG H, LAL K, YANG FF, CHEN J. The pathological role and prognostic impact of MIR-181 in acute myeloid leukemia. Cancer Genet 2015; 208: 225-229.
6. MUTLU S, MUTLU H, KIRKBES S, EROGLU S, KABUKCUOGLU YS, KABUKCUOGLU F, DUYMUS TM, ISIK M, ULASLI M. The expression of MIR-181a-5p and MIR-371b-5p in chondrosarcoma. Eur Rev Med Pharmacol Sci 2015; 19: 2384-2388
7. VASA-NICOTERA M, CHEN H, TUCCI P, YANG AL, SAINTIGNY G, MENGHINI R, MAHÈ C, AGOSTINI M, KNIGHT RA, MELINO G, FEDERICI M. MIR-146a is modulated in human endothelial cell with aging. Atherosclerosis 2011; 217: 326-330.
8. MENGHINI R, CASAGRANDE V, CARDELLINI M, MARTELLI E, TERRINONI A, AMATI F, VASA-NICOTERA M, IPPOLITI A, NOVELLI G, MELINO G, LAURO R, FEDERICI M. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 2009; 120: 1524-1532.
9. ITO T, YAGI S, YAMAKUCHI M. MicroRNA-34a regulation of endothelial senescence. Biochem Biophys Res Commun 2010; 398: 735-740.
10. VITA JA. Endothelial function. Circulation 2011; 124: e906-e912.
11. RAJENDRAN P, RENGARAJAN T, THANGAVEL J, NISHIGAKI Y, SAKTHISEKARAN D, SETHI G, NISHIGAKI I. The vascular endothelium and human diseases. Int J Biol Sci 2013; 9: 1057-1069.
12. DEANFIELD JE, HALCOX JP, RABELINK TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation 2007; 115: 1285-1295.
13. ZHANG PY, XU X, LI XC. Cardiovascular diseases: oxidative damage and antioxidant protection. Eur Rev Med Pharmacol Sci 2014; 18: 3091-3096.
14. CZABOTAR PE, LESSENE G, STRASSER A, ADAMS JM. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 2014; 15: 49-63.
15. WEYHENMEYER B, MURPHY AC, PREHN JH, MURPHY BM. Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer. Exp Oncol 2012; 34: 192-199.
16. THORP E, LI Y, BAO L, YAO PM, KURIAKOSE G, RONG J, FISHER EA, TABAS I. Increased apoptosis in advanced atherosclerotic lesions of Apoe-/-mice lacking macrophage Bcl-2. Arterioscler Thromb Vasc Biol 2009; 29: 169-172.
17. OUYANG YB, LU Y, YUE S, GIFFARD RG. MIR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes. Mitochondrion 2012; 12: 213-219.
18. MADRIGAL-MATUTE J, ROTLLAN N, ARANDA JF, FERNÁNDEZ-HERNANDO C. MicroRNAs and atherosclerosis. Curr Atheroscler Rep 2013; 15: 322.
19. SONG Z, LIU Y, HAO B, YU S, ZHANG H, LIU D, ZHOU B, WU L, WANG M, XIONG Z, WU C, ZHU J, QIAN X. Ginsenoside Rb1 prevents H2O2-induced HUVEC senescence by stimulating sirtuin-1 pathway. PLoS One 2014; 9: e112699.
20. MAGENTA A, GRECO S, GAETANO C, MARTELLI F. Oxidative stress and microRNAs in vascular diseases. Int J Mol Sci 2013; 14: 17319-17346.
21. ARANDA JF, MADRIGAL-MATUTE J, ROTLLAN N, FERNÁNDEZ-HERNANDO C. MicroRNA modulation of lipid metabolism and oxidative stress in cardiometabolic diseases. Free Radic Biol Med 2013; 64: 31-39.
22. REMUS EW, LYLE AN, WEISS D, LANDÀZURI N, WEBER M, SEARLES C, TAYLOR WR. MIR181a protects against angiotensin II-induced osteopontin expression in vascular smooth muscle cells. Atherosclerosis 2013; 228: 168-174.
23. MONTEZANO AC, TOUYZ RM. Reactive oxygen species and endothelial function-role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases. Basic Clin Pharmacol Toxicol 2012; 110: 87-94.
24. KARAFLOU M, LAMBRINOUDAKI I, CHRISTODOULAKOS G. Apoptosis in atherosclerosis: a mini-review. Mini Rev Med Chem 2008; 8: 912-918.