The role of vitamin D in maintaining bone health in older people

Therapeutic Advances in Musculoskeletal Disease

Volumn 9, Issue 4, 2017, Pages 89-95

  Hill, Thomas R ^a   Aspray, Terry J ^b,c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b FREEMAN HOSPITAL   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

bone health; older people; osteomalacia; osteoporosis; Vitamin D

Indexed keywords

CALCIFEDIOL; CALCIUM; COLECALCIFEROL; PARATHYROID HORMONE; VITAMIN D;

BONE; BONE CHARACTERISTICS AND FUNCTIONS; BONE DENSITY; BONE MASS; CALCIUM ABSORPTION; CALCIUM INTAKE; CLINICAL TRIAL (TOPIC); DIETARY REFERENCE INTAKE; FALLING; FRACTURE; FRAIL ELDERLY; FRAILTY; GLOMERULUS FILTRATION RATE; HUMAN; HYDROXYLATION; KIDNEY FUNCTION; META ANALYSIS (TOPIC); MORPHOMETRY; MULTICENTER STUDY (TOPIC); MUSCLE WEAKNESS; OSTEOMALACIA; OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SARCOPENIA; SYSTEMATIC REVIEW (TOPIC); VITAMIN D DEFICIENCY; VITAMIN D METABOLISM; VITAMIN SUPPLEMENTATION;

EID: 85016217372     PISSN: 1759720X     EISSN: 17597218     Source Type: Journal    
DOI: 10.1177/1759720X17692502     Document Type: Review

References (54)

1. Maclaughlin J, Holick MF., Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 1985; 76: 1536–1538.
2. Holick MF, Matsuoka LY, Wortsman J., Age, vitamin D, and solar ultraviolet. Lancet 1989; 2: 1104–1105.
3. Matsuoka LY, Wortsman J, Dannenberg MJ. Clothing prevents ultraviolet-B radiation-dependent photosynthesis of vitamin D3. J Clin Endocrinol Metab 1992; 75: 1099–1103.
4. Holick MF., Mccollum award lecture, 1994: vitamin D—new horizons for the 21st century. Am J Clin Nutr 1994; 60: 619–630.
5. Craig R, Mindell J, Hirani V, (eds). Health Survey for England 2008: physical activity and fitness. London: The NHS Information Centre, 2009.
6. Ireland P, Fordtran JS., Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J Clin Invest 1973; 52: 2672–2681.
7. Dawson-Hughes B, Harris S, Kramich C. Calcium retention and hormone levels in black and white women on high- and low-calcium diets. J Bone Miner Res 1993; 8: 779–787.
8. Bullamore JR, Wilkinson R, Gallagher JC. Effect of age on calcium absorption. Lancet 1970; 2: 535–537.
9. Baker MR, Peacock M, Nordin BE., The decline in vitamin D status with age. Age Ageing 1980; 9: 249–252.
10. Francis RM, Peacock M, Barkworth SA., Renal impairment and its effects on calcium metabolism in elderly women. Age Ageing 1984; 13: 14–20.
11. Eastell R, Yergey AL, Vieira NE. Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function, and age in women: evidence of an age-related intestinal resistance to 1,25-dihydroxyvitamin D action. J Bone Miner Res 1991; 6: 125–132.
12. Heaney RP, Recker RR, Stegman MR. Calcium absorption in women: relationships to calcium intake, estrogen status, and age. J Bone Miner Res 1989; 4: 469–475.
13. Gallagher JC, Yalamanchili V, Smith LM., The effect of vitamin D on calcium absorption in older women. J Clin Endocrinol Metab 2012; 97: 3550–3556.
14. Epstein S, Bryce G, Hinman JW. The influence of age on bone mineral regulating hormones. Bone 1986; 7: 421–425.
15. Vieth R, Ladak Y, Walfish PG., Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 2003; 88: 185–191.
16. Priemel M, Von Domarus C, Klatte TO. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 2010; 25: 305–312.
17. Aspray TJ, Francis RM., What can we learn about vitamin D requirements from post-mortem data? Osteoporos Int 2013; 24: 1769–1770.
18. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary reference intakes for calcium and vitamin D. Washington: National Academies Press, 2011.
19. Wahl DA, Cooper C, Ebeling PR. A global representation of vitamin D status in healthy populations. Arch Osteoporos 2012; 7: 155–172.
20. Fraser WD, Milan AM., Vitamin D assays: past and present debates, difficulties, and developments. Calcif Tissue Int 2013; 92: 118–127.
21. International Osteoporosis Federation. Vitamin D status around the world, https://www.iofbonehealth.org/facts-and-statistics/vitamin-d-studies-map, 2012.
22. Thacher TD, Smith L, Fischer PR. Optimal dose of calcium for treatment of nutritional rickets: a randomized controlled trial. J Bone Miner Res 2016; 31: 2024–2031.
23. Van Der Wielen RP, Lowik MR, Van Den, Berg H. Serum vitamin D concentrations among elderly people in Europe. Lancet 1995; 346: 207–210.
24. Andersen R, Molgaard C, Skovgaard LT. Teenage girls and elderly women living in Northern Europe have low winter vitamin D status. Eur J Clin Nutr 2005; 59: 533–541.
25. Lips P, Hosking D, Lippuner K. The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med 2006; 260: 245–254.
26. Lanham-New SA, Buttriss JL, Miles LM. Proceedings of the rank forum on vitamin D. Br J Nutr 2011; 105: 144–156.
27. Hill TR, Granic A, Davies K. Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the newcastle 85+ study. Osteoporos Int 2016; 27: 1199–1208.
28. Mathei C, Van Pottelbergh G, Vaes B. No relation between vitamin D status and physical performance in the oldest old: results from the belfrail study. Age & Ageing 2013; 42: 186–190.
29. Bruyere O, Slomianr J, Beaudart C. Prevalence of vitamin D inadequacy in European women aged over 80 years. Arch Gerontol Geriatr 2014; 59: 78–82.
30. Cashman KD, Wallace JM, Horigan G. Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age. Am J Clin Nutr 2009; 89: 1366–1374.
31. NIH Consensus. Development panel on osteoporosis prevention, diagnosis, and therapy, March 7–29, 2000: highlights of the conference. South Med J 2001; 94: 569–573.
32. European Food Safety Authority Panel on Dietetic Products Nutrition and Allergies (NDA). Guidance on the scientific requirements for health claims related to bone, joints, and oral health. Parma: European Food Safety Authority, 2011.
33. Bischoff-Ferrari HA, Dietrich T, Orav EJ. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 2004; 116: 634–639.
34. Reid IR, Bolland MJ, Grey A., Effects of 2014 vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 2014; 383: 146–155.
35. Macdonald HM, Wood AD, Aucott LS. Hip bone loss is attenuated with 1000 IU but not 400 IU daily vitamin D3: a 1 year double-blind RCT in postmenopausal women. J Bone Miner Res 2013; 28: 2202–2213.
36. Bhambri R, Naik V, Malhotra N. Changes in bone mineral density following treatment of osteomalacia. J Clin Densitom 2006; 9: 120–127.
37. Macdonald H, Aspray TJ., Vitamin D supplements and bone mineral density. Lancet 2014; 383: 1292.
38. Bischoff-Ferrari HA, Willett WC, Wong JB. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005; 293: 2257–2264.
39. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 2009; 339: b3692.
40. Bischoff-Ferrari HA, Willett WC, Orav EJ. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012; 367: 40–49.
41. DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 2010; 340: b5463.
42. Avenell A, Mak JC, O’Connell D., Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 2014; 4: CD000227.
43. Trivedi DP, Doll R, Khaw KT., Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003; 326: 469.
44. Law M, Withers H, Morris J. Vitamin D supplementation and the prevention of fractures and falls: results of a randomised trial in elderly people in residential accommodation. Age Ageing 2006; 35: 482–486.
45. Smith H, Anderson F, Raphael H. Effect of annual intramuscular vitamin D on fracture risk in elderly men and women—a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology (Oxford) 2007; 46: 1852–1857.
46. Sanders KM, Stuart AL, Williamson EJ. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 2010; 303: 1815–1822.
47. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ. Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. JAMA Intern Med 2016; 176: 175–183.
48. Bouillon R, Gielen E, Vanderschueren D., Vitamin D receptor and vitamin D action in muscle. Endocrinology 2014; 155: 3210–3213.
49. Snijder MB, Van Schoor NM, Pluijm SM. Vitamin D status in relation to one-year risk of recurrent falling in older men and women. J Clin Endocrinol Metab 2006; 91: 2980–2985.
50. Kim MK, Baek KH, Song KH. Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the fourth Korea National Health and Nutrition Examination Surveys (Knhanes Iv) 2009. J Clin Endocrinol Metab 2011; 96: 3250–3256.
51. Ceglia L, Niramitmahapanya S, Da Silva Morais M. A randomized study on the effect of vitamin D(3) supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab 2013; 98: E1927–E1935.
52. Tomlinson PB, Joseph C, Angioi M., Effects of vitamin D supplementation on upper and lower body muscle strength levels in healthy individuals. A systematic review with meta-analysis. J Sci Med Sport 2015; 18: 575–580.
53. Stockton KA, Mengersen K, Paratz JD. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int 2011; 22: 859–871.
54. Hita-Contreras F, Martinez-Amat A, Cruz-Diaz D. Osteosarcopenic obesity and fall prevention strategies. Maturitas 2015; 80: 126–132.