Cytokine modulation in patients with idiopathic pulmonary fibrosis undergoing treatment with steroids, immunosuppressants, and IFN-γ 1b

Journal of Biological Regulators and Homeostatic Agents

Volumn 31, Issue 1, 2017, Pages 59-69

  Marinari, S ^a   De Iuliis, V ^b   Dadorante, V ^b   Colella, S ^a   Marino, A ^b   Nunziata, A ^b   Flati, V ^c   Caruso, M ^b   Pennelli, A ^b   De Benedetto, F ^d   Matera, S ^b   Capodifoglio, S ^b   Martinotti, S ^b   Caputi, S ^b   Toniato, E ^b  

^a Policlinico SS Annunziata   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d AIMAR (Interdisciplinary Association for the Study of Respiratory Diseases)   (Italy)

Author keywords

Cytokines; Idiopathic pulmonary fibrosis; IFN 1b treatment

Indexed keywords

ACETYLCYSTEINE; AZATHIOPRINE; CYTOKINE; GAMMA INTERFERON; GAMMA1B INTERFERON; GLUCOCORTICOID; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; METHYLPREDNISOLONE; RANTES; TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENT; IL6 PROTEIN, HUMAN; MAPKAP1 PROTEIN, HUMAN; RECOMBINANT PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AGED; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CORTICOSTEROID THERAPY; CYTOKINE RELEASE; DISEASE CLASSIFICATION; FEMALE; FIBROSING ALVEOLITIS; FORCED VITAL CAPACITY; HISTOLOGY; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LUNG FUNCTION; LUNG FUNCTION TEST; LUNG LAVAGE; MAINTENANCE DRUG DOSE; MALE; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PREDICTIVE VALUE; RIBONUCLEASE PROTECTION ASSAY; THORAX RADIOGRAPHY; TOTAL LUNG CAPACITY; TREATMENT DURATION; VITAL CAPACITY; BRONCHOALVEOLAR LAVAGE FLUID; CYTOLOGY; DRUG ADMINISTRATION; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; IDIOPATHIC PULMONARY FIBROSIS; IMMUNOLOGY; LUNG; LUNG ALVEOLUS MACROPHAGE; MIDDLE AGED; PATHOLOGY; TREATMENT OUTCOME;

ACETYLCYSTEINE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; ANTI-INFLAMMATORY AGENTS; AZATHIOPRINE; BRONCHOALVEOLAR LAVAGE FLUID; DRUG ADMINISTRATION SCHEDULE; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; INTERFERON-GAMMA; INTERLEUKIN-1; INTERLEUKIN-12; INTERLEUKIN-6; LUNG; MACROPHAGES, ALVEOLAR; MALE; METHYLPREDNISOLONE; MIDDLE AGED; RECOMBINANT PROTEINS; RESPIRATORY FUNCTION TESTS; TREATMENT OUTCOME;

EID: 85016198927     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Gross TJ, Hunninghake GW. Idiopathic pulmonary fibrosis. N Engl J Med 2001;345:517-25.
2. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. Am J Respir Crit Care Med 2000;161:646-64.
3. King TE Jr, Tooze JA, Schwarz MI, Brown KR, Cherniack RM. Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am J Respir Crit Care Med 2001;164:1171-81.
4. Prasse A, Pechkovsky DV, Toews GB, et al. A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. Am J Respir Crit Care Med 2006;173:781-92.
5. Shearer JD, Richards JR, Mills CD, Caldwell MD. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am J Physiol 1997;272:E181-E190.
6. Keane MP. The role of chemokines and cytokines in lung fibrosis. Eur Respir Rev 2008;17:109, 151-56.
7. Strieter RM, Gomperts BN, Keane MP. The role of CXC chemokines in pulmonary fibrosis. J Clin Invest 2007;117:549-56.
8. Smadja DM, Dorfmuller P, Guerin CL, et al. Cooperation between human fibrocytes and endothelial colonyforming cells increases angiogenesis via the CXCR4 pathway. Thromb Haemost 2014;112(5):1002-13.
9. De Biasi S, Cerri S, Bianchini E, et al. Levels of circulating endothelial cells are low in idiopathic pulmonary fibrosis and are further reduced by antifibrotic treatments. BMC Medicine 2015;13:277.
10. Raghu G, Brown KK, Bradford WZ, Starko K, Noble PW, Schwartz DA, King TE Jr. Idiopathic Pulmonary Fibrosis Study Group. A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis. N Engl J Med 2004;350:125-33.
11. Egan JJ. New treatments for pulmonary fibrosis? Lancet 1999;354:1839-840.
12. Antoniou KM, Alexandrakis M, Sfiridaki K, et al. Th1 cytokine pattern (IL-12 and IL-18) in bronchoalveolar lavage fluid (BALF) before and after treatment with interferon gamma-1b (IFN-γ-1b) or colchicine in patients with idiopathic pulmonary fibrosis (IPF/UIP). Sarcoidosis Vasc Diffuse Lung Dis 2004;21:105-10.
13. Narayanan AS, Whithey J, Souza A, Raghu G. Effect of γ-interferon on collagen synthesis by normal and fibrotic human lung fibroblasts. Chest 1992;101:1326-31.
14. Karimfar MH, Rostami S, Haghani K, Bakhtiyari S, Noori-Zadeh A. Melatonin alleviates bleomycininduced pulmonary fibrosis in mice. J Biol Regul Homeost Agents 2015;29(2):327-34.
15. Gurujeyalakshmi G, Giri SN. Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycinmouse model of lung fibrosis: downregulation of TGF-β and procollagen I and III gene expression. Exp Lung Res 1995;21:791-808.
16. Ziesche R, Hofbauer E, Wittmann K, Petkov V, Block LH. A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. N Engl J Med 2000;342:524.
17. Raghu G, Brown KK, Bradford WZ, Starko K, Noble PW, Schwartz DA, King TE Jr. A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis. N Engl J Med 2004;350:125-33.
18. American Thoracic Society. ATS/ERS International Multidisciplinary Consensus Classification of Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med 2002;165:277-304.
19. Hyslop PA, Sklar LA. A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: its use in the simultaneous fluorimetric assay of cellular activation processes. Anal Biochem 1984;141:280-86.
20. Report of the European Society of Pneumonology Task Group 1989. Technical recommendations and guidelines for bronchoalveolar lavage (BAL). Eur Respir J 1989;2:561-85.
21. Song A, Nikolcheva T, Krensky AM. Transcriptional regulation of Rantes expression in T lymphocytes. Immunol Rev 2000;177:236-45.