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Volumn 376, Issue 10, 2017, Pages 917-927

Long-term outcomes of imatinib treatment for chronic myeloid leukemia

(15)  Hochhaus, Andreas a   Larson, Richard A b   Guilhot, François c   Radich, Jerald P d   Branford, Susan e   Hughes, Timothy P f   Baccarani, Michele g   Deininger, Michael W h   Cervantes, Francisco i   Fujihara, Satoko j   Ortmann, Christine Elke j   Menssen, Hans D j   Kantarjian, Hagop k   O'Brien, Stephen G l   Druker, Brian J m  


Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTARABINE; IMATINIB; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR;

EID: 85015641837     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1609324     Document Type: Article
Times cited : (946)

References (38)
  • 1
    • 78951475990 scopus 로고    scopus 로고
    • Molecular pathogenesis of Philadelphia-positive chronic myeloid leukemia - Is it all BCR-ABL?
    • Rumpold H, Webersinke G. Molecular pathogenesis of Philadelphia-positive chronic myeloid leukemia - is it all BCR-ABL? Curr Cancer Drug Targets 2011;11:3-19.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 3-19
    • Rumpold, H.1    Webersinke, G.2
  • 2
    • 0036094117 scopus 로고    scopus 로고
    • Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia
    • Cohen MH, Williams G, Johnson JR, et al. Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res 2002;8:935-42.
    • (2002) Clin Cancer Res , vol.8 , pp. 935-942
    • Cohen, M.H.1    Williams, G.2    Johnson, J.R.3
  • 3
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 4
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408-17.
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 5
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A, O'Brien SG, Guilhot F, et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009;23:1054-61.
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1    O'Brien, S.G.2    Guilhot, F.3
  • 6
    • 77958595179 scopus 로고    scopus 로고
    • Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the International Randomized Study of Interferon and STI571 (IRIS)
    • Hughes TP, Hochhaus A, Branford S, et al. Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood 2010;116:3758-65.
    • (2010) Blood , vol.116 , pp. 3758-3765
    • Hughes, T.P.1    Hochhaus, A.2    Branford, S.3
  • 7
    • 33748133844 scopus 로고    scopus 로고
    • Survival advantage from imatinib compared with the combination interferonalpha plus cytarabine in chronic-phase chronic myelogenous leukemia: Historical comparison between two phase 3 trials
    • Roy L, Guilhot J, Krahnke T, et al. Survival advantage from imatinib compared with the combination interferonalpha plus cytarabine in chronic-phase chronic myelogenous leukemia: historical comparison between two phase 3 trials. Blood 2006;108:1478-84.
    • (2006) Blood , vol.108 , pp. 1478-1484
    • Roy, L.1    Guilhot, J.2    Krahnke, T.3
  • 8
    • 84857731311 scopus 로고    scopus 로고
    • Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: A single-institution historical experience
    • Kantarjian H, O'Brien S, Jabbour E, et al. Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience. Blood 2012;119:1981-7.
    • (2012) Blood , vol.119 , pp. 1981-1987
    • Kantarjian, H.1    O'Brien, S.2    Jabbour, E.3
  • 9
    • 85006803131 scopus 로고    scopus 로고
    • Silver Spring, MD: Surveillance, Epidemiology, and End Results Program, September 12
    • Fast Stats: an interactive tool for access to SEER cancer statistics. Silver Spring, MD: Surveillance, Epidemiology, and End Results Program, September 12, 2016 (http://seer.cancer.gov/faststats).
    • (2016) Fast Stats: An Interactive Tool for Access to SEER Cancer Statistics
  • 10
    • 84871566401 scopus 로고    scopus 로고
    • Decreasing trend in mortality of chronic myelogenous leukemia patients after introduction of imatinib in Japan and the U.S.
    • Chihara D, Ito H, Matsuda T, et al. Decreasing trend in mortality of chronic myelogenous leukemia patients after introduction of imatinib in Japan and the U.S. Oncologist 2012;17:1547-50.
    • (2012) Oncologist , vol.17 , pp. 1547-1550
    • Chihara, D.1    Ito, H.2    Matsuda, T.3
  • 11
    • 84982090948 scopus 로고    scopus 로고
    • Life expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general population
    • Bower H, Björkholm M, Dickman PW, Höglund M, Lambert PC, Andersson TM. Life expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general population. J Clin Oncol 2016;34:2851-7.
    • (2016) J Clin Oncol , vol.34 , pp. 2851-2857
    • Bower, H.1    Björkholm, M.2    Dickman, P.W.3    Höglund, M.4    Lambert, P.C.5    Andersson, T.M.6
  • 12
    • 84937879454 scopus 로고    scopus 로고
    • Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: Results of the randomized CML Study IV
    • Saussele S, Krauss MP, Hehlmann R, et al. Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML Study IV. Blood 2015;126:42-9.
    • (2015) Blood , vol.126 , pp. 42-49
    • Saussele, S.1    Krauss, M.P.2    Hehlmann, R.3
  • 13
    • 0021336851 scopus 로고
    • Prognostic discrimination in "good-risk" chronic granulocytic leukemia
    • Sokal JE, Cox EB, Baccarani M, et al. Prognostic discrimination in "good-risk" chronic granulocytic leukemia. Blood 1984;63:789-99.
    • (1984) Blood , vol.63 , pp. 789-799
    • Sokal, J.E.1    Cox, E.B.2    Baccarani, M.3
  • 14
    • 84881298446 scopus 로고    scopus 로고
    • European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
    • Baccarani M, Deininger MW, Rosti G, et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013;122:872-84.
    • (2013) Blood , vol.122 , pp. 872-884
    • Baccarani, M.1    Deininger, M.W.2    Rosti, G.3
  • 15
    • 84897574239 scopus 로고    scopus 로고
    • Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: Results from the randomized CML-Study IV
    • Hehlmann R, Müller MC, Lauseker M, et al. Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-Study IV. J Clin Oncol 2014;32:415-23.
    • (2014) J Clin Oncol , vol.32 , pp. 415-423
    • Hehlmann, R.1    Müller, M.C.2    Lauseker, M.3
  • 16
    • 84959482245 scopus 로고    scopus 로고
    • Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-Year update of the randomized ENESTnd trial
    • Hochhaus A, Saglio G, Hughes TP, et al. Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial. Leukemia 2016;30:1044-54.
    • (2016) Leukemia , vol.30 , pp. 1044-1054
    • Hochhaus, A.1    Saglio, G.2    Hughes, T.P.3
  • 17
    • 84862744840 scopus 로고    scopus 로고
    • Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: A proposal by the European LeukemiaNet
    • Guilhot J, Baccarani M, Clark RE, et al. Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: a proposal by the European LeukemiaNet. Blood 2012;119:5963-71.
    • (2012) Blood , vol.119 , pp. 5963-5971
    • Guilhot, J.1    Baccarani, M.2    Clark, R.E.3
  • 18
    • 84929289846 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib in CML over a period of 10 years: Data from the randomized CML-Study IV
    • Kalmanti L, Saussele S, Lauseker M, et al. Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-Study IV. Leukemia 2015;29:1123-32.
    • (2015) Leukemia , vol.29 , pp. 1123-1132
    • Kalmanti, L.1    Saussele, S.2    Lauseker, M.3
  • 19
    • 34249664406 scopus 로고    scopus 로고
    • Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia
    • Hehlmann R, Berger U, Pfirrmann M, et al. Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia. Blood 2007;109:4686-92.
    • (2007) Blood , vol.109 , pp. 4686-4692
    • Hehlmann, R.1    Berger, U.2    Pfirrmann, M.3
  • 20
    • 84959355599 scopus 로고    scopus 로고
    • Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: A randomized comparison of stem cell transplantation with drug treatment
    • Gratwohl A, Pfirrmann M, Zander A, et al. Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment. Leukemia 2016;30:562-9.
    • (2016) Leukemia , vol.30 , pp. 562-569
    • Gratwohl, A.1    Pfirrmann, M.2    Zander, A.3
  • 21
    • 84871396050 scopus 로고    scopus 로고
    • It's about time: Lessons for solid tumors from chronic myelogenous leukemia therapy
    • Westin JR, Kurzrock R. It's about time: lessons for solid tumors from chronic myelogenous leukemia therapy. Mol Cancer Ther 2012;11:2549-55.
    • (2012) Mol Cancer Ther , vol.11 , pp. 2549-2555
    • Westin, J.R.1    Kurzrock, R.2
  • 22
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
    • Baccarani M, Saglio G, Goldman J, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006;108:1809-20.
    • (2006) Blood , vol.108 , pp. 1809-1820
    • Baccarani, M.1    Saglio, G.2    Goldman, J.3
  • 23
    • 77953691179 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
    • Saglio G, Kim D-W, Issaragrisil S, et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 2010;362:2251-9.
    • (2010) N Engl J Med , vol.362 , pp. 2251-2259
    • Saglio, G.1    Kim, D.-W.2    Issaragrisil, S.3
  • 24
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H, Shah NP, Hochhaus A, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010;362:2260-70.
    • (2010) N Engl J Med , vol.362 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3
  • 25
    • 84902843429 scopus 로고    scopus 로고
    • Bosutinib efficacy and safety in chronic phase chronic myeloid leukemia after imatinib resistance or intolerance: Minimum 24-month follow-up
    • Gambacorti-Passerini C, Brümmendorf TH, Kim DW, et al. Bosutinib efficacy and safety in chronic phase chronic myeloid leukemia after imatinib resistance or intolerance: minimum 24-month follow-up. Am J Hematol 2014;89:732-42.
    • (2014) Am J Hematol , vol.89 , pp. 732-742
    • Gambacorti-Passerini, C.1    Brümmendorf, T.H.2    Kim, D.W.3
  • 26
    • 84887127701 scopus 로고    scopus 로고
    • A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias
    • Cortes JE, Kim D-W, Pinilla-Ibarz J, et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med 2013;369:1783-96.
    • (2013) N Engl J Med , vol.369 , pp. 1783-1796
    • Cortes, J.E.1    Kim, D.-W.2    Pinilla-Ibarz, J.3
  • 27
    • 84893136765 scopus 로고    scopus 로고
    • Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-Year follow-up from a randomized phase 3 trial (DASISION)
    • Jabbour E, Kantarjian HM, Saglio G, et al. Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION). Blood 2014;123:494-500.
    • (2014) Blood , vol.123 , pp. 494-500
    • Jabbour, E.1    Kantarjian, H.M.2    Saglio, G.3
  • 28
    • 0032478962 scopus 로고    scopus 로고
    • A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa
    • Hasford J, Pfirrmann M, Hehlmann R, et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J Natl Cancer Inst 1998;90:850-8.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 850-858
    • Hasford, J.1    Pfirrmann, M.2    Hehlmann, R.3
  • 29
    • 79960685618 scopus 로고    scopus 로고
    • Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: The EUTOS score
    • Hasford J, Baccarani M, Hoffmann V, et al. Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood 2011;118:686-92.
    • (2011) Blood , vol.118 , pp. 686-692
    • Hasford, J.1    Baccarani, M.2    Hoffmann, V.3
  • 30
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Branford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003;349:1423-32.
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 31
    • 84953356030 scopus 로고    scopus 로고
    • Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia
    • Pfirrmann M, Baccarani M, Saussele S, et al. Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia. Leukemia 2016;30:48-56.
    • (2016) Leukemia , vol.30 , pp. 48-56
    • Pfirrmann, M.1    Baccarani, M.2    Saussele, S.3
  • 32
    • 84953351161 scopus 로고    scopus 로고
    • Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: Results from the European ENEST1st study
    • Hochhaus A, Rosti G, Cross NC, et al. Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the European ENEST1st study. Leukemia 2016;30:57-64.
    • (2016) Leukemia , vol.30 , pp. 57-64
    • Hochhaus, A.1    Rosti, G.2    Cross, N.C.3
  • 33
    • 84973176467 scopus 로고    scopus 로고
    • The concept of treatment-free remission in chronic myeloid leukemia
    • Saußele S, Richter J, Hochhaus A, Mahon FX. The concept of treatment-free remission in chronic myeloid leukemia. Leukemia 2016;30:1638-47.
    • (2016) Leukemia , vol.30 , pp. 1638-1647
    • Saußele, S.1    Richter, J.2    Hochhaus, A.3    Mahon, F.X.4
  • 34
    • 85015645382 scopus 로고    scopus 로고
    • Impact of treatment with frontline nilotinib (NIL) vs imatinib (IM) on sustained deep molecular response (MR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP)
    • abstract
    • Hochhaus A, Saglio G, Hughes TP, et al. Impact of treatment with frontline nilotinib (NIL) vs imatinib (IM) on sustained deep molecular response (MR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP). Blood 2015;126:2781. abstract.
    • (2015) Blood , vol.126 , pp. 2781
    • Hochhaus, A.1    Saglio, G.2    Hughes, T.P.3
  • 35
    • 79953880772 scopus 로고    scopus 로고
    • Multicenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinib
    • Gambacorti-Passerini C, Antolini L, Mahon FX, et al. Multicenter independent assessment of outcomes in chronic myeloid leukemia patients treated with imatinib. J Natl Cancer Inst 2011;103:553-61.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 553-561
    • Gambacorti-Passerini, C.1    Antolini, L.2    Mahon, F.X.3
  • 36
    • 73149122765 scopus 로고    scopus 로고
    • High rates of durable response are achieved with imatinib after treatment with interferon alpha plus cytarabine: Results from the International Randomized Study of Interferon and STI571 (IRIS) trial
    • Guilhot F, Druker B, Larson RA, et al. High rates of durable response are achieved with imatinib after treatment with interferon alpha plus cytarabine: results from the International Randomized Study of Interferon and STI571 (IRIS) trial. Haematologica 2009;94:1669-75.
    • (2009) Haematologica , vol.94 , pp. 1669-1675
    • Guilhot, F.1    Druker, B.2    Larson, R.A.3
  • 37
    • 84873568081 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-Month follow-up results of a phase II study
    • Giles FJ, le Coutre PD, Pinilla-Ibarz J, et al. Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study. Leukemia 2013;27:107-12.
    • (2013) Leukemia , vol.27 , pp. 107-112
    • Giles, F.J.1    Le Coutre, P.D.2    Pinilla-Ibarz, J.3
  • 38
    • 84899072118 scopus 로고    scopus 로고
    • Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: Follow-up of a phase 3 study
    • Shah NP, Guilhot F, Cortes JE, et al. Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of a phase 3 study. Blood 2014;123:2317-24.
    • (2014) Blood , vol.123 , pp. 2317-2324
    • Shah, N.P.1    Guilhot, F.2    Cortes, J.E.3


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