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Volumn 23, Issue 4, 2017, Pages 229-233

Clinical considerations for optimal use of the polymyxins: A focus on agent selection and dosing

Author keywords

Colistin; Dosing; Efficacy; Gram negative; Nephrotoxicity; Polymyxin; Resistance

Indexed keywords

COLISTIN; POLYMYXIN B; ANTIINFECTIVE AGENT; POLYMYXIN;

EID: 85015441618     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2017.02.023     Document Type: Review
Times cited : (59)

References (28)
  • 1
    • 77951219685 scopus 로고
    • The chemical basis for the classification of the polymyxins
    • [1] Jones, T.S.G., The chemical basis for the classification of the polymyxins. Biochem J, 43(2), 1948, xxvi.
    • (1948) Biochem J , vol.43 , Issue.2 , pp. xxvi
    • Jones, T.S.G.1
  • 2
    • 80051701366 scopus 로고    scopus 로고
    • Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006–09)
    • [2] Gales, A.C., Jones, R.N., Sader, H.S., Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006–09). J Antimicrob Chemother 66 (2011), 2070–2074.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2070-2074
    • Gales, A.C.1    Jones, R.N.2    Sader, H.S.3
  • 3
    • 84903952314 scopus 로고    scopus 로고
    • Colistin and polymyxin B: peas in a pod, or chalk and cheese?
    • [3] Nation, R.L., Velkov, T., Li, J., Colistin and polymyxin B: peas in a pod, or chalk and cheese?. Clin Infect Dis 59 (2014), 88–94.
    • (2014) Clin Infect Dis , vol.59 , pp. 88-94
    • Nation, R.L.1    Velkov, T.2    Li, J.3
  • 4
    • 67749145541 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by Gram-negative bacteria
    • [4] Plachouras, D., Karvanen, M., Friberg, L.E., Papadomichelakis, E., Antoniadou, A., Tsangaris, I., et al. Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by Gram-negative bacteria. Antimicrob Agents Chemother 53 (2008), 3430–3436.
    • (2008) Antimicrob Agents Chemother , vol.53 , pp. 3430-3436
    • Plachouras, D.1    Karvanen, M.2    Friberg, L.E.3    Papadomichelakis, E.4    Antoniadou, A.5    Tsangaris, I.6
  • 5
    • 84912133849 scopus 로고    scopus 로고
    • New colistin population pharmacokinetic data in critically ill patients suggesting an alternative loading dose rationale
    • [5] Gregoire, N., Mimoz, O., Megarbane, B., Comets, E., Chatelier, D., Lasocki, S., et al. New colistin population pharmacokinetic data in critically ill patients suggesting an alternative loading dose rationale. Antimicrob Agents Chemother 58 (2014), 7324–7330.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 7324-7330
    • Gregoire, N.1    Mimoz, O.2    Megarbane, B.3    Comets, E.4    Chatelier, D.5    Lasocki, S.6
  • 6
    • 84880939299 scopus 로고    scopus 로고
    • Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens
    • [6] Sandri, A.M., Landersdorfer, C.B., Jacob, J., Boniatti, M.M., Dalarosa, M.G., Falci, D.R., et al. Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens. Clin Infect Dis 57 (2013), 524–531.
    • (2013) Clin Infect Dis , vol.57 , pp. 524-531
    • Sandri, A.M.1    Landersdorfer, C.B.2    Jacob, J.3    Boniatti, M.M.4    Dalarosa, M.G.5    Falci, D.R.6
  • 7
    • 79956309225 scopus 로고    scopus 로고
    • Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers
    • [7] Couet, W., Gregoire, N., Gobin, P., Saulnier, P.J., Frasca, D., Marchand, S., et al. Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers. Clin Pharmacol Ther 89 (2011), 875–879.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 875-879
    • Couet, W.1    Gregoire, N.2    Gobin, P.3    Saulnier, P.J.4    Frasca, D.5    Marchand, S.6
  • 9
    • 84898606478 scopus 로고    scopus 로고
    • In vitro assessment and multicenter cohort study of comparative nephrotoxicity rates associated with colistimethate versus polymyxin B
    • [9] Phe, K., Lee, Y., McDaneld, P.M., Prasad, N., Yin, T., Figueroa, D.A., et al. In vitro assessment and multicenter cohort study of comparative nephrotoxicity rates associated with colistimethate versus polymyxin B. Antimicrob Agents Chemother 58 (2014), 2740–2746.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 2740-2746
    • Phe, K.1    Lee, Y.2    McDaneld, P.M.3    Prasad, N.4    Yin, T.5    Figueroa, D.A.6
  • 10
    • 84897982911 scopus 로고    scopus 로고
    • Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methanesulfonate sodium
    • [10] Tuon, F.F., Rigatto, M.H., Lopes, C.K., Kamei, L.K., Rocha, J.L., Zavascki, A.P., Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methanesulfonate sodium. Int J Antimicrob Agents 43 (2014), 349–352.
    • (2014) Int J Antimicrob Agents , vol.43 , pp. 349-352
    • Tuon, F.F.1    Rigatto, M.H.2    Lopes, C.K.3    Kamei, L.K.4    Rocha, J.L.5    Zavascki, A.P.6
  • 12
    • 84886901842 scopus 로고    scopus 로고
    • Higher incidence of acute kidney injury with intravenous colistimethate sodium compared with polymyxin B in critically ill patients at a tertiary medical center
    • [12] Akajagbor, D.S., Wilson, S.L., Shere-Wolfe, K.D., Dakum, P., Charurat, M.E., Gilliam, B.L., Higher incidence of acute kidney injury with intravenous colistimethate sodium compared with polymyxin B in critically ill patients at a tertiary medical center. Clin Infect Dis 57 (2013), 1300–1303.
    • (2013) Clin Infect Dis , vol.57 , pp. 1300-1303
    • Akajagbor, D.S.1    Wilson, S.L.2    Shere-Wolfe, K.D.3    Dakum, P.4    Charurat, M.E.5    Gilliam, B.L.6
  • 14
    • 84865428411 scopus 로고    scopus 로고
    • Characterization of Polymyxin B induced nephrotoxicity: implications for dosing regimen design
    • [14] Abdelraouf, K., Braggs, K.H., Yin, T., Truong, L.D., Hu, M., Tam, V.H., Characterization of Polymyxin B induced nephrotoxicity: implications for dosing regimen design. Antimicrob Agents Chemother 56 (2012), 4625–4629.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 4625-4629
    • Abdelraouf, K.1    Braggs, K.H.2    Yin, T.3    Truong, L.D.4    Hu, M.5    Tam, V.H.6
  • 15
    • 79959248672 scopus 로고    scopus 로고
    • Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients
    • [15] Garonzik, S.M., Li, J., Thamlikitkul, V., Paterson, D.L., Shoham, S., Jacob, J., et al. Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients. Antimicrob Agents Chemother 55 (2011), 3284–3294.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 3284-3294
    • Garonzik, S.M.1    Li, J.2    Thamlikitkul, V.3    Paterson, D.L.4    Shoham, S.5    Jacob, J.6
  • 16
    • 85016714508 scopus 로고    scopus 로고
    • Monarch Pharmaceuticals Rochester, MI
    • [16] Colo-Mycin M [package insert], 2006, Monarch Pharmaceuticals, Rochester, MI.
    • (2006) Colo-Mycin M [package insert]
  • 17
    • 85016770508 scopus 로고    scopus 로고
    • Polymyxin Artical 31 referral – Annex III Amendments to relevant sections of the summary of product charactersitics and the package leaflets
    • Available at: [Accessed 14 November 2016]
    • [17] European-Medicines-Agency, Polymyxin Artical 31 referral – Annex III Amendments to relevant sections of the summary of product charactersitics and the package leaflets. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Polymyxin_31/WC500176332.pdf, 2014 [Accessed 14 November 2016].
    • (2014)
    • European-Medicines-Agency1
  • 18
    • 84921024881 scopus 로고    scopus 로고
    • Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus
    • [18] Nation, R.L., Li, J., Cars, O., Couet, W., Dudley, M.N., Kaye, K.S., et al. Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus. Lancet Infect Dis 15 (2015), 225–234.
    • (2015) Lancet Infect Dis , vol.15 , pp. 225-234
    • Nation, R.L.1    Li, J.2    Cars, O.3    Couet, W.4    Dudley, M.N.5    Kaye, K.S.6
  • 20
    • 84963971763 scopus 로고    scopus 로고
    • Colistin: understanding and applying recent pharmacokinetic advances
    • [20] Ortwine, J.K., Kaye, K.S., Li, J., Pogue, J.M., Colistin: understanding and applying recent pharmacokinetic advances. Pharmacotherapy 35 (2015), 11–16.
    • (2015) Pharmacotherapy , vol.35 , pp. 11-16
    • Ortwine, J.K.1    Kaye, K.S.2    Li, J.3    Pogue, J.M.4
  • 21
    • 84893059151 scopus 로고    scopus 로고
    • Trial for the treatment of extensively drug-resistant gram-negative bacilli
    • In: Bethesda (MD): National Library of Medicine (US). 2000–20160920. Available at: URL of the record NLM Identifier: NCT01597973.
    • [21] Kaye KS. Trial for the treatment of extensively drug-resistant gram-negative bacilli. In: ClinicalTrials.gov. Bethesda (MD): National Library of Medicine (US). 2000–20160920. Available at: URL of the record NLM Identifier: NCT01597973.
    • Kaye, K.S.1
  • 22
    • 85046565321 scopus 로고    scopus 로고
    • Xellia Pharmaceuticals Big Flats, NY
    • [22] Polymyxin B [package insert], 2015, Xellia Pharmaceuticals, Big Flats, NY.
    • (2015) Polymyxin B [package insert]
  • 23
    • 84946239353 scopus 로고    scopus 로고
    • Clinical outcomes associated with polymyxin B dose in patients with bloodstream infections due to carbapenem-resistant Gram-negative rods
    • [23] Nelson, B.C., Eiras, D.P., Gomez-Simmonds, A., Loo, A.S., Satlin, M.J., Jenkins, S.G., et al. Clinical outcomes associated with polymyxin B dose in patients with bloodstream infections due to carbapenem-resistant Gram-negative rods. Antimicrob Agents Chemother 59 (2015), 7000–7006.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 7000-7006
    • Nelson, B.C.1    Eiras, D.P.2    Gomez-Simmonds, A.3    Loo, A.S.4    Satlin, M.J.5    Jenkins, S.G.6
  • 24
    • 81555224261 scopus 로고    scopus 로고
    • Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine
    • [24] Satlin, M.J., Kubin, C.J., Blumenthal, J.S., Cohen, A.B., Furuya, E.Y., Wilson, S.J., et al. Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine. Antimicrob Agents Chemother 55 (2011), 5893–5899.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5893-5899
    • Satlin, M.J.1    Kubin, C.J.2    Blumenthal, J.S.3    Cohen, A.B.4    Furuya, E.Y.5    Wilson, S.J.6
  • 25
    • 84929746737 scopus 로고    scopus 로고
    • Risk factors for acute kidney injury (AKI) in patients treated with polymyxin B and influence of AKI on mortality: a multicentre prospective cohort study
    • [25] Rigatto, M.H., Behle, T.F., Falci, D.R., Freitas, T., Lopes, N.T., Nunes, M., et al. Risk factors for acute kidney injury (AKI) in patients treated with polymyxin B and influence of AKI on mortality: a multicentre prospective cohort study. J Antimicrob Chemother 70 (2015), 1552–1557.
    • (2015) J Antimicrob Chemother , vol.70 , pp. 1552-1557
    • Rigatto, M.H.1    Behle, T.F.2    Falci, D.R.3    Freitas, T.4    Lopes, N.T.5    Nunes, M.6
  • 26
    • 84952787431 scopus 로고    scopus 로고
    • Head and neck hyperpigmentation probably associated with polymyxin B therapy
    • [26] Zavascki, A.P., Manfro, R.C., Maciel, R.A., Falci, D.R., Head and neck hyperpigmentation probably associated with polymyxin B therapy. Ann Pharmacother 49 (2015), 1171–1172.
    • (2015) Ann Pharmacother , vol.49 , pp. 1171-1172
    • Zavascki, A.P.1    Manfro, R.C.2    Maciel, R.A.3    Falci, D.R.4
  • 27
    • 84994218506 scopus 로고    scopus 로고
    • Histopathological findings of pigmented lesion and recovery of natural skin colour in a patient with polymyxin B-associated diffuse hyperpigmentation
    • [27] Zavascki, A.P., Schuster, L.F., Duquia, R.P., Histopathological findings of pigmented lesion and recovery of natural skin colour in a patient with polymyxin B-associated diffuse hyperpigmentation. Int J Antimicrob Agents 48 (2016), 579–580.
    • (2016) Int J Antimicrob Agents , vol.48 , pp. 579-580
    • Zavascki, A.P.1    Schuster, L.F.2    Duquia, R.P.3
  • 28
    • 85016746673 scopus 로고    scopus 로고
    • FDA alert 06.28. Available at:.
    • [28] FDA alert 06.28. 2007. Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124896.htm.
    • (2007)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.