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Volumn 3, Issue 3, 2017, Pages 366-373

Systemic therapy for previously untreated advanced BRAF-mutated melanoma a systematic review and network meta-Analysis of randomized clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; B RAF KINASE; BRAF PROTEIN, HUMAN; CTLA4 PROTEIN, HUMAN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN KINASE INHIBITOR;

EID: 85015350581     PISSN: 23742437     EISSN: 23742445     Source Type: Journal    
DOI: 10.1001/jamaoncol.2016.4877     Document Type: Article
Times cited : (54)

References (57)
  • 1
    • 1542611579 scopus 로고    scopus 로고
    • Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma
    • Lens MB, DawesM. Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma. Br J Dermatol. 2004;150(2): 179-185.
    • (2004) Br J Dermatol , vol.150 , Issue.2 , pp. 179-185
    • Lens, M.B.1    Dawes, M.2
  • 2
    • 84863863368 scopus 로고    scopus 로고
    • Update on the current state of melanoma incidence
    • Little EG, Eide MJ. Update on the current state of melanoma incidence. Dermatol Clin. 2012;30(3): 355-361.
    • (2012) Dermatol Clin , vol.30 , Issue.3 , pp. 355-361
    • Little, E.G.1    Eide, M.J.2
  • 4
    • 84903741191 scopus 로고    scopus 로고
    • Patient perception of the benefit of a BRAF inhibitor in metastatic melanoma: Quality-of-life analyses of the BREAK-3 study comparing dabrafenib with dacarbazine
    • Grob JJ, Amonkar MM, Martin-Algarra S, et al. Patient perception of the benefit of a BRAF inhibitor in metastatic melanoma: quality-of-life analyses of the BREAK-3 study comparing dabrafenib with dacarbazine. Ann Oncol. 2014;25 (7):1428-1436.
    • (2014) Ann Oncol , vol.25 , Issue.7 , pp. 1428-1436
    • Grob, J.J.1    Amonkar, M.M.2    Martin-Algarra, S.3
  • 5
    • 1442274619 scopus 로고    scopus 로고
    • Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
    • Tsao H, Goel V, Wu H, Yang G, Haluska FG. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol. 2004;122(2):337-341.
    • (2004) J Invest Dermatol , vol.122 , Issue.2 , pp. 337-341
    • Tsao, H.1    Goel, V.2    Wu, H.3    Yang, G.4    Haluska, F.G.5
  • 6
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353(20):2135-2147.
    • (2005) N Engl J Med , vol.353 , Issue.20 , pp. 2135-2147
    • Curtin, J.A.1    Fridlyand, J.2    Kageshita, T.3
  • 7
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417 (6892):949-954.
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 8
    • 36849035139 scopus 로고    scopus 로고
    • Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): A novel strategy for the treatment of melanoma and other malignancies
    • ODay SJ, Hamid O, UrbaWJ. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): A novel strategy for the treatment of melanoma and other malignancies. Cancer. 2007;110(12):2614-2627.
    • (2007) Cancer , vol.110 , Issue.12 , pp. 2614-2627
    • Oday, S.J.1    Hamid, O.2    Urba, W.J.3
  • 9
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26): 2443-2454.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 10
    • 84920031180 scopus 로고    scopus 로고
    • In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
    • Wang C, Thudium KB, Han M, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res. 2014;2 (9):846-856.
    • (2014) Cancer Immunol Res , vol.2 , Issue.9 , pp. 846-856
    • Wang, C.1    Thudium, K.B.2    Han, M.3
  • 11
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • BRIM-3 Study Group
    • Chapman PBH, Hauschild A, Robert C, et al; BRIM-3 Study Group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507-2516.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2507-2516
    • Pbh, C.1    Hauschild, A.2    Robert, C.3
  • 12
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob JJ, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012;380(9839):358-365.
    • (2012) Lancet , vol.380 , Issue.9839 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3
  • 13
    • 84908245075 scopus 로고    scopus 로고
    • Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
    • Larkin J, Ascierto PA, Dréno B, et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med. 2014;371(20):1867-1876.
    • (2014) N Engl J Med , vol.371 , Issue.20 , pp. 1867-1876
    • Larkin, J.1    Ascierto, P.A.2    Dréno, B.3
  • 14
    • 84938739283 scopus 로고    scopus 로고
    • Dabrafenib and trametinib vs dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial
    • Long GV, Stroyakovskiy D, Gogas H, et al. Dabrafenib and trametinib vs dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial. Lancet. 2015;386(9992):444-451.
    • (2015) Lancet , vol.386 , Issue.9992 , pp. 444-451
    • Long, G.V.1    Stroyakovskiy, D.2    Gogas, H.3
  • 15
    • 84920394727 scopus 로고    scopus 로고
    • Improved overall survival in melanoma with combined dabrafenib and trametinib
    • Robert C, Karaszewska B, Schachter J, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med. 2015;372(1):30-39.
    • (2015) N Engl J Med , vol.372 , Issue.1 , pp. 30-39
    • Robert, C.1    Karaszewska, B.2    Schachter, J.3
  • 17
    • 77954801079 scopus 로고    scopus 로고
    • N Engl J Med. 2010;363(8):711-723.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
  • 18
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373(1):23-34.
    • (2015) N Engl J Med , vol.373 , Issue.1 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 19
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab vs ipilimumab in untreated melanoma
    • PostowMA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab vs ipilimumab in untreated melanoma. N Engl J Med. 2015;372(21): 2006-2017.
    • (2015) N Engl J Med , vol.372 , Issue.21 , pp. 2006-2017
    • Postowma Chesney, J.1    Pavlick, A.C.2
  • 20
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab vs investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
    • Ribas A, Puzanov I, Dummer R, et al. Pembrolizumab vs investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial. Lancet Oncol. 2015;16(8):908-918.
    • (2015) Lancet Oncol , vol.16 , Issue.8 , pp. 908-918
    • Ribas, A.1    Puzanov, I.2    Dummer, R.3
  • 21
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517-2526.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 22
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab vs chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
    • Weber JS, DAngelo SP, Minor D, et al. Nivolumab vs chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2015;16(4):375-384.
    • (2015) Lancet Oncol , vol.16 , Issue.4 , pp. 375-384
    • Weber, J.S.1    Dangelo, S.P.2    Minor, D.3
  • 23
    • 84980602745 scopus 로고    scopus 로고
    • Efficacy and safety of nivolumab in patients with BRAF V600 mutant and BRAF wild-Type advanced melanoma: A pooled analysis of 4 clinical trials
    • Larkin J, Lao CD, UrbaWJ, et al. Efficacy and safety of nivolumab in patients with BRAF V600 mutant and BRAF wild-Type advanced melanoma: A pooled analysis of 4 clinical trials. JAMA Oncol. 2015;1(4):433-440.
    • (2015) JAMA Oncol , vol.1 , Issue.4 , pp. 433-440
    • Larkin, J.1    Urbawj, L.C.D.2
  • 24
    • 84862494584 scopus 로고    scopus 로고
    • Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab
    • Shahabi V, Whitney G, Hamid O, et al. Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab. Cancer Immunol Immunother. 2012; 61(5):733-737.
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.5 , pp. 733-737
    • Shahabi, V.1    Whitney, G.2    Hamid, O.3
  • 25
    • 52649100566 scopus 로고    scopus 로고
    • Bayesian meta-Analysis of multiple treatment comparisons: An introduction to mixed treatment comparisons
    • Jansen JP, Crawford B, Bergman G, StamW. Bayesian meta-Analysis of multiple treatment comparisons: An introduction to mixed treatment comparisons. Value Health. 2008;11(5):956-964.
    • (2008) Value Health , vol.11 , Issue.5 , pp. 956-964
    • Jansen, J.P.1    Crawford, B.2    Bergman, G.3    Stam, W.4
  • 28
    • 77955266157 scopus 로고    scopus 로고
    • Enhancing retrieval of best evidence for health care from bibliographic databases: Calibration of the hand search of the literature
    • Wilczynski NL, McKibbon KA, Haynes RB. Enhancing retrieval of best evidence for health care from bibliographic databases: calibration of the hand search of the literature. Stud Health Technol Inform. 2001;84(Pt 1):390-393.
    • (2001) Stud Health Technol Inform , vol.84 , pp. 390-393
    • Wilczynski, N.L.1    McKibbon, K.A.2    Haynes, R.B.3
  • 29
    • 85018707810 scopus 로고    scopus 로고
    • NCI Common Terminology Criteria for Adverse Events (CTCAE) v.4 [April 16, 2016] . Accessed September 21, 2016
    • NCI Common Terminology Criteria for Adverse Events (CTCAE) v.4 2010 [April 16, 2016]. http://evsnci.nih.gov/ftp1/CTCAE/CTCAE-4.03-2010-06-14-QuickReference-8.5x11.pdf. Accessed September 21, 2016.
    • (2010)
  • 30
    • 84979645289 scopus 로고    scopus 로고
    • Enhanced secondary analysis of survival data: Reconstructing the data from published Kaplan-Meier survival curves
    • Guyot P, Ades AE, Ouwens MJ, Welton NJ. Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves. BMC Med ResMethodol. 2012;12:9.
    • (2012) BMC Med ResMethodol , vol.12 , pp. 9
    • Guyot, P.1    Ades, A.E.2    Ouwens, M.J.3    Welton, N.J.4
  • 31
    • 0017360990 scopus 로고
    • The measurement of observer agreement for categorical data
    • Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159-174.
    • (1977) Biometrics , vol.33 , Issue.1 , pp. 159-174
    • Landis, J.R.1    Koch, G.G.2
  • 32
    • 84902732271 scopus 로고
    • Evaluating coding decisions
    • Cooper H, Hedges LV, eds. New York, NY: Russell Sage Foundation
    • Orwin RG. Evaluating coding decisions. In: Cooper H, Hedges LV, eds. The Handbook of Research Synthesis. New York, NY: Russell Sage Foundation; 1994:177-200.
    • (1994) The Handbook of Research Synthesis , pp. 177-200
    • Orwin, R.G.1
  • 34
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in ameta-Analysis
    • Higgins JP, Thompson SG. Quantifying heterogeneity in ameta-Analysis. Stat Med. 2002; 21(11):1539-1558.
    • (2002) Stat Med , vol.21 , Issue.11 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 35
    • 77949420042 scopus 로고    scopus 로고
    • Checking consistency in mixed treatment comparison meta-Analysis
    • Dias S, Welton NJ, Caldwell DM, Ades AE. Checking consistency in mixed treatment comparison meta-Analysis. Stat Med. 2010;29(7-8): 932-944.
    • (2010) Stat Med , vol.29 , Issue.7-8 , pp. 932-944
    • Dias, S.1    Welton, N.J.2    Caldwell, D.M.3    Ades, A.E.4
  • 36
    • 78650509651 scopus 로고    scopus 로고
    • Graphical methods and numerical summaries for presenting results from multiple-Treatment meta-Analysis: An overview and tutorial
    • Salanti G, Ades AE, Ioannidis JP. Graphical methods and numerical summaries for presenting results from multiple-Treatment meta-Analysis: An overview and tutorial. J Clin Epidemiol. 2011;64(2): 163-171.
    • (2011) J Clin Epidemiol , vol.64 , Issue.2 , pp. 163-171
    • Salanti, G.1    Ades, A.E.2    Ioannidis, J.P.3
  • 37
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • Ribas A, Kefford R, Marshall MA, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol. 2013;31(5): 616-622.
    • (2013) J Clin Oncol , vol.31 , Issue.5 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3
  • 38
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JDH, Hoos A, ODay S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res. 2009;15(23):7412-7420.
    • (2009) Clin Cancer Res , vol.15 , Issue.23 , pp. 7412-7420
    • Jdh, W.1    Hoos, A.2    Oday, S.3
  • 39
    • 84942122991 scopus 로고    scopus 로고
    • Is there still a role for tremelimumab in the treatment of cancer?
    • Ascierto PA. Is there still a role for tremelimumab in the treatment of cancer? Transl Cancer Res. 2013;2(1):48-50.
    • (2013) Transl Cancer Res , vol.2 , Issue.1 , pp. 48-50
    • Ascierto, P.A.1
  • 40
    • 84905987840 scopus 로고    scopus 로고
    • DOC-MEK: A double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-Type BRAF advanced melanoma
    • Gupta A, Love S, Schuh A, et al. DOC-MEK: A double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-Type BRAF advanced melanoma. Ann Oncol. 2014;25(5): 968-974.
    • (2014) Ann Oncol , vol.25 , Issue.5 , pp. 968-974
    • Gupta, A.1    Love, S.2    Schuh, A.3
  • 41
    • 84908664534 scopus 로고    scopus 로고
    • Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: A randomized clinical trial
    • Hodi FSL, Lee S, McDermott DF, et al. Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: A randomized clinical trial. JAMA. 2014;312(17): 1744-1753.
    • (2014) JAMA , vol.312 , Issue.17 , pp. 1744-1753
    • Fsl, H.1    Lee, S.2    McDermott, D.F.3
  • 42
    • 84856009717 scopus 로고    scopus 로고
    • Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma
    • Kirkwood JM, Bastholt L, Robert C, et al. Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma. Clin Cancer Res. 2012;18(2):555-567.
    • (2012) Clin Cancer Res , vol.18 , Issue.2 , pp. 555-567
    • Kirkwood, J.M.1    Bastholt, L.2    Robert, C.3
  • 43
    • 84896714827 scopus 로고    scopus 로고
    • Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study
    • McArthur GAC, Chapman PB, Robert C, et al. Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol. 2014;15(3):323-332.
    • (2014) Lancet Oncol , vol.15 , Issue.3 , pp. 323-332
    • Gac, M.1    Chapman, P.B.2    Robert, C.3
  • 44
    • 84879717023 scopus 로고    scopus 로고
    • Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: A phase 2 double-blind randomised study
    • Robert C, Dummer R, Gutzmer R, et al. Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: A phase 2 double-blind randomised study. Lancet Oncol. 2013; 14(8):733-740.
    • (2013) Lancet Oncol , vol.14 , Issue.8 , pp. 733-740
    • Robert, C.1    Dummer, R.2    Gutzmer, R.3
  • 45
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320-330.
    • (2015) N Engl J Med , vol.372 , Issue.4 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 46
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab vs Ipilimumab in Advanced Melanoma
    • KEYNOTE-006 investigators
    • Robert C, Schachter J, Long GV, et al; KEYNOTE-006 investigators. Pembrolizumab vs Ipilimumab in Advanced Melanoma. N Engl J Med. 2015;372(26):2521-2532.
    • (2015) N Engl J Med , vol.372 , Issue.26 , pp. 2521-2532
    • Robert, C.1    Schachter, J.2    Long, G.V.3
  • 47
    • 84927651609 scopus 로고    scopus 로고
    • Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial
    • Maio M, Grob JJ, Aamdal S, et al. Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial. J Clin Oncol. 2015;33 (10):1191-1196.
    • (2015) J Clin Oncol , vol.33 , Issue.10 , pp. 1191-1196
    • Maio, M.1    Grob, J.J.2    Aamdal, S.3
  • 48
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-Type RAF to activate the MAPK pathway and enhance growth
    • Hatzivassiliou G, Song K, Yen I, et al. RAF inhibitors prime wild-Type RAF to activate the MAPK pathway and enhance growth. Nature. 2010; 464(7287):431-435.
    • (2010) Nature , vol.464 , Issue.7287 , pp. 431-435
    • Hatzivassiliou, G.1    Song, K.2    Yen, I.3
  • 49
    • 84938739283 scopus 로고    scopus 로고
    • Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial
    • Long GV, Stroyakovskiy D, Gogas H, et al. Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial. Lancet. 2015;386(9992):444-451.
    • (2015) Lancet , vol.386 , Issue.9992 , pp. 444-451
    • Long, G.V.1    Stroyakovskiy, D.2    Gogas, H.3
  • 50
    • 84978034236 scopus 로고    scopus 로고
    • Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
    • Long GV, Menzies AM, Nagrial AM, et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol. 2011;29(10):1239-1246.
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1239-1246
    • Long, G.V.1    Menzies, A.M.2    Nagrial, A.M.3
  • 51
    • 84856363696 scopus 로고    scopus 로고
    • First-line temozolomide combined with bevacizumab in metastatic melanoma: A multicentre phase II trial (SAKK 50/07
    • von Moos R, Seifert B, Simcock M, et al. First-line temozolomide combined with bevacizumab in metastatic melanoma: A multicentre phase II trial (SAKK 50/07). Ann Oncol. 2012;23(2):531-536.
    • (2012) Ann Oncol , vol.23 , Issue.2 , pp. 531-536
    • Von Moos, R.1    Seifert, B.2    Simcock, M.3
  • 52
    • 85015462586 scopus 로고    scopus 로고
    • Impact of BRAF mutation status in the prognosis of cutaneous melanoma: An area of ongoing research
    • Bhatia P, Friedlander P, Zakaria EA, Kandil E. Impact of BRAF mutation status in the prognosis of cutaneous melanoma: An area of ongoing research. Ann Transl Med. 2015;3(2):24.
    • (2015) Ann Transl Med , vol.3 , Issue.2 , pp. 24
    • Bhatia, P.1    Friedlander, P.2    Zakaria, E.A.3    Kandil, E.4
  • 53
    • 0033848628 scopus 로고    scopus 로고
    • High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: Long-Term survival update
    • Atkins MB, Kunkel L, Sznol M, Rosenberg SA. High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-Term survival update. Cancer J Sci Am. 2000;6(suppl 1): S11-S14.
    • (2000) Cancer J Sci Am , vol.6 , pp. S11-S14
    • Atkins, M.B.1    Kunkel, L.2    Sznol, M.3    Rosenberg, S.A.4
  • 54
    • 68149126262 scopus 로고    scopus 로고
    • Current systemic therapy for metastatic melanoma
    • Agarwala SS. Current systemic therapy for metastatic melanoma. Expert Rev Anticancer Ther. 2009;9(5):587-595.
    • (2009) Expert Rev Anticancer Ther , vol.9 , Issue.5 , pp. 587-595
    • Agarwala, S.S.1
  • 55
    • 0033989205 scopus 로고    scopus 로고
    • Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma
    • Jun
    • Middleton MR, Grob JJ, Aaronson N, et al. Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. [Erratum appears in J Clin Oncol 2000 Jun;18(11):2351].
    • (2000) Erratum Appears in J Clin Oncol , vol.18 , Issue.11 , pp. 2351
    • Middleton, M.R.1    Grob, J.J.2    Aaronson, N.3
  • 56
    • 0033989205 scopus 로고    scopus 로고
    • J Clin Oncol. 2000;18(1):158-166.
    • (2000) J Clin Oncol , vol.18 , Issue.1 , pp. 158-166


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.