The Gut Microbiome and Its Role in Cardiovascular Diseases

Circulation

Volumn 135, Issue 11, 2017, Pages 1008-1010

  Wilson Tang, W H ^a,b   Hazen, Stanley L ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Center for Microbiome and Human Health   (United States)

Author keywords

coronary artery disease; diet; gut microbes; heart failure; metabolism; nutrition

Indexed keywords

CARNITINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLCHOLINE; SCAVENGER RECEPTOR A; SHORT CHAIN FATTY ACID; TRANSFORMING GROWTH FACTOR BETA; TRIMETHYLAMINE; TRIMETHYLAMINE OXIDE;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CHOLESTEROL TRANSPORT; COLON CELL; CORONARY ARTERY DISEASE; HUMAN; INTESTINE FLORA; METABOLOMICS; MICROBIAL COMMUNITY; NONHUMAN; PRIORITY JOURNAL; DISEASE PREDISPOSITION; METABOLISM; PATHOPHYSIOLOGY;

CARDIOVASCULAR DISEASES; DISEASE SUSCEPTIBILITY; GASTROINTESTINAL MICROBIOME; HUMANS;

EID: 85015255319     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.024251     Document Type: Article

References (5)

1. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL, Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011 472 57 63. doi: 10.1038/nature09922
2. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL, Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013 19 576 585. doi: 10.1038/nm.3145
3. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL, Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013 368 1575 1584. doi: 10.1056/NEJMoa1109400
4. Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WH, DiDonato JA, Brown JM, Lusis AJ, Hazen SL, Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 2016 165 111 124. doi: 10.1016/j.cell.2016.02.011
5. Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL, Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell 2015 163 1585 1595. doi: 10.1016/j.cell.2015.11.055