-
2
-
-
0032486433
-
Teratogen-mediated inhibition of target tissue response to Shh signaling
-
Cooper MK, Porter JA, Young KE, et al. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 1998; 280:1603–1607.
-
(1998)
Science
, vol.280
, pp. 1603-1607
-
-
Cooper, M.K.1
Porter, J.A.2
Young, K.E.3
-
3
-
-
0031748962
-
The use a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events
-
Kochhar DM, Jiang H, Penner JD, et al. The use a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events. Int J Dev Biol 1998; 42:601–608.
-
(1998)
Int J Dev Biol
, vol.42
, pp. 601-608
-
-
Kochhar, D.M.1
Jiang, H.2
Penner, J.D.3
-
4
-
-
0032568871
-
Embryonic folate metabolism and mouse neural tube defects
-
Fleming A, Copp AJ. Embryonic folate metabolism and mouse neural tube defects. Science 1998; 280:2107–2109.
-
(1998)
Science
, vol.280
, pp. 2107-2109
-
-
Fleming, A.1
Copp, A.J.2
-
5
-
-
0031847377
-
Teratogen-induced cell death in postimplantation mouse embryos: Differential tissue sensitivity and hallmarks of apoptosis
-
Mirkes PE, Little SA. Teratogen-induced cell death in postimplantation mouse embryos: Differential tissue sensitivity and hallmarks of apoptosis. Cell Death Differ 1998; 5:592–600.
-
(1998)
Cell Death Differ
, vol.5
, pp. 592-600
-
-
Mirkes, P.E.1
Little, S.A.2
-
7
-
-
2942751518
-
Microarray applications in developmental toxicology
-
Perspectives in Gene Expression, Appasani K, ed
-
Knudsen TB, Charlap JH, Nemeth KR. Microarray applications in developmental toxicology. In Perspectives in Gene Expression, Appasani K, ed. Eaton Publishing/BioTechniques Press, Westboro, MA, 2003:173–194.
-
(2003)
Eaton Publishing/Biotechniques Press, Westboro, MA
, pp. 173-194
-
-
Knudsen, T.B.1
Charlap, J.H.2
Nemeth, K.R.3
-
8
-
-
33845999956
-
Genomics and developmental risk assessment
-
Daston GP. Genomics and developmental risk assessment. Birth Defects Res A 2007; 79:1–7.
-
(2007)
Birth Defects Res A
, vol.79
, pp. 1-7
-
-
Daston, G.P.1
-
9
-
-
0035224392
-
DNA arrays and functional genomics in neurobiology
-
Thibault C, Wang L, Zhang L, et al. DNA arrays and functional genomics in neurobiology. Int Rev Neurobiol 2001; 48:219–253.
-
(2001)
Int Rev Neurobiol
, vol.48
, pp. 219-253
-
-
Thibault, C.1
Wang, L.2
Zhang, L.3
-
10
-
-
15944425036
-
Computational systems analysis of developmental toxicity: Design, development and implementation of a birth defects systems manager (BDSM)
-
Singh AV, Knudsen KB, Knudsen TB. Computational systems analysis of developmental toxicity: Design, development and implementation of a birth defects systems manager (BDSM). Reprod Toxicol 2005; 19:421–439.
-
(2005)
Reprod Toxicol
, vol.19
, pp. 421-439
-
-
Singh, A.V.1
Knudsen, K.B.2
Knudsen, T.B.3
-
11
-
-
33745790677
-
A system-based approach to interpret dose-and time-dependent microarray data: Quantitative integration of gene ontology analysis for risk assessment
-
Yu X, Griffith WC, Hanspers K, et al. A system-based approach to interpret dose-and time-dependent microarray data: Quantitative integration of gene ontology analysis for risk assessment. Toxicol Sci 2006; 92:560–577.
-
(2006)
Toxicol Sci
, vol.92
, pp. 560-577
-
-
Yu, X.1
Griffith, W.C.2
Hanspers, K.3
-
12
-
-
33846913002
-
Reprogramming of genetic networks during initiation of the fetal alcohol syndrome
-
Green ML, Singh AV, Zhang Y, et al. Reprogramming of genetic networks during initiation of the fetal alcohol syndrome. Devel Dynam 2007; 236:613–631.
-
(2007)
Devel Dynam
, vol.236
, pp. 613-631
-
-
Green, M.L.1
Singh, A.V.2
Zhang, Y.3
-
13
-
-
85056973675
-
Synergy between medical informatics and bioinformatics: Facilitating genomic medicine for future healthcare
-
EC-IST 2001–35024
-
BIOINFOMED Study. Synergy between medical informatics and bioinformatics: Facilitating genomic medicine for future healthcare. European Commission (EC)—Directorate General: Information Society, Brussels. EC-IST 2001–35024, 2003. http://www.infobiomed.org/paginas en/project.htm
-
(2003)
European Commission (EC)—Directorate General: Information Society, Brussels
-
-
-
14
-
-
34249994131
-
Integrative database management for mouse development: Systems and concepts
-
Singh AV, Rouhka EC, Rempala GA, et al. Integrative database management for mouse development: systems and concepts. Birth Defects Res C 2007; 81:1–19.
-
(2007)
Birth Defects Res C
, vol.81
, pp. 1-19
-
-
Singh, A.V.1
Rouhka, E.C.2
Rempala, G.A.3
-
16
-
-
15944417084
-
A systems biology approach to developmental toxicology
-
Cummings A, Kavlock RJ. A systems biology approach to developmental toxicology. Reprod Toxicol 2005; 19:281–290.
-
(2005)
Reprod Toxicol
, vol.19
, pp. 281-290
-
-
Cummings, A.1
Kavlock, R.J.2
-
17
-
-
26444446582
-
A systems-based computational model for dose-response comparisons of two mode of action hypothesis for ethanol-induced neurodevelopmental toxicity
-
Gohlke JM, Griffith WC, Faustman EM. A systems-based computational model for dose-response comparisons of two mode of action hypothesis for ethanol-induced neurodevelopmental toxicity. Toxicol Sci 2005; 86:470–484.
-
(2005)
Toxicol Sci
, vol.86
, pp. 470-484
-
-
Gohlke, J.M.1
Griffith, W.C.2
Faustman, E.M.3
-
18
-
-
85012830925
-
Integrative analysis of the mouse embryonic transcriptome
-
Singh AV, Knudsen KB, Knudsen TB. Integrative analysis of the mouse embryonic transcriptome. Bioinformation 2007; 1:24–30.
-
(2007)
Bioinformation
, vol.1
, pp. 24-30
-
-
Singh, A.V.1
Knudsen, K.B.2
Knudsen, T.B.3
-
19
-
-
0035996075
-
Gene expression profile induced by 17ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat
-
Naciff JM, Jump ML, Torontali SM, et al. Gene expression profile induced by 17ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat. Toxicol Sci 2002; 68:184–199.
-
(2002)
Toxicol Sci
, vol.68
, pp. 184-199
-
-
Naciff, J.M.1
Jump, M.L.2
Torontali, S.M.3
-
20
-
-
2942744822
-
Alterations in gene expression induced in day-9 mouse embryos exposed to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP): Analysis using cDNA microarrays
-
Mikheeva S, Barrier M, Little SA, et al. Alterations in gene expression induced in day-9 mouse embryos exposed to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP): Analysis using cDNA microarrays. Toxicol Sci 2004; 79:345–359.
-
(2004)
Toxicol Sci
, vol.79
, pp. 345-359
-
-
Mikheeva, S.1
Barrier, M.2
Little, S.A.3
-
21
-
-
13444284760
-
Ontogeny of transcription profiles during mouse early craniofacial development
-
Karoly ED, Schmid JE, Hunter ES III. Ontogeny of transcription profiles during mouse early craniofacial development. Reprod Toxicol 2005; 19:339–352.
-
(2005)
Reprod Toxicol
, vol.19
, pp. 339-352
-
-
Karoly, E.D.1
Schmid, J.E.2
Hunter, E.S.3
-
22
-
-
13444296577
-
Searching for biomarkers of developmental toxicity with microarrays: Normal eye morphogenesis in rodent embryos
-
Nemeth KA, Singh AV, Knudsen TB. Searching for biomarkers of developmental toxicity with microarrays: Normal eye morphogenesis in rodent embryos. Toxicol Appl Pharmacol 2005; 206:219–228.
-
(2005)
Toxicol Appl Pharmacol
, vol.206
, pp. 219-228
-
-
Nemeth, K.A.1
Singh, A.V.2
Knudsen, T.B.3
-
23
-
-
0036843726
-
PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects
-
Qin P, Cimildoro R, Kochhar DM, et al. PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects. Teratology 2002; 66:224–234.
-
(2002)
Teratology
, vol.66
, pp. 224-234
-
-
Qin, P.1
Cimildoro, R.2
Kochhar, D.M.3
-
24
-
-
33749625926
-
Novel retinoid targets in the mouse limb during organogenesis
-
Ali-Khan SE, Hales BF. Novel retinoid targets in the mouse limb during organogenesis. Toxicol Sci 2006; 94:139–152.
-
(2006)
Toxicol Sci
, vol.94
, pp. 139-152
-
-
Ali-Khan, S.E.1
Hales, B.F.2
-
25
-
-
20444369930
-
A gene(S) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11
-
Lee GS, Cantor RM, Abnoosian A, et al. A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11. Genetics 2005; 170:345–353.
-
(2005)
Genetics
, vol.170
, pp. 345-353
-
-
Lee, G.S.1
Cantor, R.M.2
Abnoosian, A.3
-
26
-
-
33846064113
-
NCBI GEO: Mining tens of millions of expression profiles—database and tools update
-
Barrett T, Troup DB, Wilhite SE, et al. NCBI GEO: Mining tens of millions of expression profiles—database and tools update. Nucl Acids Res 2007; 35:D760-D765.
-
(2007)
Nucl Acids Res
, vol.35
, pp. D760-D765
-
-
Barrett, T.1
Troup, D.B.2
Wilhite, S.E.3
-
27
-
-
38549098540
-
The molecular biology database collection: 2008 update
-
Galperin MY. The molecular biology database collection: 2008 update. Nucleic Acids Res 2008; 36 (database issue) D2-D4 (doi:10.1093/nar/gkm1037).
-
(2008)
Nucleic Acids Res
, vol.36
, pp. D2-D4
-
-
Galperin, M.Y.1
-
28
-
-
19444375186
-
Bioinformatic methods for integrating whole-genome expression results into cellular networks
-
Cavalieri D, De Filippo C. Bioinformatic methods for integrating whole-genome expression results into cellular networks. Drug Dis Ther 2005; 10:727– 734.
-
(2005)
Drug Dis Ther
, vol.10
, pp. 727-734
-
-
Cavalieri, D.1
de Filippo, C.2
-
29
-
-
33644777676
-
Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use
-
Corvi R, Ahr H-J, Albertini S, et al. Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use. Env Health Perspect 2006; 114:420–429.
-
(2006)
Env Health Perspect
, vol.114
, pp. 420-429
-
-
Corvi, R.1
Ahr, H.-J.2
Albertini, S.3
-
30
-
-
33749335282
-
The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb J, Crawford ED, Peck D, et al. The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease. Science 2006; 313:1929– 1935.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
-
31
-
-
33845620001
-
The ToxCast program for prioritizing toxicity testing of environmental chemicals
-
Dix DJ, Houck KA, Martin MT, et al. The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol Sci 2007; 95:5–12.
-
(2007)
Toxicol Sci
, vol.95
, pp. 5-12
-
-
Dix, D.J.1
Houck, K.A.2
Martin, M.T.3
-
32
-
-
34249994847
-
The role of data mining in turning bio-data into bioinformation
-
Perrizo W. The role of data mining in turning bio-data into bioinformation. Bioinformation 2007; 1:351–355.
-
(2007)
Bioinformation
, vol.1
, pp. 351-355
-
-
Perrizo, W.1
-
33
-
-
33645124061
-
DbZach: A MIAME-compliant toxicogenomic supportive relational database
-
Burgoon LD, Boutros PC, Dere E, et al. dbZach: A MIAME-compliant toxicogenomic supportive relational database. Toxicol Sci 2006; 90:558–568.
-
(2006)
Toxicol Sci
, vol.90
, pp. 558-568
-
-
Burgoon, L.D.1
Boutros, P.C.2
Dere, E.3
-
34
-
-
33646844277
-
The art of data mining the minefields of toxicity databases to link chemistry to biology
-
Yang C, Richard AM, Cross KP. The art of data mining the minefields of toxicity databases to link chemistry to biology. Curr Comp Aided Drug Des 2006; 2:135– 150.
-
(2006)
Curr Comp Aided Drug Des
, vol.2
, pp. 135-150
-
-
Yang, C.1
Richard, A.M.2
Cross, K.P.3
-
35
-
-
21744458565
-
Data input module for birth defects systems manager
-
Knudsen KB, Singh AV, Knudsen TB. Data input module for birth defects systems manager. Reprod Toxicol 2005; 20:369–375.
-
(2005)
Reprod Toxicol
, vol.20
, pp. 369-375
-
-
Knudsen, K.B.1
Singh, A.V.2
Knudsen, T.B.3
-
36
-
-
34548447203
-
Systems developmental biology: The use of ontologies in annotating models and in identifying gene function within and across species
-
Bard J. Systems developmental biology: The use of ontologies in annotating models and in identifying gene function within and across species. Mamm Genome 2007; 18:402–411.
-
(2007)
Mamm Genome
, vol.18
, pp. 402-411
-
-
Bard, J.1
-
37
-
-
0242331726
-
An ontology of human developmental anatomy
-
Hunter A, Kaufman MH, McKay A, et al. An ontology of human developmental anatomy. J Anat 2007; 203;347–355.
-
(2007)
J Anat
, vol.203
, pp. 347-355
-
-
Hunter, A.1
Kaufman, M.H.2
McKay, A.3
-
39
-
-
33644875982
-
EMAGE: A spatial database of gene expression patterns during mouse embryo development
-
Christiansen JH, Yang Y, Venkataraman S, et al. EMAGE: A spatial database of gene expression patterns during mouse embryo development. Nucl Acids Res 2006; 34:D637–D641.
-
(2006)
Nucl Acids Res
, vol.34
, pp. D637-D641
-
-
Christiansen, J.H.1
Yang, Y.2
Venkataraman, S.3
-
40
-
-
0026899029
-
A real mouse for your computer
-
Baldock R, Bard J, Kaufman M, et al. A real mouse for your computer. Bio Essays 1992; 14:501–503.
-
(1992)
Bio Essays
, vol.14
, pp. 501-503
-
-
Baldock, R.1
Bard, J.2
Kaufman, M.3
-
41
-
-
0027986618
-
A database for mouse development
-
Ringwald M, Baldock R, Bard J, et al. A database for mouse development. Science 1994; 265:2033–2034.
-
(1994)
Science
, vol.265
, pp. 2033-2034
-
-
Ringwald, M.1
Baldock, R.2
Bard, J.3
-
42
-
-
10744232767
-
EMAP and EMAGE: A framework for understanding spatially organized data
-
Baldock RA, Bard JB, Burger A, et al. EMAP and EMAGE: A framework for understanding spatially organized data. Neuroinformatics 2003; 1:309–325.
-
(2003)
Neuroinformatics
, vol.1
, pp. 309-325
-
-
Baldock, R.A.1
Bard, J.B.2
Burger, A.3
-
43
-
-
9144253908
-
The mouse Gene Expression Database (GXD): Updates and enhancements
-
Hill DP, Begley DA, Finger JH, et al. The mouse Gene Expression Database (GXD): Updates and enhancements. Nucl Acids Res 2004; 32:D568–D571.
-
(2004)
Nucl Acids Res
, vol.32
, pp. D568-D571
-
-
Hill, D.P.1
Begley, D.A.2
Finger, J.H.3
-
44
-
-
85056919806
-
Computational approaches for assessment of toxicity: A historical perspective and current status
-
Environmental Chemicals, Ekins S, ed. John Wiley & Sons, Hoboken, NJ
-
Gombar VK, Mattioni BE, Zwickl C, et al. Computational approaches for assessment of toxicity: A historical perspective and current status. In Computational Toxicology. Risk Assessment for Pharmaceutical and Environmental Chemicals, Ekins S, ed. John Wiley & Sons, Hoboken, NJ, 2007:815.
-
(2007)
Computational Toxicology. Risk Assessment for Pharmaceutical And
, pp. 815
-
-
Gombar, V.K.1
Mattioni, B.E.2
Zwickl, C.3
-
45
-
-
85056957959
-
Computational tools for regulatory needs
-
Environmental Chemicals, Ekins S, ed. John Wiley & Sons, Hoboken, NJ
-
Bassan A, Worth AP. Computational tools for regulatory needs. In Computational Toxicology. Risk Assessment for Pharmaceutical and Environmental Chemicals, Ekins S, ed. John Wiley & Sons, Hoboken, NJ, 2007:815.
-
(2007)
Computational Toxicology. Risk Assessment for Pharmaceutical And
, pp. 815
-
-
Bassan, A.1
Worth, A.P.2
-
49
-
-
0035865253
-
-
Butler D. Are you ready for the revolution? Nature 2001; 409:758–760.
-
(2001)
Nature
, vol.409
, pp. 758-760
-
-
Butler, D.1
-
50
-
-
84880927782
-
Integrated regulatory and metabolic models
-
Kriete A, Eils R, eds. Elsevier Academic Press, New York
-
Covert MW. Integrated regulatory and metabolic models. In Computational Systems Biology, Kriete A, Eils R, eds. Elsevier Academic Press, New York, 2006:191–204.
-
(2006)
Computational Systems Biology
, pp. 191-204
-
-
Covert, M.W.1
-
51
-
-
30444445381
-
Fundamental issues in systems biology
-
O’Malley MA, Dupré J. Fundamental issues in systems biology. Bio Essays 2005; 27:1270–1276.
-
(2005)
Bio Essays
, vol.27
, pp. 1270-1276
-
-
O’Malley, M.A.1
Dupré, J.2
-
52
-
-
85056925278
-
Toxicogenomics and systems toxicology
-
Environmental Chemicals, Ekins S, ed. John Wiley & Sons, Hoboken, NJ
-
Waters MD, Fostel JM, Wetmore BA, et al. Toxicogenomics and systems toxicology. In Computational Toxicology. Risk Assessment for Pharmaceutical and Environmental Chemicals, Ekins S, ed. John Wiley & Sons, Hoboken, NJ, 2007:815.
-
(2007)
Computational Toxicology. Risk Assessment for Pharmaceutical And
, vol.815
-
-
Waters, M.D.1
Fostel, J.M.2
Wetmore, B.A.3
-
53
-
-
84882299374
-
Reconstruction of metabolic networks from genome information and its structural and functional analysis
-
Kriete A, Eils R, eds. Elsevier Academic Press, New York
-
Ma H-W, Zeng A-P. Reconstruction of metabolic networks from genome information and its structural and functional analysis. In Computational Systems Biology, Kriete A, Eils R, eds. Elsevier Academic Press, New York, 2006:169–189.
-
(2006)
Computational Systems Biology
, pp. 169-189
-
-
Ma, H.-W.1
Zeng, A.-P.2
-
55
-
-
39849087727
-
Computational models of ethanol-induced neurodevelopmental toxicity across species: Implications for risk assessment
-
Gohlke JM, Griffith WC, Faustman EM. Computational models of ethanol-induced neurodevelopmental toxicity across species: Implications for risk assessment. Birth Defects Res B 2008; 83:1–11.
-
(2008)
Birth Defects Res B
, vol.83
, pp. 1-11
-
-
Gohlke, J.M.1
Griffith, W.C.2
Faustman, E.M.3
-
56
-
-
1042303692
-
Hazard identification and predictability of children’s health risk from animal data
-
Morford LL, Henck JW, Breslin WJ, et al. Hazard identification and predictability of children’s health risk from animal data. Env Health Perspect 2004; 112:266– 271.
-
(2004)
Env Health Perspect
, vol.112
, pp. 266-271
-
-
Morford, L.L.1
Henck, J.W.2
Breslin, W.J.3
-
57
-
-
39449106623
-
Advancing understanding of the embryo transcriptome co-regulation using meta-, functional, and gene network analysis tools
-
Rodriguez-Zas SL, Ko Y, Adams HA, et al. Advancing understanding of the embryo transcriptome co-regulation using meta-, functional, and gene network analysis tools. Reproduction 2008; 135:213–224.
-
(2008)
Reproduction
, vol.135
, pp. 213-224
-
-
Rodriguez-Zas, S.L.1
Ko, Y.2
Adams, H.A.3
-
58
-
-
17644385076
-
Computational representation of developmental genetic regulatory networks
-
Longabaugh WJR, Davidson EH, Bolouri H. Computational representation of developmental genetic regulatory networks. Devel Biol 2005; 283:1–16.
-
(2005)
Devel Biol
, vol.283
, pp. 1-16
-
-
Longabaugh, W.J.R.1
Davidson, E.H.2
Bolouri, H.3
-
59
-
-
32444446240
-
Gene regulatory networks and the evolution of animal body plans
-
Davidson EH, Erwin DH. Gene regulatory networks and the evolution of animal body plans. Science 2006; 311:796–800.
-
(2006)
Science
, vol.311
, pp. 796-800
-
-
Davidson, E.H.1
Erwin, D.H.2
-
60
-
-
33749361499
-
Gene regulatory networks in the evolution and development of the heart
-
Olson EN. Gene regulatory networks in the evolution and development of the heart. Science 2006; 313:1922–1927.
-
(2006)
Science
, vol.313
, pp. 1922-1927
-
-
Olson, E.N.1
-
62
-
-
38549180536
-
COXPRESdb: A database of coexpressed networks in mammals
-
Obayashi T, Hayashi S, Shibaoka M, et al. COXPRESdb: A database of coexpressed networks in mammals. Nucl Acids Res 2007; 36:D77–D82.
-
(2007)
Nucl Acids Res
, vol.36
, pp. D77-D82
-
-
Obayashi, T.1
Hayashi, S.2
Shibaoka, M.3
-
65
-
-
0036578795
-
Network motifs in the transcriptional regulation network of Escherichia coli
-
Shen-Orr SS, Milo R, Mangan S, et al. Network motifs in the transcriptional regulation network of Escherichia coli. Nature Gen 2002; 31:64–68.
-
(2002)
Nature Gen
, vol.31
, pp. 64-68
-
-
Shen-Orr, S.S.1
Milo, R.2
Mangan, S.3
-
66
-
-
33746778773
-
Effects of topology on network evolution
-
Oikonomou P, Cluzel P. Effects of topology on network evolution. Nature Phys 2006; 2:532–536.
-
(2006)
Nature Phys
, vol.2
, pp. 532-536
-
-
Oikonomou, P.1
Cluzel, P.2
-
67
-
-
77955933695
-
-
2 March
-
Wikepedia contributors. Scale-free network, Wikipedia, The Free Encyclopedia, 2 March 2008 (http://en.wikipedia.org/w/index.php?title = Scale-free network&oldid = 195352029).
-
(2008)
The Free Encyclopedia
-
-
-
68
-
-
85056936644
-
An introduction to toxicology and its methodologies
-
Environmental Chemicals, Ekins S, ed. John Wiley & Sons, Hoboken, NJ
-
Combs AB, Acosta DA Jr. An introduction to toxicology and its methodologies. In Computational Toxicology. Risk Assessment for Pharmaceutical and Environmental Chemicals, Ekins S, ed. John Wiley & Sons, Hoboken, NJ, 2007:815.
-
(2007)
Computational Toxicology. Risk Assessment for Pharmaceutical And
, vol.815
-
-
Combs, A.B.1
Acosta, D.A.2
-
69
-
-
18544410441
-
Hierarchization of animal teratology findings for improving the human risk evaluation of drug
-
Guittina P, Elefant E, Saint–Salvic B. Hierarchization of animal teratology findings for improving the human risk evaluation of drug. Reprod Toxicol 2000; 14:369–375.
-
(2000)
Reprod Toxicol
, vol.14
, pp. 369-375
-
-
Guittina, P.1
Elefant, E.2
Saint–Salvic, B.3
-
70
-
-
39749161008
-
The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the “no observed adverse effect level”
-
Chernoff NA, Rogers EA, Gage MI, et al. The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the “no observed adverse effect level”. Reprod Toxicol 2008; 25:192–202.
-
(2008)
Reprod Toxicol
, vol.25
, pp. 192-202
-
-
Chernoff, N.A.1
Rogers, E.A.2
Gage, M.I.3
-
71
-
-
85056959010
-
-
1991 and FQPA 10x Safety Factor Update. FIFRA Scientific Advisory Panel Meeting, SAP Report No. 99–01 C, January 22
-
EPA. Guidelines for Developmental Toxicity Risk Assessment; Notice. Fed Reg 56: 63798–63826, 1991 and FQPA 10x Safety Factor Update. FIFRA Scientific Advisory Panel Meeting, SAP Report No. 99–01 C, January 22, 1999. (http://www.epa.gov/scipoly/sap/meetings/1998/december/final3.pdf)
-
(1999)
Notice. Fed Reg
, vol.56
, pp. 63798-63826
-
-
-
72
-
-
0026328965
-
Carcinogenicity evaluations and ongoing studies: The IARC databases
-
Vainio H, Coleman M, Wilburn J. Carcinogenicity evaluations and ongoing studies: The IARC databases. Environ Health Perspect 1991; 96:5–9.
-
(1991)
Environ Health Perspect
, vol.96
, pp. 5-9
-
-
Vainio, H.1
Coleman, M.2
Wilburn, J.3
-
74
-
-
36048974254
-
Struggles for equivalence: In vitro developmental toxicity model evolution in pharmaceuticals in 2006
-
Chapin R, Stedman D, Paquette J, et al. Struggles for equivalence: In vitro developmental toxicity model evolution in pharmaceuticals in 2006. Toxicol In Vitro 2007; 21:1545–1551.
-
(2007)
Toxicol in Vitro
, vol.21
, pp. 1545-1551
-
-
Chapin, R.1
Stedman, D.2
Paquette, J.3
-
75
-
-
42149152647
-
Computational toxicology—a state of the science mini review
-
Kavlock RJ, Ankley GA, Blancato J, et al. Computational toxicology—a state of the science mini review. Toxicol Sci 2008; 103:14–27.
-
(2008)
Toxicol Sci
, vol.103
, pp. 14-27
-
-
Kavlock, R.J.1
Ankley, G.A.2
Blancato, J.3
-
76
-
-
77957180789
-
A new method for determining allowable intakes
-
Crump K. A new method for determining allowable intakes. Fund Appl Toxicol 1984; 4:854–871.
-
(1984)
Fund Appl Toxicol
, vol.4
, pp. 854-871
-
-
Crump, K.1
-
77
-
-
77957180190
-
Dose-response assessment for developmental toxicity. I. Characterization of the database and determination of the no observed adverse effect level
-
Faustman EM, Allen BC, Kavlock RJ, et al. Dose-response assessment for developmental toxicity. I. Characterization of the database and determination of the no observed adverse effect level. Fund Appl Toxicol 1994; 23:478–486.
-
(1994)
Fund Appl Toxicol
, vol.23
, pp. 478-486
-
-
Faustman, E.M.1
Allen, B.C.2
Kavlock, R.J.3
-
78
-
-
77957183026
-
Dose response assessment for developmental toxicity. II. Comparison of generic benchmark dose estimates with no observed adverse effect levels
-
Allen BC, Kavlock RJ, Kimmel CA, et al. Dose response assessment for developmental toxicity. II. Comparison of generic benchmark dose estimates with no observed adverse effect levels. Fund Appl Toxicol 1994; 23:487–495.
-
(1994)
Fund Appl Toxicol
, vol.23
, pp. 487-495
-
-
Allen, B.C.1
Kavlock, R.J.2
Kimmel, C.A.3
-
79
-
-
77957176940
-
Dose response assessment for developmental toxicity. III. Statistical models
-
Allen BC, Kavlock RJ, Kimmel CA, et al. Dose response assessment for developmental toxicity. III. Statistical models. Fund Appl Toxicol 1994; 23:496–509.
-
(1994)
Fund Appl Toxicol
, vol.23
, pp. 496-509
-
-
Allen, B.C.1
Kavlock, R.J.2
Kimmel, C.A.3
-
80
-
-
0029069658
-
Dose-response assessment for developmental toxicity. IV. Benchmark doses for fetal weight changes
-
Kavlock RJ, Allen BC, Faustman EM, et al. Dose-response assessment for developmental toxicity. IV. Benchmark doses for fetal weight changes. Fund Appl Toxicol 1995; 26:211–222.
-
(1995)
Fund Appl Toxicol
, vol.26
, pp. 211-222
-
-
Kavlock, R.J.1
Allen, B.C.2
Faustman, E.M.3
-
81
-
-
0030175717
-
A simulation study of the influence of study design on the estimation of benchmark doses for developmental toxicity
-
Kavlock RJ, Schmid JE, Setzer RW. A simulation study of the influence of study design on the estimation of benchmark doses for developmental toxicity. Risk Anal 1996; 16:399–410.
-
(1996)
Risk Anal
, vol.16
, pp. 399-410
-
-
Kavlock, R.J.1
Schmid, J.E.2
Setzer, R.W.3
-
82
-
-
36949003263
-
Quantitative extrapolation of in vitro whole embryo culture embryotoxicity data to developmental toxicity in vivo using the benchmark dose approach
-
Piersma AH, Janer G, Wolterink G, et al. Quantitative extrapolation of in vitro whole embryo culture embryotoxicity data to developmental toxicity in vivo using the benchmark dose approach. Toxicol Sci 2008; 101:91–100.
-
(2008)
Toxicol Sci
, vol.101
, pp. 91-100
-
-
Piersma, A.H.1
Janer, G.2
Wolterink, G.3
-
84
-
-
0027353745
-
Structure-activity approaches in the screening of environmental agents for developmental toxicity
-
Kavlock RJ. Structure-activity approaches in the screening of environmental agents for developmental toxicity. Reprod Toxicol 1993; 7:113–166.
-
(1993)
Reprod Toxicol
, vol.7
, pp. 113-166
-
-
Kavlock, R.J.1
-
85
-
-
11144263227
-
Challenges in constructing statistically based structure-activity models for developmental toxicity
-
Julien E, Willhite CC, Richard AM, et al. Challenges in constructing statistically based structure-activity models for developmental toxicity. Birth Defects Res A 2004; 70:902–911.
-
(2004)
Birth Defects Res A
, vol.70
, pp. 902-911
-
-
Julien, E.1
Willhite, C.C.2
Richard, A.M.3
-
86
-
-
85056961424
-
-
Accelrys. http://www.accelrys. com/products/topkat/index.html. Accessed Jan 15 2008, 2004.
-
(2008)
-
-
-
87
-
-
0028991114
-
Assessment of developmental toxicity potential of chemicals by quantitative structure-activity relationship models
-
Gombar VK, Enslein K, Blake BW. Assessment of developmental toxicity potential of chemicals by quantitative structure-activity relationship models. Chemosphere 1995; 31:2499–2510.
-
(1995)
Chemosphere
, vol.31
, pp. 2499-2510
-
-
Gombar, V.K.1
Enslein, K.2
Blake, B.W.3
-
88
-
-
85056954723
-
-
MultiCase. http://wwwmulticasecom/2004. Accessed Jan 15 2008.
-
(2008)
-
-
-
89
-
-
0030923022
-
Structural determinants associated with the risk of human developmental toxicity
-
Ghanooni M, Mattison DR, Zhang YP, et al. Structural determinants associated with the risk of human developmental toxicity. Am J Obstet Gynecol 1997; 176: 799–805.
-
(1997)
Am J Obstet Gynecol
, vol.176
, pp. 799-805
-
-
Ghanooni, M.1
Mattison, D.R.2
Zhang, Y.P.3
-
90
-
-
0025344243
-
Potential human teratogenicity of frequently prescribed drugs
-
Friedman JM, Little BB, Brent RL, et al. Potential human teratogenicity of frequently prescribed drugs. Obstet Gynecol 1990; 75:594–599.
-
(1990)
Obstet Gynecol
, vol.75
, pp. 594-599
-
-
Friedman, J.M.1
Little, B.B.2
Brent, R.L.3
-
91
-
-
0003460676
-
-
5th ed. Williams and Wilkins, Baltimore, MD
-
Briggs GG, Freeman RK, Yaffee SJ. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. 5th ed. Williams and Wilkins, Baltimore, MD, 2005:1888.
-
(2005)
Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk
, pp. 1888
-
-
Briggs, G.G.1
Freeman, R.K.2
Yaffee, S.J.3
-
93
-
-
84958742166
-
-
No. 58 ENV/JM/MONO(2006)25
-
OECD. Report on Regulatory Uses and Applications in OECD Member Countries of (Quantitative) Structure-Activity Relationships [(Q)SAR] Models in the Assessment of New and Existing Chemicals. OECD Environmental Health and Safety Publications, Series on Testing and Assessment, No. 58 ENV/JM/MONO(2006)25, 2007.
-
(2007)
OECD Environmental Health and Safety Publications, Series on Testing and Assessment
-
-
-
94
-
-
0030748672
-
Terminology of developmental abnormalities in common laboratory mammals (Version 1)
-
Wise LD, Beck SL, Beltrame D, et al. Terminology of developmental abnormalities in common laboratory mammals (version 1). Teratology 1997; 55:249–292.
-
(1997)
Teratology
, vol.55
, pp. 249-292
-
-
Wise, L.D.1
Beck, S.L.2
Beltrame, D.3
-
95
-
-
0033036901
-
Classification terms in developmental toxicology: Need for harmonization. Report of the second workshop on the terminology in developmental toxicology Berlin
-
27–28 August 1998
-
Chahoud I, Buschmann J, Clark R, et al. Classification terms in developmental toxicology: need for harmonization. Report of the second workshop on the terminology in developmental toxicology Berlin, 27–28 August 1998. Reprod Toxicol 1999; 13:77–82.
-
(1999)
Reprod Toxicol
, vol.13
, pp. 77-82
-
-
Chahoud, I.1
Buschmann, J.2
Clark, R.3
-
98
-
-
4444273205
-
Assessment of prediction confidence and domain extrapolation of two structure-activity relationship models for predicting estrogen receptor binding activity
-
Tong W, Xie Q, Hong H, et al. Assessment of prediction confidence and domain extrapolation of two structure-activity relationship models for predicting estrogen receptor binding activity. Environ Health Perspect 2004; 112:1249–1254.
-
(2004)
Environ Health Perspect
, vol.112
, pp. 1249-1254
-
-
Tong, W.1
Xie, Q.2
Hong, H.3
-
99
-
-
33845277149
-
QSAR prediction of estrogen activity for a large set of diverse chemicals under the guidance of OECD principles
-
Lui H, Papa E, Grammatica P. QSAR prediction of estrogen activity for a large set of diverse chemicals under the guidance of OECD principles. Chem Res Toxicol 2006; 19;1540–1548.
-
(2006)
Chem Res Toxicol
, vol.19
, pp. 1540-1548
-
-
Lui, H.1
Papa, E.2
Grammatica, P.3
-
100
-
-
18044382708
-
QSAR models using a large diverse set of estrogens
-
Shi LM, Fang H, Tong W, et al. QSAR models using a large diverse set of estrogens. J Chem Inf Comput Sci 2001; 41:186–195.
-
(2001)
J Chem Inf Comput Sci
, vol.41
, pp. 186-195
-
-
Shi, L.M.1
Fang, H.2
Tong, W.3
-
101
-
-
39049168646
-
Understanding mechanisms of toxicity: Insights from drug discovery research
-
Houck KA, Kavlock RJ. Understanding mechanisms of toxicity: Insights from drug discovery research. Toxicol Appl Pharm 2008; 227:163–178.
-
(2008)
Toxicol Appl Pharm
, vol.227
, pp. 163-178
-
-
Houck, K.A.1
Kavlock, R.J.2
-
103
-
-
33750245442
-
Future of toxicology–predictive toxicology: An expanded view of “chemical toxicity”
-
Richard A. Future of toxicology–predictive toxicology: An expanded view of “chemical toxicity”. Chem Res Toxicol 2006; 19:1258–1262.
-
(2006)
Chem Res Toxicol
, vol.19
, pp. 1258-1262
-
-
Richard, A.1
-
104
-
-
41049117650
-
Toxicity data informatics: Supporting a new paradigm for toxicity prediction
-
Richard A, Yang C, Judson R. Toxicity data informatics: Supporting a new paradigm for toxicity prediction. Toxicol Meth Mech 2008; 18:103–118.
-
(2008)
Toxicol Meth Mech
, vol.18
, pp. 103-118
-
-
Richard, A.1
Yang, C.2
Judson, R.3
-
107
-
-
85056924525
-
-
EPA DSSTox. U.S. Environmental Protection Agency’s Distributed Structure-Searchable Toxicity (DSSTox) Database Network, 2007. (http://www.epa.gov/ncct/dsstox/index.html)
-
(2007)
-
-
-
108
-
-
55649116409
-
ACToR—aggregated computational toxicology resource
-
press (online
-
Judson R, Richard A, Dix D, et al. ACToR—aggregated computational toxicology resource. Toxicol Appl Pharmacol 2008; in press (online, doi: 10.1016/j.taap.2007.12.037).
-
(2008)
Toxicol Appl Pharmacol
-
-
Judson, R.1
Richard, A.2
Dix, D.3
-
109
-
-
41049116682
-
Linking regulatory toxicological information on environmental chemicals with high-throughput screening (HTS) and genomic data
-
Martin MT, Houck KA, McLaurin K, et al. Linking regulatory toxicological information on environmental chemicals with high-throughput screening (HTS) and genomic data. Toxicol CD–J Soc Toxicol 2007; 96:219–220.
-
(2007)
Toxicol CD–J Soc Toxicol
, vol.96
, pp. 219-220
-
-
Martin, M.T.1
Houck, K.A.2
McLaurin, K.3
-
111
-
-
0037259150
-
Evaluation of physiologically based models of pregnancy and lactation for their application in children’s health assessments
-
Corley RA, Mast TJ, Carney EW, et al. Evaluation of physiologically based models of pregnancy and lactation for their application in children’s health assessments. Crit Rev Toxicol 2003; 33:137–211.
-
(2003)
Crit Rev Toxicol
, vol.33
, pp. 137-211
-
-
Corley, R.A.1
Mast, T.J.2
Carney, E.W.3
-
112
-
-
11344264355
-
Framework for evaluation of physiologically based pharmacokinetic models for use in safety and risk assessment
-
Clark LH, Setzer RW, Barton HA. Framework for evaluation of physiologically based pharmacokinetic models for use in safety and risk assessment. Risk Analysis 2004; 24:1697–1717.
-
(2004)
Risk Analysis
, vol.24
, pp. 1697-1717
-
-
Clark, L.H.1
Setzer, R.W.2
Barton, H.A.3
-
113
-
-
0036398887
-
Review and evaluation of the potential impact of age-and gender-specific pharmacokinetic differences in tissue dosimetry
-
Clewell HJ, Tueguarden J, McDonald T, et al. Review and evaluation of the potential impact of age-and gender-specific pharmacokinetic differences in tissue dosimetry. Crit Rev Toxicol 2002; 32:329–390.
-
(2002)
Crit Rev Toxicol
, vol.32
, pp. 329-390
-
-
Clewell, H.J.1
Tueguarden, J.2
McDonald, T.3
-
114
-
-
39149105293
-
Predicting maternal and pup exposures: How different are they?
-
Yoon M, Barton HA. Predicting maternal and pup exposures: How different are they? Toxicol Sci 2008; 102:15–32.
-
(2008)
Toxicol Sci
, vol.102
, pp. 15-32
-
-
Yoon, M.1
Barton, H.A.2
-
115
-
-
0035796786
-
Mode of action and tissue dosimetry in current and future risk assessments
-
Andersen ME, Dennison JE. Mode of action and tissue dosimetry in current and future risk assessments. Sci Total Environ 2001; 274:3–14.
-
(2001)
Sci Total Environ
, vol.274
, pp. 3-14
-
-
Andersen, M.E.1
Dennison, J.E.2
-
116
-
-
0025141187
-
Two-event model for carcinogenesis: Biological, mathematical and statistical considerations
-
Moolgavkar SH, Luebeck G. Two-event model for carcinogenesis: Biological, mathematical and statistical considerations. Risk Anal 1990; 10:323– 341.
-
(1990)
Risk Anal
, vol.10
, pp. 323-341
-
-
Moolgavkar, S.H.1
Luebeck, G.2
-
117
-
-
0030221452
-
A biologically based dose-response model for developmental toxicology
-
Leroux B, Leisenring W, Moolgavkar S, et al. A biologically based dose-response model for developmental toxicology. Risk Anal 1996; 16:449–458.
-
(1996)
Risk Anal
, vol.16
, pp. 449-458
-
-
Leroux, B.1
Leisenring, W.2
Moolgavkar, S.3
-
118
-
-
0032821717
-
Biologically-based dose-response models for developmental toxicology: Lessons from methylmercury
-
Faustman EM, Lewandowski T, Ponce R, et al. Biologically-based dose-response models for developmental toxicology: Lessons from methylmercury. Inhal Toxicol 1999; 11:559–572.
-
(1999)
Inhal Toxicol
, vol.11
, pp. 559-572
-
-
Faustman, E.M.1
Lewandowski, T.2
Ponce, R.3
-
119
-
-
0034066744
-
Evaluation of biologically based dose-response modeling for developmental toxicity: A workshop report
-
Lau C, Andersen ME, Crawford-Brown D, et al. Evaluation of biologically based dose-response modeling for developmental toxicity: A workshop report. Regul Toxicol Pharmacol 2000; 31:190–199.
-
(2000)
Regul Toxicol Pharmacol
, vol.31
, pp. 190-199
-
-
Lau, C.1
Andersen, M.E.2
Crawford-Brown, D.3
-
120
-
-
0035154364
-
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil: A mathematical construct
-
Setzer RW, Lau C, Mole ML, et al. Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil: a mathematical construct. Toxicol Sci 2001; 59:49–58.
-
(2001)
Toxicol Sci
, vol.59
, pp. 49-58
-
-
Setzer, R.W.1
Lau, C.2
Mole, M.L.3
-
121
-
-
17744370732
-
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil: Acquisition of experimental data
-
Lau C, Mole ML, Copeland F, et al. Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil: Acquisition of experimental data. Toxicol Sci 2001; 59:37–48.
-
(2001)
Toxicol Sci
, vol.59
, pp. 37-48
-
-
Lau, C.1
Mole, M.L.2
Copeland, F.3
-
122
-
-
0029882011
-
The road to embryologically based dose-response models
-
Kavlock RJ, Setzer RW. The road to embryologically based dose-response models. Environ Health Perspect 1996; 104(Suppl 1):107–121.
-
(1996)
Environ Health Perspect
, vol.104
, pp. 107-121
-
-
Kavlock, R.J.1
Setzer, R.W.2
-
123
-
-
0000135489
-
Simulation of biological cell sorting using a two-dimensional extended Potts model
-
Graner F, Glazier JA. Simulation of biological cell sorting using a two-dimensional extended Potts model. Phys Rev Lett 1992; 69:2013–2016.
-
(1992)
Phys Rev Lett
, vol.69
, pp. 2013-2016
-
-
Graner, F.1
Glazier, J.A.2
-
124
-
-
1542344734
-
Modeling of self-organized avascular tumor growth with a hybrid cellular automaton
-
Dormann S, Deutsch A. Modeling of self-organized avascular tumor growth with a hybrid cellular automaton. In Silico Biol 2002; 2:0035.
-
(2002)
In Silico Biol
, vol.2
, pp. 35
-
-
Dormann, S.1
Deutsch, A.2
-
125
-
-
2442700260
-
CompuCell, a multi-model framework for simulation of morphogenesis
-
Izaguirre JA, Chaturvedi R, Huang C, et al. CompuCell, a multi-model framework for simulation of morphogenesis. Bioinformatics 2004; 20:1129–1137.
-
(2004)
Bioinformatics
, vol.20
, pp. 1129-1137
-
-
Izaguirre, J.A.1
Chaturvedi, R.2
Huang, C.3
-
128
-
-
38049172599
-
Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior
-
Robertson SH, Smith CK, Langhans AL, et al. Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior. BMC Syst Biol 2007; 1:46, doi:10.1186/1752–0509–1–46.
-
(2007)
BMC Syst Biol
, vol.1
, pp. 46
-
-
Robertson, S.H.1
Smith, C.K.2
Langhans, A.L.3
-
131
-
-
0034870266
-
Exposure-disease continuum for 2-chloro-2’-deoxyadenosine, a prototype ocular teratogen. I. Dose-response analysis
-
Wubah JA, Setzer RW, Lau C, et al. Exposure-disease continuum for 2-chloro-2’-deoxyadenosine, a prototype ocular teratogen. I. Dose-response analysis. Teratology 2001; 64:154–169.
-
(2001)
Teratology
, vol.64
, pp. 154-169
-
-
Wubah, J.A.1
Setzer, R.W.2
Lau, C.3
-
134
-
-
33947715468
-
-
CRC Press, Taylor & Francis Group, Boca Raton, FL
-
Konopka AK. Systems biology. Principles, methods, and concepts. CRC Press, Taylor & Francis Group, Boca Raton, FL, 2007:244.
-
(2007)
Systems Biology. Principles, Methods, and Concepts
, pp. 244
-
-
Konopka, A.K.1
-
135
-
-
0003781230
-
Preparation of ambiguous stimulus materials
-
Fisher GH. Preparation of ambiguous stimulus materials. Perc Psychophys 1967; 2:421–422.
-
(1967)
Perc Psychophys
, vol.2
, pp. 421-422
-
-
Fisher, G.H.1
|