Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

Cell

Volumn 168, Issue 6, 2017, Pages 1053-1064.e15

  Kim, Ah Ram ^a,b   Ulirsch, Jacob C ^a,b   Wilmes, Stephan ^c   Unal, Ekrem ^d   Moraga, Ignacio ^e   Karakukcu, Musa ^d   Yuan, Daniel ^a   Kazerounian, Shideh ^a   Abdulhay, Nour J ^a,b   King, David S ^f   Gupta, Namrata ^b   Gabriel, Stacey B ^b   Lander, Eric S ^b   Patiroglu, Turkan ^d   Ozcan, Alper ^d   Ozdemir, Mehmet Akif ^d   Garcia, K Christopher ^e   Piehler, Jacob ^c   Gazda, Hanna T ^a,b   Klein, Daryl E ^g   Sankaran, Vijay G ^a,b   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c UNIVERSITY OF OSNABRÜCK   (Germany)

^d ERCIYES UNIVERSITY   (Turkey)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cytokine; erythropoiesis; erythropoietin; functional selectivity; hematopoiesis; JAK2; receptor; signaling

Indexed keywords

CORTICOSTEROID; CYTOKINE; ERYTHROPOIETIN; JANUS KINASE 2; LIGAND; STAT5 PROTEIN; EPO PROTEIN, HUMAN; ERYTHROPOIETIN RECEPTOR; JAK2 PROTEIN, HUMAN;

ARTICLE; BINDING KINETICS; BLACKFAN DIAMOND ANEMIA; BONE MARROW TRANSPLANTATION; CAPILLARY LEAK SYNDROME; CASE REPORT; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD; DIMERIZATION; DYNAMICS; ENZYME PHOSPHORYLATION; ERYTHROCYTE TRANSFUSION; ERYTHROID CELL; GASTROINTESTINAL GRAFT VERSUS DISEASE; GRAFT VERSUS HOST REACTION; HOMOZYGOSITY; HUMAN; HUMAN CELL; MALE; MUTANT; MUTATION; OSTEOPENIA; PRIORITY JOURNAL; WILD TYPE; ANEMIA, DIAMOND-BLACKFAN; CHEMISTRY; CONSANGUINITY; ENZYME ACTIVATION; ERYTHROPOIESIS; FEMALE; GENETICS; KINETICS; METABOLISM; MISSENSE MUTATION; PATHOLOGY; SIGNAL TRANSDUCTION;

ANEMIA, DIAMOND-BLACKFAN; CHILD; CONSANGUINITY; ENZYME ACTIVATION; ERYTHROPOIESIS; ERYTHROPOIETIN; FEMALE; HUMANS; JANUS KINASE 2; KINETICS; MALE; MUTATION, MISSENSE; RECEPTORS, ERYTHROPOIETIN; SIGNAL TRANSDUCTION;

EID: 85014852966     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.02.026     Document Type: Article

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