Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus

Neurology

Volumn 88, Issue 10, 2017, Pages 938-943

  Cervenka, MacKenzie C ^a   Hocker, Sara ^b   Koenig, Matthew ^c   Bar, Barak ^d   Henry Barron, Bobbie ^a,e   Kossoff, Eric H ^a   Hartman, Adam L ^a   Probasco, John C ^a   Benavides, David R ^a   Venkatesan, Arun ^a   Hagen, Eliza C ^c   Dittrich, Denise ^c   Stern, Tracy ^c   Radzik, Batya ^a   Depew, Marie ^a   Caserta, Filissa M ^a   Nyquist, Paul ^a   Kaplan, Peter W ^f   Geocadin, Romergryko G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

^c QUEEN S MEDICAL CENTER   (United States)

^d LOYOLA UNIVERSITY HEALTH SYSTEM   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CORTICOSTEROID; MIDAZOLAM; PROPOFOL;

ADULT; AGED; ARTICLE; BODY WEIGHT DISORDER; CLINICAL ARTICLE; CONSTIPATION; EPILEPTIC STATE; FEASIBILITY STUDY; FEMALE; HUMAN; HYPERLIPIDEMIA; HYPOGLYCEMIA; HYPONATREMIA; ILEUS; KETOACIDOSIS; KETOGENESIS; KETOGENIC DIET; MALE; METABOLIC ACIDOSIS; MULTICENTER STUDY; OPEN STUDY; OUTCOME ASSESSMENT; PATIENT PARTICIPATION; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; STOMACH TUBE; SUPERREFRACTORY STATUS EPILEPTICUS; THERAPY DELAY; THERAPY EFFECT; WEIGHT REDUCTION; ADOLESCENT; CLINICAL TRIAL; DIET THERAPY; MIDDLE AGED; PROCEDURES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; KETOGENIC DIET; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STATUS EPILEPTICUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85014815065     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000003690     Document Type: Article

References (13)

1. Hocker SE, Britton JW, Mandrekar JN, Wijdicks EF, Rabinstein AA. Predictors of outcome in refractory status epilepticus. JAMA Neurol 2013;70:72-77.
2. Ferlisi M, Shorvon S. The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. Brain 2012;135:2314-2328.
3. Hocker S, Tatum WO, LaRoche S, Freeman WD. Refractory and super-refractory status epilepticus: an update. Curr Neurol Neurosci Rep 2014;14:452.
4. Young GB, Jordan KG, Doig GS. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology 1996;47:83-89.
5. Sutter R, Marsch S, Fuhr P, Kaplan PW, Ruegg S. Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study. Neurology 2014;82:656-664.
6. McNally MA, Hartman AL. Ketone bodies in epilepsy. J Neurochem 2012;121:28-35.
7. Thakur KT, Probasco JC, Hocker SE, et al. Ketogenic diet for adults in super-refractory status epilepticus. Neurology 2014;82:665-670.
8. Nabbout R, Mazzuca M, Hubert P, et al. Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia 2010;51:2033-2037.
9. Wusthoff CJ, Kranick SM, Morley JF, Christina Bergqvist AG. The ketogenic diet in treatment of two adults with prolonged nonconvulsive status epilepticus. Epilepsia 2010; 51:1083-1085.
10. Amer S, Shah P, Kommineni V. Refractory status epilepticus from NMDA receptor encephalitis successfully treated with an adjunctive ketogenic diet. Ann Indian Acad Neurol 2015;18:256-257.
11. Dupuis N, Curatolo N, Benoist JF, Auvin S. Ketogenic diet exhibits anti-inflammatory properties. Epilepsia 2015; 56:e95-e98.
12. Kanes S, Rosenthal E, Vaitkevicius H, et al. 547-SSE-201 for super-refractory status epilepticus: response and relationship to underlying patient characteristics (S14.003). Neurology 2016;86(suppl S14.003).
13. Baumeister FA, Oberhoffer R, Liebhaber GM, et al. Fatal propofol infusion syndrome in association with ketogenic diet. Neuropediatrics 2004;35:250-252.