Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice

Aging Cell

Volumn 14, Issue 4, 2015, Pages 704-706

  Mendias, Christopher L ^a   Bakhurin, Konstantin I ^a   Gumucio, Jonathan P ^a   Shallal Ayzin, Mark V ^a   Davis, Carol S ^a   Faulkner, John A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

GDF 8; longevity; muscle atrophy; muscle con tractility; myostatin; sarcopenia; skeletal muscle

Indexed keywords

MSTN PROTEIN, HUMAN; MYOSTATIN;

AGING; ANIMAL; DEFICIENCY; FEMALE; GENE EXPRESSION; GENETICS; HAPLOINSUFFICIENCY; HETEROZYGOTE; HOMOZYGOTE; KNOCKOUT MOUSE; LIFE EXPECTANCY; LONGEVITY; MALE; METABOLISM; MOUSE; MUSCLE ATROPHY; MUSCLE CONTRACTION; PATHOLOGY; SKELETAL MUSCLE;

AGING; ANIMALS; FEMALE; GENE EXPRESSION; HAPLOINSUFFICIENCY; HETEROZYGOTE; HOMOZYGOTE; LIFE EXPECTANCY; LONGEVITY; MALE; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MYOSTATIN;

EID: 85014732450     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/ACEL.12339     Document Type: Article

References (12)

1. Bish LT, George I, Maybaum S, Yang J, Chen JM, Sweeney HL (2011) Myostatin is elevated in congenital heart disease and after mechanical unloading. PLoS One 6, e23818.
2. Blagosklonny MV (2013) Big mice die young but large animals live longer. Aging (Albany NY) 5, 227–233.
3. Brooks SV, Faulkner JA (1988) Contractile properties of skeletal muscles from young, adult and aged mice. J. Physiol. (Lond) 404, 71–82.
4. Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan van Kan G, Andrieu S, Bauer J, Breuille D, Cederholm T, Chandler J, De Meynard C, Donini L, Harris T, Kannt A, Keime Guibert F, Onder G, Papanicolaou D, Rolland Y, Rooks D, Sieber C, Souhami E, Verlaan S, Zamboni M (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J. Am. Med. Dir. Assoc. 12, 249–256.
5. Graber TG, Ferguson-Stegall L, Kim J-H, Thompson LV (2013) C57BL/6 neuro-muscular healthspan scoring system. J. Gerontol. A Biol. Sci. Med. Sci. 68, 1326– 1336.
6. Gumucio JP, Mendias CL (2013) Atrogin-1, MuRF-1, and sarcopenia. Endocrine 43, 12–21.
7. Lakatta EG, Levy D (2003) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease. Circulation 107, 346–354.
8. Lynch GS, Hinkle RT, Chamberlain JS, Brooks SV, Faulkner JA (2001) Force and power output of fast and slow skeletal muscles from mdx mice 6–28 months old. J. Physiol. (Lond) 535, 591–600.
9. Mendias CL, Marcin JE, Calerdon DR, Faulkner JA (2006) Contractile properties of EDL and soleus muscles of myostatin-deficient mice. J. Appl. Physiol. 101, 898– 905.
10. Mendias CL, Bakhurin KI, Faulkner JA (2008) Tendons of myostatin-deficient mice are small, brittle, and hypocellular. Proc. Natl Acad. Sci. USA 105, 388– 393.
11. Miller MD, Crotty M, Giles LC, Bannerman E, Whitehead C, Cobiac L, Daniels LA, Andrews G (2002) Corrected arm muscle area: an independent predictor of long-term mortality in community-dwelling older adults? J. Am. Geriatr. Soc. 50, 1272–1277.
12. Ramaswamy KS, Palmer ML, Van der Meulen JH, Renoux A, Kostrominova TY, Michele DE, Faulkner JA (2011) Lateral transmission of force is impaired in skeletal muscles of dystrophic mice and very old rats. J. Physiol. (Lond) 589, 1195–1208.