Effect of fibrinogen concentrate on intraoperative blood loss among patients with intraoperative bleeding during high-risk cardiac surgery: A randomized clinical trial

JAMA - Journal of the American Medical Association

Volumn 317, Issue 7, 2017, Pages 738-747

  Bilecen, Süleyman ^a,b   De Groot, Joris A H ^a   Kalkman, Cor J ^a   Spanjersberg, Alexander J ^b   Brandon Bravo Bruinsma, George J ^b   Moons, Karel G M ^a   Nierich, Arno P ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Department of Cardiothoracic Anesthesia and Intensive Care ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; FIBRINOGEN CONCENTRATE; PLACEBO; COAGULATING AGENT;

AGED; ALLERGIC REACTION; AORTIC ROOT SURGERY; ARTICLE; BLOOD VOLUME; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG TOLERABILITY; FEMALE; FIBRINOGEN BLOOD LEVEL; HEART INFARCTION; HEART SURGERY; HIGH RISK PATIENT; HOSPITAL MORTALITY; HUMAN; INFECTION; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; OPERATIVE BLOOD LOSS; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REOPERATION; SINGLE DRUG DOSE; THORACIC CAVITY; THORACOTOMY; THROMBOEMBOLISM; TRANSIENT ISCHEMIC ATTACK; VALVULOPLASTY; ADVERSE EFFECTS; AORTA; BLOOD; BLOOD LOSS, SURGICAL; CARDIOPULMONARY BYPASS; ELECTIVE SURGERY; HEART VALVE REPLACEMENT; INTRAOPERATIVE COMPLICATIONS; ISCHEMIC ATTACK, TRANSIENT; MYOCARDIAL INFARCTION; OPERATION DURATION; PROCEDURES; RENAL INSUFFICIENCY; RISK; SAMPLE SIZE; STATISTICS AND NUMERICAL DATA; STROKE; SURGERY;

AGED; AORTA; BLOOD LOSS, SURGICAL; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; COAGULANTS; DOUBLE-BLIND METHOD; ELECTIVE SURGICAL PROCEDURES; FEMALE; FIBRINOGEN; HEART VALVE PROSTHESIS IMPLANTATION; HUMANS; INTRAOPERATIVE COMPLICATIONS; ISCHEMIC ATTACK, TRANSIENT; MALE; MYOCARDIAL INFARCTION; NETHERLANDS; OPERATIVE TIME; PROSPECTIVE STUDIES; RENAL INSUFFICIENCY; RISK; SAMPLE SIZE; STROKE;

EID: 85014691052     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2016.21037     Document Type: Article

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