True story about HIV: Theory of viral sequestration and reserve infection

HIV/AIDS - Research and Palliative Care

Volumn 3, Issue , 2011, Pages 125-133

  Barasa, Simon Situma ^a  

^a Kenya Polytechnic University College   (Kenya)

Author keywords

Acquired immunodeficiency syndrome; AIDS; HIV; Human immunodeficiency virus; Viral sequestration

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BONE MARROW; BONE MARROW TRANSPLANTATION; DISEASE CLASSIFICATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; LATENT VIRUS INFECTION; NONHUMAN; PRIMARY INFECTION; SECONDARY INFECTION; STAGING; STEM CELL TRANSPLANTATION; VACCINATION; VIRAL CLEARANCE; VIRAL PHENOMENA AND FUNCTIONS; VIRAL SEQUESTRATION; VIROLOGY; VIRUS INFECTIVITY; VIRUS LATENCY;

EID: 85014469360     PISSN: None     EISSN: 11791373     Source Type: Journal    
DOI: 10.2147/HIV.S26578     Document Type: Article

References (40)

1. Weiss RA. How does HIV cause AIDS? Science. 1993;260: 1273-1279.
2. Douek DC, Roederer M, Koup RA. Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med. 2009;60: 471-484.
3. Joint United Nations Programme on HIV/AIDS. Overview of the global AIDS epidemic. UN report on the global AIDS epidemic 2006. Available from: http://data.unaids.org/pub/GlobalReport/2006/2006_ GR_CH02_en.pdf. Accessed November 13, 2011.
4. Joint United Nations Programme on HIV/AIDS. Overview of the global AIDS epidemic. UN report on the global AIDS epidemic 2010. Available from: http://www.unaids.org/globalreport/Global_report.htm. Accessed November 13, 2011.
5. Greener R. AIDS and macroeconomic impact. In: Forsyth S, editor. State of The Art: AIDS and Economics. Available from: http://www. iaen.org/library/statepidemic/chapter7.pdf. Accessed November 13, 2011.
6. Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338: 853-860.
7. Cunningham AL, Donaghy H, Harman AN, Kim M, Turville SG. Manipulation of dendritic cell function by viruses. Curr Opin Microbiol. 2010;13: 524-529.
8. Migueles SA, Connors M. Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV. JAMA. 2010;304: 194-201.
9. Lawn SD. AIDS in Africa: the impact of coinfections on the pathogenesis of HIV-1 infection. J Infect. 2004;48: 1-12.
10. Buchbinder SP, Katz MH, Hessol NA, O’Malley PM, Holmberg SD. Long-term HIV-1 infection without immunologic progression. AIDS. 1994;8: 1123-1128.
11. [No authors listed]. Time from HIV-1 seroconversion to AIDS and death before widespread use of highly active antiretroviral therapy: a collaborative re-analysis. Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action. Concerted Action on SeroConversion to AIDS and Death in Europe. Lancet. 2000;355: 1131-1137.
12. Morgan D, Mahe C, Mayanja B, Okongo JM, Lubega R, Whitworth JA. HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries. AIDS. 2002;16: 597-632.
13. Schneider MF, Gange SJ, Williams CM, et al. Patterns of the hazard of death after AIDS through the evolution of antiretroviral therapy: 1984-2004. AIDS. 2005;19: 2009-2018.
14. International Committee on Taxonomy of Viruses 61.0.6. Lentivirus. National Institutes of Health. 2002. Available from: http://www. ncbi.nlm.nih.gov/ICTVdb/ICTVdB/61060000.htm. Accessed November 13, 2011.
15. International Committee on Taxonomy of Viruses.61. Retroviridae. National Institutes of Health. 2002. Available from: http://www. ncbi.nlm.nih.gov/ICTVdb/ICTVdB/61000000.htm. Accessed November 13, 2011.
16. Smith JA, Daniel R. Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses. ACS Chem Biol. 2006;1: 217-226.
17. Reeves JD, Doms RW. Human immunodeficiency virus type 2. J Gen Virol. 2002;83(Pt 6): 1253-1265.
18. Gilbert PB, McKeague IW, Eisen G, et al. Comparison of HIV-1 and HIV-2 infectivity from a prospective cohort study in Senegal. Stat Med. 2003;22: 573-593.
19. Kahn JO, Walker BD. Acute human immunodef iciency virus type 1 infection. N Engl J Med. 1998;331: 33-39.
20. Piatak M Jr, Saag MS, Yang LC, et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science. 1993;259: 1749-1754.
21. Pantaleo G, Demarest JF, Schacker T, et al. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci U S A. 1997;94: 254-258.
22. Burton GF, Keele BF, Estes JD, Thacker TC, Gartner S. Follicular dendritic cell contributions to HIV pathogenesis. Semin Immunol. 2002;14: 275-284.
23. Clapham PR, McKnight A. HIV-1 receptors and cell tropism. Br Med Bull. 2001;58: 43-59.
24. Kitahata MM, Gange SJ, Abraham AG, et al. Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med. 2009;360: 1815-1826.
25. Morgan D, Mahe C, Mayanja B, Okongo JM, Lubega R, Whitworth JA. HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries? AIDS. 2002;16: 597-632.
26. Grabar S, Selinger-Leneman H, Abgrall S, Pialoux G, Weiss L, Costagliola D. Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV. AIDS. 2009;23: 1163-1169.
27. Blankson JN. Control of HIV-1 replication in elite suppressors. Discov Med. 2010;9: 261-266.
28. Chan DC, Fass D, Berger JM, Kim PS. Core structure of gp41 from the HIV envelope glycoprotein (PDF). Cell. 1997;89: 263-273.
29. Levy Y, Lacabaratz C, Weiss L, et al. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest. 2009; 119: 997-1007.
30. Tincati C, d’Arminio Monforte A, Marchetti G. Immunological mechanisms of interleukin-2 (IL-2) treatment in HIV/AIDS disease. Curr Mol Pharmacol. 2009;2: 40-45.
31. Schneider MF, Gange SJ, Williams CM, et al. Patterns of the hazard of death after AIDS through the evolution of antiretroviral therapy: 1984-2004. AIDS. 2005;19: 2009-2018.
32. HIV vaccine "reduces infection". BBC News. September 24, 2009. Available at: http://news.bbc.co.uk/2/hi/health/8272113.stm. Accessed March 30, 2010.
33. [No authors listed]. A (prime) boost for HIV vaccine research? Lancet. 2009;374: 1119.
34. National Institute of Allergy and Infectious Diseases. Treating HIVinfected people with antiretrovirals protects partners from infection. National Institutes of Health News, May 2011. Available from: http:// www.niaid.nih.gov/news/newsreleases/2011/Pages/HPTN052.aspx. Accessed November 12, 2011.
35. Mark Schoofs. A Doctor, a Mutation and a Potential Cure for AIDS. The Wall Street Journal. November 7, 2008. Available from: http:// online.wsj.com/article/SB122602394113507555.html. Accessed November 13, 2011.
36. Hütter G, Nowak D, Mossner M, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360: 692-698. Available from: http://content.nejm.org/cgi/content/ abstract/360/7/692. Accessed November 13, 2011.
37. Allers K, Hutter G, Hofmann J, et al. Evidence for the cure of HIV infection by CCR5 32/32 stem cell transplantation. Blood. 2010; 117: 2791-2799.
38. Coovadia H. Antiretroviral agents - how best to protect infants from HIV and save their mothers from AIDS. N Engl J Med. 2004;351: 289-292.
39. Horvath T, Madi BC, Iuppa IM, et al. Interventions for prevention of late postnatal mother-to-child transmission of HIV. Available from: http://www.cochrane.org/reviews/en/ab006734.html. Accessed November 13, 2011.
40. The Joint United Nations Programme on HIV and AIDS. 2009 AIDS Epidemic Update. http://data.unaids.org/pub/Report/2009/JC1700_Epi_ Update_2009_en.pdf. Accessed November 13, 2011.