Knowledge of Patients' Human Papillomavirus Status at the Time of Cytologic Review Significantly Affects the Performance of Cervical Cytology in the ATHENA Study

American Journal of Clinical Pathology

Volumn 146, Issue 3, 2016, Pages 391-398

  Wright, Thomas C ^a   Stoler, Mark H ^b   Aslam, Shagufta ^c   Behrens, Catherine M ^c  

^a Department of Medicine   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c ROCHE MOLECULAR SYSTEMS   (United States)

Author keywords

Cervical cancer; Cervical cytology; HPV; Screening

Indexed keywords

ADULT; ALGORITHM; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HEALTH STATUS; HIGH RISK PATIENT; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN TISSUE; KNOWLEDGE; MAJOR CLINICAL STUDY; PAPILLOMAVIRUS INFECTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX BIOPSY; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY; CERVICAL INTRAEPITHELIAL NEOPLASIA; COLPOSCOPY; CYTODIAGNOSIS; EARLY CANCER DIAGNOSIS; ISOLATION AND PURIFICATION; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PATHOLOGY; UTERINE CERVICAL NEOPLASMS; VAGINA SMEAR; VIROLOGY; YOUNG ADULT;

ADULT; CERVICAL INTRAEPITHELIAL NEOPLASIA; COLPOSCOPY; CYTODIAGNOSIS; EARLY DETECTION OF CANCER; FEMALE; HUMANS; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; SENSITIVITY AND SPECIFICITY; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS; YOUNG ADULT;

EID: 85014431961     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1093/ajcp/aqw125     Document Type: Conference Paper

References (25)

1. Wright TC Jr, Stoler MH, Behrens CM, et al. The ATHENA human papillomavirus study: design, methods, and baseline results. Am J Obstet Gynecol. 2012;206:46.e1-e11.
2. Ronco G, Segnan N, Giorgi-Rossi P, et al. Human papillomavirus testing and liquid-based cytology: results at recruitment from the new technologies for cervical cancer randomized controlled trial. J Natl Cancer Inst. 2006;98:765-774.
3. Petry KU, Menton S, Menton M, et al. Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients. Br J Cancer. 2003;88:1570-1577.
4. Naucler P, Ryd W, Tornberg S, et al. Human papillomavirus and Papanicolaou tests to screen for cervical cancer. N Engl J Med. 2007;357:1589-1597.
5. Reid JL, Wright TC Jr, Stoler MH, et al. Human papillomavirus oncogenic mRNA testing for cervical cancer screening: baseline and longitudinal results from the CLEAR study. Am J Clin Pathol. 2015;144:473-483.
6. Rijkaart DC, Berkhof J, van Kemenade FJ, et al. HPV DNA testing in population-based cervical screening (VUSAScreen study): results and implications. Br J Cancer. 2012;106:975-981.
7. Bergeron C, Giorgi-Rossi P, Cas F, et al. Informed cytology for triaging HPV-positive women substudy nested in the NTCC randomized controlled trial. J Natl Cancer Inst. 2015;107.
8. Kotaniemi-Talonen L, Nieminen P, Anttila A, et al. Routine cervical screening with primary HPV testing and cytology triage protocol in a randomised setting. Br J Cancer. 2005;93:862-867.
9. Benoy IH, Vanden Broeck D, Ruymbeke MJ, et al. Prior knowledge of HPV status improves detection of CIN2 by cytology screening. Am J Obstet Gynecol. 2011;205:569.e1-567.
10. Wright TC, Stoler MH, Behrens CM, et al. Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test. Gynecol Oncol. 2015;136:189-197.
11. Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA. 2002;287:2114-2119.
12. Wright TC, Ronnet B Kurman RJ, et al. Precancerous lesions of the cervix. In: Kurman RJ, Ellenson LH, Ronnet B, eds. Blaustein's Pathology of the Female Genital Tract. 6th ed. New York, NY: Springer-Verlag; 2011:194-252.
13. Wright TC Jr, Stoler MH, Behrens CM, et al. Interlaboratory variation in the performance of liquid-based cytology: insights from the ATHENA trial. Int J Cancer. 2014;134:1835-1843.
14. Stoler MH, Schiffman M. Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS-LSIL Triage Study. JAMA. 2001;285:1500-1505.
15. Schiffman M, Wentzensen N, Wacholder S, et al. Human papillomavirus testing in the prevention of cervical cancer. J Natl Cancer Inst. 2011;103:368-383.
16. Bergeron C, Ordi J, Schmidt D, et al. Conjunctive p16INK4a testing significantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasia. Am J Clin Pathol. 2010;133:395-406.
17. Ikenberg H, Bergeron C, Schmidt D, et al. Screening for cervical cancer precursors with p16/Ki-67 dual-stained cytology: results of the PALMS study. J Natl Cancer Inst. 2013;105:1550-1557.
18. Stoler MH. Toward objective cervical cancer screening: maybe the eyes do have it. Am J Clin Pathol. 2010;134:5-6.
19. Richardson LR, El-Zein M, Agnihotram V, et al. HPV DNA testing with cytology triage in cervical cancer screening: influence of revealing HPV infection status. Cancer. 2015;123:745-754.
20. Moriarty AT, Nayar R, Arnold T, et al. The Tahoe study bias in the interpretation of Papanicolaou test results when human papillomavirus status is known. Arch Pathol Lab Med. 2014;138:1182-1185.
21. Saslow D, Solomon D, Lawson HW, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Am J Clin Pathol. 2012;137:516-542.
22. Moyer VA; US Preventive Services Task Force. Screening for cervical cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2012;156:880-891.
23. Blatt AJ, Kennedy R, Luff RD, et al. Comparison of cervical cancer screening results among 256,648 women in multiple clinical practices. Cancer Cytopathol. 2015;123:282-288.
24. Sawaya GF, Kulasingam S, Denberg TD, et al. Cervical cancer screening in average-risk women: best practice advice from the clinical guidelines committee of the American College of Physicians. Ann Intern Med. 2015;162:851-859.
25. Castle PE. Comparison of cervical cancer screening results among 256,648 women in multiple clinical practices. Cancer Cytopathol. 2015;123:566.