Recombinant Human ACE2 and the Angiotensin 1-7 Axis as Potential New Therapies for Heart Failure

Canadian Journal of Cardiology

Volumn 33, Issue 7, 2017, Pages 943-946

  Patel, Vaibhav B ^a   Lezutekong, Judith N ^a   Chen, Xueyi ^a   Oudit, Gavin Y ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSIN[1-7]; RENIN; ACE PROTEIN, HUMAN; ANGIOTENSIN I; ANGIOTENSIN I (1-7); DIPEPTIDYL CARBOXYPEPTIDASE; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; VASODILATOR AGENT;

ARTICLE; ENZYME INHIBITION; HEART FAILURE; HUMAN; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); RANDOMIZED CONTROLLED TRIAL (TOPIC); RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; METABOLISM;

ANGIOTENSIN I; HEART FAILURE; HUMANS; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; RECOMBINANT PROTEINS; RENIN-ANGIOTENSIN SYSTEM; VASODILATOR AGENTS;

EID: 85014400615     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2016.12.012     Document Type: Article

References (5)

1. Patel, V.B., Zhong, J.C., Grant, M.B., Oudit, G.Y., Role of the ACE2/angiotensin 1-7 axis of the renin-angiotensin system in heart failure. Circ Res 118 (2016), 1313–1326.
2. Patel, V.B., Mori, J., McLean, B.A., et al. ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity. Diabetes 65 (2016), 85–95.
3. Basu, R., Poglitsch, M., Yogasundaram, H., et al. Roles of angiotensin peptides and recombinant human ACE2 in heart failure. J Am Coll Cardiol 69 (2017), 805–819.
4. Mori, J., Patel, V.B., Abo Alrob, O., et al. Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation. Circ Heart Fail 7 (2014), 327–339.
5. Zhong, J., Basu, R., Guo, D., et al. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation 122 (2010), 717–728.