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Volumn 5, Issue 3, 2017, Pages 502-510
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A rapid albumin-binding 5-fluorouracil prodrug with a prolonged circulation time and enhanced antitumor activity
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Author keywords
[No Author keywords available]
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Indexed keywords
AMINO ACIDS;
BINS;
BLOOD;
BODY FLUIDS;
CARDIOVASCULAR SYSTEM;
DRUG PRODUCTS;
MAMMALS;
MEDICAL NANOTECHNOLOGY;
TUMORS;
5-FLUOROURACIL (5-FU);
ANTI-TUMOR ACTIVITIES;
BOVINE SERUM ALBUMINS;
CLINICAL APPLICATION;
INTRAVENOUS ADMINISTRATION;
INTRAVENOUS INJECTIONS;
SPECIFIC DISTRIBUTION;
UNSTABLE COMPOUNDS;
RESIDENCE TIME DISTRIBUTION;
1 ALKYLCARBONYLOXYMETHYL 5 FLUOROURACIL;
5 CHLOROURACIL DERIVATIVE;
ANTINEOPLASTIC ANTIMETABOLITE;
BOVINE SERUM ALBUMIN;
CYSTEINE;
EMC 5FU;
FLUOROURACIL;
FLUOROURACIL DERIVATIVE;
MALEIMIDE;
PRODRUG;
UNCLASSIFIED DRUG;
ANTINEOPLASTIC AGENT;
PROTEIN BINDING;
ACIDITY;
ALKALINITY;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANIMAL TISSUE;
ANTINEOPLASTIC ACTIVITY;
AREA UNDER THE CURVE;
AREA UNDER THE MOMENT CURVE;
ARTICLE;
CANCER INHIBITION;
CIRCULATION TIME;
CONTROLLED STUDY;
DRUG ACCUMULATION;
DRUG BLOOD LEVEL;
DRUG CLEARANCE;
DRUG CONJUGATION;
DRUG DELIVERY SYSTEM;
DRUG DETERMINATION;
DRUG DISTRIBUTION;
DRUG EFFICACY;
DRUG HYDROLYSIS;
DRUG PROTEIN BINDING;
DRUG RELEASE;
DRUG STABILITY;
ELIMINATION HALF-LIFE;
ELIMINATION RATE CONSTANT;
FEMALE;
FLUORESCENCE IMAGING;
HEPATOCELLULAR CARCINOMA CELL LINE;
IN VITRO STUDY;
IN VIVO STUDY;
LIVER CELL CARCINOMA;
MALE;
MEAN RESIDENCE TIME;
NANOMEDICINE;
NONHUMAN;
PLASMA CONCENTRATION-TIME CURVE;
PRIORITY JOURNAL;
RAT;
VOLUME OF DISTRIBUTION;
ANALOGS AND DERIVATIVES;
ANIMAL;
BLOOD;
BOVINE;
CHEMISTRY;
HALF LIFE TIME;
METABOLISM;
MOLECULAR MODEL;
MOUSE;
NEOPLASM;
PATHOLOGY;
SPRAGUE DAWLEY RAT;
ANIMALS;
ANTINEOPLASTIC AGENTS;
CATTLE;
FEMALE;
FLUOROURACIL;
HALF-LIFE;
MICE;
MODELS, MOLECULAR;
NEOPLASMS;
PRODRUGS;
PROTEIN BINDING;
RATS;
RATS, SPRAGUE-DAWLEY;
SERUM ALBUMIN, BOVINE;
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EID: 85014276317
PISSN: 20474830
EISSN: 20474849
Source Type: Journal
DOI: 10.1039/c6bm00884d Document Type: Article |
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Times cited : (46)
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References (32)
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