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Volumn 56, Issue 10, 2017, Pages 1115-1124

Clinical Pharmacokinetics of Dasabuvir

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DASABUVIR; ABT-333; SULFONAMIDE; URACIL;

EID: 85014199121     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-017-0519-3     Document Type: Review
Times cited : (18)

References (33)
  • 1
    • 84923224881 scopus 로고    scopus 로고
    • In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor
    • PID: 25534735
    • Kati W, Koev G, Irvin M, Beyer J, Liu Y, Krishnan P, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015;59(3):1505–11.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.3 , pp. 1505-1511
    • Kati, W.1    Koev, G.2    Irvin, M.3    Beyer, J.4    Liu, Y.5    Krishnan, P.6
  • 4
    • 84899068302 scopus 로고    scopus 로고
    • Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin
    • COI: 1:CAS:528:DC%2BC2cXnt1Grsrg%3D, PID: 24720703
    • Feld JJ, Kowdley KV, Coakley E, Sigal S, Nelson DR, Crawford D, et al. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370(17):1594–603.
    • (2014) N Engl J Med , vol.370 , Issue.17 , pp. 1594-1603
    • Feld, J.J.1    Kowdley, K.V.2    Coakley, E.3    Sigal, S.4    Nelson, D.R.5    Crawford, D.6
  • 5
    • 84901044326 scopus 로고    scopus 로고
    • ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV
    • PID: 24795200
    • Ferenci P, Bernstein D, Lalezari J, Cohen D, Luo Y, Cooper C, et al. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med. 2014;370(21):1983–92.
    • (2014) N Engl J Med , vol.370 , Issue.21 , pp. 1983-1992
    • Ferenci, P.1    Bernstein, D.2    Lalezari, J.3    Cohen, D.4    Luo, Y.5    Cooper, C.6
  • 6
    • 84899106124 scopus 로고    scopus 로고
    • Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin
    • COI: 1:CAS:528:DC%2BC2cXnt1Grsrk%3D, PID: 24720679
    • Zeuzem S, Jacobson IM, Baykal T, Marinho RT, Poordad F, Bourliere M, et al. Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370(17):1604–14.
    • (2014) N Engl J Med , vol.370 , Issue.17 , pp. 1604-1614
    • Zeuzem, S.1    Jacobson, I.M.2    Baykal, T.3    Marinho, R.T.4    Poordad, F.5    Bourliere, M.6
  • 7
    • 84931569160 scopus 로고    scopus 로고
    • Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial
    • COI: 1:CAS:528:DC%2BC2MXls1Grt7k%3D, PID: 25837829
    • Hezode C, Asselah T, Reddy KR, Hassanein T, Berenguer M, Fleischer-Stepniewska K, et al. Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial. Lancet. 2015;385(9986):2502–9.
    • (2015) Lancet , vol.385 , Issue.9986 , pp. 2502-2509
    • Hezode, C.1    Asselah, T.2    Reddy, K.R.3    Hassanein, T.4    Berenguer, M.5    Fleischer-Stepniewska, K.6
  • 8
    • 84904647749 scopus 로고    scopus 로고
    • ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection
    • Andreone P, Colombo MG, Enejosa JV, Koksal I, Ferenci P, Maieron A, et al. ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection. Gastroenterology. 2014;147(2):359 e1–365 e1.
    • (2014) Gastroenterology. , vol.147 , Issue.2 , pp. 359 e1-365 e1
    • Andreone, P.1    Colombo, M.G.2    Enejosa, J.V.3    Koksal, I.4    Ferenci, P.5    Maieron, A.6
  • 9
    • 84954286001 scopus 로고    scopus 로고
    • Sustained virologic response of 100% in HCV genotype 1b patients with cirrhosis receiving ombitasvir/paritaprevir/r and dasabuvir for 12 weeks
    • COI: 1:CAS:528:DC%2BC2MXhvVaqsbbN, PID: 26476290
    • Feld JJ, Moreno C, Trinh R, Tam E, Bourgeois S, Horsmans Y, et al. Sustained virologic response of 100% in HCV genotype 1b patients with cirrhosis receiving ombitasvir/paritaprevir/r and dasabuvir for 12 weeks. J Hepatol. 2016;64(2):301–7.
    • (2016) J Hepatol , vol.64 , Issue.2 , pp. 301-307
    • Feld, J.J.1    Moreno, C.2    Trinh, R.3    Tam, E.4    Bourgeois, S.5    Horsmans, Y.6
  • 13
    • 84941933839 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of co-administered paritaprevir plus ritonavir, ombitasvir, and dasabuvir in hepatic impairment
    • COI: 1:CAS:528:DC%2BC2MXht1amsb7O, PID: 26070406
    • Khatri A, Menon RM, Marbury TC, Lawitz EJ, Podsadecki TJ, Mullally VM, et al. Pharmacokinetics and safety of co-administered paritaprevir plus ritonavir, ombitasvir, and dasabuvir in hepatic impairment. J Hepatol. 2015;63(4):805–12.
    • (2015) J Hepatol , vol.63 , Issue.4 , pp. 805-812
    • Khatri, A.1    Menon, R.M.2    Marbury, T.C.3    Lawitz, E.J.4    Podsadecki, T.J.5    Mullally, V.M.6
  • 14
    • 84978175737 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of anti-hepatitis C virus treatment with ombitasvir, paritaprevir, ritonavir, with or without dasabuvir, in subjects with renal impairment
    • COI: 1:CAS:528:DC%2BC2sXht12ltbw%3D, PID: 27389403
    • Khatri A, Dutta S, Marbury T, Preston RA, Rodrigues L Jr, Wang H, et al. Pharmacokinetics and tolerability of anti-hepatitis C virus treatment with ombitasvir, paritaprevir, ritonavir, with or without dasabuvir, in subjects with renal impairment. Clin Pharmacokinet. 2017;56(2):153–63.
    • (2017) Clin Pharmacokinet , vol.56 , Issue.2 , pp. 153-163
    • Khatri, A.1    Dutta, S.2    Marbury, T.3    Preston, R.A.4    Rodrigues, L.5    Wang, H.6
  • 16
    • 84978069596 scopus 로고    scopus 로고
    • Metabolism and disposition of hepatitis C polymerase inhibitor dasabuvir in humans
    • COI: 1:CAS:528:DC%2BC28Xhsl2gurjF, PID: 27179126
    • Shen J, Serby M, Reed A, Lee AJ, Menon R, Zhang X, et al. Metabolism and disposition of hepatitis C polymerase inhibitor dasabuvir in humans. Drug Metab Dispos. 2016;44(8):1139–47.
    • (2016) Drug Metab Dispos , vol.44 , Issue.8 , pp. 1139-1147
    • Shen, J.1    Serby, M.2    Reed, A.3    Lee, A.J.4    Menon, R.5    Zhang, X.6
  • 19
    • 85029280413 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research. Application number 206619Orig1s000
    • US FDA, Accessed 16 Jan 2017
    • US FDA, Center for Drug Evaluation and Research. Application number 206619Orig1s000. Summary review. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206619Orig1s000SumR.pdf. Accessed 16 Jan 2017.
    • Summary review.
  • 20
    • 84966565215 scopus 로고    scopus 로고
    • Effects of mild and moderate renal impairment on ombitasvir, paritaprevir, ritonavir, dasabuvir, and ribavirin pharmacokinetics in patients with chronic HCV infection
    • Polepally AR, Badri PS, Eckert D, Mensing S, Menon RM. Effects of mild and moderate renal impairment on ombitasvir, paritaprevir, ritonavir, dasabuvir, and ribavirin pharmacokinetics in patients with chronic HCV infection. Eur J Drug Metab Pharmacokinet. doi:10.1007/s13318-016-0341-6.
    • Eur J Drug Metab Pharmacokinet
    • Polepally, A.R.1    Badri, P.S.2    Eckert, D.3    Mensing, S.4    Menon, R.M.5
  • 21
    • 84966733521 scopus 로고    scopus 로고
    • Efficacy of direct-acting antiviral combination for patients with hepatitis C virus genotype 1 infection and severe renal impairment or end-stage renal disease
    • COI: 1:CAS:528:DC%2BC28XptVCgur8%3D, PID: 26976799
    • Pockros PJ, Reddy KR, Mantry PS, Cohen E, Bennett M, Sulkowski MS, et al. Efficacy of direct-acting antiviral combination for patients with hepatitis C virus genotype 1 infection and severe renal impairment or end-stage renal disease. Gastroenterology. 2016;150(7):1590–8.
    • (2016) Gastroenterology , vol.150 , Issue.7 , pp. 1590-1598
    • Pockros, P.J.1    Reddy, K.R.2    Mantry, P.S.3    Cohen, E.4    Bennett, M.5    Sulkowski, M.S.6
  • 22
    • 85029325766 scopus 로고    scopus 로고
    • Ombitasvir, paritaprevir, ritonavir, dasabuvir and ribavirin pharmacokinetics in HCV-infected subjects with chronic kidney disease stage 4 (severe renal impairment) or stage 5 (end-stage renal disease)
    • Shuster DL, Menon RM, Ding B, Li H, Cohen E, Cohen DE, et al. Ombitasvir, paritaprevir, ritonavir, dasabuvir and ribavirin pharmacokinetics in HCV-infected subjects with chronic kidney disease stage 4 (severe renal impairment) or stage 5 (end-stage renal disease). Hepatology. 2016;64(1 Suppl):975A.
    • (2016) Hepatology , vol.64 , pp. 975A
    • Shuster, D.L.1    Menon, R.M.2    Ding, B.3    Li, H.4    Cohen, E.5    Cohen, D.E.6
  • 23
    • 85012868132 scopus 로고    scopus 로고
    • Population pharmacokinetics of paritaprevir, ombitasvir, dasabuvir, ritonavir and ribavirin in hepatitis C virus genotype 1 infection: analysis of six phase III trials
    • Mensing S, Eckert D, Sharma S, Polepally AR, Khatri A, Podsadecki TJ, et al. Population pharmacokinetics of paritaprevir, ombitasvir, dasabuvir, ritonavir and ribavirin in hepatitis C virus genotype 1 infection: analysis of six phase III trials. Br J Clin Pharmacol. doi:10.1111/bcp.13138.
    • Br J Clin Pharmacol
    • Mensing, S.1    Eckert, D.2    Sharma, S.3    Polepally, A.R.4    Khatri, A.5    Podsadecki, T.J.6
  • 24
    • 84966269226 scopus 로고    scopus 로고
    • Exposure-efficacy analyses of ombitasvir, paritaprevir/ritonavir with dasabuvir ± ribavirin in HCV genotype 1-infected patients
    • COI: 1:CAS:528:DC%2BC28XnsFWluro%3D, PID: 27153823
    • Khatri A, Mensing S, Podsadecki T, Awni W, Menon R, Dutta S. Exposure-efficacy analyses of ombitasvir, paritaprevir/ritonavir with dasabuvir ± ribavirin in HCV genotype 1-infected patients. Clin Drug Investig. 2016;36(8):625–35.
    • (2016) Clin Drug Investig , vol.36 , Issue.8 , pp. 625-635
    • Khatri, A.1    Mensing, S.2    Podsadecki, T.3    Awni, W.4    Menon, R.5    Dutta, S.6
  • 25
    • 84928569640 scopus 로고    scopus 로고
    • Drug–drug interaction profile of the all-oral anti-hepatitis C virus regimen of paritaprevir/ritonavir, ombitasvir, and dasabuvir
    • COI: 1:CAS:528:DC%2BC2MXmvFakt74%3D, PID: 25646891
    • Menon RM, Badri PS, Wang T, Polepally AR, Zha J, Khatri A, et al. Drug–drug interaction profile of the all-oral anti-hepatitis C virus regimen of paritaprevir/ritonavir, ombitasvir, and dasabuvir. J Hepatol. 2015;63(1):20–9.
    • (2015) J Hepatol , vol.63 , Issue.1 , pp. 20-29
    • Menon, R.M.1    Badri, P.S.2    Wang, T.3    Polepally, A.R.4    Zha, J.5    Khatri, A.6
  • 26
    • 84957885452 scopus 로고    scopus 로고
    • Drug interactions with the direct-acting antiviral combination of ombitasvir and paritaprevir-ritonavir
    • PID: 26459906
    • Badri PS, Dutta S, Wang H, Podsadecki TJ, Polepally AR, Khatri A, et al. Drug interactions with the direct-acting antiviral combination of ombitasvir and paritaprevir-ritonavir. Antimicrob Agents Chemother. 2015;60(1):105–14.
    • (2015) Antimicrob Agents Chemother , vol.60 , Issue.1 , pp. 105-114
    • Badri, P.S.1    Dutta, S.2    Wang, H.3    Podsadecki, T.J.4    Polepally, A.R.5    Khatri, A.6
  • 27
    • 84983080825 scopus 로고    scopus 로고
    • Drug–drug interactions between the anti-hepatitis C virus 3D regimen of ombitasvir, paritaprevir/ritonavir, and dasabuvir and eight commonly used medications in healthy volunteers
    • COI: 1:CAS:528:DC%2BC28XjtlKjtLc%3D, PID: 26895022
    • Polepally AR, King JR, Ding B, Shuster DL, Dumas EO, Khatri A, et al. Drug–drug interactions between the anti-hepatitis C virus 3D regimen of ombitasvir, paritaprevir/ritonavir, and dasabuvir and eight commonly used medications in healthy volunteers. Clin Pharmacokinet. 2016;55(8):1003–14.
    • (2016) Clin Pharmacokinet , vol.55 , Issue.8 , pp. 1003-1014
    • Polepally, A.R.1    King, J.R.2    Ding, B.3    Shuster, D.L.4    Dumas, E.O.5    Khatri, A.6
  • 28
    • 84964825681 scopus 로고    scopus 로고
    • Evaluation of drug–drug interactions between hepatitis C antiviral agents ombitasvir, paritaprevir/ritonavir, and dasabuvir and HIV-1 protease inhibitors
    • PID: 26740513
    • Khatri A, Dutta S, Wang H, Podsadecki T, Trinh R, Awni W, et al. Evaluation of drug–drug interactions between hepatitis C antiviral agents ombitasvir, paritaprevir/ritonavir, and dasabuvir and HIV-1 protease inhibitors. Clin Infect Dis. 2016;62(8):972–9.
    • (2016) Clin Infect Dis , vol.62 , Issue.8 , pp. 972-979
    • Khatri, A.1    Dutta, S.2    Wang, H.3    Podsadecki, T.4    Trinh, R.5    Awni, W.6
  • 29
    • 84957928513 scopus 로고    scopus 로고
    • Drug–drug interactions between sofosbuvir and ombitasvir–paritaprevir–ritonavir with or without dasabuvir
    • PID: 26596948
    • King JR, Dutta S, Cohen D, Podsadecki TJ, Ding B, Awni WM, et al. Drug–drug interactions between sofosbuvir and ombitasvir–paritaprevir–ritonavir with or without dasabuvir. Antimicrob Agents Chemother. 2015;60(2):855–61.
    • (2015) Antimicrob Agents Chemother , vol.60 , Issue.2 , pp. 855-861
    • King, J.R.1    Dutta, S.2    Cohen, D.3    Podsadecki, T.J.4    Ding, B.5    Awni, W.M.6
  • 30
    • 84947997686 scopus 로고    scopus 로고
    • Drug interactions between hepatoprotective agents ursodeoxycholic acid or glycyrrhizin and ombitasvir/paritaprevir/ritonavir in healthy japanese subjects
    • COI: 1:CAS:528:DC%2BC2MXhs1Cqur3K, PID: 26505529
    • Zha J, Badri PS, Ding B, Uchiyama N, Alves K, Rodrigues-Jr L, et al. Drug interactions between hepatoprotective agents ursodeoxycholic acid or glycyrrhizin and ombitasvir/paritaprevir/ritonavir in healthy japanese subjects. Clin Ther. 2015;37(11):2560–71.
    • (2015) Clin Ther , vol.37 , Issue.11 , pp. 2560-2571
    • Zha, J.1    Badri, P.S.2    Ding, B.3    Uchiyama, N.4    Alves, K.5    Rodrigues-Jr, L.6
  • 31
    • 84928068548 scopus 로고    scopus 로고
    • Pharmacokinetics and dose recommendations for cyclosporine and tacrolimus when coadministered with ABT-450, ombitasvir, and dasabuvir
    • COI: 1:CAS:528:DC%2BC2MXmslWmsr8%3D, PID: 25708713
    • Badri P, Dutta S, Coakley E, Cohen D, Ding B, Podsadecki T, et al. Pharmacokinetics and dose recommendations for cyclosporine and tacrolimus when coadministered with ABT-450, ombitasvir, and dasabuvir. Am J Transplant. 2015;15(5):1313–22.
    • (2015) Am J Transplant , vol.15 , Issue.5 , pp. 1313-1322
    • Badri, P.1    Dutta, S.2    Coakley, E.3    Cohen, D.4    Ding, B.5    Podsadecki, T.6
  • 32
    • 84959142485 scopus 로고    scopus 로고
    • Dosing recommendations for concomitant medications during 3D anti-HCV therapy
    • COI: 1:CAS:528:DC%2BC2MXhsVyms7bK, PID: 26330025
    • Badri PS, King JR, Polepally AR, McGovern BH, Dutta S, Menon RM. Dosing recommendations for concomitant medications during 3D anti-HCV therapy. Clin Pharmacokinet. 2016;55(3):275–95.
    • (2016) Clin Pharmacokinet , vol.55 , Issue.3 , pp. 275-295
    • Badri, P.S.1    King, J.R.2    Polepally, A.R.3    McGovern, B.H.4    Dutta, S.5    Menon, R.M.6
  • 33
    • 84992222009 scopus 로고    scopus 로고
    • Drug–drug interaction between the direct-acting antiviral regimen of ombitasvir/paritaprevir/ritonavir plus dasabuvir and the hiv antiretroviral agents dolutegravir or abacavir plus lamivudine
    • COI: 1:CAS:528:DC%2BC2sXhtlKltL4%3D, PID: 27503645
    • Khatri A, Trinh R, Zhao W, Podsadecki T, Menon R. Drug–drug interaction between the direct-acting antiviral regimen of ombitasvir/paritaprevir/ritonavir plus dasabuvir and the hiv antiretroviral agents dolutegravir or abacavir plus lamivudine. Antimicrob Agents Chemother. 2016;60(10):6244–51.
    • (2016) Antimicrob Agents Chemother , vol.60 , Issue.10 , pp. 6244-6251
    • Khatri, A.1    Trinh, R.2    Zhao, W.3    Podsadecki, T.4    Menon, R.5


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