Efficacy of theta burst stimulation (TBS) for major depression: An exploratory meta-analysis of randomized and sham-controlled trials

Journal of Psychiatric Research

Volumn 90, Issue , 2017, Pages 102-109

  Berlim, Marcelo T ^a   McGirr, Alexander ^b   Rodrigues dos Santos, Nicole ^a   Tremblay, Sara ^a,c   Martins, Ruben ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Acceptability; Efficacy; Major depression; Meta analysis; Repetitive transcranial magnetic stimulation; rTMS; TBS; Theta burst stimulation

Indexed keywords

ARTICLE; DISEASE SEVERITY; EMBASE; HAMILTON DEPRESSION RATING SCALE; HUMAN; MAJOR DEPRESSION; MEDLINE; META ANALYSIS; PRIORITY JOURNAL; PSYCINFO; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION; SYSTEMATIC REVIEW; THERAPY EFFECT; THETA BURST STIMULATION; TREATMENT OUTCOME; TREATMENT RESPONSE; BIBLIOGRAPHIC DATABASE; FEMALE; MALE; META ANALYSIS (TOPIC); PROCEDURES; STATISTICS AND NUMERICAL DATA; TRANSCRANIAL MAGNETIC STIMULATION;

DATABASES, BIBLIOGRAPHIC; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; MALE; META-ANALYSIS AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME;

EID: 85013915240     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2017.02.015     Document Type: Article

References (63)

1. APA, Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). 1994, American Psychiatric Association, Washington, DC.
2. Arns, M., Drinkenburg, W.H., Fitzgerald, P.B., Kenemans, J.L., Neurophysiological predictors of non-response to rTMS in depression. Brain Stimul. 5 (2012), 569–576.
3. Bakker, N., Shahab, S., Giacobbe, P., Blumberger, D.M., Daskalakis, Z.J., Kennedy, S.H., Downar, J., rTMS of the dorsomedial prefrontal cortex for major depression: safety, tolerability, effectiveness, and outcome predictors for 10 Hz versus intermittent theta-burst stimulation. Brain Stimul. 8 (2015), 208–215.
4. Berlim, M.T., Broadbent, H., Van den Eynde, F., Blinding integrity in clinical trials of high frequency repetitive transcranial magnetic stimulation (rTMS) for depression: a meta-analysis. Int. J. Neuropsychopharmacol. 16 (2013), 1173–1181.
5. Berlim, M.T., Van den Eynde, F., Daskalakis, Z.J., Clinically meaningful efficacy and acceptability of low-frequency repetitive transcranial magnetic stimulation (rTMS) for treating primary major depression: a meta-analysis of randomized, double-blind and sham-controlled trials. Neuropsychopharmacology 38 (2013), 543–551.
6. Berlim, M.T., Van den Eynde, F., Perdomo, S.T., Daskalakis, Z.J., Response, remission and dropout rates following high frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials. Psychol. Med. 44 (2014), 225–239.
7. Blumberger, D.M., Vila-Rodriguez, F., Dunlop, K., Schulze, L., Giacobbe, P., Kennedy, S.H., Daskalakis, Z.J., Downar, J., Intermittent theta-burst versus 10 Hz left dorsolateral prefrontal rTMS for treatment resistant depression: preliminary results from a two-site, randomized, single blind noninferiority trial. Brain Stimul., 8, 2015, 329.
8. Borenstein, M., Hedges, L.V., Higgins, J.P.T., Rothstein, H.R., Introduction to Meta-analysis. 2009, Wiley & Sons Ltd., West Sussex, England.
9. Cardenas-Morales, L., Nowak, D.A., Kammer, T., Wolf, R.C., Schonfeldt-Lecuona, C., Mechanisms and applications of theta-burst rTMS on the human motor cortex. Brain Topogr. 22 (2010), 294–306.
10. Chistyakov, A.V., Kreinin, B., Marmor, S., Kaplan, B., Khatib, A., Darawsheh, N., Koren, D., Zaaroor, M., Klein, E., Preliminary assessment of the therapeutic efficacy of continuous theta-burst magnetic stimulation (cTBS) in major depression: a double-blind sham-controlled study. J. Affect. Disord. 170 (2015), 225–229.
11. Chistyakov, A.V., Rubicsek, O., Kaplan, B., Zaaroor, M., Klein, E., Safety, tolerability and preliminary evidence for antidepressant efficacy of theta-burst transcranial magnetic stimulation in patients with major depression. Int. J. Neuropsychopharmacol. 13 (2010), 387–393.
12. Chung, S.W., Hoy, K.E., Fitzgerald, P.B., Theta-burst stimulation: a new form of TMS treatment for depression?. Depress. Anxiety 32 (2015), 182–192.
13. Citrome, L., Number needed to treat: what it is and what it isn't, and why every clinician should know how to calculate it. J. Clin. Psychiatry 72 (2011), 412–413.
14. Cooper, H., Hedges, L.V., Valentine, J.C., The Handbook of Research Synthesis and Meta-analysis. 2009, Russell Sage Foundation Publications, New York, U.S.
15. Daskalakis, Z.J., Theta-burst transcranial magnetic stimulation in depression: when less may be more. Brain 137 (2014), 1860–1862.
16. Davies, C.H., Starkey, S.J., Pozza, M.F., Collingridge, G.L., GABA autoreceptors regulate the induction of LTP. Nature 349 (1991), 609–611.
17. Duprat, R., Desmyter, S., Rudi de, R., van Heeringen, K., Van den Abbeele, D., Tandt, H., Bakic, J., Pourtois, G., Dedoncker, J., Vervaet, M., Van Autreve, S., Lemmens, G.M., Baeken, C., Accelerated intermittent theta burst stimulation treatment in medication-resistant major depression: a fast road to remission?. J. Affect. Disord. 200 (2016), 6–14.
18. Fergusson, D., Aaron, S.D., Guyatt, G., Hebert, P., Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis. BMJ 325 (2002), 652–654.
19. Fitzgerald, P.B., Hoy, K.E., McQueen, S., Maller, J.J., Herring, S., Segrave, R., Bailey, M., Been, G., Kulkarni, J., Daskalakis, Z.J., A randomized trial of rTMS targeted with MRI based neuro-navigation in treatment-resistant depression. Neuropsychopharmacology 34 (2009), 1255–1262.
20. Franca, M., Koch, G., Mochizuki, H., Huang, Y.Z., Rothwell, J.C., Effects of theta burst stimulation protocols on phosphene threshold. Clin. Neurophysiol. 117 (2006), 1808–1813.
21. Gamboa, O.L., Antal, A., Laczo, B., Moliadze, V., Nitsche, M.A., Paulus, W., Impact of repetitive theta burst stimulation on motor cortex excitability. Brain Stimul. 4 (2011), 145–151.
22. Gamboa, O.L., Antal, A., Moliadze, V., Paulus, W., Simply longer is not better: reversal of theta burst after-effect with prolonged stimulation. Exp. Brain Res. 204 (2010), 181–187.
23. George, M.S., Aston-Jones, G., Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). Neuropsychopharmacology 35 (2010), 301–316.
24. George, M.S., Lisanby, S.H., Avery, D., McDonald, W.M., Durkalski, V., Pavlicova, M., Anderson, B., Nahas, Z., Bulow, P., Zarkowski, P., Holtzheimer, P.E. 3rd, Schwartz, T., Sackeim, H.A., Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Arch. Gen. Psychiatry 67 (2010), 507–516.
25. Grissom, R.J., Kim, J.J., Effect Sizes for Research – Univariate and Multivariate Application. 2012, Routledge, New York, NY.
26. Hamilton, M., A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23 (1960), 56–62.
27. Herwig, U., Fallgatter, A.J., Hoppner, J., Eschweiler, G.W., Kron, M., Hajak, G., Padberg, F., Naderi-Heiden, A., Abler, B., Eichhammer, P., Grossheinrich, N., Hay, B., Kammer, T., Langguth, B., Laske, C., Plewnia, C., Richter, M.M., Schulz, M., Unterecker, S., Zinke, A., Spitzer, M., Schonfeldt-Lecuona, C., Antidepressant effects of augmentative transcranial magnetic stimulation: randomised multicentre trial. Br. J. Psychiatry 191 (2007), 441–448.
28. Hess, G., Aizenman, C.D., Donoghue, J.P., Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex. J. Neurophysiol. 75 (1996), 1765–1778.
29. Higgins, J.P.T., Green, S., Cochrane Handbook for Systematic Reviews of Interventions. 2008, John Wiley & Sons Ltd., West Sussex, England.
30. Holzer, M., Padberg, F., Intermittent theta burst stimulation (iTBS) ameliorates therapy-resistant depression: a case series. Brain Stimul. 3 (2010), 181–183.
31. Hoogendam, J.M., Ramakers, G.M., Di Lazzaro, V., Physiology of repetitive transcranial magnetic stimulation of the human brain. Brain Stimul. 3 (2010), 95–118.
32. Huang, Y.-Z., Edwards, M.J., Rounis, E., Bhatia, K.P., Rothwell, J.C., Theta burst stimulation of the human motor cortex. Neuron 45 (2005), 201–206.
33. Huang, Y.Z., Rothwell, J.C., The effect of short-duration bursts of high-frequency, low-intensity transcranial magnetic stimulation on the human motor cortex. Clin. Neurophysiol. 115 (2004), 1069–1075.
34. Hubl, D., Nyffeler, T., Wurtz, P., Chaves, S., Pflugshaupt, T., Luthi, M., von Wartburg, R., Wiest, R., Dierks, T., Strik, W.K., Hess, C.W., Muri, R.M., Time course of blood oxygenation level-dependent signal response after theta burst transcranial magnetic stimulation of the frontal eye field. Neuroscience 151 (2008), 921–928.
35. Iwabuchi, S.J., Raschke, F., Auer, D.P., Liddle, P.F., Lankappa, S.T., Palaniyappan, L., Targeted transcranial theta-burst stimulation alters fronto-insular network and prefrontal GABA. Neuroimage S1053-8119:16 (2016), 30520–30521.
36. Kedzior, K.K., Reitz, S.K., Short-term efficacy of repetitive transcranial magnetic stimulation (rTMS) in depression- reanalysis of data from meta-analyses up to 2010. BMC Psychol., 2, 2014, 39.
37. Kedzior, K.K., Reitz, S.K., Azorina, V., Loo, C., Durability of the antidepressant effect of the high-frequency repetitive transcranial magnetic stimulation (rTMS) in the absence of maintenance treatment in major depression: a systematic review and meta-analysis of 16 double-blind, randomized, sham-controlled trials. Depress. Anxiety 32 (2015), 193–203.
38. Koerselman, F., Laman, D.M., van Duijn, H., van Duijn, M.A., Willems, M.A., A 3-month, follow-up, randomized, placebo-controlled study of repetitive transcranial magnetic stimulation in depression. J. Clin. Psychiatry 65 (2004), 1323–1328.
39. Li, C.T., Chen, M.H., Juan, C.H., Huang, H.H., Chen, L.F., Hsieh, J.C., Tu, P.C., Bai, Y.M., Tsai, S.J., Lee, Y.C., Su, T.P., Efficacy of prefrontal theta-burst stimulation in refractory depression: a randomized sham-controlled study. Brain 137 (2014), 2088–2098.
40. Maxwell, S.E., Kelley, K., Rausch, J.R., Sample size planning for statistical power and accuracy in parameter estimation. Annu. Rev. Psychol. 59 (2008), 537–563.
41. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ, 339, 2009 b2535–b2535.
42. Mosimann, U.P., Schmitt, W., Greenberg, B.D., Kosel, M., Muri, R.M., Berkhoff, M., Hess, C.W., Fisch, H.U., Schlaepfer, T.E., Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patients. Psychiatry Res. 126 (2004), 123–133.
43. Nettekoven, C., Volz, L.J., Kutscha, M., Pool, E.M., Rehme, A.K., Eickhoff, S.B., Fink, G.R., Grefkes, C., Dose-dependent effects of theta burst rTMS on cortical excitability and resting-state connectivity of the human motor system. J. Neurosci. 34 (2014), 6849–6859.
44. Nettekoven, C., Volz, L.J., Leimbach, M., Pool, E.M., Rehme, A.K., Eickhoff, S.B., Fink, G.R., Grefkes, C., Inter-individual variability in cortical excitability and motor network connectivity following multiple blocks of rTMS. Neuroimage 118 (2015), 209–218.
45. Noh, N.A., Fuggetta, G., Manganotti, P., Fiaschi, A., Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation. PLoS One, 7, 2012, e35080.
46. O'Reardon, J.P., Solvason, H.B., Janicak, P.G., Sampson, S., Isenberg, K.E., Nahas, Z., McDonald, W.M., Avery, D., Fitzgerald, P.B., Loo, C., Demitrack, M.A., George, M.S., Sackeim, H.A., Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol. Psychiatry 62 (2007), 1208–1216.
47. Oberman, L., Edwards, D., Eldaief, M., Pascual-Leone, A., Safety of theta burst transcranial magnetic stimulation: a systematic review of the literature. J. Clin. Neurophysiol. 28 (2011), 67–74.
48. Opitz, A., Fox, M.D., Craddock, R.C., Colcombe, S., Milham, M.P., An integrated framework for targeting functional networks via transcranial magnetic stimulation. Neuroimage 127 (2016), 86–96.
49. Padberg, F., Zwanzger, P., Thoma, H., Kathmann, N., Haag, C., Greenberg, B.D., Hampel, H., Moller, H.J., Repetitive transcranial magnetic stimulation (rTMS) in pharmacotherapy-refractory major depression: comparative study of fast, slow and sham rTMS. Psychiatry Res. 88 (1999), 163–171.
50. Plewnia, C., Pasqualetti, P., Grosse, S., Schlipf, S., Wasserka, B., Zwissler, B., Fallgatter, A., Treatment of major depression with bilateral theta burst stimulation: a randomized controlled pilot trial. J. Affect. Disord. 156 (2014), 219–223.
51. Prasser, J., Schecklmann, M., Poeppl, T.B., Frank, E., Kreuzer, P.M., Hajak, G., Rupprecht, R., Landgrebe, M., Langguth, B., Bilateral prefrontal rTMS and theta burst TMS as an add-on treatment for depression: a randomized placebo controlled trial. World J. Biol. Psychiatry 16 (2015), 57–65.
52. Ragert, P., Franzkowiak, S., Schwenkreis, P., Tegenthoff, M., Dinse, H.R., Improvement of tactile perception and enhancement of cortical excitability through intermittent theta burst rTMS over human primary somatosensory cortex. Exp. Brain Res. 184 (2008), 1–11.
53. Riley, R.D., Higgins, J.P., Deeks, J.J., Interpretation of random effects meta-analyses. BMJ, 342, 2011, d549.
54. Rosa, M.A., Lisanby, S.H., Somatic treatments for mood disorders. Neuropsychopharmacology 37 (2012), 102–116.
55. Rosenthal, R., The file drawer problem and tolerance for null results. Psychol. Bull. 86 (1979), 638–641.
56. Rosenthal, R., Meta-analytic Procedures for Social Research. 1993, Sage Publications, Newbury Park, CA.
57. Rossi, S., Hallett, M., Rossini, P.M., Pascual-Leone, A., Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin. Neurophysiol. 120 (2009), 2008–2039.
58. Rush, A.J., Kraemer, H.C., Sackeim, H.A., Fava, M., Trivedi, M.H., Frank, E., Ninan, P.T., Thase, M.E., Gelenberg, A.J., Kupfer, D.J., Regier, D.A., Rosenbaum, J.F., Ray, O., Schatzberg, A.F., Report by the ACNP Task Force on response and remission in major depressive disorder. Neuropsychopharmacology 31 (2006), 1841–1853.
59. Seghier, M.L., Zeidman, P., Neufeld, N.H., Leff, A.P., Price, C.J., Identifying abnormal connectivity in patients using dynamic causal modeling of FMRI responses. Front. Syst. Neurosci., 4, 2010.
60. Stagg, C.J., Wylezinska, M., Matthews, P.M., Johansen-Berg, H., Jezzard, P., Rothwell, J.C., Bestmann, S., Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy. J. Neurophysiol. 101 (2009), 2872–2877.
61. Thompson, S.G., Higgins, J.P., How should meta-regression analyses be undertaken and interpreted?. Stat. Med. 21 (2002), 1559–1573.
62. Urban, J., Kossut, M., Hess, G., Long-term depression and long-term potentiation in horizontal connections of the barrel cortex. Eur. J. Neurosci. 16 (2002), 1772–1776.
63. WHO, The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. 1992, World Health Organization, Geneva, Switzerland.