Erythroferrone and matriptase-2 independently regulate hepcidin expression

American Journal of Hematology

Volumn 92, Issue 5, 2017, Pages E61-E63

  Aschemeyer, Sharraya ^a   Gabayan, Victoria ^a   Ganz, Tomas ^a   Nemeth, Elizabeta ^a   Kautz, Léon ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UMR 1220 TCEM (INRA ENITAB)   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROFERRONE; HEPCIDIN; HORMONE; MATRIPTASE 2; MESSENGER RNA; UNCLASSIFIED DRUG; CTRP15 PROTEIN, MOUSE; CYTOKINE; HAMP1 PROTEIN, MOUSE; MEMBRANE PROTEIN; MUSCLE PROTEIN; SERINE PROTEINASE;

BODY WEIGHT; HEMATOLOGICAL PARAMETERS; HORMONE BLOOD LEVEL; HUMAN; IN VITRO STUDY; LETTER; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN WEIGHT; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; HEPCIDINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; SERINE ENDOPEPTIDASES;

EID: 85013759633     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.24672     Document Type: Letter

References (6)

1. Kautz L, Jung G, Nemeth E, Ganz T. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014;124(16):2569–2574.
2. Kautz L, Jung G, Valore EV, et al. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46(7):678–684.
3. De Falco L, Sanchez M, Silvestri L, et al. Iron refractory iron deficiency anemia. Haematologica. 2013;98(6):845–853.
4. Nicolas G, Deschemin JC, Ramsay AJ, et al. Is EPO therapy able to correct iron deficiency anaemia caused by matriptase-2 deficiency? Br J Haematol. 2011;152(4):498–500.
5. Nai A, Rubio A, Campanella A, et al. Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice. Blood. 2016;127(19):2327–2336.
6. Kautz L, Jung G, Du X, et al. Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of beta-thalassemia. Blood. 2015;126(17):2031–2037.