메뉴 건너뛰기




Volumn 62, Issue , 2008, Pages 357-373

Health-promoting transgenic rice: Application of rice seeds as a direct delivery system for bioactive peptides in human health

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85013755780     PISSN: 0934943X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-74250-0_26     Document Type: Chapter
Times cited : (19)

References (55)
  • 1
    • 18044401913 scopus 로고    scopus 로고
    • A mainstay of functional food science in Japan – history, present status, and future outlook
    • Arai S, Osawa T, Ohigashi H, et al. (2001) A mainstay of functional food science in Japan – history, present status, and future outlook. Biosci Biotechnol Biochem 65:1–13
    • (2001) Biosci Biotechnol Biochem , vol.65 , pp. 1-13
    • Arai, S.1    Osawa, T.2    Ohigashi, H.3
  • 2
    • 0032168897 scopus 로고    scopus 로고
    • Compartment-specific accumulation of recombinant immunoglobulins in plant cells: An essential tool for antibody production and immunomodulation of physiological functions and pathogen activity
    • Conrad U, Fiedler U (1998) Compartment-specific accumulation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol Biol 38:101–109
    • (1998) Plant Mol Biol , vol.38 , pp. 101-109
    • Conrad, U.1    Fiedler, U.2
  • 3
    • 16544384639 scopus 로고    scopus 로고
    • Targeting of proteins to endoplasmic reticulum-derived compartments in plants. The importance of RNA localization
    • Croft AJ, Washida H, Okita TW, Ogawa M, Kumamaru T, Satoh H (2004) Targeting of proteins to endoplasmic reticulum-derived compartments in plants. The importance of RNA localization. Plant Physiol 136:3414–3419
    • (2004) Plant Physiol , vol.136 , pp. 3414-3419
    • Croft, A.J.1    Washida, H.2    Okita, T.W.3    Ogawa, M.4    Kumamaru, T.5    Satoh, H.6
  • 4
    • 0035212386 scopus 로고    scopus 로고
    • Medical molecular farming: Production of antibodies, biopharmaceuticals and edible vaccines in plants
    • Daniell H, Streatfield SJ, Wycoff K (2001) Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci 6:219–226
    • (2001) Trends Plant Sci , vol.6 , pp. 219-226
    • Daniell, H.1    Streatfield, S.J.2    Wycoff, K.3
  • 5
    • 0344357096 scopus 로고
    • Glucogon-like peptide 1 stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
    • Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF (1987) Glucogon-like peptide 1 stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci USA 84:3434–3438
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3434-3438
    • Drucker, D.J.1    Philippe, J.2    Mojsov, S.3    Chick, W.L.4    Habener, J.F.5
  • 6
    • 0033667765 scopus 로고    scopus 로고
    • Molecular farming of pharmaceutical proteins
    • Fischer R, Emans N (2000) Molecular farming of pharmaceutical proteins. Transgenic Res 9:279–299
    • (2000) Transgenic Res , vol.9 , pp. 279-299
    • Fischer, R.1    Emans, N.2
  • 8
    • 0037323510 scopus 로고    scopus 로고
    • Immunotherapy of allergic disease
    • Frew AJ (2003) Immunotherapy of allergic disease. J Allergy Clin Immunol 111:S712–S719
    • (2003) J Allergy Clin Immunol , vol.111 , pp. S712-S719
    • Frew, A.J.1
  • 9
    • 10744232402 scopus 로고    scopus 로고
    • Dual regulated RNA transport pathways to the cortical region in developing rice endosperm
    • Hamada S, Ishiyama K, Sakulsingharoj C, et al. (2003) Dual regulated RNA transport pathways to the cortical region in developing rice endosperm. Plant Cell 15:2265–2272
    • (2003) Plant Cell , vol.15 , pp. 2265-2272
    • Hamada, S.1    Ishiyama, K.2    Sakulsingharoj, C.3
  • 10
    • 0034919459 scopus 로고    scopus 로고
    • Preclinical evaluation of an immunotherapeutic peptide comprising 7 T-cell determinats of Cry j 1 and Cry j 2, the major Japanese cedar pollen allergens
    • Hirahara K, Tatsuta T, Takatori T, et al. (2001) Preclinical evaluation of an immunotherapeutic peptide comprising 7 T-cell determinats of Cry j 1 and Cry j 2, the major Japanese cedar pollen allergens. J Allergy Clin Immunol 108:94–100
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 94-100
    • Hirahara, K.1    Tatsuta, T.2    Takatori, T.3
  • 11
    • 33750798367 scopus 로고    scopus 로고
    • Peptide immunotherapy for allergeic diseases using a rice-based edible vaccine
    • Hiroi T, Takaiwa F (2006) Peptide immunotherapy for allergeic diseases using a rice-based edible vaccine. Curr Opin Allergy Clin Immunol 6:455–460
    • (2006) Curr Opin Allergy Clin Immunol , vol.6 , pp. 455-460
    • Hiroi, T.1    Takaiwa, F.2
  • 12
    • 0036901079 scopus 로고    scopus 로고
    • Monoclonal antibody manufacturing in transgenic plants – myths and realities
    • Hood EE, Woodard SL, Horn ME (2002) Monoclonal antibody manufacturing in transgenic plants – myths and realities. Curr Opin Biotechnol 13:630–635
    • (2002) Curr Opin Biotechnol , vol.13 , pp. 630-635
    • Hood, E.E.1    Woodard, S.L.2    Horn, M.E.3
  • 13
    • 84891694871 scopus 로고
    • Screening and genetic analysis of rice seed storage protein mutants
    • Iida S (1995) Screening and genetic analysis of rice seed storage protein mutants. Gamma Field Symp 34:31–48
    • (1995) Gamma Field Symp , vol.34 , pp. 31-48
    • Iida, S.1
  • 14
    • 31344450409 scopus 로고    scopus 로고
    • The critical role of disulfide bond formation in protein sorting in the endosperm of rice
    • Kawagoe Y, Suzuki K, Tasaki M, et al. (2005) The critical role of disulfide bond formation in protein sorting in the endosperm of rice. Plant Cell 17:1141–1153
    • (2005) Plant Cell , vol.17 , pp. 1141-1153
    • Kawagoe, Y.1    Suzuki, K.2    Tasaki, M.3
  • 16
    • 0038058742 scopus 로고    scopus 로고
    • Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery
    • Kitts DD, Weiler K (2003) Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr Pharm Des 9:1309–1323
    • (2003) Curr Pharm Des , vol.9 , pp. 1309-1323
    • Kitts, D.D.1    Weiler, K.2
  • 17
    • 0038397146 scopus 로고    scopus 로고
    • Food-derived bioactive peptides – opportunities for designing future foods
    • Korhonen H, Pihlanto A (2003) Food-derived bioactive peptides – opportunities for designing future foods. Curr Pharm Des 9:1297–1308
    • (2003) Curr Pharm Des , vol.9 , pp. 1297-1308
    • Korhonen, H.1    Pihlanto, A.2
  • 18
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • Larche M, Wraith DC (2005) Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 11:S69–S76
    • (2005) Nat Med , vol.11 , pp. S69-S76
    • Larche, M.1    Wraith, D.C.2
  • 19
    • 0141706699 scopus 로고    scopus 로고
    • The production of recombinant pharmaceutical proteins in plants
    • Ma JKC, Pascal MW, Drake PW, Christou P (2003) The production of recombinant pharmaceutical proteins in plants. Nat Rev Genet 4:794–805
    • (2003) Nat Rev Genet , vol.4 , pp. 794-805
    • Ma, J.1    Pascal, M.W.2    Drake, P.W.3    Christou, P.4
  • 20
    • 0033042906 scopus 로고    scopus 로고
    • A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery
    • Matoba N, Usui H, Fujita H, Yoshikawa M (1999) A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett 452:181–184
    • (1999) FEBS Lett , vol.452 , pp. 181-184
    • Matoba, N.1    Usui, H.2    Fujita, H.3    Yoshikawa, M.4
  • 21
    • 0035907064 scopus 로고    scopus 로고
    • Design and production of genetically modified soybean protein with anti-hypertensive activity by incorporating potent analogue of ovokinin (2–7)
    • Matoba N, Doyama N, Yamada Y, Maruyama N, Utsumi S Yoshikawa M (2001) Design and production of genetically modified soybean protein with anti-hypertensive activity by incorporating potent analogue of ovokinin (2–7). FEBS Lett 497:50–54
    • (2001) FEBS Lett , vol.497 , pp. 50-54
    • Matoba, N.1    Doyama, N.2    Yamada, Y.3    Maruyama, N.4    Utsumi S Yoshikawa, M.5
  • 22
    • 2942620546 scopus 로고    scopus 로고
    • Therapeutic potential of oral tolerance
    • Mayer L, Shao L (2004) Therapeutic potential of oral tolerance. Nature Rev Immunol 4:407–419
    • (2004) Nature Rev Immunol , vol.4 , pp. 407-419
    • Mayer, L.1    Shao, L.2
  • 23
    • 0034804066 scopus 로고    scopus 로고
    • Identification of novel hypocholesterolemic peptides derived from bovine milk beta-lactoglobulin
    • Nagaoka S, Futamura Y, Miwa K, et al. (2001) Identification of novel hypocholesterolemic peptides derived from bovine milk beta-lactoglobulin. Biochem Biophys Res Commun 281:11–17
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 11-17
    • Nagaoka, S.1    Futamura, Y.2    Miwa, K.3
  • 24
    • 0036806486 scopus 로고    scopus 로고
    • Expression of human lactoferrin in transgenic rice grains for the application in infant formula
    • Nandi S, Suzuki YA, Huang J, et al. (2002) Expression of human lactoferrin in transgenic rice grains for the application in infant formula. Plant Sci 163:713–722
    • (2002) Plant Sci , vol.163 , pp. 713-722
    • Nandi, S.1    Suzuki, Y.A.2    Huang, J.3
  • 25
    • 7744222164 scopus 로고    scopus 로고
    • Lifestyle interventions or drugs for patients with essential hypertension: A systematic review
    • Nicolson DJ, Dikinson HO, Campbell F, Mason JM (2004) Lifestyle interventions or drugs for patients with essential hypertension: a systematic review. J Hypertens 22:2043–2048
    • (2004) J Hypertens , vol.22 , pp. 2043-2048
    • Nicolson, D.J.1    Dikinson, H.O.2    Campbell, F.3    Mason, J.M.4
  • 26
    • 1542284546 scopus 로고    scopus 로고
    • Optimal designing of beta-conglycinin to genetically incorporate RPLKPW, a potent anti-hypertensive peptide
    • Onishi K, Matoba N, Yamada Y, et al. (2004) Optimal designing of beta-conglycinin to genetically incorporate RPLKPW, a potent anti-hypertensive peptide. Peptides 25:37–43
    • (2004) Peptides , vol.25 , pp. 37-43
    • Onishi, K.1    Matoba, N.2    Yamada, Y.3
  • 27
    • 0035958051 scopus 로고    scopus 로고
    • A rice functional transcriptional activator, RISBZ1, responsible for endosperm-specific expression of storage protein genes through GCN4 motif
    • Onodera Y, Suzuki A, Wu CY, Washida H, Takaiwa F (2001) A rice functional transcriptional activator, RISBZ1, responsible for endosperm-specific expression of storage protein genes through GCN4 motif. J Biol Chem 276:14139–14152
    • (2001) J Biol Chem , vol.276 , pp. 14139-14152
    • Onodera, Y.1    Suzuki, A.2    Wu, C.Y.3    Washida, H.4    Takaiwa, F.5
  • 28
    • 33646812873 scopus 로고    scopus 로고
    • Design of genetically modified soybean proglycinin A1aB1b with multiple copies of bioactive peptide sequences
    • Prak K, Maruyama Y, Maruyama N, Utsumi S (2006) Design of genetically modified soybean proglycinin A1aB1b with multiple copies of bioactive peptide sequences. Peptide 27:1179–1186
    • (2006) Peptide , vol.27 , pp. 1179-1186
    • Prak, K.1    Maruyama, Y.2    Maruyama, N.3    Utsumi, S.4
  • 29
    • 12744254466 scopus 로고    scopus 로고
    • Evaluation of tissue specificity and expression strength of rice seed component gene promoters in transgenic rice
    • Qu LQ, Takaiwa F (2004) Evaluation of tissue specificity and expression strength of rice seed component gene promoters in transgenic rice. Plant Biotech J 2:113–125
    • (2004) Plant Biotech J , vol.2 , pp. 113-125
    • Qu, L.Q.1    Takaiwa, F.2
  • 31
    • 0030087974 scopus 로고    scopus 로고
    • The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco
    • Schouten A, Roosien J, van Engelen FA, et al. (1996) The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco. Plant Mol Biol 30:781–793
    • (1996) Plant Mol Biol , vol.30 , pp. 781-793
    • Schouten, A.1    Roosien, J.2    Van Engelen, F.A.3
  • 32
    • 0034721744 scopus 로고    scopus 로고
    • Transgenic expression of cecropin B, an antibacterial peptide from Bombyx mori, confers enhanced resistance to bacterial leaf blight in rice
    • Sharma A, Sharma R, Imamura M, Yamakawa M, Machii H (2000) Transgenic expression of cecropin B, an antibacterial peptide from Bombyx mori, confers enhanced resistance to bacterial leaf blight in rice. FEBS Lett 484:7–11
    • (2000) FEBS Lett , vol.484 , pp. 7-11
    • Sharma, A.1    Sharma, R.2    Imamura, M.3    Yamakawa, M.4    Machii, H.5
  • 33
    • 17044406723 scopus 로고    scopus 로고
    • Sowing the seeds of success: Pharmaceutical proteins from plants
    • Stoger E, Ma JKC, Fischer R, Christou P (2005) Sowing the seeds of success: pharmaceutical proteins from plants. Curr Opin Biotech 16:167–173
    • (2005) Curr Opin Biotech , vol.16 , pp. 167-173
    • Stoger, E.1    Ma, J.2    Fischer, R.3    Christou, P.4
  • 34
    • 13844261195 scopus 로고    scopus 로고
    • Genetically modified rice seeds accumulating GLP-1 analogue stimulate insulin secretion from a mouse pancreatic beta-cell line
    • Sugita K, Endo-Kasahara S, Tada Y, et al. (2005) Genetically modified rice seeds accumulating GLP-1 analogue stimulate insulin secretion from a mouse pancreatic beta-cell line. FEBS Lett 579:1085–1088
    • (2005) FEBS Lett , vol.579 , pp. 1085-1088
    • Sugita, K.1    Endo-Kasahara, S.2    Tada, Y.3
  • 35
    • 13844274216 scopus 로고    scopus 로고
    • Foreign gene products can be enhanced by introduction into low storage protein mutants
    • Tada Y, Utsumi S, Takaiwa F (2003) Foreign gene products can be enhanced by introduction into low storage protein mutants. Plant Biotech J 1:411–422
    • (2003) Plant Biotech J , vol.1 , pp. 411-422
    • Tada, Y.1    Utsumi, S.2    Takaiwa, F.3
  • 36
    • 28444454488 scopus 로고    scopus 로고
    • A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses
    • Takagi H, Hiroi T, Yang L, et al. (2005a) A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci USA 102:17525–17530
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17525-17530
    • Takagi, H.1    Hiroi, T.2    Yang, L.3
  • 38
    • 33846487545 scopus 로고    scopus 로고
    • Biochemical safety evaluation of transgenic rice seeds expressing T cell epitopes of Japanese cedar pollen allergens
    • Takagi H, Hirose S, Yasuda H, Takaiwa F (2006) Biochemical safety evaluation of transgenic rice seeds expressing T cell epitopes of Japanese cedar pollen allergens. J Agric Food Chem 54:9901–9905
    • (2006) J Agric Food Chem , vol.54 , pp. 9901-9905
    • Takagi, H.1    Hirose, S.2    Yasuda, H.3    Takaiwa, F.4
  • 39
    • 33845807398 scopus 로고    scopus 로고
    • Endosperm tissue is good production platform for artificial recombinant proteins in transgenic rice
    • Takaiwa F, Takagi H, Hirose S, Wakasa Y (2007) Endosperm tissue is good production platform for artificial recombinant proteins in transgenic rice. Plant Biotech J 5:84–92
    • (2007) Plant Biotech J , vol.5 , pp. 84-92
    • Takaiwa, F.1    Takagi, H.2    Hirose, S.3    Wakasa, Y.4
  • 40
    • 0035193739 scopus 로고    scopus 로고
    • Native and artificial reticuloplasmins coaccumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments
    • Torres E, Gonzalez-Melendi P, Stoger E, et al. (2001) Native and artificial reticuloplasmins coaccumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments. Plant Physiol 127:1212–1223
    • (2001) Plant Physiol , vol.127 , pp. 1212-1223
    • Torres, E.1    Gonzalez-Melendi, P.2    Stoger, E.3
  • 42
    • 33747589432 scopus 로고    scopus 로고
    • High accumulation of bioactive peptide in transgenic rice seeds by expression of introduced multiple genes
    • Wakasa Y, Yasuda H, Takaiwa F (2006) High accumulation of bioactive peptide in transgenic rice seeds by expression of introduced multiple genes. Plant Biotech J 4:499–510
    • (2006) Plant Biotech J , vol.4 , pp. 499-510
    • Wakasa, Y.1    Yasuda, H.2    Takaiwa, F.3
  • 43
    • 0030222373 scopus 로고    scopus 로고
    • Peptide therapy for treatment of allergic diseases
    • Wallner BP, Gefter ML (1996) Peptide therapy for treatment of allergic diseases. Clin Immunol Immunopathol 80:105–109
    • (1996) Clin Immunol Immunopathol , vol.80 , pp. 105-109
    • Wallner, B.P.1    Gefter, M.L.2
  • 44
    • 0034026208 scopus 로고    scopus 로고
    • Plants for delivery of edible vaccines
    • Walmsley AM, Arntzen CJ (2000) Plants for delivery of edible vaccines. Curr Opin Biotech 11:126–129
    • (2000) Curr Opin Biotech , vol.11 , pp. 126-129
    • Walmsley, A.M.1    Arntzen, C.J.2
  • 45
    • 0026834063 scopus 로고
    • Vicillin with carboxy-terminal KDEL is retained in the endoplasmic reticulum and accumulates to high levels in the leaves of transgenic plants
    • Wandelt CI, Khan MRI, Craig S, Schroeder HE, Spencer D, Higgins TJV (1992) Vicillin with carboxy-terminal KDEL is retained in the endoplasmic reticulum and accumulates to high levels in the leaves of transgenic plants. Plant J 2:181–192
    • (1992) Plant J , vol.2 , pp. 181-192
    • Wandelt, C.I.1    Khan, M.2    Craig, S.3    Schroeder, H.E.4    Spencer, D.5    Higgins, T.6
  • 46
    • 0024515406 scopus 로고
    • Glucagon-like peptide 1 (7–37) actions on endocrine pancreas
    • Weir GC, Mojsov S, Hendrick GK, Hebener JF (1989) Glucagon-like peptide 1 (7–37) actions on endocrine pancreas. Diabetes 38:338–342
    • (1989) Diabetes , vol.38 , pp. 338-342
    • Weir, G.C.1    Mojsov, S.2    Hendrick, G.K.3    Hebener, J.F.4
  • 47
    • 0032104487 scopus 로고    scopus 로고
    • The GCN4 motif in a rice glutelin gene is essential for endosperm-specific gene expression and is activated by Opaque-2 in transgenic rice plants
    • Wu CY, Suzuki A, Washida H, Takaiwa F (1998) The GCN4 motif in a rice glutelin gene is essential for endosperm-specific gene expression and is activated by Opaque-2 in transgenic rice plants. Plant J 14:673–683
    • (1998) Plant J , vol.14 , pp. 673-683
    • Wu, C.Y.1    Suzuki, A.2    Washida, H.3    Takaiwa, F.4
  • 49
    • 33747088519 scopus 로고    scopus 로고
    • Synergism between RPBF Dof and RISBZ1 bZIP activators in the regulation of rice seed expression genes
    • Yamamoto MP, Onodera Y, Touno SM, Takaiwa F (2006) Synergism between RPBF Dof and RISBZ1 bZIP activators in the regulation of rice seed expression genes. Plant Physiol 141:1694–1707
    • (2006) Plant Physiol , vol.141 , pp. 1694-1707
    • Yamamoto, M.P.1    Onodera, Y.2    Touno, S.M.3    Takaiwa, F.4
  • 50
    • 33646539784 scopus 로고    scopus 로고
    • A transgenic rice seed accumulating an antihypertensive peptide reduces the blood pressure of spontaneously hypertensive rats
    • Yang LJ, Tada Y, Yamamoto MP, Zhao H, Yoshikawa M, Takaiwa F (2006) A transgenic rice seed accumulating an antihypertensive peptide reduces the blood pressure of spontaneously hypertensive rats. FEBS Lett 580:3315–3320
    • (2006) FEBS Lett , vol.580 , pp. 3315-3320
    • Yang, L.J.1    Tada, Y.2    Yamamoto, M.P.3    Zhao, H.4    Yoshikawa, M.5    Takaiwa, F.6
  • 51
    • 0036008330 scopus 로고    scopus 로고
    • Expression of a synthetic porcine á-lactoalbumin gene in the kernels of transgenic maize
    • Yang SH, Moran DL, Jia HW, Bicar EH, Lee M, Scott MP (2002) Expression of a synthetic porcine á-lactoalbumin gene in the kernels of transgenic maize. Trangenic Res 11:11–20
    • (2002) Trangenic Res , vol.11 , pp. 11-20
    • Yang, S.H.1    Moran, D.L.2    Jia, H.W.3    Bicar, E.H.4    Lee, M.5    Scott, M.P.6
  • 53
    • 33745374449 scopus 로고    scopus 로고
    • The correlation between expression and localization of a foreign gene product in rice endosperm
    • Yasuda H, Hayashi Y, Jomori T, Takaiwa F (2006) The correlation between expression and localization of a foreign gene product in rice endosperm. Plant Cell Physiol 47:756–763
    • (2006) Plant Cell Physiol , vol.47 , pp. 756-763
    • Yasuda, H.1    Hayashi, Y.2    Jomori, T.3    Takaiwa, F.4
  • 54
    • 0034495131 scopus 로고    scopus 로고
    • Bioactive peptides derived from food proteins preventing lifestyle-related diseases
    • Yoshikawa M, Fujita H, Matoba N, et al. (2000) Bioactive peptides derived from food proteins preventing lifestyle-related diseases. BioFactors 12:143–146
    • (2000) Biofactors , vol.12 , pp. 143-146
    • Yoshikawa, M.1    Fujita, H.2    Matoba, N.3
  • 55
    • 0036884050 scopus 로고    scopus 로고
    • Three T-cell determinants of Cry j 1 and Cry j 2, the major Japanese cedar pollen antigens, retain their immunogenicity and tolerogenicity in a linked peptide
    • Yoshitomi T, Hirahara K, Kawaguchi J, et al. (2002) Three T-cell determinants of Cry j 1 and Cry j 2, the major Japanese cedar pollen antigens, retain their immunogenicity and tolerogenicity in a linked peptide. Immunology 107:517–522
    • (2002) Immunology , vol.107 , pp. 517-522
    • Yoshitomi, T.1    Hirahara, K.2    Kawaguchi, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.