High dose omega-3 fatty acid administration and skeletal muscle protein turnover in maintenance hemodialysis patients

Clinical Journal of the American Society of Nephrology

Volumn 11, Issue 7, 2016, Pages 1227-1235

  Deger, Serpil Muge ^a,b   Hung, Adriana M ^a,b   Ellis, Charles D ^a   Booker, Cindy ^a   Bian, Aihua ^a   Chen, Guanhua ^a   Abumrad, Naji N ^a   Ikizler, T Alp ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diabetes mellitus; Forearm; Hemodialysis; Homeostasis; Humans; Inflammation; Muscle protein turnover; Muscle Proteins; Omega 3 fatty acids; Protein energy wasting

Indexed keywords

AMINO ACID; C REACTIVE PROTEIN; DOCOSAHEXAENOIC ACID; GLUCOSE; ICOSAPENTAENOIC ACID; INSULIN; INTERLEUKIN 6; MUSCLE PROTEIN; OMEGA 3 FATTY ACID; PLACEBO;

ADULT; ARTICLE; BODY COMPOSITION; CLINICAL ARTICLE; CLINICAL OUTCOME; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; FAT MASS; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MALE; METABOLIC DISORDER; PROTEIN DEGRADATION; PROTEIN ENERGY WASTING DISEASE; PROTEIN HOMEOSTASIS; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; AGED; BIOSYNTHESIS; BLOOD; CHRONIC KIDNEY FAILURE; DIETARY SUPPLEMENT; DRUG EFFECTS; FOREARM; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED;

ADULT; AGED; AMINO ACIDS; BLOOD GLUCOSE; C-REACTIVE PROTEIN; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FEMALE; FOREARM; HUMANS; INFLAMMATION; INSULIN RESISTANCE; MALE; MIDDLE AGED; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN BIOSYNTHESIS; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC;

EID: 85013713011     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.04150415     Document Type: Article

References (21)

1. Carrero JJ, Stenvinkel P, Cuppari L, Ikizler TA, Kalantar-Zadeh K, Kaysen G, Mitch WE, Price SR, Wanner C, Wang AY, ter Wee P, Franch HA: Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr 23: 77-90, 2013
2. Pupim LB, Caglar K, Hakim RM, Shyr Y, Ikizler TA: Uremic malnutrition is a predictor of death independent of inflammatory status. Kidney Int 66: 2054-2060, 2004
3. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R: Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 38: 1154-1163, 2013
4. Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B: Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr 93: 402-412, 2011
5. Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B: Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia- hyperaminoacidaemia in healthy young and middle- aged men and women. Clin Sci (Lond) 121: 267-278, 2011
6. Kamolrat T, Gray SR: The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes. Biochem Biophys Res Commun 432: 593-598, 2013
7. Gingras AA, White PJ, Chouinard PY, Julien P, Davis TA, Dombrowski L, Couture Y, Dubreuil P, Myre A, Bergeron K, Marette A, Thivierge MC: Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-m TOR-S6K1 pathway and insulin sensitivity. J Physiol 579: 269-284, 2007
8. Hu Z, Wang H, Lee IH, Du J, Mitch WE: Endogenous glucocorticoids and impaired insulin signaling are both required to stimulatemuscle wasting under pathophysiological conditions in mice. J Clin Invest 119: 3059-3069, 2009
9. Hung AM, Booker C, Ellis CD, Siew ED, Graves AJ, Shintani A, Abumrad NN, Himmelfarb J, Ikizler TA: Omega-3 fatty acids inhibit the up-regulation of endothelial chemokines in maintenance hemodialysis patients. Nephrol Dial Transplant 30: 266-274, 2015
10. Taccone-Gallucci M, Manca-di-Villahermosa S, Battistini L, Stuffler RG, Tedesco M, Maccarrone M: N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity. Kidney Int 69: 1450-1454, 2006
11. Siew ED, Ikizler TA: Insulin resistance and protein energy metabolism in patients with advanced chronic kidney disease. Semin Dial 23: 378-382, 2010
12. Pupim LB, Flakoll PJ, Majchrzak KM, Aftab Guy DL, Stenvinkel P, Ikizler TA: Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus. Kidney Int 68: 1857-1865, 2005
13. Heinrikson RL, Meredith SC: Amino acid analysis by reversephase high-performance liquid chromatography: precolumn derivatization with phenylisothiocyanate. Anal Biochem 136: 65-74, 1984
14. Gelfand RA, Barrett EJ: Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J Clin Invest 80: 1-6, 1987
15. Wolfe RR: Radioactive and Stable Isotope Tracers in Biomedicine:Principles and Practice of Kinetic Analysis, New York, Wiley-Liss, 1992, pp 283-316
16. Shoji T, Emoto M, Nishizawa Y: HOMA index to assess insulin resistance in renal failure patients. Nephron 89: 348-349, 2001
17. Raj DS, Moseley P, Dominic EA, Onime A, Tzamaloukas AH, Boyd A, Shah VO, Glew R, Wolfe R, Ferrando A: Interleukin-6 modulates hepatic and muscle protein synthesis during hemodialysis. Kidney Int 73: 1054-1061, 2008
18. Biolo G, Ciocchi B, Bosutti A, Situlin R, Toigo G, Guarnieri G: Pentoxifylline acutely reduces protein catabolism in chronically uremic patients. Am J Kidney Dis 40: 1162-1172, 2002
19. Palmer RM, Wahle KW: Protein synthesis and degradation in isolated muscle. Effect of omega 3 and omega 6 fatty acids. Biochem J 242: 615-618, 1987
20. Rodacki CL, Rodacki AL, Pereira G, Naliwaiko K, Coelho I, Pequito D, Fernandes LC: Fish-oil supplementation enhances the effects of strength training in elderly women. Am J Clin Nutr 95: 428-436, 2012
21. Rooyackers OE, Nair KS: Hormonal regulation of human muscle protein metabolism. Annu Rev Nutr 17: 457-485, 1997