Clinical utility of methicillin-resistant Staphylococcus aureus nasal polymerase chain reaction assay in critically ill patients with nosocomial pneumonia

Journal of Critical Care

Volumn 38, Issue , 2017, Pages 168-171

  Smith, Melanie N ^a   Erdman, Michael J ^a   Ferreira, Jason A ^a   Aldridge, Petra ^a   Jankowski, Christopher A ^a  

^a UNIVERSITY OF FLORIDA HEALTH JACKSONVILLE   (United States)

Author keywords

Antimicrobial stewardship; Critically ill; MRSA; Negative predictive value; Pneumonia; Polymerase chain reaction

Indexed keywords

VANCOMYCIN; ANTIINFECTIVE AGENT;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; COST CONTROL; CRITICALLY ILL PATIENT; DIAGNOSTIC TEST ACCURACY STUDY; DRUG COST; DRUG MONITORING; DRUG WITHDRAWAL; FEMALE; FLORIDA; HEALTH CARE ASSOCIATED PNEUMONIA; HUMAN; INTENSIVE CARE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PREVALENCE; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TERTIARY CARE CENTER; CRITICAL ILLNESS; CROSS INFECTION; EVALUATION STUDY; INTENSIVE CARE UNIT; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; PNEUMONIA, STAPHYLOCOCCAL;

AGED; ANTI-BACTERIAL AGENTS; CRITICAL CARE; CRITICAL ILLNESS; CROSS INFECTION; FEMALE; FLORIDA; HUMANS; INTENSIVE CARE UNITS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; PNEUMONIA, STAPHYLOCOCCAL; POLYMERASE CHAIN REACTION; PREVALENCE; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 85013642935     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2016.11.008     Document Type: Article

References (27)

1. [1] Xu, J., Murphy, S.L., Kochanek, K.D., Bastian, B.A., Deaths: final data for 2013. Natl Vital Stat Rep 64:2 (2016), 1–119.
2. [2] Kollef, M.H., Shorr, A., Tabak, Y.P., Gupta, V., Liu, L.Z., Johannes, R.S., Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest 128:6 (2005), 3854–3862.
3. [3] Rubinstein, E., Kollef, M.H., Nathwani, D., Pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis 46:Suppl. 5 (2008), S378–S385.
4. [4] Shorr, A.F., Tabak, Y.P., Gupta, V., Johannes, R.S., Liu, L.Z., Kollef, M.H., Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia. Crit Care, 10(3), 2006, R97.
5. [5] American Thoracic Society, Infectious Diseases Society of America, Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:4 (2005), 388–416.
6. [6] Kalil, A.C., Metersky, M.L., Klompas, M., Muscedere, J., Sweeney, D.A., Palmer, L.B., et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis 63 (2016), 1–51.
7. [7] Harris, A.D., Furuno, J.P., Roghmann, M.C., Johnson, J.K., Conway, L.J., Venezia, R.A., et al. Targeted surveillance of methicillin-resistant Staphylococcus aureus and its potential use to guide empiric antibiotic therapy. Antimicrob Agents Chemother 54:8 (2010), 3143–3148.
8. [8] Kuehnert, M.J., Kruszon-Moran, D., Hill, H.A., McQuillan, G., McAllister, S.K., Fosheim, G., et al. Prevalence of Staphylococcus aureus nasal colonization in the United States, 2001-2002. J Infect Dis 193:2 (2006), 172–179.
9. [9] Sarikonda, K.V., Micek, S.T., Doherty, J.A., Reichley, R.M., Warren, D., Kollef, M.H., Methicillin-resistant Staphylococcus aureus nasal colonization is a poor predictor of intensive care unit-acquired methicillin-resistant Staphylococcus aureus infections requiring antibiotic treatment. Crit Care Med 38:10 (2010), 1991–1995.
10. [10] Safdar, N., Bradley, E.A., The risk of infection after nasal colonization with Staphylococcus aureus. Am J Med 121:4 (2008), 310–315.
11. [11] Chan, J.D., Dellit, T.H., Choudhuri, J.A., McNamara, E., Melius, E.J., Evans, H.L., et al. Active surveillance cultures of methicillin-resistant Staphylococcus aureus as a tool to predict methicillin-resistant S. aureus ventilator-associated pneumonia. Crit Care Med 40:5 (2012), 1437–1442.
12. [12] Dangerfield, B., Chung, A., Webb, B., Seville, M.T., Predictive value of methicillin-resistant Staphylococcus aureus (MRSA) nasal swab PCR assay for MRSA pneumonia. Antimicrob Agents Chemother 58:2 (2014), 859–864.
13. [13] Tilahun, B., Faust, A.C., McCorstin, P., Ortegon, A., Nasal colonization and lower respiratory tract infections with methicillin-resistant Staphylococcus aureus. Am J Crit Care 24:1 (2015), 8–12.
14. [14] Hiett, J., Patel, R.K., Tate, V., Smulian, G., Kelly, A., Using active methicillin-resistant Staphylococcus aureus surveillance nasal swabs to predict clinical respiratory culture results. Am J Health Syst Pharm 72:11 Suppl. 1 (2015), S20–S24.
15. [15] Johnson, J.A., Wright, M.E., Sheperd, L.A., Musher, D.M., Dang, B.N., Nasal methicillin-resistant Staphylococcus aureus polymerase chain reaction: a potential use in guiding antibiotic therapy for pneumonia. Perm J 19:1 (2015), 34–36.
16. [16] Langsjoen, J., Brady, C., Obenauf, E., Kellie, S., Nasal screening is useful in excluding methicillin-resistant Staphylococcus aureus in ventilator-associated pneumonia. Am J Infect Control 42:9 (2014), 1014–1015.
17. [17] Robicsek, A., Suseno, M., Beaumont, J.L., Thomson, R.B. Jr., Peterson, L.R., Prediction of methicillin-resistant Staphylococcus aureus involvement in disease sites by concomitant nasal sampling. J Clin Microbiol 46:2 (2008), 588–592.
18. [18] Hombach, M., Pfyffer, G.E., Roos, M., Lucke, K., Detection of methicillin-resistant Staphylococcus aureus (MRSA) in specimens from various body sites: performance characteristics of the BD GeneOhm MRSA assay, the Xpert MRSA assay, and broth-enriched culture in an area with a low prevalence of MRSA infections. J Clin Microbiol 48:11 (2010), 3882–3887.
19. [19] Kelley, P.G., Grabsch, E.A., Howden, B.P., Gao, W., Grayson, M.L., Comparison of the Xpert methicillin-resistant Staphylococcus aureus (MRSA) assay, BD GeneOhm MRSA assay, and culture for detection of nasal and cutaneous groin colonization by MRSA. J Clin Microbiol 47:11 (2009), 3769–3772.
20. [20] Andersen, B.M., Tollefsen, T., Seljordslia, B., Hochlin, K., Syversen, G., Jonassen, T.O., et al. Rapid MRSA test in exposed persons: costs and savings in hospitals. J Infect 60:4 (2010), 293–299.
21. [21] DiBardino, D.M., Wunderink, R.G., Aspiration pneumonia: a review of modern trends. J Crit Care 30:1 (2015), 40–48.
22. [22] Harris, P.A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., Conde, J.G., Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:2 (2009), 377–381.
23. [23] Mehta, R.L., Kellum, J.A., Shah, S.V., Molitoris, B.A., Ronco, C., Warnock, D.G., et al. Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit Care, 11(2), 2007, R31.
24. [24] Hoste, E.A., Clermont, G., Kersten, A., Venkataraman, R., Angus, D.C., De Bacquer, D., et al. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care, 10(3), 2006, R73, 10.1186/cc4915.
25. [25] Boyce, J.M., Pop, O.F., Abreu-Lanfranco, O., Hung, W.Y., Fisher, A., Karjoo, A., et al. A trial of discontinuation of empiric vancomycin therapy in patients with suspected methicillin-resistant Staphylococcus aureus health care-associated pneumonia. Antimicrob Agents Chemother 57:3 (2013), 1163–1168.
26. [26] Quartin, A.A., Scerpella, E.G., Puttagunta, S., Kett, D.H., A comparison of microbiology and demographics among patients with healthcare-associated, hospital-acquired, and ventilator-associated pneumonia: a retrospective analysis of 1184 patients from a large, international study. BMC Infect Dis, 13, 2013, 561, 10.1186/1471-2334-13-561.
27. [27] Pirracchio, R., Mateo, J., Raskine, L., Rigon, M.R., Lukaszewicz, A.C., Mebazaa, A., et al. Can bacteriological upper airway samples obtained at intensive care unit admission guide empiric antibiotherapy for ventilator-associated pneumonia?. Crit Care Med 37:9 (2009), 2559–2563.