Infantile spasms in Down syndrome: A good response to vitamin B6

Journal of Pediatric Neurology

Volumn 2, Issue 1, 2004, Pages 15-19

  Caraballo, Roberto H ^a   Cersósimo, Ricardo O ^a   Garro, Fernanda ^a   Kesler, Karina ^a   Fejerman, Natalio ^a  

^a HOSPITAL DE PEDIATRÍA PROF DR JUAN P GARRAHAN   (Argentina)

Author keywords

Down syndrome; Infantile spasms; Pyridoxine; Vitamin B6; West syndrome

Indexed keywords

EID: 85013587711     PISSN: 13042580     EISSN: 13050613     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Tatsuno M, Hayashi M, Iwamoto H, Suzuki Y, Kuroki Y. Epilepsy in childhood Down syndrome. Brain Dev 1984; 6: 37-44.
2. Tsuboi T. Epilepsy and chromosomal aberrations. Epilepsia 1974; 15: 637 (abstract).
3. Stafstrom CE, Konkol RJ. Infantile spasms in children with Down syndrome. Dev Med Child Neurol 1994; 36: 576-585.
4. Coriat LF, Fejerman N. Epilepsia en flexión generalizada en niños con trisomía 21. La semana médica en Pediatría 1969; 15: 493-500 (in French).
5. Pollack MA, Golden GS, Schmidt R, Davis JA, Leeds N. Infantile spasms in Down syndrome; a report of 5 cases and review of the literature. Ann Neurol 1978; 3: 406-408.
6. van Dyke DC, Lang DJ, Miller JD, Heide F, van Duyne S, Chang H. Common medical problems. In: van Dyke DC, Lang DC, Heide F, van Duyne S, Soucek MJ (eds). Clinical Perspectives in the Management of Down Syndrome. New York: Springer, 1990, pp 3-14.
7. Kurokawa T, Goya N, Fukuyama Y, Suzuki M, Seki T, Ohtahara S. West syndrome and Lennox-Gastaut syndrome: a survey of natural history. Pediatrics 1980; 65: 81-88.
8. Becker LE, Armstrong DL, Chan F. Dendritic atrophy in children with Down’s syndrome. Ann Neurol 1986; 20: 520-526.
9. Wisniewski KE, Schimdt-Sidor B. Myelinitation in Down’s syndrome brains (pre and post-natal maduration and some clinical-pathological correlations). Ann Neurol 1986; 20: 429-300.
10. Stafstrom CE. Epilepsy and Down syndrome: clinical aspects and possible mechanisms. Am J Ment Retard 1993; 98: 12-26.
11. Spies TD, Hightower DP, Hubbard IH. Some recent advances in vitamin therapy. J Ann Med Assoc 1940; 115: 292-297.
12. Ekelund H, Gamstorp I, Von Studnitz W. Apparent response of impaired development, minor motor epilepsy and ataxia to pyridoxine. Acta Paediatr Scand 1969; 58: 572-576.
13. Fox JT, Tullidge GM. Pyridoxine in epilepsy. Lancet 1946; 2: 345 (abstract).
14. Livingston S, Jeng MH, Petersen DC. Ineffectiveness of pyridoxine (vitamin B6) in treatment of epilepsy. Pediatrics 1955; 16: 250-251.
15. Baxter P. Vitamin Responsive Conditions in Paediatric Neurology. International Child Neurology Association: Mac Keith Press, 2001.
16. Ohtahara S, Ohtsuka Y, Yamatogi Y, Oka E. The early-infantile epileptic encephalopathy with suppression-bursts: developmental aspects. Brain Dev 1987; 9: 371-376.
17. Caraballo R, Cersósimo R, Arroyo H, Fejerman N. Síndrome de West sintomático: asociaciones etiológicas particulares con respuesta inesperada al tratamiento. Rev Neurol (Barc) 1998; 26: 372-375 (in Spanish).
18. Pollack MA, Golden GS, Schmidt R. Infantile spasms in Down syndrome: a report of 5 cases and review of the literature. Ann Neurol 1978; 3: 406-408.
19. Cassidy S, Gainey A, Holmes G. Infantile spasms in Down syndrome: an appreciated association. Am J Hum Genet 1983; 35: 82 (abstract).
20. Marks WA, Readen S, Wilson S. Infantile spasms in Down syndrome. Epilepsia 1990; 31: 664 (abstract).
21. Escofet C, Poo P, Valbuena O, Gassio R, Sanmarti FX. Campistol J. Infantile spasm in children with Down’s syndrome. Rev Neurol 1995; 23: 315-317 (in Spanish).
22. Romano C, Tiné A, Fazio G et al. Seizures in patients with trisomy 21. Am J Med Genet 1990; Suppl 7: 298-300.
23. Nabbout R, Melki I, Gerbaka B, Dulac O, Akatcherian C. Infantile spasms in Down syndrome: good response to a short course of vigabatrin. Epilepsia 2001; 42: 1580-1583.
24. Ohtsuka Y. Matsuda M, Ogino T. Kobayashi K. Ohtahara S. Treatment of West syndrome with high- dose pyridoxal phosphate. Brain Dev 1987; 9: 418-421.
25. Toribe Y. High-dose vitamin B6 treatment in West syndrome. Brain Dev 2001; 23: 654-657.
26. Blennow G, Starck L. High dose B6 treatment in infantile spasms. Neuropediatrics 1986; 17: 7-10.
27. Pietz J, Benninger C, Schafer H, Sontheimer D, Mittermaier G, Rating D. Treatment of infantile spasms with high-dosage vitamin B6. Epilepsia 1993; 34: 757-763.
28. Ohtsuka Y, Ogino T, Asano T, Hattori J, Ohta H, Oka E. Long-term follow up of vitamin B6-responsive West syndrome. Pediatr Neurol 2000; 23: 202-206.
29. Ito M, Mikawa H, Taniguchi T. Cerebrospinal fluid GABA levels in children with infantile spasms. Neurology 1984; 34: 235-238.
30. Kurlemann G, Deufel T, Schuierer G. Pyridoxine-responsive West syndrome and gamma-aminobutiric acid. Eur J Pediatr 1997; 156: 158-159.
31. Ito M, Okuno T, Hattori H, Fujii T, Mikawa H. Vitamin B6 and valproic acid in treatment of infantile spasms. Pediatr Neurol 1991; 7: 91-96.