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Volumn 79, Issue 3, 2017, Pages 569-578
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NC-6004 phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis
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Author keywords
Acute kidney injury; Cisplatin; Micelles; NC 6004; Population PK PD analysis
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Indexed keywords
ANTINEOPLASTIC AGENT;
CISPLATIN;
GEMCITABINE;
NC 6004;
UNCLASSIFIED DRUG;
ANTINEOPLASTIC ANTIMETABOLITE;
DEOXYCYTIDINE;
PLATINUM;
PLATINUM COMPLEX;
POLYGLUTAMIC ACID;
ADULT;
ADVANCED CANCER;
AGED;
ARTICLE;
CANCER COMBINATION CHEMOTHERAPY;
CANCER PATIENT;
CENTRAL VOLUME OF DISTRIBUTION;
CLINICAL EFFECTIVENESS;
DRUG TOLERABILITY;
FEMALE;
HUMAN;
HYPOKALEMIA;
IC50;
JAPANESE (PEOPLE);
LEUKOCYTE COUNT;
LEUKOPENIA;
MAJOR CLINICAL STUDY;
MALE;
MAXIMUM TOLERATED DOSE;
METABOLIC DISORDER;
MONOTHERAPY;
MULTIPLE CYCLE TREATMENT;
NEUTROPENIA;
NEUTROPHIL COUNT;
NUTRITIONAL DISORDER;
OPEN STUDY;
PATIENT SAFETY;
PERIPHERAL VOLUME OF DISTRIBUTION;
PHASE 1 CLINICAL TRIAL;
PRIORITY JOURNAL;
RECOMMENDED DRUG DOSE;
SIDE EFFECT;
SOLID MALIGNANT NEOPLASM;
THROMBOCYTOPENIA;
TREATMENT RESPONSE;
ACUTE KIDNEY FAILURE;
ANALOGS AND DERIVATIVES;
ASIAN CONTINENTAL ANCESTRY GROUP;
BLOOD;
CAUCASIAN;
CHEMICALLY INDUCED;
CLINICAL TRIAL;
DOSE RESPONSE;
GLOMERULUS FILTRATION RATE;
MIDDLE AGED;
NEOPLASMS;
PATHOPHYSIOLOGY;
YOUNG ADULT;
ACUTE KIDNEY INJURY;
ADULT;
AGED;
ANTIMETABOLITES, ANTINEOPLASTIC;
ANTINEOPLASTIC AGENTS;
ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS;
ASIAN CONTINENTAL ANCESTRY GROUP;
CISPLATIN;
DEOXYCYTIDINE;
DOSE-RESPONSE RELATIONSHIP, DRUG;
EUROPEAN CONTINENTAL ANCESTRY GROUP;
FEMALE;
GLOMERULAR FILTRATION RATE;
HUMANS;
MALE;
MAXIMUM TOLERATED DOSE;
MIDDLE AGED;
NEOPLASMS;
ORGANOPLATINUM COMPOUNDS;
PLATINUM;
POLYGLUTAMIC ACID;
YOUNG ADULT;
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EID: 85013391399
PISSN: 03445704
EISSN: 14320843
Source Type: Journal
DOI: 10.1007/s00280-017-3254-4 Document Type: Article |
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Times cited : (25)
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References (7)
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