MICA/IL-12: A novel bifunctional protein for killer cell activation

Oncology Reports

Volumn 37, Issue 3, 2017, Pages 1889-1895

  Tietje, Ashlee ^a   Yang, Xi ^b   Yu, Xianzhong ^b   Wei, Yanzhang ^b  

^a Southern Wesleyan University   (United States)

^b CLEMSON UNIVERSITY   (United States)

Author keywords

Bifunctional protein; Fusion gene; IL 12; Immunotherapy; MICA; NK cell; NKG2D

Indexed keywords

GAMMA INTERFERON; HYBRID PROTEIN; MHC CLASS I POLYPEPTIDE RELATED SEQUENCE A INTERLEUKIN 12 FUSION PROTEIN; NATURAL KILLER CELL RECEPTOR NKG2D; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 1; INTERLEUKIN 12; MESSENGER RNA; MHC CLASS I-RELATED CHAIN A; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K;

ARTICLE; CELL ENGINEERING; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; LUNG CARCINOMA; LYMPHOCYTE ACTIVATION; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; ANIMAL; APOPTOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG TUMOR; METABOLISM; MONONUCLEAR CELL; MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERLEUKIN-12; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LUNG NEOPLASMS; LYMPHOCYTE ACTIVATION; MICE; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 85013270553     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2017.5375     Document Type: Article

References (17)

1. Berke G: The binding and lysis of target cells by cytotoxic lymphocytes: Molecular and cellular aspects. Annu Rev Immunol 12: 735-773, 1994.
2. Salih HR, Rammensee H-G and Steinle A: Cutting edge: Downregulation of MICA on human tumors by proteolytic shedding. J Immunol 169: 4098-4102, 2002.
3. Dunn GP, Old LJ and Schreiber RD: The three Es of cancer immunoediting. Annu Rev Immunol 22: 329-360, 2004.
4. Robertson MJ, Soiffer RJ, Wolf SF, Manley TJ, Donahue C, Young D, Herrmann SH and Ritz J: Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): Cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J Exp Med 175: 779-788, 1992.
5. Zhu L, Zhao Z, Wei Y, Marcotte W Jr, Wagner TE and Yu X: An IL-12/Shh-C domain fusion protein-based IL-12 autocrine loop for sustained natural killer cell activation. Int J Oncol 41: 661-669, 2012.
6. Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M, Wolf SF and Gately MK: Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 178: 1223-1230, 1993.
7. Voest EE, Kenyon BM, O'Reilly MS, Truitt G, D'Amato RJ and Folkman J: Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst 87: 581-586, 1995.
8. Tietje A, Li J, Yu X and Wei Y: MULT1E/mIL-12: A novel bifunctional protein for natural killer cell activation. Gene Ther 21: 468-475, 2014.
9. Schoenhaut DS, Chua AO, Wolitzky AG, Quinn PM, Dwyer CM, McComas W, Familletti PC, Gately MK and Gubler U: Cloning and expression of murine IL-12. J Immunol 148: 3433-3440, 1992.
10. Halenius A, Gerke C and Hengel H: Classical and non-classical MHC I molecule manipulation by human cytomegalovirus: So many targets-but how many arrows in the quiver? Cell Mol Immunol 12: 139-153, 2015.
11. Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH and Spies T: Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci USA 96: 6879-6884, 1999.
12. Baltz KM, Krusch M, Baessler T, Schmiedel BJ, Bringmann A, Brossart P and Salih HR: Neutralization of tumor-derived soluble glucocorticoid-induced TNFR-related protein ligand increases NK cell anti-tumor reactivity. Blood 112: 3735-3743, 2008.
13. Liu C, Yu S, Zinn K, Wang J, Zhang L, Jia Y, Kappes JC, Barnes S, Kimberly RP, Grizzle WE, et al: Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J Immunol 176: 1375-1385, 2006.
14. Buggins AG, Milojkovic D, Arno MJ, Lea NC, Mufti GJ, Thomas NS and Hirst WJ: Microenvironment produced by acute myeloid leukemia cells prevents T cell activation and proliferation by inhibition of NF-kappaB, c-Myc, and pRb pathways. J Immunol 167: 6021-6030, 2001.
15. Urosevic M and Dummer R: HLA-G and IL-10 expression in human cancer-different stories with the same message. Semin Cancer Biol 13: 337-342, 2003.
16. Maki G, Klingemann HG, Martinson JA and Tam YK: Factors regulating the cytotoxic activity of the human natural killer cell line, NK-92. J Hematother Stem Cell Res 10: 369-383, 2001.
17. Jin L, Zeng X, Liu M, Deng Y and He N: Current progress in gene delivery technology based on chemical methods and nanocarriers. Theranostics 4: 240-255, 2014.