Synergistic antibacterial effect of apigenin with ß-lactam antibiotics and modulation of bacterial resistance by a possible membrane effect against methicillin resistant Staphylococcus aureus

Cellular and Molecular Biology

Volumn 62, Issue 14, 2016, Pages 74-82

  Akilandeswari, K ^a   Ruckmani, K ^a  

^a ANNA UNIVERSITY   (India)

Author keywords

Ampicillin; Apigenin; Ceftriaxone; Inner membrane permeability; Microbial resistance; MRSA; Outer membrane permeability assay; Synergistic activity

Indexed keywords

AMPICILLIN; APIGENIN; CEFTRIAXONE; ANTIINFECTIVE AGENT; BETA LACTAM;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL COUNT; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BROTH DILUTION; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL SHAPE; CHECKER BOARD METHOD; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INNER MEMBRANE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OUTER MEMBRANE; PENICILLIN RESISTANCE; PROCEDURES; SCANNING ELECTRON MICROSCOPY; TIME KILL ASSAY; TRANSMISSION ELECTRON MICROSCOPY; CELL WALL; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; ULTRASTRUCTURE;

AMPICILLIN; ANTI-BACTERIAL AGENTS; APIGENIN; BETA-LACTAMS; CEFTRIAXONE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL WALL; DRUG RESISTANCE, BACTERIAL; DRUG SYNERGISM; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 85013115095     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.14715/cmb/2016.62.14.13     Document Type: Article

References (23)

1. Snider J, Rivard B. Methicillin-resistant Staphylococcus aureus: A review of Current Antibiotic Therapy. Spectrum Health Grand Rapids Michigan 2012; pp.1-25.
2. Al-Talib HI, Yean CY, Al-Jashamy K, Hasan H. Methicillin-resistant Staphylococcus aureus nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007. Ann. Saudi. Med. 2007; 30(5): 358-63.
3. Ghaznavi-Rad E, Nor Shamsudin M, Sekawi Z, Khoon LY. Predominance and emergence of clones of hospital-acquired methicillin- resistant Staphylococcus aureus in Malaysia. J. of Clin. Microb. 2010; 48(3): 867-72.
4. Yothin T, Nongluk A, Sirichaiwetchakoon K, Krubphachaya P, Kupittayanant S, Eumkeb G. Synergistic activity and mechanism of action of Stephania suberosa Forman extract and Ampicillin combination against Ampicillin-resistant Staphylococcus aureus. J. of Biomed.Sci. 2014; 21: 90.
5. Issam AL-Ani, Stefan Z, Jurgen R, Michael W. Pharmacological synergism of bee venom and melittin with antibiotics and plant secondary metabolites against multi-drug resistant microbial pathogens. Phytomedicine 2015; 22:11.
6. Rasha AA, Hatil HA, Aisha ZA. Synergistic Antibacterial Interaction between Trachyspermum ammi, Senna alexandrina Mill and Vachellia nilotica spp. Nilotica Extract and Antibiotics. Pak. J. of Biol. Sci. 2015; 18 (3): 115-121.
7. Mun, SH, Joung DK, Kim YS, Kang OH, Kim SB, Seo YS et al. Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus. Phytomedicine 2013; 20: 714-8.
8. Alsaba F, Furqan A, Inshad AK, Abdul SS, Daljit SA, Bhahwal AS et al. Anti-staphylococcal and biofilm inhibitory activities of acetyl-11-keto-b -boswellic acid from Boswellia serrata. BMC Microbiology 2011; 11:54.
9. Tsao SH, Hsu CC, Yin MC. Garlic extract and two diallyl sulphides inhibit methicillin-resistant Staphylococcus aureus infection in BALB/c mice. J. of Antimicrob.Chemo. 2003; 52: 974-980.
10. Eumkeb G, Somnuk C. Synergistic activity and mechanism of action of ceftazidime and AP combination against ceftazidime- resistant Enterobacter cloacae. Phytomedicine 2013; 20: 262- 269.
11. Cappuccino J, Sherman N. Antimicrobial susceptibility procedure. In: Practical microbiology manual. 5th edn. New York, Benjamin/ Cummings Science Publishing 2002; 254-56.
12. Chou TC and Talalay P.Analysis of combined drug effects: A new look at a very old problem. Trends Pharmacol. Sci 1983; 450-454.
13. Devi KP, Arif Nisha S, Sakthivel R, Pandian SK. Eugenol (an essential oil of clove) acts as antibacterial agents against salmonella typhi by disrupting the cellular membrane. Journal of J.Ethnopharmacol. 2010; 130: 107-115.
14. Akilandeswari K, Ruckmani K. Antibacterial potentiality of antiulcer and antispasmodic drugs with selected antibiotics against methicillin resistant Staphylococcus aureus: In vitro and in silico studies. Bangladesh J Pharmacol 2015; 10: 875-883.
15. Abdi WS, Pharkphoom P. Synergistic effect of artocarpin on antibacterial activity of some antibiotics against methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pharm Biol 2015; 1-6.
16. Rathna C, Sayani M, Sauradip S, Sreedipa B, Sanjukta D, Hemanta K. Antimicrobial activity of Sesbania grandifolra flower polyphenol extracts on some pathogenic bacteria and growth stimulatory effect on the probiotic organism Lactobacillus acidophilus. Micobiol. Res. 2012; 167: 500-506.
17. Kamel C, Bochra K, Hanene J, Kacem M, Amina B. Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation. BMC Complement. Altern. Med. 2011; 11:29.
18. Tim Cushnie TP, Lamb AJ. Antimicrobial activity of flavonoids. Int. J. Antimicro. Ag. 2005; 26: 343-356.
19. Wu D, Kong Y, Han C, Chen J. d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int. J. Antimicro. Ag. 2008; 32: 421-426.
20. Eriksson M, Nielsen PE, Good L. Cell permeabilization and uptake of antisense peptide-peptide nucleic acid (PNA) into Escherichia coli. J. of Biol. Chem. 2002; 277: 7144-7147.
21. Eumkeb G, Siriwong S, Phitaktim S, Rojtinnakorn N. Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli. J. of App. Microb. 2012; 112: 55-64.
22. Eumkeb G, Siriwong S, Thumanu K. Synergistic activity of luteolin and amoxicillin combination against amoxicillin-resis-tant Escherichia coli and mode of action', J. of Photochem.Photo-biol.2012; 117: 247-253.
23. Ankur, G., Surabhi, M., Rajendra, S.: Evaluation of antimicrobial activity of Curcuma longa rhizome extract against Staphylococcus aureus. Biotechnology reports, 2015; 6: 51-55.