Residual renal function: a paradigm shift

Kidney International

Volumn 91, Issue 3, 2017, Pages 561-565

  Lowenstein, Jerome ^a   Grantham, Jared J ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

biomarkers of progression; chronic kidney disease; ESRD; hippurate clearance; indoxyl sulfate clearance; organic anion excretion; progressive renal disease

Indexed keywords

4 AMINOHIPPURIC ACID; 4 CRESOL SULFATE; CREATININE; HIPPURIC ACID; INDICAN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; UREA; UREMIC TOXIN; TOXIN;

ANION TRANSPORT; CONCENTRATION (PARAMETERS); CREATININE BLOOD LEVEL; DISEASE COURSE; GLOMERULUS FILTRATION RATE; HEMODIALYSIS PATIENT; HUMAN; KIDNEY INJURY; KIDNEY PLASMA FLOW; KIDNEY TUBULE ABSORPTION; KIDNEY TUMOR; NEPHRON; NONHUMAN; RENAL CLEARANCE; RESIDUAL RENAL FUNCTION; SHORT SURVEY; UREA BLOOD LEVEL; URINARY EXCRETION; ANIMAL; BLOOD; GLOMERULUS; HEMODIALYSIS; KIDNEY FAILURE, CHRONIC; METABOLISM; NOMENCLATURE; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; RENAL INSUFFICIENCY, CHRONIC; TREATMENT OUTCOME; UREMIA;

ANIMALS; DISEASE PROGRESSION; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY GLOMERULUS; PREDICTIVE VALUE OF TESTS; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC; TERMINOLOGY AS TOPIC; TOXINS, BIOLOGICAL; TREATMENT OUTCOME; UREMIA;

EID: 85012964508     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2016.09.052     Document Type: Short Survey

References (23)

1. 1 Shafi, T., Michels, W.M., Levey, A.S., et al. Estimating residual kidney function in dialysis patients without urine collection. Kidney Int 89 (2016), 1099–1110.
2. 2 Perl, J., Bargman, J.M., The importance of residual kidney function for patients on dialysis: a critical review. Am J Kidney Dis 53 (2009), 1068–1081.
3. 3 Termorshuizen, F., Dekker, F.W., van Manen, J.G., et al. Relative contribution of residual renal function and different measures of adequacy to survival in hemodialysis patients: an analysis of the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD)-2. J Am Soc Nephrol 15 (2004), 1061–1070.
4. 4 Eknoyan, G., Beck, G.J., Cheung, A.K., et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med 347 (2002), 2010–2019.
5. 5 Vanholder, R., De Smet, R., Glorieux, G., et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 63 (2003), 1934–1943.
6. 6 Meyer, T.W., Hostetter, T.H., Uremia. N Engl J Med 357 (2007), 1316–1325.
7. 7 Sekine, T., Miyazaki, H., Endou, H., Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol 290 (2006), F251–F261.
8. 8 Masereeuw, R., Mutsaers, H.A., Toyohara, T., et al. The kidney and uremic toxin removal: glomerulus or tubule?. Semin Nephrol 34 (2014), 191–208.
9. 9 Smith, H.W., The Kidney: Structure and Function in Health and Disease. 1951, Oxford University Press, New York, NY.
10. 10 Sirich, T.L., Aronov, P.A., Plummer, N.S., et al. Numerous protein-bound solutes are cleared by the kidney with high efficiency. Kidney Int 84 (2013), 585–590.
11. 11 Shannon, J.A., Renal tubular excretion. Physiol Rev 19 (1939), 63–93.
12. 12 Kojima, R., Sekine, T., Kawachi, M., et al. Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol 13 (2002), 848–857.
13. 13 Grantham, J.J., Qualizza, P.B., Irwin, R.L., Net fluid secretion in proximal straight renal tubules in vitro: role of PAH. Am J Physiol 226 (1974), 191–197.
14. 14 Grantham, J.J., Irwin, R.L., Qualizza, P.B., et al. Fluid secretion in isolated proximal straight renal tubules. Effect of human uremic serum. J Clin Invest 52 (1973), 2441–2450.
15. 15 Marquez, I.O., Tambra, S., Luo, F.Y., et al. Contribution of residual function to removal of protein-bound solutes in hemodialysis. Clin J Am Soc Nephrol 6 (2011), 290–296.
16. 16 Beyenbach, K.W., Kidneys sans glomeruli. Am J Physiol Renal Physiol 286 (2004), F811–F827.
17. 17 Aronov, P.A., Luo, F.J., Plummer, N.S., et al. Colonic contribution to uremic solutes. J Am Soc Nephrol 22 (2011), 1769–1776.
18. 18 Suchy-Dicey, A.M., Laha, T., Hoofnagle, A., et al. Tubular secretion in CKD. J Am Soc Nephrol 27 (2016), 2148–2155.
19. 19 Bricker, N.S., Morrin, P.A., Kime, S.W. Jr., The pathologic physiology of chronic Bright's disease. An exposition of the “intact nephron hypothesis”. Am J Med 28 (1960), 77–98.
20. 20 Torres, V.E., King, B.F., Chapman, A.B., et al. Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 2 (2007), 112–120.
21. 21 Lees, H.J., Swann, J.R., Wilson, I.D., et al. Hippurate: the natural history of a mammalian-microbial cometabolite. J Proteome Res 12 (2013), 1527–1546.
22. 22 Meijers, B., Glorieux, G., Poesen, R., Bakker, S.J., Nonextracorporeal methods for decreasing uremic solute concentration: a future way to go?. Semin Nephrol 34 (2014), 228–243.
23. 23 Smith, H.W., Lectures on the Kidney. Porter lecture series IX. 1943, Waverly Press, Baltimore, MD.