Radiotherapy induced Lewis lung cancer cell apoptosis via inactivating β-catenin mediated by upregulated HOTAIR

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 7, 2015, Pages 7878-7886

  Chen, Jianxiang ^a   Shen, Zhuping ^a   Zheng, Yuanda ^a   Wang, Shengye ^a   Mao, Weimin ^a  

^a ZHEJIANG CANCER HOSPITAL   (China)

Author keywords

Lewis lung cancer; Radiotherapy; WIF 1; Xenograft model; catenin

Indexed keywords

BETA CATENIN; CTNNB1 PROTEIN, MOUSE; HOTAIR LONG NON-CODING RNA, MOUSE; LONG UNTRANSLATED RNA; MESSENGER RNA; SCLEROPROTEIN; SIGNAL PEPTIDE; WIF1 PROTEIN, MOUSE;

ANIMAL; APOPTOSIS; C57BL MOUSE; CARCINOMA, LEWIS LUNG; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; MALE; METABOLISM; PATHOLOGY; RADIATION RESPONSE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR CELL LINE; TUMOR VOLUME; UPREGULATION;

ANIMALS; APOPTOSIS; BETA CATENIN; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE, INBRED C57BL; RNA INTERFERENCE; RNA, LONG NONCODING; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; UP-REGULATION;

EID: 85012960705     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Esposito L, Conti D, Ailavajhala R, Khalil N and Giordano A. Lung Cancer: Are we up to the Challenge? Curr Genomics 2010; 11: 513-518.
2. Amini A, Yeh N, Gaspar LE, Kavanagh B and Karam SD. Stereotactic body radiation therapy (SBRT) for lung cancer patients previously treated with conventional radiotherapy: a review. Radiat Oncol 2014; 9: 210.
3. He J, Hua J, Ding N, Xu S, Sun R, Zhou G, Xie X and Wang J. Modulation of microRNAs by ionizing radiation in human gastric cancer. Oncol Rep 2014; 32: 787-793.
4. Mao A, Liu Y, Zhang H, Di C and Sun C. microRNA expression and biogenesis in cellular response to ionizing radiation. DNA Cell Biol 2014; 33: 667-679.
5. Cellini F, Morganti AG, Genovesi D, Silvestris N and Valentini V. Role of microRNA in response to ionizing radiations: evidences and potential impact on clinical practice for radiotherapy. Molecules 2014; 19: 5379-5401.
6. Lipovich L, Johnson R and Lin CY. MacroRNA underdogs in a microRNA world: evolutionary, regulatory, and biomedical significance of ma-mmalian long non-protein-coding RNA. Bio-chim Biophys Acta 2010; 1799: 597-615.
7. Harries LW. Long non-coding RNAs and human disease. Biochem Soc Trans 2012; 40: 902-906.
8. Ma H, Rao L, Wang HL, Mao ZW, Lei RH, Yang ZY, Qing H and Deng YL. Transcriptome analysis of glioma cells for the dynamic response to gamma-irradiation and dual regulation of apo-ptosis genes: a new insight into radiotherapy for glioblastomas. Cell Death Dis 2013; 4: e895.
9. Lu L, Zhu G, Zhang C, Deng Q, Katsaros D, Mayne ST, Risch HA, Mu L, Canuto EM, Gregori G, Benedetto C and Yu H. Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer. Breast Cancer Res Treat 2012; 136: 875-883.
10. Ishibashi M, Kogo R, Shibata K, Sawada G, Takahashi Y, Kurashige J, Akiyoshi S, Sasaki S, Iwaya T, Sudo T, Sugimachi K, Mimori K, Wakabayashi G and Mori M. Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol Rep 2013; 29: 946-950.
11. Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S and Safe S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 2013; 32: 1616-1625.
12. Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S and Mori M. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res 2011; 71: 6320-6326.
13. Zhuang Y, Wang X, Nguyen HT, Zhuo Y, Cui X, Fewell C, Flemington EK and Shan B. Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen. J Hematol Oncol 2013; 6: 35.
14. Itoh N, Semba S, Ito M, Takeda H, Kawata S and Yamakawa M. Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 2002; 94: 3127-3134.
15. Shi X, Sun M, Liu H, Yao Y and Song Y. Long non-coding RNAs: a new frontier in the study of human diseases. Cancer Lett 2013; 339: 159-166.
16. Zhao W, An Y, Liang Y and Xie XW. Role of HOTAIR long noncoding RNA in metastatic progression of lung cancer. Eur Rev Med Phar-macol Sci 2014; 18: 1930-1936.
17. Ono H, Motoi N, Nagano H, Miyauchi E, Ushijima M, Matsuura M, Okumura S, Nishio M, Hirose T, Inase N and Ishikawa Y. Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer. Cancer Med 2014; 3: 632-642.
18. Liu Z, Sun M, Lu K, Liu J, Zhang M, Wu W, De W, Wang Z and Wang R. The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression. PL-oS One 2013; 8: e77293.
19. Nakagawa T, Endo H, Yokoyama M, Abe J, Tamai K, Tanaka N, Sato I, Takahashi S, Kondo T and Satoh K. Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. Biochem Biophys Res Commun 2013; 436: 319-324.
20. Wilusz JE, Freier SM and Spector DL. 3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell 2008; 135: 919-932.
21. Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB and Nathans J. A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 1999; 398: 431-436.
22. Li ZR, Wu YF, Ma CY, Nie SD, Mao XH and Shi YZ. Down-regulation of c-Myc expression inhibits the invasion of bile duct carcinoma cells. Cell Biol Int 2011; 35: 799-802.
23. Villar J, Cabrera NE, Valladares F, Casula M, Flores C, Blanch L, Quilez ME, Santana-Rodriguez N, Kacmarek RM and Slutsky AS. Activation of the Wnt/beta-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. PLoS One 2011; 6: e23914.
24. Zeilstra J, Joosten SP, Dokter M, Verwiel E, Spaargaren M and Pals ST. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res 2008; 68: 3655-3661.
25. Zhang J, Gill AJ, Issacs JD, Atmore B, Johns A, Delbridge LW, Lai R and McMullen TP. The Wnt/beta-catenin pathway drives increased cyclin D1 levels in lymph node metastasis in papillary thyroid cancer. Hum Pathol 2012; 43: 1044-1050.