Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes

Toxicology Letters

Volumn 270, Issue , 2017, Pages 12-16

  Kasteel, Emma E J ^a   Westerink, Remco H S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Acute reference dose (ARfD); Human risk assessment; Interspecies extrapolation; Marine neurotoxin; Tetrodotoxin (TTX)

Indexed keywords

TETRODOTOXIN; VOLTAGE GATED SODIUM CHANNEL; NEUROTOXIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; BODY WEIGHT; BRAIN CELL CULTURE; COCULTURE; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; LD50; MICROELECTRODE; NERVE CELL; NERVE CELL NETWORK; NERVE FIBER MEMBRANE POTENTIAL; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PLURIPOTENT STEM CELL; SYNAPTIC TRANSMISSION;

ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; LETHAL DOSE 50; NEURONS; NEUROTOXINS; PLURIPOTENT STEM CELLS; RATS; RISK ASSESSMENT; SYNAPTIC TRANSMISSION; TETRODOTOXIN; VOLTAGE-GATED SODIUM CHANNELS;

EID: 85012924926     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2017.02.014     Document Type: Article

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