A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers

Stem Cell Reports

Volumn 8, Issue 3, 2017, Pages 728-742

  Yang, Shi Yu ^a   Beavan, Michelle ^a   Chau, Kai Yin ^a   Taanman, Jan Willem ^a   Schapira, Anthony H V ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

ambroxol; chaperone; dopaminergic neurons; GBA1 mutation; GBA1 associated PD; glucocerebrosidase; neural crest stem cells; Parkinson disease; PD modeling; synuclein

Indexed keywords

ALPHA SYNUCLEIN; AMBROXOL; CHAPERONE; GLUCOSYLCERAMIDASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOPAMINERGIC NERVE CELL; GBA1 GENE; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROAUTOPHAGY; MUTATOR GENE; NEURAL CREST CELL; NEURAL STEM CELL; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ADIPOSE TISSUE; ANIMAL; AUTOPHAGY; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; EMBRYOLOGY; ENZYME ACTIVATION; GENETICS; METABOLISM; MOUSE; MUTATION; NEURAL CREST;

ADIPOSE TISSUE; ALPHA-SYNUCLEIN; AMBROXOL; ANIMALS; AUTOPHAGY; CELL DIFFERENTIATION; DOPAMINERGIC NEURONS; ENZYME ACTIVATION; GLUCOSYLCERAMIDASE; HETEROZYGOTE; HUMANS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MICE; MUTATION; NEURAL CREST; NEURAL STEM CELLS; PARKINSON DISEASE;

EID: 85012881393     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2017.01.011     Document Type: Article

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