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Volumn 10, Issue 2, 2016, Pages 216-225

Impact of new treatments on hospitalisation, surgery, infection, and mortality in IBD: A Focus paper by the epidemiology committee of ECCO

Author keywords

Anti Tumour necrosis factor; Cancer; Crohn s disease; Hospitalisation; Immunosuppressant therapy; Infections; Mortality; Surgery; Ulcerative colitis

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; BIOLOGICAL PRODUCT; CORTICOSTEROID; CYCLOSPORINE; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; NATALIZUMAB; PREDNISONE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR INHIBITOR; USTEKINUMAB;

EID: 85012179675     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1093/ecco-jcc/jjv190     Document Type: Review
Times cited : (98)

References (105)
  • 2
    • 85159728247 scopus 로고    scopus 로고
    • Epidemiology and Natural History Task Force of the International Organization for the Study of Inflammatory Bowel Disease [IOIBD]. Hospitalisations and surgery in Crohn s disease
    • Bernstein CN, Loftus EV Jr, Ng SC, Lakatos PL, Moum B. Epidemiology and Natural History Task Force of the International Organization for the Study of Inflammatory Bowel Disease [IOIBD]. Hospitalisations and surgery in Crohn s disease. Gut 2012;61:622 9.
    • (2012) Gut , vol.61 , pp. 6229
    • Bernstein, CN1    Loftus, EV2    Ng, SC3    Lakatos, PL4    Moum, B.5
  • 3
    • 85159728872 scopus 로고    scopus 로고
    • COIN study group and the Dutch Initiative on Crohn and Colitis. Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the COIN study
    • van der Valk ME, Mangen MJ, Leenders M, et al. COIN study group and the Dutch Initiative on Crohn and Colitis. Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the COIN study. Gut 2014;63:72 9.
    • (2014) Gut , vol.63 , pp. 729
    • van der Valk, ME1    Mangen, MJ2    Leenders, M3
  • 4
    • 84883855280 scopus 로고    scopus 로고
    • Cumulative incidence and risk factors for hospitalization and surgery in a population-based cohort of ulcerative colitis
    • 1858 66
    • Samuel S, Ingle SB, Dhillon S, , et al. Cumulative incidence and risk factors for hospitalization and surgery in a population-based cohort of ulcerative colitis. Inflamm Bowel Dis 2013;19:1858 66.
    • (2013) Inflamm Bowel Dis , vol.19
    • Samuel, S1    Ingle, SB2    Dhillon, S3
  • 5
    • 79960008583 scopus 로고    scopus 로고
    • Outcomes of patients with Crohn s disease improved from 1988 to 2008 and were associated with increased specialist care
    • Nguyen GC, Nugent Z, Shaw S, Bernstein CN. Outcomes of patients with Crohn s disease improved from 1988 to 2008 and were associated with increased specialist care. Gastroenterology 2011;141:90 7.
    • (2011) Gastroenterology , vol.141 , pp. 907
    • Nguyen, GC1    Nugent, Z2    Shaw, S3    Bernstein, CN.4
  • 6
    • 84918507762 scopus 로고    scopus 로고
    • Hospitalisation, surgical and medical recurrence rates in inflammatory bowel disease 2003 2011 a Danish population-based cohort study
    • Vester-Andersen MK, Vind I, Prosberg MV, et al. Hospitalisation, surgical and medical recurrence rates in inflammatory bowel disease 2003 2011 a Danish population-based cohort study. J Crohns Colitis 2014;8:1675 83.
    • (2014) J Crohns Colitis , vol.8 , pp. 1675-1683
    • Vester-Andersen, MK1    Vind, I2    Prosberg, MV3
  • 7
    • 34247489201 scopus 로고    scopus 로고
    • Trends in hospitalization rates for inflammatory bowel disease in the United States
    • Bewtra M, Su C, Lewis JD. Trends in hospitalization rates for inflammatory bowel disease in the United States. Clin Gastroenterol Hepatol 2007 5:597 601.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 597-601
    • Bewtra, M1    Su, C2    Lewis, JD.3
  • 8
    • 67650973622 scopus 로고    scopus 로고
    • Time trends in therapies and outcomes for adult inflammatory bowel disease, Northern California, 1998 2005
    • Herrinton LJ, Liu L, Fireman B, et al. Time trends in therapies and outcomes for adult inflammatory bowel disease, Northern California, 1998 2005. Gastroenterology 2009;137:502 11.
    • (2009) Gastroenterology , vol.137 , pp. 50211
    • Herrinton, LJ1    Liu, L2    Fireman, B3
  • 9
    • 84888368701 scopus 로고    scopus 로고
    • Trends in hospitalizations of children with inflammatory bowel disease within the United States from 2000 to 2009
    • Pant C, Anderson MP, Deshpande A, et al. Trends in hospitalizations of children with inflammatory bowel disease within the United States from 2000 to 2009. J Investig Med 2013;61:1036 8.
    • (2013) J Investig Med , vol.61 , pp. 10368
    • Pant, C1    Anderson, MP2    Deshpande, A3
  • 10
    • 84925829511 scopus 로고    scopus 로고
    • Increasing hospitalizations in inflammatory bowel disease among children in the United States, 1988 2011
    • Sandberg KC, Davis MM, Gebremariam A, Adler J. Increasing hospitalizations in inflammatory bowel disease among children in the United States, 1988 2011. Inflamm Bowel Dis 2014;20:1754 6.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 17546
    • Sandberg, KC1    Davis, MM2    Gebremariam, A3    Adler, J.4
  • 11
    • 84901466374 scopus 로고    scopus 로고
    • Rising hospitalization rates for inflammatory bowel disease in Poland
    • Jakubowski A, Zagorowicz E, Kraszewska E, Bartnik W. Rising hospitalization rates for inflammatory bowel disease in Poland. Pol Arch Med Wewn 2014;124:180 90.
    • (2014) Pol Arch Med Wewn , vol.124 , pp. 180-190
    • Jakubowski, A1    Zagorowicz, E2    Kraszewska, E3    Bartnik, W.4
  • 12
    • 84981238906 scopus 로고    scopus 로고
    • Hospital burden and gastrointestinal surgery in inflammatory bowel disease patients in Italy: A retrospective observational study
    • Meregaglia M, Banks H, Fattore G. Hospital burden and gastrointestinal surgery in inflammatory bowel disease patients in Italy: A retrospective observational study. J Crohns Colitis 2015;9:853 62.
    • (2015) J Crohns Colitis , vol.9 , pp. 853-862
    • Meregaglia, M1    Banks, H2    Fattore, G.3
  • 13
    • 84884577666 scopus 로고    scopus 로고
    • Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease: A systematic review and meta-Analysis
    • Costa J, Magro F, Caldeira D, Alarcao J, Sousa R, Vaz-Carneiro A. Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease: A systematic review and meta-Analysis. Inflamm Bowel Dis 2013;19:2098 110.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2098-2110
    • Costa, J1    Magro, F2    Caldeira, D3    Alarcao, J4    Sousa, R5    Vaz-Carneiro, A.6
  • 14
    • 0030954732 scopus 로고    scopus 로고
    • A short-Term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn s disease. Crohn s Disease cA2 Study Group
    • Targan SR, Hanauer SB, van Deventer SJ et al. A short-Term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn s disease. Crohn s Disease cA2 Study Group. N Engl J Med 1997;337:1029 35.
    • (1997) N Engl J Med , vol.337 , pp. 102935
    • Targan, SR1    Hanauer, SB2    van Deventer, SJ3
  • 15
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn s disease: The ACCENT I randomized trial
    • Hanauer SB, Feagan BG, Lichtenstein GR, et al; ACCENT I Study Group. Maintenance infliximab for Crohn s disease: The ACCENT I randomized trial. Lancet 2002;359:1541 9.
    • (2002) Lancet , vol.359 , pp. 15419
    • Hanauer, SB1    Feagan, BG2    Lichtenstein, GR3
  • 16
    • 10744224387 scopus 로고    scopus 로고
    • Comparison of scheduled and episodic treatment strategies of infliximab in Crohn s disease
    • Rutgeerts P, Feagan BG, Lichtenstein GR, et al. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn s disease. Gastroenterology 2004;126:402 13.
    • (2004) Gastroenterology , vol.126 , pp. 40213
    • Rutgeerts, P1    Feagan, BG2    Lichtenstein, GR3
  • 17
    • 10744221312 scopus 로고    scopus 로고
    • Infliximab maintenance therapy for fistulizing Crohn s disease
    • Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn s disease. N Engl J Med 2004;350:876 85.
    • (2004) N Engl J Med , vol.350 , pp. 876-885
    • Sands, BE1    Anderson, FH2    Bernstein, CN3
  • 18
    • 17144388945 scopus 로고    scopus 로고
    • Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn s disease
    • Lichtenstein GR, Yan S, Bala M, Blank M, Sands BE. Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn s disease. Gastroenterology 2005;128:862 9.
    • (2005) Gastroenterology , vol.128 , pp. 8629
    • Lichtenstein, GR1    Yan, S2    Bala, M3    Blank, M4    Sands, BE.5
  • 19
    • 77957226063 scopus 로고    scopus 로고
    • Clinical trial: colectomy after rescue therapy in ulcerative colitis-3-year follow-up of the Swedish-Danish controlled infliximab study
    • Gustavsson A, Jarnerot G, Hertervig E, et al. Clinical trial: colectomy after rescue therapy in ulcerative colitis-3-year follow-up of the Swedish-Danish controlled infliximab study. Aliment Pharmacol Ther 2010;32:984 9.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 9849
    • Gustavsson, A1    Jarnerot, G2    Hertervig, E3
  • 20
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005;353:2462 76.
    • (2005) N Engl J Med , vol.353 , pp. 246276
    • Rutgeerts, P1    Sandborn, WJ2    Feagan, BG3
  • 21
    • 70349418632 scopus 로고    scopus 로고
    • Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab
    • Sandborn WJ, Rutgeerts P, Feagan BG, et al. Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab. Gastroenterology 2009;137:1250 60.
    • (2009) Gastroenterology , vol.137 , pp. 1250-1260
    • Sandborn, WJ1    Rutgeerts, P2    Feagan, BG3
  • 22
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn s disease: The CHARM trial
    • Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn s disease: The CHARM trial. Gastroenterology 2007;132:52 65.
    • (2007) Gastroenterology , vol.132 , pp. 52-65
    • Colombel, JF1    Sandborn, WJ2    Rutgeerts, P3
  • 23
    • 77952748486 scopus 로고    scopus 로고
    • Adalimumab sustains clinical remission and overall clinical benefit after 2 years of therapy for Crohn s disease
    • Panaccione R, Colombel JF, Sandborn WJ, et al. Adalimumab sustains clinical remission and overall clinical benefit after 2 years of therapy for Crohn s disease. Aliment Pharmacol Ther 2010;31:1296 309.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 1296-1309
    • Panaccione, R1    Colombel, JF2    Sandborn, WJ3
  • 24
    • 79959952608 scopus 로고    scopus 로고
    • Adalimumab sustains steroid-free remission after 3 years of therapy for Crohn s disease
    • Kamm MA, Hanauer SB, Panaccione R, et al. Adalimumab sustains steroid-free remission after 3 years of therapy for Crohn s disease. Aliment Pharmacol Ther 2011;34:306 17.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 30617
    • Kamm, MA1    Hanauer, SB2    Panaccione, R3
  • 25
    • 84862777782 scopus 로고    scopus 로고
    • EXTEND Investigators. Adalimumab induces and maintains mucosal healing in patients with Crohn s disease: data from the EXTEND trial
    • 1
    • Rutgeerts P1, Van Assche G, Sandborn WJ, et al. EXTEND Investigators. Adalimumab induces and maintains mucosal healing in patients with Crohn s disease: data from the EXTEND trial. Gastroenterology. 2012;142:1102 11.
    • (2012) Gastroenterology , vol.142 , pp. 110211
    • Rutgeerts, P1    Van Assche, G2    Sandborn, WJ3
  • 26
    • 84890688226 scopus 로고    scopus 로고
    • Adalimumab therapy is associated with reduced risk of hospitalization in patients with ulcerative colitis
    • Feagan BG, Sandborn WJ, Lazar A, et al. Adalimumab therapy is associated with reduced risk of hospitalization in patients with ulcerative colitis. Gastroenterology 2014;146:110 8.
    • (2014) Gastroenterology , vol.146 , pp. 1108
    • Feagan, BG1    Sandborn, WJ2    Lazar, A3
  • 27
    • 63849101007 scopus 로고    scopus 로고
    • Long-Term outcome of treatment with infliximab in 614 patients with Crohn s disease: results from a single centre cohort
    • Schnitzler F, Fidder H, Ferrante M, et al. Long-Term outcome of treatment with infliximab in 614 patients with Crohn s disease: results from a single centre cohort. Gut 2009;58:492 500.
    • (2009) Gut , vol.58 , pp. 492-500
    • Schnitzler, F1    Fidder, H2    Ferrante, M3
  • 28
    • 73949091371 scopus 로고    scopus 로고
    • Adherence to infliximab maintenance therapy and health care utilization and costs by Crohn s disease patients
    • Kane SV, Chao J, Mulani PM. Adherence to infliximab maintenance therapy and health care utilization and costs by Crohn s disease patients. Adv Ther 2009;26:936 46.
    • (2009) Adv Ther , vol.26 , pp. 936-946
    • Kane, SV1    Chao, J2    Mulani, PM.3
  • 29
    • 78649893669 scopus 로고    scopus 로고
    • A multicenter experience with infliximab for ulcerative colitis: outcomes and predictors of response, optimization, colectomy, and hospitalization
    • Oussalah A, Evesque L, Laharie D, et al. A multicenter experience with infliximab for ulcerative colitis: outcomes and predictors of response, optimization, colectomy, and hospitalization. Am J Gastroenterol 2010;105:2617 25.
    • (2010) Am J Gastroenterol , vol.105 , pp. 261725
    • Oussalah, A1    Evesque, L2    Laharie, D3
  • 30
    • 78449289970 scopus 로고    scopus 로고
    • Costs of care for Crohn s disease following the introduction of infliximab: A single-centre UK experience
    • Sprakes MB, Ford AC, Suares NC, et al. Costs of care for Crohn s disease following the introduction of infliximab: A single-centre UK experience. Aliment Pharmacol Ther 2010;32:1357 63.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 1357-1363
    • Sprakes, MB1    Ford, AC2    Suares, NC3
  • 31
    • 79960746475 scopus 로고    scopus 로고
    • Hospitalization and surgical rates in patients with Crohn s disease treated with infliximab: A matched analysis
    • Leombruno JP, Nguyen GC, Grootendorst P, Juurlink D, Einarson T. Hospitalization and surgical rates in patients with Crohn s disease treated with infliximab: A matched analysis. Pharmacoepidemiol Drug Saf 2011;20:838 48.
    • (2011) Pharmacoepidemiol Drug Saf , vol.20 , pp. 838-848
    • Leombruno, JP1    Nguyen, GC2    Grootendorst, P3    Juurlink, D4    Einarson, T.5
  • 32
    • 82455164284 scopus 로고    scopus 로고
    • Impact of infliximab adherence on Crohn s disease-related healthcare utilization and inpatient costs
    • Carter CT, Waters HC, Smith DB. Impact of infliximab adherence on Crohn s disease-related healthcare utilization and inpatient costs. Adv Ther 2011;28:671 83.
    • (2011) Adv Ther , vol.28 , pp. 671-683
    • Carter, CT1    Waters, HC2    Smith, DB.3
  • 33
    • 80054724965 scopus 로고    scopus 로고
    • Health care resource use and costs in Crohn s disease before and after infliximab therapy
    • Loomes DE, Teshima C, Jacobs P, Fedorak RN. Health care resource use and costs in Crohn s disease before and after infliximab therapy. Can J Gastroenterol 2011;25:497 502.
    • (2011) Can J Gastroenterol , vol.25 , pp. 497-502
    • Loomes, DE1    Teshima, C2    Jacobs, P3    Fedorak, RN.4
  • 34
    • 84856028560 scopus 로고    scopus 로고
    • Resource utilization before and during infliximab therapy in patients with inflammatory bowel disease
    • Waters HC, Vanderpoel JE, Nejadnik B, et al. Resource utilization before and during infliximab therapy in patients with inflammatory bowel disease. J Med Econ 2012;15:45 52.
    • (2012) J Med Econ , vol.15 , pp. 45-52
    • Waters, HC1    Vanderpoel, JE2    Nejadnik, B3
  • 35
    • 84884352968 scopus 로고    scopus 로고
    • Dual therapy with infliximab and immunomodulator reduces one-year rates of hospitalization and surgery among veterans with inflammatory bowel disease
    • Abraham NS, Richardson P, Castillo D, Kane SV. Dual therapy with infliximab and immunomodulator reduces one-year rates of hospitalization and surgery among veterans with inflammatory bowel disease. Clin Gastroenterol Hepatol 2013;11:1281 7.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 12817
    • Abraham, NS1    Richardson, P2    Castillo, D3    Kane, SV.4
  • 36
    • 84905465791 scopus 로고    scopus 로고
    • Utilization trends of anti-TNF agents and health outcomes in adults and children with inflammatory bowel diseases: A single-center experience
    • Park KT, Sin A, Wu M, Bass D, Bhattacharya J. Utilization trends of anti-TNF agents and health outcomes in adults and children with inflammatory bowel diseases: A single-center experience. Inflamm Bowel Dis 2014;20:1242 9.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 12429
    • Park, KT1    Sin, A2    Wu, M3    Bass, D4    Bhattacharya, J.5
  • 37
    • 84908220857 scopus 로고    scopus 로고
    • Decreasing trends in hospitalizations during anti-TNF therapy are associated with time to anti-TNF therapy: Results from two referral centres
    • Mandel MD, Balint A, Golovics PA, et al. Decreasing trends in hospitalizations during anti-TNF therapy are associated with time to anti-TNF therapy: Results from two referral centres. Dig Liver Dis 2014;46:985 90.
    • (2014) Dig Liver Dis , vol.46 , pp. 985-990
    • Mandel, MD1    Balint, A2    Golovics, PA3
  • 38
    • 84973444990 scopus 로고    scopus 로고
    • Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort
    • Vegh Z, Burisch J, Pedersen N, et al. Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort. J Crohns Colitis 2015;9:747 53.
    • (2015) J Crohns Colitis , vol.9 , pp. 747-753
    • Vegh, Z1    Burisch, J2    Pedersen, N3
  • 39
    • 0026761751 scopus 로고
    • Colorectal cancer risk and mortality in patients with ulcerative colitis
    • Langholz E, Munkholm P, Davidsen M, Binder V. Colorectal cancer risk and mortality in patients with ulcerative colitis. Gastroenterology 1992;103:1444 51.
    • (1992) Gastroenterology , vol.103 , pp. 144451
    • Langholz, E1    Munkholm, P2    Davidsen, M3    Binder, V.4
  • 40
    • 0027131566 scopus 로고
    • Intestinal cancer risk and mortality in patients with Crohn s disease
    • Munkholm P, Langholz E, Davidsen M, Binder V. Intestinal cancer risk and mortality in patients with Crohn s disease. Gastroenterology 1993;105:1716 23.
    • (1993) Gastroenterology , vol.105 , pp. 171623
    • Munkholm, P1    Langholz, E2    Davidsen, M3    Binder, V.4
  • 41
    • 80855131631 scopus 로고    scopus 로고
    • Pediatric inflammatory bowel disease: increasing incidence, decreasing surgery rate, and compromised nutritional status: A prospective population-based cohort study 2007 2009
    • Jakobsen C, Paerregaard A, Munkholm P, et al. Pediatric inflammatory bowel disease: increasing incidence, decreasing surgery rate, and compromised nutritional status: A prospective population-based cohort study 2007 2009. Inflamm Bowel Dis 2011;17:2541 50.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 2541-2550
    • Jakobsen, C1    Paerregaard, A2    Munkholm, P3
  • 42
    • 33744783677 scopus 로고    scopus 로고
    • Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003 2005: A population-based study from the Danish Crohn colitis database
    • Vind I, Riis L, Jess T, et al.; DCCD study group. Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003 2005: A population-based study from the Danish Crohn colitis database. Am J Gastroenterol 2006;101:1274 82.
    • (2006) Am J Gastroenterol , vol.101 , pp. 1274-1282
    • Vind, I1    Riis, L2    Jess, T3
  • 43
    • 84899907895 scopus 로고    scopus 로고
    • Disease course and surgery rates in inflammatory bowel disease: A population-based, 7-year follow-up study in the era of immunomodulating therapy
    • Vester-Andersen MK, Prosberg MV, Jess T, et al. Disease course and surgery rates in inflammatory bowel disease: A population-based, 7-year follow-up study in the era of immunomodulating therapy Am J Gastroenterol 2014;109:705 14.
    • (2014) Am J Gastroenterol , vol.109 , pp. 70514
    • Vester-Andersen, MK1    Prosberg, MV2    Jess, T3
  • 44
    • 84869456003 scopus 로고    scopus 로고
    • Strategies for the care of adults hospitalized for active ulcerative colitis
    • Pola S, Patel D, Ramamoorthy S, et al. Strategies for the care of adults hospitalized for active ulcerative colitis. Clin Gastroenterol Hepatol 2012;10:1315 25.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 1315-1325
    • Pola, S1    Patel, D2    Ramamoorthy, S3
  • 45
    • 20444479336 scopus 로고    scopus 로고
    • Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: A randomized, placebocontrolled study
    • Jarnerot G, Hertervig E, Friis-Liby I, et al. Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: A randomized, placebocontrolled study. Gastroenterology 2005;128:1805 11.
    • (2005) Gastroenterology , vol.128 , pp. 180511
    • Jarnerot, G1    Hertervig, E2    Friis-Liby, I3
  • 46
    • 80053130407 scopus 로고    scopus 로고
    • Early mucosal healing with infliximab is associated with improved long-Term clinical outcomes in ulcerative colitis
    • Colombel JF, Rutgeerts P, Reinisch W. Early mucosal healing with infliximab is associated with improved long-Term clinical outcomes in ulcerative colitis. Gastroenterology 2011;141:1194 201.
    • (2011) Gastroenterology , vol.141 , pp. 1194-1201
    • Colombel, JF1    Rutgeerts, P2    Reinisch, W.3
  • 47
    • 84923922038 scopus 로고    scopus 로고
    • Risk factors for repetitive ileocolic resection in patients with Crohn s disease: results of an observational cohort study
    • Investigators of the Swiss IBD Cohort Study
    • Manser CN, Frei P, Grandinetti T, et al.; Investigators of the Swiss IBD Cohort Study. Risk factors for repetitive ileocolic resection in patients with Crohn s disease: results of an observational cohort study. Inflamm Bowel Dis 2014;20:1548 54.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 1548-1554
    • Manser, CN1    Frei, P2    Grandinetti, T3
  • 48
    • 84905509865 scopus 로고    scopus 로고
    • Early use of thiopurines or methotrexate reduces major abdominal and perianal surgery in Crohn s disease
    • Kariyawasam VC, Selinger CP, Katelaris PH, et al. Early use of thiopurines or methotrexate reduces major abdominal and perianal surgery in Crohn s disease. Inflamm Bowel Dis 2014;20:1382 90.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 1382-1390
    • Kariyawasam, VC1    Selinger, CP2    Katelaris, PH3
  • 49
    • 84884352968 scopus 로고    scopus 로고
    • Dual therapy with infliximab and immunomodulator reduces one-year rates of hospitalization and surgery among veterans with inflammatory bowel disease
    • Abraham NS, Richardson P, Castillo D, Kane SV. Dual therapy with infliximab and immunomodulator reduces one-year rates of hospitalization and surgery among veterans with inflammatory bowel disease. Clin Gastroenterol Hepatol 2013;11:1281 7.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 12817
    • Abraham, NS1    Richardson, P2    Castillo, D3    Kane, SV.4
  • 50
    • 84881546979 scopus 로고    scopus 로고
    • Incidence and natural history of ulcerative colitis in the Uppsala Region of Sweden 2005 2009-results from the IBD cohort of the Uppsala Region [ICURE]
    • Sjoberg D, Holmstrom T, Larsson M, et al. Incidence and natural history of ulcerative colitis in the Uppsala Region of Sweden 2005 2009-results from the IBD cohort of the Uppsala Region [ICURE]. J Crohns Colitis 2013;7:351 7.
    • (2013) J Crohns Colitis , vol.7 , pp. 3517
    • Sjoberg, D1    Holmstrom, T2    Larsson, M3
  • 51
    • 84864593946 scopus 로고    scopus 로고
    • The epidemiology of colectomy in ulcerative colitis: results from a population-based cohort
    • Targownik LE, Singh H, Nugent Z, Bernstein CN. The epidemiology of colectomy in ulcerative colitis: results from a population-based cohort. Am J Gastroenterol 2012;107:1228 35.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1228-1235
    • Targownik, LE1    Singh, H2    Nugent, Z3    Bernstein, CN.4
  • 52
    • 84907719849 scopus 로고    scopus 로고
    • Changes in medical treatment and surgery rates in inflammatory bowel disease: A nationwide cohort study 1979 2011
    • Rungoe C, Langholz E, Andersson M, et al. Changes in medical treatment and surgery rates in inflammatory bowel disease: A nationwide cohort study 1979 2011. Gut 2014;63:1607 16.
    • (2014) Gut , vol.63 , pp. 160716
    • Rungoe, C1    Langholz, E2    Andersson, M3
  • 53
    • 84936980921 scopus 로고    scopus 로고
    • Association between tumour necrosis factor-α inhibitors and risk of serious infections in people with inflammatory bowel disease: nationwide Danish cohort study
    • Nyboe Andersen N, Pasternak B, Friis-Moller N, Andersson M, Jess T. Association between tumour necrosis factor-α inhibitors and risk of serious infections in people with inflammatory bowel disease: nationwide Danish cohort study. BMJ 2015;350:h2809.
    • (2015) BMJ , vol.350 , pp. h2809
    • Nyboe Andersen, N1    Pasternak, B2    Friis-Moller, N3    Andersson, M4    Jess, T.5
  • 54
    • 84866122837 scopus 로고    scopus 로고
    • Serious infection and mortality in patients with Crohn s disease: more than 5 years of follow-up in the TREAT registry
    • Lichtenstein GR, Feagan BG, Cohen RD, et al. Serious infection and mortality in patients with Crohn s disease: more than 5 years of follow-up in the TREAT registry. Am J Gastroenterol 2012;107:1409 22.
    • (2012) Am J Gastroenterol , vol.107 , pp. 140922
    • Lichtenstein, GR1    Feagan, BG2    Cohen, RD3
  • 55
    • 41349088375 scopus 로고    scopus 로고
    • Risk factors for opportunistic infections in patients with inflammatory bowel disease
    • Toruner M, Loftus EV, Harmsen WS, et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology 2008;134:929 36.
    • (2008) Gastroenterology , vol.134 , pp. 92936
    • Toruner, M1    Loftus, EV2    Harmsen, WS3
  • 56
    • 84878109302 scopus 로고    scopus 로고
    • A prospective analysis of the incidence of and risk factors for opportunistic infections in patients with inflammatory bowel disease
    • Naganuma M, Kunisaki R, Yoshimura N, Takeuchi Y, Watanabe M. A prospective analysis of the incidence of and risk factors for opportunistic infections in patients with inflammatory bowel disease. J Gastroenterol 2013;48:595 600.
    • (2013) J Gastroenterol , vol.48 , pp. 595-600
    • Naganuma, M1    Kunisaki, R2    Yoshimura, N3    Takeuchi, Y4    Watanabe, M.5
  • 57
    • 84964312661 scopus 로고    scopus 로고
    • Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biological ThERapy [SABER] study
    • Baddley JW, Winthrop KL, Chen L, et al. Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biological ThERapy [SABER] study. Ann Rheum. Dis 2014;73:1942 8.
    • (2014) Ann Rheum. Dis , vol.73 , pp. 19428
    • Baddley, JW1    Winthrop, KL2    Chen, L3
  • 58
    • 83055173186 scopus 로고    scopus 로고
    • Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseases
    • Grijalva CG, Chen L, Delzell E, et al. Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseases. JAMA 2011;306:2331 9.
    • (2011) JAMA , vol.306 , pp. 23319
    • Grijalva, CG1    Chen, L2    Delzell, E3
  • 59
    • 84874748525 scopus 로고    scopus 로고
    • Association between the initiation of anti-Tumor necrosis factor therapy and the risk of herpes zoster
    • Winthrop KL, Baddley JW, Chen L, et al. Association between the initiation of anti-Tumor necrosis factor therapy and the risk of herpes zoster. JAMA 2013;309:887 95.
    • (2013) JAMA , vol.309 , pp. 887-895
    • Winthrop, KL1    Baddley, JW2    Chen, L3
  • 60
    • 67650430007 scopus 로고    scopus 로고
    • Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections
    • Schneeweiss S, Korzenik J, Solomon DH, Canning C, Lee J, Bressler B. Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections. Aliment Pharmacol Ther 2009;30:253 64.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 253-264
    • Schneeweiss, S1    Korzenik, J2    Solomon, DH3    Canning, C4    Lee, J5    Bressler, B.6
  • 61
    • 78649661962 scopus 로고    scopus 로고
    • Advanced age is an independent risk factor for severe infections and mortality in patients given anti-Tumor necrosis factor therapy for inflammatory bowel disease
    • Cottone M, Kohn A, Daperno M, et al. Advanced age is an independent risk factor for severe infections and mortality in patients given anti-Tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol 2011;9:30 5.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 305
    • Cottone, M1    Kohn, A2    Daperno, M3
  • 62
    • 84881187537 scopus 로고    scopus 로고
    • Opportunistic infections with anti-Tumor necrosis factor-α therapy in inflammatory bowel disease: meta-Analysis of randomized controlled trials
    • Ford AC, Peyrin-Biroulet L. Opportunistic infections with anti-Tumor necrosis factor-α therapy in inflammatory bowel disease: meta-Analysis of randomized controlled trials. Am J Gastroenterol 2013;108:1268 76.
    • (2013) Am J Gastroenterol , vol.108 , pp. 1268-1276
    • Ford, AC1    Peyrin-Biroulet, L.2
  • 63
    • 44649187924 scopus 로고    scopus 로고
    • Efficacy and safety of tumor necrosis factor antagonists in Crohn s disease: meta-Analysis of placebo-controlled trials
    • Peyrin-Biroulet L, Deltenre P, de Suray N, Branche J, Sandborn WJ, Colombel JF. Efficacy and safety of tumor necrosis factor antagonists in Crohn s disease: meta-Analysis of placebo-controlled trials. Clin Gastroenterol Hepatol 2008;6:644 53.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 64453
    • Peyrin-Biroulet, L1    Deltenre, P2    de Suray, N3    Branche, J4    Sandborn, WJ5    Colombel, JF.6
  • 64
    • 84863724798 scopus 로고    scopus 로고
    • A pooled analysis of infections, malignancy, and mortality in infliximab-and immunomodulator-treated adult patients with inflammatory bowel disease
    • Lichtenstein GR, Rutgeerts P, Sandborn WJ, et al. A pooled analysis of infections, malignancy, and mortality in infliximab-and immunomodulator-treated adult patients with inflammatory bowel disease. Am J Gastroenterol 2012;107:1051 63.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1051-1063
    • Lichtenstein, GR1    Rutgeerts, P2    Sandborn, WJ3
  • 65
    • 84886770149 scopus 로고    scopus 로고
    • Elevated risk of opportunistic viral infection in patients with Crohn s disease during biological therapies: A meta analysis of randomized controlled trials
    • Wang X, Zhou F, Zhao J, et al. Elevated risk of opportunistic viral infection in patients with Crohn s disease during biological therapies: A meta analysis of randomized controlled trials. Eur J Clin Pharmacol 2013;69:1891 9.
    • (2013) Eur J Clin Pharmacol , vol.69 , pp. 18919
    • Wang, X1    Zhou, F2    Zhao, J3
  • 66
    • 70349707016 scopus 로고    scopus 로고
    • Adalimumab safety in global clinical trials of patients with Crohn s disease
    • Colombel JF, Sandborn WJ, Panaccione R, et al. Adalimumab safety in global clinical trials of patients with Crohn s disease. Inflamm Bowel Dis 2009;15:1308 19.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 130819
    • Colombel, JF1    Sandborn, WJ2    Panaccione, R3
  • 67
    • 80955130782 scopus 로고    scopus 로고
    • Meta-Analysis: efficacy and safety of combination therapy of infliximab and immunosuppressives for Crohn s disease
    • Lin Z, Bai Y, Zheng P. Meta-Analysis: efficacy and safety of combination therapy of infliximab and immunosuppressives for Crohn s disease. Eur J Gastroenterol Hepatol 2011;23:1100 10.
    • (2011) Eur J Gastroenterol Hepatol , vol.23 , pp. 110010
    • Lin, Z1    Bai, Y2    Zheng, P.3
  • 68
    • 67650462325 scopus 로고    scopus 로고
    • Clinical trial: benefits and risks of immunomodulators and maintenance infliximab for IBDsubgroup analyses across four randomized trials
    • Lichtenstein GR, Diamond RH, Wagner CL, et al. Clinical trial: benefits and risks of immunomodulators and maintenance infliximab for IBDsubgroup analyses across four randomized trials. Aliment Pharmacol Ther 2009;30:210 26.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 210-226
    • Lichtenstein, GR1    Diamond, RH2    Wagner, CL3
  • 69
    • 84931371979 scopus 로고    scopus 로고
    • Effectiveness and safety of immunomodulators with anti-Tumor necrosis factor therapy in Crohn s Disease
    • Osterman MT, Haynes K, Delzell E, et al. Effectiveness and safety of immunomodulators with anti-Tumor necrosis factor therapy in Crohn s Disease. Clin Gastroenterol Hepatol 2015;13:1293-301.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 1293-1301
    • Osterman, MT1    Haynes, K2    Delzell, E3
  • 70
    • 0001032953 scopus 로고
    • The sigmoidoscopic picture of chronic ulcerativecolitis [non-specific]
    • Crohn BB, Rosenberg H. The sigmoidoscopic picture of chronic ulcerativecolitis [non-specific]. Am J Med Sci 1925;170:220 8.
    • (1925) Am J Med Sci , vol.170 , pp. 2208
    • Crohn, BB1    Rosenberg, H.2
  • 71
    • 84888269838 scopus 로고    scopus 로고
    • American Gastroenterological Association Institute technical review on the use of thiopurines, methotrexate, and anti-TNF-α biologic drugs for the induction and maintenance of remission in inflammatory Crohn s disease
    • Dassopoulos T, Sultan S, Falck-Ytter YT, et al. American Gastroenterological Association Institute technical review on the use of thiopurines, methotrexate, and anti-TNF-α biologic drugs for the induction and maintenance of remission in inflammatory Crohn s disease. Gastroenterology 2013;145:1464 7.
    • (2013) Gastroenterology , vol.145 , pp. 14647
    • Dassopoulos, T1    Sultan, S2    Falck-Ytter, YT3
  • 72
    • 53849115754 scopus 로고    scopus 로고
    • PTCH mutations in basal cell carcinomas from azathioprine-Treated organ transplant recipients
    • Harwood CA, Attard NR, O Donovan P et al. PTCH mutations in basal cell carcinomas from azathioprine-Treated organ transplant recipients. Br J Cancer 2008;99:1276 84.
    • (2008) Br J Cancer , vol.99 , pp. 1276-1284
    • Harwood, CA1    Attard, NR2    O Donovan, P3
  • 73
    • 56949101640 scopus 로고    scopus 로고
    • Immune escape by Epstein-Barr virus associated malignancies
    • Munz C, Moormann A. Immune escape by Epstein-Barr virus associated malignancies. Semin Cancer Biol 2008;18:381 7.
    • (2008) Semin Cancer Biol , vol.18 , pp. 3817
    • Munz, C1    Moormann, A.2
  • 74
    • 33748987908 scopus 로고    scopus 로고
    • Cancer despite immunosurveillance: immunoselection and immunosubversion
    • Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol 2006;6:715 27.
    • (2006) Nat Rev Immunol , vol.6 , pp. 71527
    • Zitvogel, L1    Tesniere, A2    Kroemer, G.3
  • 75
    • 84905581315 scopus 로고    scopus 로고
    • Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer
    • Beaugerie L, Carrat F, Colombel JF, et al. Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer. Gut 2014;63:1416 23.
    • (2014) Gut , vol.63 , pp. 141623
    • Beaugerie, L1    Carrat, F2    Colombel, JF3
  • 76
    • 84878557076 scopus 로고    scopus 로고
    • Use of azathioprine and the risk of cancer in inflammatory bowel disease
    • Pasternak B, Svanstrom H, Schmiegelow K, Jess T, Hviid A. Use of azathioprine and the risk of cancer in inflammatory bowel disease. Am J Epidemiol 2013;177:1296 305.
    • (2013) Am J Epidemiol , vol.177 , pp. 1296-1305
    • Pasternak, B1    Svanstrom, H2    Schmiegelow, K3    Jess, T4    Hviid, A.5
  • 77
    • 85033233134 scopus 로고    scopus 로고
    • Risk of Lymphoma in Patients With Inflammatory Bowel Disease Treated With Azathioprine and 6-Mercaptopurine: A Meta-Analysis
    • Kotlyar DS, Lewis JD, Beaugerie L, et al. Risk of Lymphoma in Patients With Inflammatory Bowel Disease Treated With Azathioprine and 6-Mercaptopurine: A Meta-Analysis. Clin Gastroenterol Hepatol 2015;13:847 58.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 847-858
    • Kotlyar, DS1    Lewis, JD2    Beaugerie, L3
  • 79
    • 84864225717 scopus 로고    scopus 로고
    • Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease
    • Long MD, Martin CF, Pipkin CA, Herfarth HH, Sandler RS, Kappelman MD. Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease. Gastroenterology 2012;143:390 9.
    • (2012) Gastroenterology , vol.143 , pp. 3909
    • Long, MD1    Martin, CF2    Pipkin, CA3    Herfarth, HH4    Sandler, RS5    Kappelman, MD.6
  • 80
    • 80054862378 scopus 로고    scopus 로고
    • Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease
    • Peyrin-Biroulet L, Khosrotehrani K, Carrat F, et al. Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology 2011;141:1621 8.
    • (2011) Gastroenterology , vol.141 , pp. 16218
    • Peyrin-Biroulet, L1    Khosrotehrani, K2    Carrat, F3
  • 82
    • 84893772239 scopus 로고    scopus 로고
    • Association between thiopurine use and nonmelanoma skin cancers in patients with inflammatory bowel disease: A meta-Analysis
    • Ariyaratnam J, Subramanian V. Association between thiopurine use and nonmelanoma skin cancers in patients with inflammatory bowel disease: A meta-Analysis. Am J Gastroenterol 2014;109:163 9.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1639
    • Ariyaratnam, J1    Subramanian, V.2
  • 83
    • 84929072705 scopus 로고    scopus 로고
    • Are Patients with Inflammatory Bowel Disease on Chronic Immunosuppressive Therapy at Increased Risk of Cervical High-grade Dysplasia/Cancer? A Meta-Analysis
    • Allegretti JR, Barnes EL, Cameron A. Are Patients with Inflammatory Bowel Disease on Chronic Immunosuppressive Therapy at Increased Risk of Cervical High-grade Dysplasia/Cancer? A Meta-Analysis. Inflamm Bowel Dis 2015;21:1089 97.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 1089-1097
    • Allegretti, JR1    Barnes, EL2    Cameron, A.3
  • 84
    • 40949087267 scopus 로고    scopus 로고
    • Higher incidence of abnormal Pap smears in women with inflammatory bowel disease
    • Kane S, Khatibi B, Reddy D. Higher incidence of abnormal Pap smears in women with inflammatory bowel disease. Am J Gastroenterol 2008;103:631 6.
    • (2008) Am J Gastroenterol , vol.103 , pp. 6316
    • Kane, S1    Khatibi, B2    Reddy, D.3
  • 85
    • 84899719594 scopus 로고    scopus 로고
    • Second European Evidence-based Consensus on the prevention, diagnosis, and management of opportunistic infections in inflammatory bowel disease
    • Rahier JF, Magro F, Abreu C, et al. Second European Evidence-based Consensus on the prevention, diagnosis, and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis 2014;8:443 68.
    • (2014) J Crohns Colitis , vol.8 , pp. 443-468
    • Rahier, JF1    Magro, F2    Abreu, C3
  • 86
    • 34249908092 scopus 로고    scopus 로고
    • Immunosuppressive Therapy and Malignancy in Organ Transplant Recipients. A Systematic Review
    • Gutierrez-Dalmau A, Campistol JM. Immunosuppressive Therapy and Malignancy in Organ Transplant Recipients. A Systematic Review. Drugs 2007;67:1167 98.
    • (2007) Drugs , vol.67 , pp. 1167-1198
    • Gutierrez-Dalmau, A1    Campistol, JM.2
  • 87
    • 70449100743 scopus 로고    scopus 로고
    • Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: A prospective observational cohort study
    • Beaugerie L, Brousse N, Bouvier AM, et al. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: A prospective observational cohort study. Lancet 2009;374:1617 25.
    • (2009) Lancet , vol.374 , pp. 161725
    • Beaugerie, L1    Brousse, N2    Bouvier, AM3
  • 88
    • 77954426838 scopus 로고    scopus 로고
    • Risk of cancer in inflammatory bowel disease treated with azathioprine: A UK population-based case-control study
    • Armstrong RG, West J, Card TR. Risk of cancer in inflammatory bowel disease treated with azathioprine: A UK population-based case-control study. Am J Gastroenterol 2010;105:1604 9.
    • (2010) Am J Gastroenterol , vol.105 , pp. 16049
    • Armstrong, RG1    West, J2    Card, TR.3
  • 89
    • 84963761365 scopus 로고    scopus 로고
    • European Evidence-based Consensus: Inflammatory Bowel Disease and Malignancies
    • Aug 20. pii: jjv 141. [Epub ahead of print]
    • Annese V, Beaugerie L, Egan L, et al. European Evidence-based Consensus: Inflammatory Bowel Disease and Malignancies. J Crohns Colitis 2015, Aug 20. pii: jjv 141. [Epub ahead of print.]
    • (2015) J Crohns Colitis
    • Annese, V1    Beaugerie, L2    Egan, L3
  • 90
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-Analysis of rare harmful effects in randomized controlled trials
    • Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-Analysis of rare harmful effects in randomized controlled trials. JAMA 2006;295:2275 85.
    • (2006) JAMA , vol.295 , pp. 2275-2285
    • Bongartz, T1    Sutton, AJ2    Sweeting, MJ3    Buchan, I4    Matteson, EL5    Montori, V.6
  • 91
    • 34248193253 scopus 로고    scopus 로고
    • Immune surveillance of tumors
    • Swann JB, Smyth MJ. Immune surveillance of tumors. J Clin Invest 2007;117:1137 46.
    • (2007) J Clin Invest , vol.117 , pp. 113746
    • Swann, JB1    Smyth, MJ.2
  • 92
    • 84946914743 scopus 로고    scopus 로고
    • Risk of Lymphoma, Colorectal and Skin Cancer in Patients with IBD Treated with Immunomodulators and Biologicals: A Quebec Claims Database Study
    • Kopylov U, Vutcovici M, Kezouh A, Seidman E, Bitton A, Afif W. Risk of Lymphoma, Colorectal and Skin Cancer in Patients with IBD Treated with Immunomodulators and Biologicals: A Quebec Claims Database Study. Inflamm Bowel Dis 2015;21:1847 53.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 184753
    • Kopylov, U1    Vutcovici, M2    Kezouh, A3    Seidman, E4    Bitton, A5    Afif, W.6
  • 93
    • 84902574301 scopus 로고    scopus 로고
    • Association between tumor necrosis factor-Alpha antagonists and risk of cancer in patients with inflammatory bowel disease
    • Nyboe AN, Pasternak B, Basit S, et al. Association between tumor necrosis factor-Alpha antagonists and risk of cancer in patients with inflammatory bowel disease. JAMA 2014;311:2406 13.
    • (2014) JAMA , vol.311 , pp. 240613
    • Nyboe, AN1    Pasternak, B2    Basit, S3
  • 94
    • 84893734901 scopus 로고    scopus 로고
    • Systematic review with meta-Analysis: malignancies with anti-Tumour necrosis factor-Alpha therapy in inflammatory bowel disease
    • Williams CJ, Peyrin-Biroulet L, Ford AC. Systematic review with meta-Analysis: malignancies with anti-Tumour necrosis factor-Alpha therapy in inflammatory bowel disease. Aliment Pharmacol Ther 2014;39:447 58.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 44758
    • Williams, CJ1    Peyrin-Biroulet, L2    Ford, AC.3
  • 95
    • 85159731471 scopus 로고    scopus 로고
    • Survival and cause specific mortality in patients with inflammatory bowel disease: A long term outcome study in Olmsted County, Minnesota, 1940 2004
    • Jess T, Loftus EV Jr, Harmsen WS. Survival and cause specific mortality in patients with inflammatory bowel disease: A long term outcome study in Olmsted County, Minnesota, 1940 2004. Inflamm Bowel Dis 2006;55:1248 54.
    • (2006) Inflamm Bowel Dis , vol.55 , pp. 124854
    • Jess, T1    Loftus, EV2    Harmsen, WS.3
  • 96
    • 34147209477 scopus 로고    scopus 로고
    • Ulcerative colitis: no rise in mortality in a European-wide population based cohort 10 years after diagnosis
    • Hoie O, Schouten LJ, Wolters FL. Ulcerative colitis: no rise in mortality in a European-wide population based cohort 10 years after diagnosis. Gut 2007;56:497 503.
    • (2007) Gut , vol.56 , pp. 497-503
    • Hoie, O1    Schouten, LJ2    Wolters, FL.3
  • 97
    • 36549059250 scopus 로고    scopus 로고
    • Mortality by medication use among patients with inflammatory bowel disease, 1996 2003
    • Huftless SM, Weng X, Liu L. Mortality by medication use among patients with inflammatory bowel disease, 1996 2003. Gastroenterology 2007;133:1779 86.
    • (2007) Gastroenterology , vol.133 , pp. 1779-1786
    • Huftless, SM1    Weng, X2    Liu, L.3
  • 98
    • 55149124689 scopus 로고    scopus 로고
    • Infliximab for inflammatory bowel disease in Denmark 1999 2005: Clinical outcome and follow-up evaluation of malignancy and mortality
    • Caspersen S, Elkjaer M, Riis L. Infliximab for inflammatory bowel disease in Denmark 1999 2005: Clinical outcome and follow-up evaluation of malignancy and mortality. Clin Gastroenterol Hepatol 2008;6:1212 7.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 12127
    • Caspersen, S1    Elkjaer, M2    Riis, L.3
  • 99
    • 84875371455 scopus 로고    scopus 로고
    • Long-Term outcome of patients with Crohńs disease who respond to azathioprine
    • Camus M, Seksisk P, Bourrier A. Long-Term outcome of patients with Crohńs disease who respond to azathioprine. Clin Gastroenterol Hepatol 2013;11:389 94.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 389-394
    • Camus, M1    Seksisk, P2    Bourrier, A.3
  • 100
    • 44949242296 scopus 로고    scopus 로고
    • Immunosuppressant medications and mortality in inflammatory bowel disease
    • Lewis JD, Gelfand JM, Troxel AB. Immunosuppressant medications and mortality in inflammatory bowel disease. Am J Gastroenterol. 2008;103:1428 35.
    • (2008) Am J Gastroenterol , vol.103 , pp. 142835
    • Lewis, JD1    Gelfand, JM2    Troxel, AB.3
  • 101
    • 33646147141 scopus 로고    scopus 로고
    • Serious infections and mortality in association with therapies for Crohńs disease: TREAT registry
    • Serious infections and mortality in association with therapies for Crohńs disease: TREAT registry. Clin Gastroenterol Hepatol 2006;4:621 30.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 621-630
  • 102
    • 84874445437 scopus 로고    scopus 로고
    • Adalimumab: long-Term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohńs disease
    • Burmester GR, Panaccione R, Gordon KB. Adalimumab: long-Term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohńs disease. Ann Rheum Dis 2013;72:517 24.
    • (2013) Ann Rheum Dis , vol.72 , pp. 51724
    • Burmester, GR1    Panaccione, R2    Gordon, KB.3
  • 103
    • 84870698448 scopus 로고    scopus 로고
    • Association between anti-TNF-A therapy and all-cause mortality
    • Herrinton LJ, Liu L, Chen L. Association between anti-TNF-A therapy and all-cause mortality. Pharmacoepidemiol Drug Saf 2012;21:1311 20.
    • (2012) Pharmacoepidemiol Drug Saf , vol.21 , pp. 131120
    • Herrinton, LJ1    Liu, L2    Chen, L.3
  • 104
    • 63849251824 scopus 로고    scopus 로고
    • Long-Term safety of infliximab for the treatment of inflammatory bowel disease: A single-centre cohort study
    • Fidder H, Schnitzler F, Ferrante M. Long-Term safety of infliximab for the treatment of inflammatory bowel disease: A single-centre cohort study. Gut 2009;58:501 8.
    • (2009) Gut , vol.58 , pp. 5018
    • Fidder, H1    Schnitzler, F2    Ferrante, M.3
  • 105
    • 84893733126 scopus 로고    scopus 로고
    • Malignancy and mortality in pediatric patients with inflammatory bowel disease: A multinational study from the Porto Pediatric IBD group
    • De Ridder L, Turner D, Wilson DC. Malignancy and mortality in pediatric patients with inflammatory bowel disease: A multinational study from the Porto Pediatric IBD group. Inflamm Bowel Dis 2014;20:291 300.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 291-300
    • De Ridder, L1    Turner, D2    Wilson, DC.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.