메뉴 건너뛰기




Volumn 106, Issue , 2017, Pages 70-75

Immune-checkpoint inhibition in first-line treatment of advanced non-small cell lung cancer patients: Current status and future approaches

Author keywords

First line; Immunotherapy; Nivolumab; Non small cell lung cancer; Pembrolizumab

Indexed keywords

ANTINEOPLASTIC AGENT; ATEZOLIZUMAB; AVELUMAB; BIOLOGICAL MARKER; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DURVALUMAB; IMMUNE CHECKPOINT INHIBITOR; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; UNCLASSIFIED DRUG; CD274 PROTEIN, HUMAN; MONOCLONAL ANTIBODY;

EID: 85012013235     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2017.02.002     Document Type: Review
Times cited : (25)

References (42)
  • 1
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: a common denominator approach to cancer therapy
    • [1] Topalian, S.L., Drake, C.G., Pardoll, D.M., Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27 (2015), 450–461, 10.1016/j.ccell.2015.03.001.
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 2
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • [2] Pardoll, D.M., The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12 (2012), 252–264, 10.1038/nrc3239.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • [3] Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674, 10.1016/j.cell.2011.02.013.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 9
    • 85011970924 scopus 로고    scopus 로고
    • Durvalumab in ≥3rd-line locally advanced or metastatic, EGFR/ALK wild-type NSCLC: results from the Phase 2 ATLANTIC study, J. Thorac. Oncol. 2016; PL04a.03. (n.d.).
    • [9] M. Garassino, J. Vansteenkiste, J.H. Kim, H. Lena, J. Mazières, J. Powderly, P. Dennis, Y. Huang, C. Wadsworth, N. Rizvi, Durvalumab in ≥3rd-line locally advanced or metastatic, EGFR/ALK wild-type NSCLC: results from the Phase 2 ATLANTIC study, J. Thorac. Oncol. 2016; PL04a.03. (n.d.).
    • Garassino, M.1    Vansteenkiste, J.2    Kim, J.H.3    Lena, H.4    Mazières, J.5    Powderly, J.6    Dennis, P.7    Huang, Y.8    Wadsworth, C.9    Rizvi, N.10
  • 11
    • 84958643727 scopus 로고    scopus 로고
    • EGFR mutation incidence in non-small-cell lung cancer of adenocarcinoma histology: a systematic review and global map by ethnicity (mutMapII)
    • [11] Midha, A., Dearden, S., McCormack, R., EGFR mutation incidence in non-small-cell lung cancer of adenocarcinoma histology: a systematic review and global map by ethnicity (mutMapII). Am. J. Cancer. Res. 5 (2015), 2892–2911.
    • (2015) Am. J. Cancer. Res. , vol.5 , pp. 2892-2911
    • Midha, A.1    Dearden, S.2    McCormack, R.3
  • 12
    • 84883347910 scopus 로고    scopus 로고
    • Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap)
    • [12] Dearden, S., Stevens, J., Wu, Y.-L., Blowers, D., Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap). Ann. Oncol. 24 (2013), 2371–2376, 10.1093/annonc/mdt205.
    • (2013) Ann. Oncol. , vol.24 , pp. 2371-2376
    • Dearden, S.1    Stevens, J.2    Wu, Y.-L.3    Blowers, D.4
  • 16
    • 85011947758 scopus 로고    scopus 로고
    • Health-related quality of life for pembrolizumab vs chemotherapy in advanced NSCLC with PD-L1 TPS ≥50%: Data from KEYNOTE-024, J. Clin. Oncol. 34, 2016 (Suppl; Abstr 7153). (n.d.).
    • [16] J. Brahmer, D. Rodriguez-Abreu, A.G. Robinson, R. Hui, T. Csoszi, A. Fulop, M. Gottfried, N. Peled, A. Tafreshi, et al. Health-related quality of life for pembrolizumab vs chemotherapy in advanced NSCLC with PD-L1 TPS ≥50%: Data from KEYNOTE-024, J. Clin. Oncol. 34, 2016 (Suppl; Abstr 7153). (n.d.).
    • Brahmer, J.1    Rodriguez-Abreu, D.2    Robinson, A.G.3    Hui, R.4    Csoszi, T.5    Fulop, A.6    Gottfried, M.7    Peled, N.8    Tafreshi, A.9
  • 19
    • 85011987237 scopus 로고    scopus 로고
    • CheckMate 026: A phase 3 trialof nivolumab vs investigator's choice of platinumn based doublet chemotherapy as first-line therapy for stage IV/recurrent programmed death lignad 1 positive NSCLC, ESMO 2016, LBA7. (n.d.).
    • [19] M. Socinski, CheckMate 026: A phase 3 trialof nivolumab vs investigator's choice of platinumn based doublet chemotherapy as first-line therapy for stage IV/recurrent programmed death lignad 1 positive NSCLC, ESMO 2016, LBA7. (n.d.).
    • Socinski, M.1
  • 21
    • 85012033015 scopus 로고    scopus 로고
    • b. Besse, P.A. Jänne, D. Christoph, S. Peters, C. Toh, T. Kurata Atezolizumab as 1L therapy for advanced NSCLC in PD-L1–selected patients: updated ORR, PFS and OS data from the BIRCH study, J. Thorac. Oncol. 2016; Abstract 4799. (n.d.).
    • [21] M. Garassino, N. Rizvi, b. Besse, P.A. Jänne, D. Christoph, S. Peters, C. Toh, T. Kurata et al, Atezolizumab as 1L therapy for advanced NSCLC in PD-L1–selected patients: updated ORR, PFS and OS data from the BIRCH study, J. Thorac. Oncol. 2016; Abstract 4799. (n.d.).
    • Garassino, M.1    Rizvi, N.2
  • 22
    • 85012032204 scopus 로고    scopus 로고
    • M. Taylor JAVELIN Solid tumor: safety and clinical activity of avelumab (Anti-PD-L1) as first-line treatment in patients with advanced NSCLC, J. Thorac. Oncol. 2016; Abstract 3717. (n.d.).
    • [22] G. Jerusalem, F.L. Chen, D. Spigel, N. Iannotti, E.F. McClay, C.H. Redfem, J. Bennouna, M. Taylor et al. JAVELIN Solid tumor: safety and clinical activity of avelumab (Anti-PD-L1) as first-line treatment in patients with advanced NSCLC, J. Thorac. Oncol. 2016; Abstract 3717. (n.d.).
    • Jerusalem, G.1    Chen, F.L.2    Spigel, D.3    Iannotti, N.4    McClay, E.F.5    Redfem, C.H.6    Bennouna, J.7
  • 24
    • 74249120625 scopus 로고    scopus 로고
    • Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
    • [24] Liu, W.M., Fowler, D.W., Smith, P., Dalgleish, A.G., Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses. Br. J. Cancer 102 (2010), 115–123, 10.1038/sj.bjc.6605465.
    • (2010) Br. J. Cancer , vol.102 , pp. 115-123
    • Liu, W.M.1    Fowler, D.W.2    Smith, P.3    Dalgleish, A.G.4
  • 25
    • 84955288422 scopus 로고    scopus 로고
    • Chemotherapy induces programmed cell death-ligand 1 overexpression via the nuclear factor-κB to foster an immunosuppressive tumor microenvironment in ovarian cancer
    • [25] Peng, J., Hamanishi, J., Matsumura, N., Abiko, K., Murat, K., Baba, T., Yamaguchi, K., Horikawa, N., Hosoe, Y., Murphy, S.K., Konishi, I., Mandai, M., Chemotherapy induces programmed cell death-ligand 1 overexpression via the nuclear factor-κB to foster an immunosuppressive tumor microenvironment in ovarian cancer. Cancer Res. 75 (2015), 5034–5045, 10.1158/0008-5472.CAN-14-3098.
    • (2015) Cancer Res. , vol.75 , pp. 5034-5045
    • Peng, J.1    Hamanishi, J.2    Matsumura, N.3    Abiko, K.4    Murat, K.5    Baba, T.6    Yamaguchi, K.7    Horikawa, N.8    Hosoe, Y.9    Murphy, S.K.10    Konishi, I.11    Mandai, M.12
  • 26
    • 84997606111 scopus 로고    scopus 로고
    • The up-regulation of PD-L1 promotes the resistant response in non-small cell lung cancer patients with neo-adjuvant chemotherapy
    • [26] Zhang, P., Ma, Y., Lv, C., Huang, M., Li, M., Dong, B., Liu, X., An, G., Zhang, W., Zhang, J., Zhang, L., Zhang, S., Yang, Y., The up-regulation of PD-L1 promotes the resistant response in non-small cell lung cancer patients with neo-adjuvant chemotherapy. Cancer Sci., 2016, 10.1111/cas.13072.
    • (2016) Cancer Sci.
    • Zhang, P.1    Ma, Y.2    Lv, C.3    Huang, M.4    Li, M.5    Dong, B.6    Liu, X.7    An, G.8    Zhang, W.9    Zhang, J.10    Zhang, L.11    Zhang, S.12    Yang, Y.13
  • 30
    • 85012008304 scopus 로고    scopus 로고
    • G.Giaccone, D. Camidge, S. Liu, J. Powderly, S. hodi, S. Gettinger, Safety, activity and biomarkers of atezolizumab (MPDL3280A) with platinum-based chemotherapy in non-small cell lung cancer (NSCLC): a phase Ib study, J. Thorac. Oncol. 2015; 10 (suppls 2) P247 (n.d.).
    • [30] G.Giaccone, D. Camidge, S. Liu, J. Powderly, S. hodi, S. Gettinger, et al, Safety, activity and biomarkers of atezolizumab (MPDL3280A) with platinum-based chemotherapy in non-small cell lung cancer (NSCLC): a phase Ib study, J. Thorac. Oncol. 2015; 10 (suppls 2) P247 (n.d.).
  • 32
    • 84892454962 scopus 로고    scopus 로고
    • PointBreak: a randomized phase III study of pemetrexed plus carboplatin and bevacizumab followed by maintenance pemetrexed and bevacizumab versus paclitaxel plus carboplatin and bevacizumab followed by maintenance bevacizumab in patients with stage IIIB or IV nonsquamous non-small-cell lung cancer
    • [32] Patel, J.D., Socinski, M.A., Garon, E.B., Reynolds, C.H., Spigel, D.R., Olsen, M.R., Hermann, R.C., Jotte, R.M., Beck, T., Richards, D.A., Guba, S.C., Liu, J., Frimodt, M.B., John, W.J., Obasaju, C.K., Pennella, E.J., Bonomi, P., Govindan, R., PointBreak: a randomized phase III study of pemetrexed plus carboplatin and bevacizumab followed by maintenance pemetrexed and bevacizumab versus paclitaxel plus carboplatin and bevacizumab followed by maintenance bevacizumab in patients with stage IIIB or IV nonsquamous non-small-cell lung cancer. J. Clin. Oncol. 31 (2013), 4349–4357.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4349-4357
    • Patel, J.D.1    Socinski, M.A.2    Garon, E.B.3    Reynolds, C.H.4    Spigel, D.R.5    Olsen, M.R.6    Hermann, R.C.7    Jotte, R.M.8    Beck, T.9    Richards, D.A.10    Guba, S.C.11    Liu, J.12    Frimodt, M.B.13    John, W.J.14    Obasaju, C.K.15    Pennella, E.J.16    Bonomi, P.17    Govindan, R.18
  • 33
    • 76749084659 scopus 로고    scopus 로고
    • Randomized phase II clinical trial comparing tremelimumab (CP-675 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC)
    • [33] Zatloukal, P., Heo, D.S., Park, K., Kang, J., Butts, C., Bradford, D., Graziano, S., Huang, B., Healey, D., Randomized phase II clinical trial comparing tremelimumab (CP-675 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC). ASCO Meeting, 27, 2009, 8071.
    • (2009) ASCO Meeting , vol.27 , pp. 8071
    • Zatloukal, P.1    Heo, D.S.2    Park, K.3    Kang, J.4    Butts, C.5    Bradford, D.6    Graziano, S.7    Huang, B.8    Healey, D.9
  • 34
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study
    • [34] Lynch, T.J., Bondarenko, I., Luft, A., Serwatowski, P., Barlesi, F., Chacko, R., Sebastian, M., Neal, J., Lu, H., Cuillerot, J.-M., Reck, M., Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J. Clin. Oncol. 30 (2012), 2046–2054, 10.1200/JCO.2011.38.4032.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Neal, J.8    Lu, H.9    Cuillerot, J.-M.10    Reck, M.11
  • 35
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • [35] Curran, M.A., Montalvo, W., Yagita, H., Allison, J.P., PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 4275–4280, 10.1073/pnas.0915174107.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 38
    • 84942138310 scopus 로고    scopus 로고
    • Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D
    • [38] Patnaik, A., Socinski, M.A., Gubens, M.A., Gandhi, L., Stevenson, J., Bachman, R.D., Bourque, J., Yang Ge, J., Im, E., Gadgeel, S.M., Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. ASCO Meeting., 33, 2015, 8011.
    • (2015) ASCO Meeting. , vol.33 , pp. 8011
    • Patnaik, A.1    Socinski, M.A.2    Gubens, M.A.3    Gandhi, L.4    Stevenson, J.5    Bachman, R.D.6    Bourque, J.7    Yang Ge, J.8    Im, E.9    Gadgeel, S.M.10
  • 41
    • 84984984313 scopus 로고    scopus 로고
    • ESMO European Consortium Study on the availability, out-of-pocket costs and accessibility of antineoplastic medicines in Europe
    • [41] Cherny, N., Sullivan, R., Torode, J., Saar, M., Eniu, A., ESMO European Consortium Study on the availability, out-of-pocket costs and accessibility of antineoplastic medicines in Europe. Ann. Oncol. 27 (2016), 1423–1443, 10.1093/annonc/mdw213.
    • (2016) Ann. Oncol. , vol.27 , pp. 1423-1443
    • Cherny, N.1    Sullivan, R.2    Torode, J.3    Saar, M.4    Eniu, A.5
  • 42
    • 85012011746 scopus 로고    scopus 로고
    • Total mutation burden (TMB) in lung cancer and relationship with response to PD-1/PD-L1 targeted therapies, J. Clin. Oncol. 34, 2016 (Suppl; Abstr 9017). (n.d.).
    • [42] D. Spigel, A. Schrock, D. Fabrizio, G.M. Frampton, J. Sun, J. He, K. Gowen, et al. Total mutation burden (TMB) in lung cancer and relationship with response to PD-1/PD-L1 targeted therapies, J. Clin. Oncol. 34, 2016 (Suppl; Abstr 9017). (n.d.).
    • Spigel, D.1    Schrock, A.2    Fabrizio, D.3    Frampton, G.M.4    Sun, J.5    He, J.6    Gowen, K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.