-
1
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, Rolland F, Demkow T, Hutson TE, Gore M, Freeman S, Schwartz B, Shan M, Simantov R, Bukowski RM: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356:125-134.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
2
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359:378-390.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Häussinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
3
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, Xu J, Sun Y, Liang H, Liu J, Wang J, Tak WY, Pan H, Burock K, Zou J, Voliotis D, Guan Z: Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009, 10:25-34.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
Kim, J.S.6
Luo, R.7
Feng, J.8
Ye, S.9
Yang, T.S.10
Xu, J.11
Sun, Y.12
Liang, H.13
Liu, J.14
Wang, J.15
Tak, W.Y.16
Pan, H.17
Burock, K.18
Zou, J.19
Voliotis, D.20
Guan, Z.21
more..
-
4
-
-
33749238553
-
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
-
Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, Schwartz B, Simantov R, Kelley S: Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 2006, 5:835-844.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
Lowinger, T.4
Dumas, J.5
Smith, R.A.6
Schwartz, B.7
Simantov, R.8
Kelley, S.9
-
5
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M: Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 2008, 7:3129-3140.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
Villanueva, A.4
Llovet, J.M.5
Lynch, M.6
-
6
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
7
-
-
21344462378
-
Cutaneous side-effects of kinase inhibitors and blocking antibodies
-
Robert C, Soria JC, Spatz A, Le Cesne A, Malka D, Pautier P, Wechsler J, Lhomme C, Escudier B, Boige V, Armand JP, Le Chevalier T: Cutaneous side-effects of kinase inhibitors and blocking antibodies. Lancet Oncol 2005, 6:491-500.
-
(2005)
Lancet Oncol
, vol.6
, pp. 491-500
-
-
Robert, C.1
Soria, J.C.2
Spatz, A.3
Cesne, A.4
Malka, D.5
Pautier, P.6
Wechsler, J.7
Lhomme, C.8
Escudier, B.9
Boige, V.10
Armand, J.P.11
Le Chevalier, T.12
-
8
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
Ratain MJ, Eisen T, Stadler WM, Flaherty KT, Kaye SB, Rosner GL, Gore M, Desai AA, Patnaik A, Xiong HQ, Rowinsky E, Abbruzzese JL, Xia C, Simantov R, Schwartz B, O'Dwyer PJ: Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2006, 24:2505-2512.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
Flaherty, K.T.4
Kaye, S.B.5
Rosner, G.L.6
Gore, M.7
Desai, A.A.8
Patnaik, A.9
Xiong, H.Q.10
Rowinsky, E.11
Abbruzzese, J.L.12
Xia, C.13
Simantov, R.14
Schwartz, B.15
O'Dwyer, P.J.16
-
9
-
-
52949128348
-
Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib
-
Lacouture ME, Wu S, Robert C, Atkins MB, Kong HH, Guitart J, Garbe C, Hauschild A, Puzanov I, Alexandrescu DT, Anderson RT, Wood L, Dutcher JP: Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib. Oncologist 2008, 13:1001-1011.
-
(2008)
Oncologist
, vol.13
, pp. 1001-1011
-
-
Lacouture, M.E.1
Wu, S.2
Robert, C.3
Atkins, M.B.4
Kong, H.H.5
Guitart, J.6
Garbe, C.7
Hauschild, A.8
Puzanov, I.9
Alexandrescu, D.T.10
Anderson, R.T.11
Wood, L.12
Dutcher, J.P.13
-
10
-
-
79960805810
-
Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma
-
Kudo M, Imanaka K, Chida N, Nakachi K, Tak WY, Takayama T, Yoon JH, Hori T, Kumada H, Hayashi N, Kaneko S, Tsubouchi H, Suh DJ, Furuse J, Okusaka T, Tanaka K, Matsui O, Wada M, Yamaguchi I, Ohya T, Meinhardt G, Okita K: Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma. Eur J Cancer 2011, 47:2117-2127.
-
(2011)
Eur J Cancer
, vol.47
, pp. 2117-2127
-
-
Kudo, M.1
Imanaka, K.2
Chida, N.3
Nakachi, K.4
Tak, W.Y.5
Takayama, T.6
Yoon, J.H.7
Hori, T.8
Kumada, H.9
Hayashi, N.10
Kaneko, S.11
Tsubouchi, H.12
Suh, D.J.13
Furuse, J.14
Okusaka, T.15
Tanaka, K.16
Matsui, O.17
Wada, M.18
Yamaguchi, I.19
Ohya, T.20
Meinhardt, G.21
Okita, K.22
more..
-
11
-
-
84896735888
-
Management of common adverse events in patients treated with sorafenib: nurse and pharmacist perspective
-
Walko CM, Grande C: Management of common adverse events in patients treated with sorafenib: nurse and pharmacist perspective. Semin Oncol 2014, 41(Suppl 2):S17-S28.
-
(2014)
Semin Oncol
, vol.41
, pp. S17-S28
-
-
Walko, C.M.1
Grande, C.2
-
12
-
-
84884495128
-
[Examination of the usefulness of the pharmacists' outpatient clinic for treatment with oral molecule-targeting drugs]
-
Aimono Y, Nemoto M, Sato W, Saito Y, Aoyama Y, Joko F, Maruyama T, Kamoshida T: [Examination of the usefulness of the pharmacists' outpatient clinic for treatment with oral molecule-targeting drugs]. Gan to Kagaku Ryoho 2013, 40:901-905.
-
(2013)
Gan to Kagaku Ryoho
, vol.40
, pp. 901-905
-
-
Aimono, Y.1
Nemoto, M.2
Sato, W.3
Saito, Y.4
Aoyama, Y.5
Joko, F.6
Maruyama, T.7
Kamoshida, T.8
-
13
-
-
77956156643
-
The hand-foot-syndrome associated with medical tumor therapy - classification and management
-
Degen A, Alter M, Schenck F, Satzger I, Volker B, Kapp A, Gutzmer R: The hand-foot-syndrome associated with medical tumor therapy - classification and management. J Dtsch Dermatol Ges 2010, 8:652-661.
-
(2010)
J Dtsch Dermatol Ges
, vol.8
, pp. 652-661
-
-
Degen, A.1
Alter, M.2
Schenck, F.3
Satzger, I.4
Volker, B.5
Kapp, A.6
Gutzmer, R.7
-
14
-
-
38349030422
-
Uncovering Pandora's vase: the growing problem of new toxicities from novel anticancer agents. The case of sorafenib and sunitinib
-
Porta C, Paglino C, Imarisio I, Bonomi L: Uncovering Pandora's vase: the growing problem of new toxicities from novel anticancer agents. The case of sorafenib and sunitinib. Clin Exp Med 2007, 7:127-134.
-
(2007)
Clin Exp Med
, vol.7
, pp. 127-134
-
-
Porta, C.1
Paglino, C.2
Imarisio, I.3
Bonomi, L.4
-
15
-
-
79958865082
-
One-month relative dose intensity of not less than 50% predicts favourable progression-free survival in sorafenib therapy for advanced renal cell carcinoma in Japanese patients
-
Kawashima A, Takayama H, Arai Y, Tanigawa G, Nin M, Kajikawa J, Imazu T, Kinoshita T, Yasunaga Y, Inoue H, Nishimura K, Takada S, Nishimura K, Tsujimura A, Nonomura N: One-month relative dose intensity of not less than 50% predicts favourable progression-free survival in sorafenib therapy for advanced renal cell carcinoma in Japanese patients. Eur J Cancer 2011, 47:1521-1526.
-
(2011)
Eur J Cancer
, vol.47
, pp. 1521-1526
-
-
Kawashima, A.1
Takayama, H.2
Arai, Y.3
Tanigawa, G.4
Nin, M.5
Kajikawa, J.6
Imazu, T.7
Kinoshita, T.8
Yasunaga, Y.9
Inoue, H.10
Nishimura, K.11
Takada, S.12
Nishimura, K.13
Tsujimura, A.14
Nonomura, N.15
-
16
-
-
80155136807
-
Clinical outcome and prognostic factors of sorafenib in Japanese patients with advanced renal cell carcinoma in general clinical practice
-
Tanigawa G, Kawashima A, Yamaguchi S, Nishimura K, Miyoshi S, Kajikawa J, Meguro N, Yosioka T, Oka T, Hara T, Takayama H, Nonomura N: Clinical outcome and prognostic factors of sorafenib in Japanese patients with advanced renal cell carcinoma in general clinical practice. Jpn J Clin Oncol 2011, 41:1265-1270.
-
(2011)
Jpn J Clin Oncol
, vol.41
, pp. 1265-1270
-
-
Tanigawa, G.1
Kawashima, A.2
Yamaguchi, S.3
Nishimura, K.4
Miyoshi, S.5
Kajikawa, J.6
Meguro, N.7
Yosioka, T.8
Oka, T.9
Hara, T.10
Takayama, H.11
Nonomura, N.12
-
17
-
-
84856082759
-
Late-onset benefit in progressive advanced hepatocellular carcinoma with continued sorafenib therapy: a case report.
-
Okuwaki Y, Nakazawa T, Hidaka H, Shibuya A, Koizumi W: Late-onset benefit in progressive advanced hepatocellular carcinoma with continued sorafenib therapy: a case report. J Med Case Rep 2012, 6:38.
-
(2012)
J Med Case Rep
, vol.6
, pp. 38
-
-
Okuwaki, Y.1
Nakazawa, T.2
Hidaka, H.3
Shibuya, A.4
Koizumi, W.5
-
18
-
-
84871636162
-
Clinical factors related to long-term administration of sorafenib in patients with hepatocellular carcinoma
-
Nojiri S, Kusakabe A, Fujiwara K, Shinkai N, Matsuura K, Iio E, Miyaki T, Nomura T, Sobue S, Sano H, Hasegawa I, Ohno T, Takahashi Y, Orito E, Joh T: Clinical factors related to long-term administration of sorafenib in patients with hepatocellular carcinoma. Cancer Manag Res 2012, 4:423-429.
-
(2012)
Cancer Manag Res
, vol.4
, pp. 423-429
-
-
Nojiri, S.1
Kusakabe, A.2
Fujiwara, K.3
Shinkai, N.4
Matsuura, K.5
Iio, E.6
Miyaki, T.7
Nomura, T.8
Sobue, S.9
Sano, H.10
Hasegawa, I.11
Ohno, T.12
Takahashi, Y.13
Orito, E.14
Joh, T.15
-
19
-
-
77952889878
-
Complete remission of unresectable hepatocellular carcinoma treated with reduced dose of sorafenib: a case report
-
Wang SX, Byrnes A, Verma S, Pancoast JR, Rixe O: Complete remission of unresectable hepatocellular carcinoma treated with reduced dose of sorafenib: a case report. Target Oncol 2010, 5:59-63.
-
(2010)
Target Oncol
, vol.5
, pp. 59-63
-
-
Wang, S.X.1
Byrnes, A.2
Verma, S.3
Pancoast, J.R.4
Rixe, O.5
-
20
-
-
77956048116
-
Treatment outcomes of sorafenib for first line or cytokinerefractory advanced renal cell carcinoma in Japanese patients
-
Ueda T, Imamura Y, Komaru A, Fukasawa S, Sazuka T, Suyama T, Naya Y, Nihei N, Ichikawa T, Maruoka M: Treatment outcomes of sorafenib for first line or cytokinerefractory advanced renal cell carcinoma in Japanese patients. Int J Urol 2010, 17:811-815.
-
(2010)
Int J Urol
, vol.17
, pp. 811-815
-
-
Ueda, T.1
Imamura, Y.2
Komaru, A.3
Fukasawa, S.4
Sazuka, T.5
Suyama, T.6
Naya, Y.7
Nihei, N.8
Ichikawa, T.9
Maruoka, M.10
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