Severe Intraoperative Hyperglycemia is Independently Associated with Postoperative Composite Infection after Craniotomy: An Observational Study

Anesthesia and Analgesia

Volumn 125, Issue 2, 2017, Pages 556-561

  Gruenbaum, Shaun E ^a   Toscani, Laura ^b   Fomberstein, Kenneth M ^c   Ruskin, Keith J ^d   Dai, Feng ^a   Qeva, Ega ^b   Rosa, Giovanni ^b   Meng, Lingzhong ^a   Bilotta, Federico ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; GLUCOSE; INSULIN; STEROID; GLUCOSE BLOOD LEVEL;

AGED; ANESTHESIA INDUCTION; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; BOLUS INJECTION; CANCER SURGERY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRANIOTOMY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG USE; EMERGENCY SURGERY; EPILEPSY; EXTUBATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; OPERATION DURATION; PEROPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; PRIMARY TUMOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; STEROID THERAPY; TEMPORAL LOBECTOMY; TRAUMATIC BRAIN INJURY; ADULT; ADVERSE EFFECTS; ANALYSIS; BLOOD; CLINICAL TRIAL; DIABETES COMPLICATIONS; INFECTION; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; RISK FACTOR;

ADULT; AGED; BLOOD GLUCOSE; CRANIOTOMY; DIABETES COMPLICATIONS; FEMALE; HUMANS; HYPERGLYCEMIA; INFECTION; INTRAOPERATIVE COMPLICATIONS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 85011854261     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000001946     Document Type: Article

References (41)

1. McClelland S 3rd, Hall WA. Postoperative central nervous system infection: incidence and associated factors in 2111 neurosurgical procedures. Clin Infect Dis. 2007;45:55-59.
2. Dashti SR, Baharvahdat H, Spetzler RF, et al. Operative intracranial infection following craniotomy. Neurosurg Focus. 2008;24:E10.
3. van Vught LA, Wiewel MA, Klein Klouwenberg PM, et al; Molecular Diagnosis and Risk Stratification of Sepsis Consortium. Admission hyperglycemia in critically ill sepsis patients: association with outcome and host response. Crit Care Med. 2016;44:1338-1346.
4. Smith KA, Matthews TW, Dubé M, Spence G, Dort JC. Changing practice and improving care using a low-risk tracheotomy clinical pathway. JAMA Otolaryngol Head Neck Surg. 2014;140:630-634.
5. Russo N. Perioperative glycemic control. Anesthesiol Clin. 2012;30:445-466.
6. Godoy DA, Di Napoli M, Biestro A, Lenhardt R. Perioperative glucose control in neurosurgical patients. Anesthesiol Res Pract. 2012;2012:690362.
7. Lukins MB, Manninen PH. Hyperglycemia in patients administered dexamethasone for craniotomy. Anesth Analg. 2005;100:1129-1133.
8. 2015. Available at: http://www.cdc.gov/nhsn/PDFs/ pscManual/17pscNosInfDef-current.pdf. Accessed April 1, 2016.
9. Korinek AM, Golmard JL, Elcheick A, et al. Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patients. Br J Neurosurg. 2005;19:155-162.
10. Schlenk F, Vajkoczy P, Sarrafzadeh A. Inpatient hyperglycemia following aneurysmal subarachnoid hemorrhage: relation to cerebral metabolism and outcome. Neurocrit Care. 2009;11:56-63.
11. Mowery NT, Gunter OL, Guillamondegui O, et al. Stress insulin resistance is a marker for mortality in traumatic brain injury. J Trauma. 2009;66:145-151.
12. Griesdale DE, Tremblay MH, McEwen J, Chittock DR. Glucose control and mortality in patients with severe traumatic brain injury. Neurocrit Care. 2009;11:311-316.
13. McGirt MJ, Chaichana KL, Gathinji M, et al. Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas. Neurosurgery. 2008;63:286-291.
14. Bilotta F, Rosa G. Glucose management in the neurosurgical patient: are we yet any closer? Curr Opin Anaesthesiol. 2010;23:539-543.
15. Abdelmalak BB, Knittel J, Abdelmalak JB, et al. Preoperative blood glucose concentrations and postoperative outcomes after elective non-cardiac surgery: an observational study. Br J Anaesth. 2014;112:79-88.
16. Golden SH, Peart-Vigilance C, Kao WH, Brancati FL. Perioperative glycemic control and the risk of infectious complications in a cohort of adults with diabetes. Diabetes Care. 1999;22:1408-1414.
17. Hardy SJ, Nowacki AS, Bertin M, Weil RJ. Absence of an association between glucose levels and surgical site infections in patients undergoing craniotomies for brain tumors. J Neurosurg. 2010;113:161-166.
18. Gandhi GY, Nuttall GA, Abel MD, et al. Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients. Mayo Clin Proc. 2005;80:862-866.
19. Khaodhiar L, McCowen K, Bistrian B. Perioperative hyperglycemia, infection or risk? Curr Opin Clin Nutr Metab Care. 1999;2:79-82.
20. Rogers SO Jr, Zinner MJ. The role of perioperative hyperglycemia in postoperative infections. Adv Surg. 2009;43:103-109.
21. Kreisel SH, Berschin UM, Hammes HP, et al. Pragmatic management of hyperglycaemia in acute ischaemic stroke: safety and feasibility of intensive intravenous insulin treatment. Cerebrovasc Dis. 2009;27:167-175.
22. Coester A, Neumann CR, Schmidt MI. Intensive insulin therapy in severe traumatic brain injury: a randomized trial. J Trauma. 2010;68:904-911.
23. Kramer AH, Roberts DJ, Zygun DA. Optimal glycemic control in neurocritical care patients: a systematic review and metaanalysis. Crit Care. 2012;16:R203.
24. Bilotta F, Rosa G. Optimal glycemic control in neurocritical care patients. Crit Care. 2012;16:163.
25. Evans CH, Lee J, Ruhlman MK. Optimal glucose management in the perioperative period. Surg Clin North Am. 2015;95:337-354.
26. Duncan AE. Hyperglycemia and perioperative glucose management. Curr Pharm Des. 2012;18:6195-6203.
27. Bergenstal RM, Garg S, Weinzimer SA, et al. Safety of a hybrid closed-loop insulin delivery system in patients with type 1 diabetes. JAMA. 2016;316:1407-1408.
28. Gruenbaum SE, Bilotta F. Use of continuous glucose monitoring in the ICU: a review. Int J Intensive Care. 2014;21:25-29.
29. Korinek AM. Risk factors for neurosurgical site infections after craniotomy: a prospective multicenter study of 2944 patients. The French Study Group of Neurosurgical Infections, the SEHP, and the C-CLIN Paris-Nord. Service Epidémiologie Hygiène et Prévention. Neurosurgery. 1997;41:1073-1079.
30. Valentini LG, Casali C, Chatenoud L, Chiaffarino F, Uberti-Foppa C, Broggi G. Surgical site infections after elective neurosurgery: a survey of 1747 patients. Neurosurgery. 2008;62:88-95.
31. Ismael H, Horst M, Farooq M, Jordon J, Patton JH, Rubinfeld IS. Adverse effects of preoperative steroid use on surgical outcomes. Am J Surg. 2011;201:305-308.
32. Dieleman JM, Nierich AP, Rosseel PM, et al; Dexamethasone for Cardiac Surgery (DECS) Study Group. Intraoperative highdose dexamethasone for cardiac surgery: a randomized controlled trial. JAMA. 2012;308:1761-1767.
33. Marshall LF, King J, Langfitt TW. The complications of highdose corticosteroid therapy in neurosurgical patients: a prospective study. Ann Neurol. 1977;1:201-203.
34. Merkler AE, Saini V, Kamel H, Stieg PE. Preoperative steroid use and the risk of infectious complications after neurosurgery. Neurohospitalist. 2014;4:80-85.
35. Cooper PR, Moody S, Clark WK, et al. Dexamethasone and severe head injury. A prospective double-blind study. J Neurosurg. 1979;51:307-316.
36. Dearden NM, Gibson JS, McDowall DG, Gibson RM, Cameron MM. Effect of high-dose dexamethasone on outcome from severe head injury. J Neurosurg. 1986;64:81-88.
37. Erman T, Demirhindi H, Göçer AI, Tuna M, Ildan F, Boyar B. Risk factors for surgical site infections in neurosurgery patients with antibiotic prophylaxis. Surg Neurol. 2005;63:107-112.
38. Korol E, Johnston K, Waser N, et al. A systematic review of risk factors associated with surgical site infections among surgical patients. PLoS One. 2013;8:e83743.
39. Takanari K, Araki Y, Okamoto S, et al. Operative woundrelated complications after cranial revascularization surgeries. J Neurosurg. 2015;123:1145-1150.
40. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49:1373-1379.
41. Vittinghoff E, McCulloch CE. Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol. 2007;165:710-718.