Does training and support of general practitioners in intensive treatment of people with screen-detected diabetes improve medication, morbidity and mortality in people with clinically-diagnosed diabetes? Investigation of a spill-over effect in a cluster RCT

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Charles, Morten ^a   Skriver, Mette V ^a   Griffin, Simon J ^b,c   Simmons, Rebecca K ^a,c,d,e   Witte, Daniel R ^a,d   Dalsgaard, Else Marie ^a   Lauritzen, Torsten ^a   Sandbæk, Annelli ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

^e Aarhus Institute of Advanced Studies   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS AFFECTING CARBOHYDRATE METABOLISM; ANTICOAGULANT AGENT; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; CARDIOVASCULAR AGENT; GLUCOSE LOWERING AGENT; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CLUSTER ANALYSIS; CONTROLLED STUDY; DENMARK; DIABETES MELLITUS; FEMALE; FOLLOW UP; GENERAL PRACTICE; GENERAL PRACTITIONER; HEALTH STATUS; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; MORTALITY RATE; PATIENT CARE; POST HOC ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; CLINICAL TRIAL; INCIDENTAL FINDING; MASS SCREENING; MIDDLE AGED;

ADULT; AGED; DENMARK; DIABETES MELLITUS; FEMALE; GENERAL PRACTICE; GENERAL PRACTITIONERS; HUMANS; INCIDENTAL FINDINGS; MALE; MASS SCREENING; MIDDLE AGED;

EID: 85011615030     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0170697     Document Type: Article

References (16)

1. (2016) Standards of Medical Care in Diabetes-2016. Diabetes Care 39 Suppl1: S1-S2. 39/Supplement- 1/S1 [pii];.
2. Grol R, Grimshaw J (2003) From best evidence to best practice: Effective implementation of change in patients' care. Lancet 362: 1225-1230. S0140-6736(03)14546-1 [pii];. doi:10.1016/S0140-6736(03)14546-1 PMID: 14568747.
3. Cantillon P, Jones R (1999) Does continuing medical education in general practice make a difference? BMJ 318: 1276-1279. PMID: 10231265.
4. Grimshaw JM, Thomas RE, MacLennan G, Fraser C, Ramsay CR, Vale L, Whitty P, Eccles MP, Matowe L, Shirran L, Wensing M, Dijkstra R, Donaldson C (2004) Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol Assess 8: Iii-72. 94-08-29 [pii].
5. Lauritzen T, Griffin S, Borch-Johnsen K, Wareham NJ, Wolffenbuttel BH, Rutten G (2000) The ADDITION study: Proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening. Int J Obes Relat Metab Disord 24 Suppl3: S6-S11.
6. Griffin SJ, Borch-Johnsen K, Davies MJ, Khunti K, Rutten GE, Sandbaek A, Sharp SJ, Simmons RK, van den Donk M, Wareham NJ, Lauritzen T (2011) Effect of early intensive multifactorial therapy on 5- year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITIONEurope): A cluster-randomised trial. Lancet 378: 156-167. S0140-6736(11)60698-3 [pii];. doi:10.1016/S0140-6736(11)60698-3 PMID: 21705063.
7. Rasmussen SS, Glumer C, Sandbaek A, Lauritzen T, Borch-Johnsen K (2008) General effect on highrisk persons when general practitioners are trained in intensive treatment of type 2 diabetes. Scand J Prim Health Care 26: 166-173. 795457059 [pii];. doi:10.1080/02813430802264624 PMID: 18677673.
8. Sibley JC, Sackett DL, Neufeld V, Gerrard B, Rudnick KV, Fraser W(1982) A randomized trial of continuing medical education. N Engl J Med 306: 511-515. doi:10.1056/NEJM198203043060904 PMID: 7057858.
9. Charles M, Ejskjaer N, Witte DR, Borch-Johnsen K, Lauritzen T, Sandbaek A (2011) Prevalence of Neuropathy and Peripheral Arterial Disease and the Impact of Treatment in People With Screen-Detected Type 2 Diabetes: The ADDITION-Denmark study. Diabetes Care 34: 2244-2249. dc11-0903 [pii];. doi:10.2337/dc11-0903PMID: 21816977.
10. Royal College of General practitioners in Denmark (1999) Type 2 diabetes in general practice Diagnosis and treatment.
11. Royal College of General practitioners in Denmark. (2004) Type 2 diabetes in general practice An evidence based guideline.
12. Kildemoes HW, Sorensen HT, Hallas J (2011) The Danish National Prescription Registry. Scand J Public Health 39: 38-41. 39/7-suppl/38 [pii];. doi:10.1177/1403494810394717 PMID: 21775349.
13. Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 40: 373-383. PMID: 3558716.
14. Tricco AC, Ivers NM, Grimshaw JM, Moher D, Turner L, Galipeau J, Halperin I, Vachon B, Ramsay T, Manns B, Tonelli M, Shojania K (2012) Effectiveness of quality improvement strategies on the management of diabetes: A systematic review and meta-Analysis. Lancet 379: 2252-2261. S0140-6736(12) 60480-2 [pii];. doi:10.1016/S0140-6736(12)60480-2 PMID: 22683130.
15. Lauritzen T, Sandbaek A, Carlsen AH, Borch-Johnsen K (2012) All-cause mortality and pharmacological treatment intensity following a high risk screening program for diabetes. A 6.6 year follow-up of the ADDITION study, Denmark. Prim Care Diabetes 6: 193-200. S1751-9918(12)00047-2 [pii];. doi:10.1016/j.pcd.2012.04.005 PMID: 22595031.
16. Green A, Sortso C, Jensen PB, Emneus M (2015) Validation of the danish national diabetes register. Clin Epidemiol 7: 5-15. clep-7-005 [pii]. doi:10.2147/CLEP.S72768 PMID: 25565889.